Entry
Name
MAPK signaling pathway - Callithrix jacchus (white-tufted-ear marmoset)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Other DBs
Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:
cjc ]
Gene
100385367 DDIT3; DNA damage-inducible transcript 3 protein isoform X3 [KO:K04452 ]
100385605 CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X2 [KO:K04858 ]
100385627 MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436 ]
100386041 CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853 ]
100386452 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X5 [KO:K04348 ] [EC:3.1.3.16 ]
100387059 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348 ] [EC:3.1.3.16 ]
100387356 CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X4 [KO:K04862 ]
100387912 GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346 ]
100388628 PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386 ]
100388886 RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X19 [KO:K08018 ]
100389629 VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448 ]
100390087 CACNG2; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-2 subunit [KO:K04867 ]
100390112 CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857 ]
100390442 CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849 ]
100390586 TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376 ]
100390599 CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344 ]
100391798 ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405 ]
100392193 ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
100392306 NGFR; tumor necrosis factor receptor superfamily member 16 isoform X2 [KO:K02583 ]
100392463 TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377 ]
100392625 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
100392818 NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X2 [KO:K04465 ]
100393056 CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865 ]
100394399 GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402 ]
100394978 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
100395294 VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449 ]
100395882 NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469 ]
100396640 GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347 ]
100397418 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
100397803 FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
100397940 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X11 [KO:K04851 ]
100398831 CACNG7; voltage-dependent calcium channel gamma-7 subunit isoform X2 [KO:K04872 ]
100398947 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
100399193 CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873 ]
100400081 VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858 ]
100400467 CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X9 [KO:K04860 ]
100400756 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
100401347 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X3 [KO:K03171 ]
100401632 CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856 ]
100401979 TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375 ]
100402073 RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326 ]
100404109 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
100404291 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
100404392 CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871 ]
100404808 MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434 ]
100404850 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
100405187 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446 ]
100405197 MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435 ]
100405303 GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
100406548 CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852 ]
100406735 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X36 [KO:K04850 ]
100406801 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
100407908 VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449 ]
100408470 CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X3 [KO:K04859 ]
100408935 CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X6 [KO:K04855 ]
100409999 CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861 ]
100410499 CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868 ]
100410704 CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863 ]
100411269 FLT3LG; fms-related tyrosine kinase 3 ligand isoform X11 [KO:K05454 ]
100412572 GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
100412906 PDGFA; platelet-derived growth factor subunit A isoform X4 [KO:K04359 ]
100413151 MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729 ]
100413265 MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454 ]
100413467 RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349 ]
100413758 GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452 ]
100413785 CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866 ]
100414129 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
100414144 CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869 ]
100414156 ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450 ]
100415104 CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X10 [KO:K04854 ]
100415321 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
100415618 CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X3 [KO:K04864 ]
103793342 CACNG5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
Title
MAP kinases.
Journal
Reference
Authors
Tanoue T, Nishida E.
Title
Docking interactions in the mitogen-activated protein kinase cascades.
Journal
Reference
Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
Title
MAPK pathways in radiation responses.
Journal
Reference
Authors
Huang EJ, Reichardt LF.
Title
Trk receptors: roles in neuronal signal transduction.
Journal
Reference
Authors
Harper SJ, LoGrasso P.
Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
Journal
Reference
Authors
Takeda K, Ichijo H
Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
Journal
Reference
Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
Title
Transcriptional regulation by the MAP kinase signaling cascades.
Journal
Reference
Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
Journal
Reference
Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
Journal
Reference
Authors
Lemmon MA, Schlessinger J
Title
Cell signaling by receptor tyrosine kinases.
Journal
Reference
Authors
Skaper SD
Title
The neurotrophin family of neurotrophic factors: an overview.
Journal
Reference
Authors
Chu WM
Title
Tumor necrosis factor.
Journal
Reference
Authors
Newton K, Dixit VM
Title
Signaling in innate immunity and inflammation.
Journal
Reference
Authors
Gaestel M, Kotlyarov A, Kracht M
Title
Targeting innate immunity protein kinase signalling in inflammation.
Journal
Reference
Authors
Ajibade AA, Wang HY, Wang RF
Title
Cell type-specific function of TAK1 in innate immune signaling.
Journal
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Related pathway
cjc04070 Phosphatidylinositol signaling system
KO pathway