KEGG   PATHWAY: cjc04010
Entry
cjc04010                    Pathway                                
Name
MAPK signaling pathway - Callithrix jacchus (white-tufted-ear marmoset)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
cjc04010  MAPK signaling pathway
cjc04010

Other DBs
GO: 0000165
Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100385107  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X2 [KO:K04415] [EC:2.7.11.25]
100385131  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
100385221  FLNA; filamin-A isoform X1 [KO:K04437]
100385367  DDIT3; DNA damage-inducible transcript 3 protein isoform X3 [KO:K04452]
100385378  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
100385605  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X2 [KO:K04858]
100385627  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
100385862  FGF20; fibroblast growth factor 20 [KO:K04358]
100385966  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
100386041  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100386071  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
100386168  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
100386369  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
100386452  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X5 [KO:K04348] [EC:3.1.3.16]
100386568  PGF; placenta growth factor isoform X1 [KO:K16859]
100386626  [KO:K07830]
100386978  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100387059  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
100387090  SRF; serum response factor isoform X1 [KO:K04378]
100387113  ARRB2; beta-arrestin-2 [KO:K04439]
100387312  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100387356  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X4 [KO:K04862]
100387394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100387570  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
100387686  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100387692  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
100387695  FGF10; fibroblast growth factor 10 [KO:K04358]
100387775  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
100387912  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
100387931  AREG; amphiregulin [KO:K09782]
100387961  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
100388080  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100388148  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100388282  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100388404  FLT4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
100388493  RELA; transcription factor p65 isoform X1 [KO:K04735]
100388524  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
100388550  FGF16; fibroblast growth factor 16 [KO:K04358]
100388584  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100388628  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
100388651  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100388886  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X19 [KO:K08018]
100388984  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
100389089  MAX; protein max isoform X1 [KO:K04453]
100389500  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
100389596  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
100389629  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
100389716  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X24 [KO:K04407] [EC:2.7.11.1]
100389824  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
100389852  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100389889  FGF21; fibroblast growth factor 21 [KO:K22429]
100390054  FOS; protein c-Fos [KO:K04379]
100390087  CACNG2; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
100390109  MAPK10; mitogen-activated protein kinase 10 isoform X7 [KO:K04440] [EC:2.7.11.24]
100390112  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
100390192  FGFR1; fibroblast growth factor receptor 1 isoform X5 [KO:K04362] [EC:2.7.10.1]
100390206  CRKL; crk-like protein [KO:K04438]
100390258  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100390332  MRAS; ras-related protein M-Ras isoform X2 [KO:K07831]
100390442  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
100390531  FGF6; fibroblast growth factor 6 [KO:K04358]
100390586  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
100390599  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
100390905  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
100391332  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100391709  PLA2G4F; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
100391798  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
100391814  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100391837  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
100392014  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
100392049  NTF4; neurotrophin-4 [KO:K12457]
100392123  PRKACG; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
100392193  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100392306  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X2 [KO:K02583]
100392463  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
100392547  NF1; neurofibromin isoform X10 [KO:K08052]
100392625  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
100392707  FGF23; fibroblast growth factor 23 [KO:K22428]
100392721  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100392792  FGF9; fibroblast growth factor 9 [KO:K04358]
100392818  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X2 [KO:K04465]
100392970  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100392986  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100393010  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
100393056  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
100393089  INS; insulin [KO:K04526]
100393096  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
100393148  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
100393183  RAP1A; ras-related protein Rap-1A [KO:K04353]
100393258  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
100393573  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
100393730  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
100393753  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
100393766  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100393815  IGF2; insulin-like growth factor II isoform X2 [KO:K13769]
100393945  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
100393991  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100394399  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
100394813  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
100394978  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100394985  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
100395201  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
100395249  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X7 [KO:K04463] [EC:2.7.12.2]
100395294  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
100395364  TRAF6; TNF receptor-associated factor 6 isoform X2 [KO:K03175] [EC:2.3.2.27]
100395416  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
100395636  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100395682  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100395753  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
100395773  EFNA1; ephrin-A1 [KO:K05462]
100395802  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
100395882  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
100395962  NTF3; neurotrophin-3 isoform X2 [KO:K04356]
100396146  EFNA2; ephrin-A2 [KO:K05462]
100396611  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100396640  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100396700  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
100396743  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
100396967  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100397389  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X3 [KO:K04433] [EC:2.7.12.2]
100397418  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
100397484  TNF; tumor necrosis factor [KO:K03156]
100397495  ANGPT4; angiopoietin-4 [KO:K05467]
100397803  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
100397940  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X11 [KO:K04851]
100398033  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100398593  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
100398595  [KO:K04358]
100398831  CACNG7; voltage-dependent calcium channel gamma-7 subunit isoform X2 [KO:K04872]
100398947  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
100398974  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
100399039  AKT3; RAC-gamma serine/threonine-protein kinase isoform X6 [KO:K04456] [EC:2.7.11.1]
100399193  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
100399230  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100399761  EREG; proepiregulin isoform X2 [KO:K09784]
100399784  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
100399916  CRK; adapter molecule crk isoform X1 [KO:K04438]
100400023  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
100400081  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
100400411  JUN; transcription factor Jun [KO:K04448]
100400467  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X9 [KO:K04860]
100400537  [KO:K07830]
100400700  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100400737  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100400756  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100400789  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
100401112  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
100401154  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100401218  DAXX; death domain-associated protein 6 [KO:K02308]
100401286  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
100401347  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X3 [KO:K03171]
100401384  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
100401632  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
100401759  STMN1; stathmin isoform X2 [KO:K04381]
100401797  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100401809  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
100401979  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
100402073  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
