KEGG   PATHWAY: cjc05213
Entry
cjc05213                    Pathway                                
Name
Endometrial cancer - Callithrix jacchus (white-tufted-ear marmoset)
Description
Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification.
Class
Human Diseases; Cancer: specific types
Pathway map
cjc05213  Endometrial cancer
cjc05213

Disease
H00026  Endometrial cancer
Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100385653  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
100387394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100387683  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100387945  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
100387961  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
100388080  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100388651  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100389944  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X4 [KO:K06276] [EC:2.7.11.1]
100390419  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
100390556  CTNNA2; catenin alpha-2 isoform X6 [KO:K05691]
100391322  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100391332  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100391655  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100392475  AXIN1; axin-1 isoform X1 [KO:K02157]
100392639  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100393460  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100393766  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100393991  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100394399  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
100395047  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
100395682  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100396596  CTNNA3; catenin alpha-3 isoform X1 [KO:K05691]
100397972  APC2; adenomatous polyposis coli protein 2 isoform X2 [KO:K02085]
100398679  CDH1; cadherin-1 [KO:K05689]
100398849  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100399039  AKT3; RAC-gamma serine/threonine-protein kinase isoform X6 [KO:K04456] [EC:2.7.11.1]
100399154  TCF7; transcription factor 7 isoform X2 [KO:K02620]
100399759  LEF1; lymphoid enhancer-binding factor 1 isoform X5 [KO:K04492]
100400518  AXIN2; axin-2 isoform X1 [KO:K04385]
100400700  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100403091  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100403269  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
100403494  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100403963  TCF7L1; transcription factor 7-like 1 isoform X2 [KO:K04490]
100404447  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100404815  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100405303  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100406017  HRAS; GTPase HRas [KO:K02833]
100406446  FOXO3; LOW QUALITY PROTEIN: forkhead box protein O3 [KO:K09408]
100406689  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100406751  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
100406757  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
100406787  MLH1; DNA mismatch repair protein Mlh1 isoform X2 [KO:K08734]
100407624  CTNNA1; catenin alpha-1 isoform X2 [KO:K05691]
100407754  MYC; myc proto-oncogene protein [KO:K04377]
100409028  CASP9; caspase-9 isoform X3 [KO:K04399] [EC:3.4.22.62]
100410124  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100412158  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100412572  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100412880  BAD; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
100414659  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100414782  NRAS; GTPase NRas isoform X2 [KO:K07828]
100414931  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100415300  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100415710  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100894215  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
103796419  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108591807  [KO:K07828]
118144179  KRAS; GTPase KRas isoform X2 [KO:K07827]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Related
pathway
cjc04010  MAPK signaling pathway
cjc04012  ErbB signaling pathway
cjc04060  Cytokine-cytokine receptor interaction
cjc04110  Cell cycle
cjc04115  p53 signaling pathway
cjc04151  PI3K-Akt signaling pathway
cjc04310  Wnt signaling pathway
cjc04520  Adherens junction
KO pathway
ko05213   

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