KEGG   PATHWAY: cjc04110
Entry
cjc04110                    Pathway                                
Name
Cell cycle - Callithrix jacchus (white-tufted-ear marmoset)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
cjc04110  Cell cycle
cjc04110

Other DBs
GO: 0000278
Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100384907  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
100385458  [KO:K02606]
100385604  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
100385855  CDKN1C; cyclin-dependent kinase inhibitor 1C [KO:K09993]
100385889  MCM2; DNA replication licensing factor MCM2 isoform X1 [KO:K02540] [EC:5.6.2.3]
100387342  FBXO5; F-box only protein 5 [KO:K10292]
100387508  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100387683  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100387754  [KO:K09392]
100387893  CDC14B; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
100387914  CDC25C; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
100388085  [KO:K05868]
100388213  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B isoform X2 [KO:K13728]
100388293  CCNA2; cyclin-A2 [KO:K06627]
100388665  CDT1; DNA replication factor Cdt1 isoform X1 [KO:K10727]
100388842  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
100389263  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
100389280  ATRX; LOW QUALITY PROTEIN: transcriptional regulator ATRX [KO:K10779]
100389293  MAU2; MAU2 chromatid cohesion factor homolog isoform X2 [KO:K11266]
100389422  [KO:K13728]
100389970  CDK7; cyclin-dependent kinase 7 isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
100390011  [KO:K06630]
100390145  PDS5B; sister chromatid cohesion protein PDS5 homolog B isoform X5 [KO:K11267]
100390172  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100390235  E2F3; transcription factor E2F3 isoform X4 [KO:K06620]
100390333  SGO1; shugoshin 1 isoform X1 [KO:K11580]
100390586  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
100390703  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
100391291  CCNB1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
100391401  CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
100391523  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
100391611  DDX11; ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:3.6.4.13]
100392283  ORC6; origin recognition complex subunit 6 isoform X1 [KO:K02608]
100392291  ORC3; origin recognition complex subunit 3 isoform X1 [KO:K02605]
100392363  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
100392463  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
100392614  BUB3; mitotic checkpoint protein BUB3 isoform X2 [KO:K02180]
100392689  ORC2; origin recognition complex subunit 2 isoform X1 [KO:K02604]
100392894  MAD2L1BP; MAD2L1-binding protein isoform X1 [KO:K26093]
100393051  CCNA1; cyclin-A1 isoform X2 [KO:K06627]
100393248  SKP2; S-phase kinase-associated protein 2 isoform X2 [KO:K03875]
100393360  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
100393780  [KO:K02209] [EC:5.6.2.3]
100393808  SMAD3; mothers against decapentaplegic homolog 3 isoform X2 [KO:K23605]
100394189  CDKN2A; cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
100394273  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
100394399  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
100394742  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
100395201  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
100395261  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100395278  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
100395555  [KO:K02541] [EC:5.6.2.3]
100395702  CUL1; cullin-1 [KO:K03347]
100395956  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
100396002  STAG1; cohesin subunit SA-1 isoform X1 [KO:K06671]
100396126  TRIP13; pachytene checkpoint protein 2 homolog isoform X1 [KO:K22399]
100396301  [KO:K06643] [EC:2.3.2.27]
100396428  DBF4; protein DBF4 homolog A isoform X1 [KO:K06629]
100396463  ESCO1; N-acetyltransferase ESCO1 isoform X1 [KO:K11268] [EC:2.3.1.-]
100396487  E2F5; transcription factor E2F5 isoform X1 [KO:K04682]
100396520  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
100396535  HDAC8; LOW QUALITY PROTEIN: histone deacetylase 8 [KO:K11405] [EC:3.5.1.98]
100396826  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
100396829  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
100397870  DBF4B; protein DBF4 homolog B isoform X2 [KO:K06629]
100397928  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
100398044  ANAPC16; anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
100398187  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
100398414  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
100398450  MCM3; DNA replication licensing factor MCM3 isoform X2 [KO:K02541] [EC:5.6.2.3]
100398482  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
100398488  WEE2; wee1-like protein kinase 2 isoform X1 [KO:K06632] [EC:2.7.11.1]
100398536  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100398703  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100398789  PTTG1; securin isoform X1 [KO:K06635]
100399020  PRKDC; DNA-dependent protein kinase catalytic subunit isoform X1 [KO:K06642] [EC:2.7.11.1]
100399467  ANAPC7; anaphase-promoting complex subunit 7 isoform X2 [KO:K03354]
100399490  AURKB; aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
100399690  HDAC1; histone deacetylase 1 isoform X2 [KO:K06067] [EC:3.5.1.98]
100399985  MCM4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
100400280  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
100401193  MCM7; DNA replication licensing factor MCM7 isoform X1 [KO:K02210] [EC:5.6.2.3]
100401228  [KO:K06067] [EC:3.5.1.98]
100401232  PCNA; proliferating cell nuclear antigen [KO:K04802]
100401430  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
100401456  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
100401852  TTK; dual specificity protein kinase TTK isoform X1 [KO:K08866] [EC:2.7.12.1]
100401979  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
100402111  SMC1A; structural maintenance of chromosomes protein 1A [KO:K06636]
100402129  CDC7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
100402327  HDAC2; LOW QUALITY PROTEIN: histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100402387  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
100402417  YWHAH; 14-3-3 protein eta [KO:K16198]
100402949  STAG2; cohesin subunit SA-2 isoform X1 [KO:K06671]
100403019  MTBP; mdm2-binding protein isoform X1 [KO:K26116]
100403502  CDC23; cell division cycle protein 23 homolog isoform X1 [KO:K03355]
100403750  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100403983  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X7 [KO:K06679]
100403994  NIPBL; nipped-B-like protein isoform X1 [KO:K06672]
100404181  ORC5; origin recognition complex subunit 5 isoform X2 [KO:K02607]
100404434  ESPL1; separin [KO:K02365] [EC:3.4.22.49]
100404485  RAD21; double-strand-break repair protein rad21 homolog [KO:K06670]
100404610  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
100404949  CHEK2; serine/threonine-protein kinase Chk2 isoform X5 [KO:K06641] [EC:2.7.11.1]
100405037  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
100405303  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100405400  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
100405784  YWHAQ; 14-3-3 protein theta [KO:K16197]
100405841  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
100407360  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
100407451  ORC1; origin recognition complex subunit 1 isoform X1 [KO:K02603]
100407754  MYC; myc proto-oncogene protein [KO:K04377]
100408175  CDC20; cell division cycle protein 20 homolog [KO:K03363]
100408201  [KO:K25163]
100408249  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100408285  MCM6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
100408304  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100408321  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100408606  ANAPC4; anaphase-promoting complex subunit 4 isoform X2 [KO:K03351]
100408657  SFN; 14-3-3 protein sigma [KO:K06644]
100408674  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3 [KO:K03456]
100408751  [KO:K16197]
100408832  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
100408839  YWHAG; 14-3-3 protein gamma [KO:K16198]
100409054  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
100409302  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
100409415  CDCA5; sororin isoform X3 [KO:K17390]
100409434  CDC45; cell division control protein 45 homolog isoform X1 [KO:K06628]
100410298  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
100410315  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
100410450  CDC6; LOW QUALITY PROTEIN: cell division control protein 6 homolog [KO:K02213]
100410795  CDKN2D; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
100411134  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
100411457  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X3 [KO:K06633] [EC:2.7.11.1]
100411712  SMC1B; structural maintenance of chromosomes protein 1B isoform X2 [KO:K06636]
100411858  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
100411935  SMC3; structural maintenance of chromosomes protein 3 [KO:K06669]
100412101  PDS5A; sister chromatid cohesion protein PDS5 homolog A isoform X1 [KO:K11267]
100412175  ANAPC15; anaphase-promoting complex subunit 15 [KO:K25228]
100412321  ATR; serine/threonine-protein kinase ATR isoform X4 [KO:K06640] [EC:2.7.11.1]
100412512  KNL1; kinetochore scaffold 1 isoform X3 [KO:K11542]
100412572  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100413185  CDC27; cell division cycle protein 27 homolog isoform X3 [KO:K03350]
100413245  TFDP1; transcription factor Dp-1 [KO:K04683]
100413586  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1 [KO:K06637] [EC:2.7.11.1]
100413664  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100413812  CDC14A; dual specificity protein phosphatase CDC14A isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
100413827  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
100413890  E2F4; transcription factor E2F4 isoform X2 [KO:K04682]
100413983  TFDP2; transcription factor Dp-2 isoform X4 [KO:K09392]
100414007  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
100414261  E2F1; transcription factor E2F1 [KO:K17454]
100414520  TICRR; treslin isoform X1 [KO:K26117]
100414523  [KO:K03094]
100414560  WEE1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
100414776  E2F2; transcription factor E2F2 [KO:K09389]
100414837  CCNH; cyclin-H isoform X1 [KO:K06634]
100415024  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
100415056  MCM5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
100415282  NDC80; kinetochore protein NDC80 homolog [KO:K11547]
100415620  [KO:K06643] [EC:2.3.2.27]
100415710  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100894215  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100894534  ESCO2; N-acetyltransferase ESCO2 isoform X1 [KO:K11268] [EC:2.3.1.-]
103792074  PTTG2; LOW QUALITY PROTEIN: securin-2 [KO:K06635]
103793428  [KO:K03358]
103796394  [KO:K03868] [EC:2.3.2.32]
103796419  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108588135  [KO:K12456]
118143745  [KO:K16197]
Reference
PMID:7908906
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Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
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J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
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Welch PJ, Wang JY
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A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
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Cell 75:779-90 (1993)
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Reference
PMID:16936746
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Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
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Oncogene 25:5263-7 (2006)
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Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
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Oncogene 24:2796-809 (2005)
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Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
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Nat Rev Cancer 7:495-507 (2007)
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Reference
PMID:9832503
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  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
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Genes Dev 12:3499-511 (1998)
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Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
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Transcriptional regulation of the cyclin D1 gene at a glance.
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J Cell Sci 121:3853-7 (2008)
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Reference
PMID:10385618
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Sherr CJ, Roberts JM
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CDK inhibitors: positive and negative regulators of G1-phase progression.
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Genes Dev 13:1501-12 (1999)
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PMID:12809600
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Shi Y, Massague J.
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Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
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Cell 113:685-700 (2003)
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Reference
PMID:12925736
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Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
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Proc Natl Acad Sci U S A 100:10231-6 (2003)
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PMID:16212951
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Bond M, Sala-Newby GB, Wu YJ, Newby AC
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Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
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Cardiovasc Res 69:198-206 (2006)
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Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
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Oncogene 24:2899-908 (2005)
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Reference
PMID:11099028
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Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
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Nature 408:307-10 (2000)
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PMID:7973727
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Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
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Science 266:1376-80 (1994)
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PMID:9889196
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Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
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EMBO J 18:396-410 (1999)
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PMID:17018296
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Sheu YJ, Stillman B
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Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
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Mol Cell 24:101-13 (2006)
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Reference
PMID:9029154
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Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
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Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
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Reference
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CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
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Cell Cycle 4:572-7 (2005)
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Reference
PMID:17426725
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Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
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Nat Rev Mol Cell Biol 8:379-93 (2007)
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Reference
PMID:12573239
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  Title
Chromosome cohesion and separation: from men and molecules.
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Curr Biol 13:R104-14 (2003)
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Reference
PMID:15568976
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Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
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Annu Rev Genet 38:203-32 (2004)
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Reference
PMID:9618481
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Moustakas A, Kardassis D
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Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
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Proc Natl Acad Sci U S A 95:6733-8 (1998)
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Reference
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de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
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Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
cjc03030  DNA replication
cjc04010  MAPK signaling pathway
cjc04120  Ubiquitin mediated proteolysis
cjc04210  Apoptosis
KO pathway
ko04110   

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