KEGG   PATHWAY: cjc05213
Entry
cjc05213                    Pathway                                

Name
Endometrial cancer - Callithrix jacchus (white-tufted-ear marmoset)
Description
Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification.
Class
Human Diseases; Cancer: specific types
Pathway map
cjc05213  Endometrial cancer
cjc05213

Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100388651  EGF; epidermal growth factor [KO:K04357]
100412158  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
100403494  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
100391655  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
100398849  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
100406689  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
100392639  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
100414659  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
100393460  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100389944  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
100406751  ILK; integrin linked kinase [KO:K06272] [EC:2.7.11.1]
100404447  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
100399039  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
100388080  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
100409028  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
100412880  BAD; BCL2 associated agonist of cell death [KO:K02158]
100406446  FOXO3; forkhead box O3 [KO:K09408]
100395682  GRB2; growth factor receptor bound protein 2 [KO:K04364]
100414931  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
100410124  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
100406017  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
100414782  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
100387961  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
100403091  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
100415300  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
100387394  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100393991  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100400700  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100404815  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100393766  ELK1; ELK1, ETS transcription factor [KO:K04375]
100406787  MLH1; mutL homolog 1 [KO:K08734]
100398679  CDH1; cadherin 1 [KO:K05689]
100395047  CTNNB1; catenin beta 1 [KO:K02105]
100390556  CTNNA2; catenin alpha 2 [KO:K05691]
100396596  CTNNA3; catenin alpha 3 [KO:K05691]
100407624  CTNNA1; catenin alpha 1 [KO:K05691]
100392475  AXIN1; axin 1 [KO:K02157]
100400518  AXIN2; axin 2 [KO:K04385]
100397972  APC2; APC2, WNT signaling pathway regulator [KO:K02085]
100385653  APC; APC, WNT signaling pathway regulator [KO:K02085]
100387683  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
100399154  TCF7; transcription factor 7 (T-cell specific, HMG-box) [KO:K02620]
100385633  transcription factor 7-like 1 [KO:K04490]
100406757  TCF7L2; transcription factor 7 like 2 [KO:K04491]
100399759  LEF1; lymphoid enhancer binding factor 1 [KO:K04492]
100407754  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
100399312  G1/S-specific cyclin-D1-like [KO:K04503]
100415710  TP53; tumor protein p53 [KO:K04451]
100894215  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
100412572  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
100405303  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
100394399  GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
100391322  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
100387945  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
100390419  DDB2; damage specific DNA binding protein 2 [KO:K10140]
100403269  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
100391332  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Related
pathway
cjc04010  MAPK signaling pathway
cjc04012  ErbB signaling pathway
cjc04060  Cytokine-cytokine receptor interaction
cjc04110  Cell cycle
cjc04115  p53 signaling pathway
cjc04151  PI3K-Akt signaling pathway
cjc04310  Wnt signaling pathway
cjc04520  Adherens junction
KO pathway
ko05213   
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