100402439  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
100402660  FGF18; fibroblast growth factor 18 isoform X2 [KO:K04358]
100402888  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
100402923  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
100402965  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
100402978  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X3 [KO:K04733] [EC:2.7.11.1]
100403091  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100403175  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100403309  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
100403400  INSR; insulin receptor isoform X4 [KO:K04527] [EC:2.7.10.1]
100403406  RELB; transcription factor RelB isoform X1 [KO:K09253]
100403409  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
100403596  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
100403846  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100403987  MECOM; histone-lysine N-methyltransferase MECOM isoform X2 [KO:K04462] [EC:2.1.1.367]
100404028  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
100404102  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
100404109  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100404150  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
100404226  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100404291  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100404359  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
100404377  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100404392  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
100404447  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100404686  ANGPT2; angiopoietin-2 isoform X2 [KO:K05466]
100404740  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
100404784  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X5 [KO:K04425] [EC:2.7.11.25]
100404808  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
100404815  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100404850  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100404965  [KO:K04381]
100405093  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100405174  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
100405187  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
100405197  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
100405303  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100405518  PPM1A; protein phosphatase 1A isoform X2 [KO:K04457] [EC:3.1.3.16]
100405552  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100405886  FGF7; fibroblast growth factor 7 [KO:K04358]
100406017  HRAS; GTPase HRas [KO:K02833]
100406047  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
100406069  [KO:K03283]
100406322  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X2 [KO:K04426] [EC:2.7.11.25]
100406325  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
100406401  IL1A; interleukin-1 alpha [KO:K04383]
100406548  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
100406711  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
100406735  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X36 [KO:K04850]
100406769  IL1B; interleukin-1 beta isoform X1 [KO:K04519]
100406801  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100406940  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
100407045  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
100407165  HSPA1B; heat shock 70 kDa protein 1B [KO:K03283]
100407189  RPS6KA6; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
100407296  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
100407692  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100407754  MYC; myc proto-oncogene protein [KO:K04377]
100407908  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
100407933  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
100407935  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
100408063  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
100408115  [KO:K04345] [EC:2.7.11.11]
100408221  HSPB1; heat shock protein beta-1 [KO:K04455]
100408399  IGF1R; insulin-like growth factor 1 receptor isoform X3 [KO:K05087] [EC:2.7.10.1]
100408421  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
100408470  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X3 [KO:K04859]
100408551  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
100408788  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
100408935  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X6 [KO:K04855]
100409110  NRTN; neurturin [KO:K25414]
100409206  [KO:K04345] [EC:2.7.11.11]
100409412  BDNF; brain-derived neurotrophic factor isoform X2 [KO:K04355]
100409540  FGF4; fibroblast growth factor 4 [KO:K04358]
100409549  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100409608  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
100409758  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100409879  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
100409938  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100409999  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
100410124  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100410136  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100410253  FGF3; fibroblast growth factor 3 [KO:K04358]
100410499  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
100410636  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X2 [KO:K04444] [EC:2.7.11.1]
100410704  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
100410844  KITLG; kit ligand isoform X1 [KO:K05461]
100411269  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X11 [KO:K05454]
100411494  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
100411575  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100411615  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
100411763  [KO:K07836]
100411854  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
100411926  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
100412158  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100412331  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
100412389  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X2 [KO:K04442] [EC:2.7.11.1]
100412449  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
100412572  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100412817  PSPN; persephin [KO:K25416]
100412906  PDGFA; platelet-derived growth factor subunit A isoform X4 [KO:K04359]
100412930  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100412970  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
100413091  ARTN; artemin isoform X1 [KO:K25415]
100413151  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
100413220  RAP1B; ras-related protein Rap-1b [KO:K07836]
100413265  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
100413316  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
100413467  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
100413660  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X3 [KO:K04428] [EC:2.7.11.25]
100413680  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100413758  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
100413772  RRAS; ras-related protein R-Ras [KO:K07829]
100413785  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
100413870  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
100413973  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
100413985  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
100414129  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100414144  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
100414156  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
100414273  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
100414348  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
100414371  FGF22; fibroblast growth factor 22 isoform X3 [KO:K04358]
100414496  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
100414782  NRAS; GTPase NRas isoform X2 [KO:K07828]
100414864  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
100414931  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100415104  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X10 [KO:K04854]
100415187  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
100415300  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100415321  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100415618  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X3 [KO:K04864]
100415710  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100895294  [KO:K04392]
100895453  CD14; monocyte differentiation antigen CD14 [KO:K04391]
100896269  RASGRP2; RAS guanyl-releasing protein 2 isoform X2 [KO:K12361]
103789024  NTRK1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
103789824  JUND; transcription factor JunD [KO:K04449]
103789934  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
103790554  [KO:K05461]
103793292  [KO:K04453]
103793342  CACNG5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
103793489  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
103793637  [KO:K04381]
103794361  [KO:K04452]
108591807  [KO:K07828]
118142760  PLA2G4B; cytosolic phospholipase A2 beta isoform X6 [KO:K16342] [EC:3.1.1.4]
118144179  KRAS; GTPase KRas isoform X2 [KO:K07827]
118151333  [KO:K04345] [EC:2.7.11.11]
118152209  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
128929001  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
128929061  FGF19; fibroblast growth factor 19 [KO:K22603]
128931276  [KO:K07830]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
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Reference
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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Reference
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
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Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
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Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
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Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
cjc04070  Phosphatidylinositol signaling system
cjc04110  Cell cycle
cjc04115  p53 signaling pathway
cjc04210  Apoptosis
cjc04310  Wnt signaling pathway
cjc04668  TNF signaling pathway
KO pathway
ko04010   

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