KEGG   PATHWAY: cjc04115
Entry
cjc04115                    Pathway                                
Name
p53 signaling pathway - Callithrix jacchus (white-tufted-ear marmoset)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
cjc04115  p53 signaling pathway
cjc04115

Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100385528  SERPINE1; plasminogen activator inhibitor 1 isoform X1 [KO:K03982]
100385604  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
100386121  GTSE1; G2 and S phase-expressed protein 1 [KO:K10129]
100387033  ZNF385A; zinc finger protein 385A isoform X1 [KO:K26543]
100387570  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
100387604  BBC3; LOW QUALITY PROTEIN: bcl-2-binding component 3 [KO:K10132]
100388085  [KO:K05868]
100388768  ADGRB1; adhesion G protein-coupled receptor B1 isoform X4 [KO:K04596]
100388842  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
100390172  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100390178  THBS1; thrombospondin-1 [KO:K16857]
100390419  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
100390664  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
100391291  CCNB1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
100391322  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100392397  CCNG2; cyclin-G2 [KO:K10146]
100393460  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100393670  TP73; tumor protein p73 isoform X1 [KO:K10148]
100393906  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
100394189  CDKN2A; cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
100394332  COP1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
100394399  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
100394985  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
100395220  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100395977  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A isoform X1 [KO:K04722]
100396301  [KO:K06643] [EC:2.3.2.27]
100396520  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
100397065  [KO:K04722]
100397149  SESN2; sestrin-2 isoform X1 [KO:K20394]
100397231  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
100397442  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X2 [KO:K04722]
100397740  PERP; p53 apoptosis effector related to PMP-22 [KO:K10136]
100397803  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
100397820  TP53I3; quinone oxidoreductase PIG3 isoform X1 [KO:K10133] [EC:1.-.-.-]
100398703  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100398829  PPP1R13L; relA-associated inhibitor isoform X1 [KO:K27356]
100401439  ZMAT3; zinc finger matrin-type protein 3 isoform X2 [KO:K10137]
100401628  STEAP3; metalloreductase STEAP3 isoform X2 [KO:K10142] [EC:1.16.1.-]
100401663  CD82; CD82 antigen [KO:K06509]
100401718  [KO:K08738]
100401846  MDM4; protein Mdm4 isoform X6 [KO:K10127]
100401978  BCL2L1; bcl-2-like protein 1 [KO:K04570]
100402158  PIDD1; p53-induced death domain-containing protein 1 isoform X4 [KO:K10130]
100402387  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
100403350  SIVA1; apoptosis regulatory protein Siva isoform X1 [KO:K22744]
100403496  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
100403750  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100403825  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100403945  EI24; etoposide-induced protein 2.4 homolog isoform X1 [KO:K10134]
100404690  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
100404949  CHEK2; serine/threonine-protein kinase Chk2 isoform X5 [KO:K06641] [EC:2.7.11.1]
100405303  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100405400  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
100406045  CCNG1; cyclin-G1 [KO:K10145]
100406418  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X2 [KO:K10808] [EC:1.17.4.1]
100406761  [KO:K08738]
100406991  SESN3; sestrin-3 isoform X1 [KO:K10141]
100408249  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100408304  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100408321  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100408657  SFN; 14-3-3 protein sigma [KO:K06644]
100408947  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100409028  CASP9; caspase-9 isoform X3 [KO:K04399] [EC:3.4.22.62]
100409431  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
100409665  SERPINB5; serpin B5 [KO:K10139]
100410374  AIFM2; ferroptosis suppressor protein 1 isoform X2 [KO:K22745]
100411159  SESN1; sestrin-1 isoform X2 [KO:K10141]
100411417  RPRM; protein reprimo [KO:K10128]
100411492  GORAB; RAB6-interacting golgin isoform X1 [KO:K19748]
100412069  SHISA5; protein shisa-5 isoform X1 [KO:K10135]
100412321  ATR; serine/threonine-protein kinase ATR isoform X4 [KO:K06640] [EC:2.7.11.1]
100412572  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100412948  PPM1D; protein phosphatase 1D isoform X1 [KO:K10147] [EC:3.1.3.16]
100413276  [KO:K08738]
100413993  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X2 [KO:K10144] [EC:2.3.2.27]
100415620  [KO:K06643] [EC:2.3.2.27]
100415710  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100894215  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
103796419  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108588095  [KO:K08738]
108591932  [KO:K08738]
108591937  [KO:K08738]
108592162  [KO:K08738]
108593648  [KO:K08738]
108593819  [KO:K08738]
108593835  [KO:K08738]
118150617  [KO:K04506] [EC:2.3.2.27]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
cjc04110  Cell cycle
cjc04210  Apoptosis
cjc04218  Cellular senescence
KO pathway
ko04115   

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