Entry
Name
Cytokine-cytokine receptor interaction - Callithrix jacchus (white-tufted-ear marmoset)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
cjc04060 Cytokine-cytokine receptor interaction
Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:
cjc ]
Gene
100385465 TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145 ]
100385636 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
100385800 CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160 ]
100386159 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
100386273 TNFRSF21; tumor necrosis factor receptor superfamily member 21 isoform X1 [KO:K05157 ]
100386513 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
100387176 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162 ]
100387833 IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077 ]
100388189 IL2RG; cytokine receptor common subunit gamma precursor [KO:K05070 ]
100388286 OSMR; oncostatin-M-specific receptor subunit beta isoform X2 [KO:K05057 ]
100388927 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X2 [KO:K05151 ]
100390586 TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376 ]
100390883 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
100392178 CXCR3; LOW QUALITY PROTEIN: C-X-C chemokine receptor type 3 [KO:K04188 ]
100392306 NGFR; tumor necrosis factor receptor superfamily member 16 isoform X2 [KO:K02583 ]
100392463 TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377 ]
100392625 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
100392660 IL20RA; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136 ]
100393434 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
100393477 CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738 ]
100393522 TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155 ]
100393582 IL1R2; LOW QUALITY PROTEIN: interleukin-1 receptor type 2 [KO:K04387 ]
100393710 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147 ]
100394148 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141 ]
100394149 IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138 ]
100394434 CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059 ]
100394581 IL27RA; interleukin-27 receptor subunit alpha isoform X2 [KO:K19598 ]
100394922 IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137 ]
100394933 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
100395019 IL18RAP; LOW QUALITY PROTEIN: interleukin-18 receptor accessory protein [KO:K05174 ]
100395977 TNFRSF10A; tumor necrosis factor receptor superfamily member 10A isoform X1 [KO:K04722 ]
100396000 TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721 ]
100397314 TNFRSF17; tumor necrosis factor receptor superfamily member 17 isoform X3 [KO:K05153 ]
100397418 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
100397442 TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X2 [KO:K04722 ]
100397720 IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072 ]
100397803 FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
100399291 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063 ]
100399491 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
100399751 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
100400510 EDA2R; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
100401379 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
100401524 LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159 ]
100401979 TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375 ]
100403077 TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152 ]
100403465 RELT; tumor necrosis factor receptor superfamily member 19L isoform X2 [KO:K05156 ]
100403729 IL27; LOW QUALITY PROTEIN: interleukin-27 subunit alpha [KO:K22629 ]
100404122 TNFSF18; tumor necrosis factor ligand superfamily member 18 isoform X2 [KO:K05479 ]
100404682 CLCF1; cardiotrophin-like cytokine factor 1 isoform X2 [KO:K05421 ]
100404850 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
100407686 TNFRSF18; tumor necrosis factor receptor superfamily member 18 precursor [KO:K05154 ]
100408049 TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X2 [KO:K05142 ]
100408545 CSF3; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor [KO:K05423 ]
100408746 TNFRSF13B; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
100408838 IL17RC; LOW QUALITY PROTEIN: interleukin-17 receptor C [KO:K05166 ]
100410164 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
100412016 IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068 ]
100412419 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
100412493 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
100413719 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
100413804 IL15RA; LOW QUALITY PROTEIN: interleukin-15 receptor subunit alpha [KO:K05074 ]
100413917 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066 ]
100414216 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
100414222 IL5RA; interleukin-5 receptor subunit alpha precursor [KO:K05067 ]
100551509 TNFSF12; tumor necrosis factor ligand superfamily member 12 isoform 2 [KO:K05474 ]
100551510 TNFSF13; tumor necrosis factor ligand superfamily member 13 [KO:K05475 ]
100894787 IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
118150911 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway