KEGG   PATHWAY: arut04520
Entry
arut04520                   Pathway                                
Name
Adherens junction - Acipenser ruthenus (sterlet)
Description
Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
arut04520  Adherens junction
arut04520

Other DBs
GO: 0005912
Organism
Acipenser ruthenus (sterlet) [GN:arut]
Gene
117406536  nectin-1-like [KO:K06081]
117397385  nectin-1-like isoform X1 [KO:K06081]
117966668  nectin-1-like isoform X1 [KO:K06081]
117434013  nectin-1 [KO:K06531]
117964905  nectin-1-like [KO:K06531]
117433224  uncharacterized protein LOC117433224 isoform X1 [KO:K06531]
117407452  nectin-3-like isoform X1 [KO:K06592]
117968547  nectin-4-like [KO:K06593]
117410086  nectin-4 [KO:K06593]
117394603  partitioning defective 3 homolog [KO:K04237]
117399699  partitioning defective 3 homolog [KO:K04237]
117419815  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
117431239  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
117417012  FERM, ARHGEF and pleckstrin domain-containing protein 2-like isoform X1 [KO:K06082]
117423183  farp2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
117424587  cell division control protein 42 homolog [KO:K04393]
117425264  cell division control protein 42 homolog [KO:K04393]
117432225  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
117418183  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
117431016  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
117432597  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117968020  ras-related C3 botulinum toxin substrate 2-like [KO:K07860]
117423588  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
117424197  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
117416259  wasla; WASP like actin nucleation promoting factor a [KO:K23612]
117419683  LOW QUALITY PROTEIN: neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
117412548  neural Wiskott-Aldrich syndrome protein-like [KO:K05747]
117401734  LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein-like [KO:K05747]
117404208  wasb; LOW QUALITY PROTEIN: WASP actin nucleation promoting factor b [KO:K05747]
117963400  wiskott-Aldrich syndrome protein-like [KO:K05747]
117963403  neural Wiskott-Aldrich syndrome protein-like [KO:K05747]
117427590  ras GTPase-activating-like protein IQGAP1 [KO:K16848]
117429953  ras GTPase-activating-like protein IQGAP1 [KO:K16848]
117410082  brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
117969974  brain-specific angiogenesis inhibitor 1-associated protein 2-like [KO:K05627]
117424646  brain-specific angiogenesis inhibitor 1-associated protein 2-like isoform X1 [KO:K05627]
117423383  brain-specific angiogenesis inhibitor 1-associated protein 2-like isoform X1 [KO:K05627]
117411519  LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 1-like [KO:K05753]
117403404  LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 1-like [KO:K05753]
117964057  LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 2-like [KO:K05748]
117414112  wasf2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
117406101  wiskott-Aldrich syndrome protein family member 3-like isoform X1 [KO:K06083]
117407228  wiskott-Aldrich syndrome protein family member 3-like isoform X1 [KO:K06083]
117430258  wiskott-Aldrich syndrome protein family member 3-like isoform X1 [KO:K06083]
117402228  LOW QUALITY PROTEIN: afadin-like [KO:K05702]
117411391  afadin-like isoform X1 [KO:K05702]
117406941  LIM domain only protein 7-like isoform X1 [KO:K06084]
117405356  LOW QUALITY PROTEIN: LIM domain only protein 7-like [KO:K06084]
117416962  afadin- and alpha-actinin-binding protein-like isoform X1 [KO:K06085]
117404975  afadin- and alpha-actinin-binding protein-like [KO:K06085]
117418209  sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
117416038  sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
117415500  alpha-actinin-4 [KO:K05699]
117422225  alpha-actinin-1 [KO:K05699]
117419763  alpha-actinin-1 [KO:K05699]
117418596  vinculin isoform X1 [KO:K05700]
117415756  vinculin-like isoform X2 [KO:K05700]
117429450  tight junction protein ZO-1 isoform X1 [KO:K05701]
117428010  tight junction protein ZO-1-like [KO:K05701]
117425027  B-cadherin-like [KO:K05689]
117424208  LOW QUALITY PROTEIN: B-cadherin-like [KO:K05689]
117435320  catenin beta-1-like isoform X1 [KO:K02105]
117400133  catenin beta-1 [KO:K02105]
117415685  catenin alpha-3-like [KO:K05691]
117413189  ctnna1; catenin alpha-1 [KO:K05691]
117409054  catenin alpha-2 isoform X1 [KO:K05691]
117418301  catenin alpha-3-like [KO:K05691]
117421126  catenin alpha-2-like isoform X1 [KO:K05691]
117424565  actin, cytoplasmic type 5 [KO:K05692]
117418240  actin, cytoplasmic 2 [KO:K05692]
117431529  actb1; actin, cytoplasmic 1 [KO:K05692]
117423427  actin, cytoplasmic type 5 [KO:K05692]
117971333  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
117404314  rho-related GTP-binding protein RhoA-C [KO:K04513]
117429429  rho-related GTP-binding protein RhoA-D [KO:K04513]
117401697  rho-related GTP-binding protein RhoA-C [KO:K04513]
117412320  transforming protein RhoA [KO:K04513]
117962391  rho-related GTP-binding protein RhoA-D [KO:K04513]
117963525  transforming protein RhoA [KO:K04513]
117410592  acp1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
117400192  receptor-type tyrosine-protein phosphatase mu-like isoform X1 [KO:K05693] [EC:3.1.3.48]
117394169  receptor-type tyrosine-protein phosphatase mu-like isoform X1 [KO:K05693] [EC:3.1.3.48]
117415535  LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase beta-like [KO:K05694] [EC:3.1.3.48]
117408471  receptor-type tyrosine-protein phosphatase F-like isoform X1 [KO:K05695] [EC:3.1.3.48]
117417102  receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
117432607  tyrosine-protein phosphatase non-receptor type 1-like isoform X1 [KO:K05696] [EC:3.1.3.48]
117405737  tyrosine-protein phosphatase non-receptor type 1-like isoform X1 [KO:K05696] [EC:3.1.3.48]
117425781  ptpn6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
117435127  receptor-type tyrosine-protein phosphatase eta-like [KO:K05698] [EC:3.1.3.48]
117432266  LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase eta-like [KO:K05698] [EC:3.1.3.48]
117431472  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
117968459  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
117970024  casein kinase II subunit alpha-like isoform X1 [KO:K03097] [EC:2.7.11.1]
117425150  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
117400491  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
117394445  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
117424124  csnk2a2b; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
117971090  casein kinase II subunit beta [KO:K03115]
117433984  casein kinase II subunit beta [KO:K03115]
117431552  lymphoid enhancer-binding factor 1-like isoform X1 [KO:K02620]
117413262  lymphoid enhancer-binding factor 1-like isoform X1 [KO:K02620]
117397962  transcription factor 7-like 1-A isoform X1 [KO:K04490]
117962397  transcription factor 7-like 1-A isoform X1 [KO:K04490]
117418190  transcription factor 7-like 2 isoform X2 [KO:K04491]
117415317  transcription factor 7-like 2 isoform X1 [KO:K04491]
117408361  lymphoid enhancer-binding factor 1-like isoform X1 [KO:K04492]
117420543  lymphoid enhancer-binding factor 1-like isoform X1 [KO:K04492]
117963120  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
117427860  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
117428863  LOW QUALITY PROTEIN: insulin receptor-like [KO:K04527] [EC:2.7.10.1]
117966207  LOW QUALITY PROTEIN: insulin receptor-like [KO:K04527] [EC:2.7.10.1]
117415916  hepatocyte growth factor receptor-like isoform X1 [KO:K05099] [EC:2.7.10.1]
117420109  hepatocyte growth factor receptor-like isoform X2 [KO:K05099] [EC:2.7.10.1]
117400452  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
117971274  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
117433463  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
117434964  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
117397731  fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
117962604  fibroblast growth factor receptor 1-like isoform X1 [KO:K04362] [EC:2.7.10.1]
117973179  tyrosine-protein kinase Fer-like [KO:K08889] [EC:2.7.10.2]
117409278  tyrosine-protein kinase Fer [KO:K08889] [EC:2.7.10.2]
117410990  tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
117403304  tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
117400377  tyrosine-protein kinase Yes [KO:K05705] [EC:2.7.10.2]
117394654  tyrosine-protein kinase Yes-like [KO:K05705] [EC:2.7.10.2]
117973328  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117398123  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117426782  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117399868  zinc finger protein SNAI2-like [KO:K05706]
117394250  zinc finger protein SNAI2 [KO:K05706]
117425375  LOW QUALITY PROTEIN: protein snail homolog Sna-like [KO:K05707]
117964515  protein snail homolog Sna-like [KO:K05707]
117400416  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
117394350  TGF-beta receptor type-1-like isoform X1 [KO:K04674] [EC:2.7.11.30]
117426292  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
117400383  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
117394619  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
117428208  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
117429671  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
117968709  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
117962470  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
117409333  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
117421209  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
117395592  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
117432515  LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
117968047  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
117417994  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
117431768  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
117411069  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117402843  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
117398968  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
117429770  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
117430731  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
117424661  LOW QUALITY PROTEIN: cadherin-5-like [KO:K06533]
117425727  cadherin-5-like [KO:K06533]
117400991  heg1; protein HEG [KO:K24472]
117400520  krev interaction trapped protein 1-like isoform X1 [KO:K17705]
117394756  krev interaction trapped protein 1-like [KO:K17705]
117403101  cerebral cavernous malformations protein 2 homolog isoform X1 [KO:K26416]
117410656  ccm2; cerebral cavernous malformations protein 2 homolog isoform X1 [KO:K26416]
117416712  pdcd10a; programmed cell death protein 10-A [KO:K18269]
117423017  programmed cell death protein 10-like [KO:K18269]
117424634  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
117417617  E3 ubiquitin-protein ligase SMURF1-like isoform X1 [KO:K04678] [EC:2.3.2.26]
117431517  E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
117423487  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
117417594  ras-related protein Rap-1A [KO:K04353]
117431526  ras-related protein Rap-1A [KO:K04353]
117415871  ras-related protein Rap-1b [KO:K07836]
117419830  ras-related protein Rap-1b [KO:K07836]
117424239  ras-associating and dilute domain-containing protein-like [KO:K26418]
117418021  ras-associating and dilute domain-containing protein-like isoform X1 [KO:K26418]
117431512  ras-associating and dilute domain-containing protein-like isoform X1 [KO:K26418]
117423568  LOW QUALITY PROTEIN: ras-associating and dilute domain-containing protein-like [KO:K26418]
117417083  rho GTPase-activating protein 29-like isoform X1 [KO:K20644]
117411829  rho GTPase-activating protein 29-like isoform X1 [KO:K20644]
117400355  rho-associated protein kinase 1-like [KO:K04514] [EC:2.7.11.1]
117394747  rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
117410455  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
117402932  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
117426294  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
117427756  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
117397746  myosin regulatory light chain 2, atrial isoform [KO:K12754]
117966074  myosin regulatory light chain 2, atrial isoform-like [KO:K12754]
117427144  LOW QUALITY PROTEIN: myosin regulatory light polypeptide 9 [KO:K12755]
117431434  myosin regulatory light polypeptide 9 [KO:K12755]
117429842  myosin regulatory light chain 2B, cardiac muscle isoform isoform X1 [KO:K12756]
117962362  myosin regulatory light chain 2B, cardiac muscle isoform-like [KO:K12756]
117399231  myosin regulatory light polypeptide 9 [KO:K12757]
117394724  myosin regulatory light polypeptide 9 [KO:K12757]
117398970  myosin regulatory light chain 2, skeletal muscle isoform type 2-like [KO:K12758]
117398320  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
117411421  myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758]
Reference
PMID:15001769
  Authors
Nelson WJ, Nusse R.
  Title
Convergence of Wnt, beta-catenin, and cadherin pathways.
  Journal
Science 303:1483-7 (2004)
DOI:10.1126/science.1094291
Reference
PMID:10204118
  Authors
Potter E, Bergwitz C, Brabant G.
  Title
The cadherin-catenin system: implications for growth and differentiation of endocrine tissues.
  Journal
Endocr Rev 20:207-39 (1999)
DOI:10.1210/edrv.20.2.0362
Reference
PMID:10959047
  Authors
Beavon IR.
  Title
The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation.
  Journal
Eur J Cancer 36:1607-20 (2000)
DOI:10.1016/S0959-8049(00)00158-1
Reference
PMID:15489912
  Authors
Reynolds AB, Roczniak-Ferguson A.
  Title
Emerging roles for p120-catenin in cell adhesion and cancer.
  Journal
Oncogene 23:7947-56 (2004)
DOI:10.1038/sj.onc.1208161
Reference
PMID:11171368
  Authors
Angst BD, Marcozzi C, Magee AI.
  Title
The cadherin superfamily: diversity in form and function.
  Journal
J Cell Sci 114:629-41 (2001)
Reference
PMID:11984870
  Authors
Lilien J, Balsamo J, Arregui C, Xu G.
  Title
Turn-off, drop-out: functional state switching of cadherins.
  Journal
Dev Dyn 224:18-29 (2002)
DOI:10.1002/dvdy.10087
Reference
PMID:12640114
  Authors
Piedra J, Miravet S, Castano J, Palmer HG, Heisterkamp N, Garcia de Herreros A, Dunach M.
  Title
p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.
  Journal
Mol Cell Biol 23:2287-97 (2003)
DOI:10.1128/MCB.23.7.2287-2297.2003
Reference
PMID:14623871
  Authors
Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P, Ben-Ze'ev A.
  Title
Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK.
  Journal
J Cell Biol 163:847-57 (2003)
DOI:10.1083/jcb.200308162
Reference
PMID:11703922
  Authors
Ciruna B, Rossant J.
  Title
FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak.
  Journal
Dev Cell 1:37-49 (2001)
DOI:10.1016/S1534-5807(01)00017-X
Reference
PMID:12665527
  Authors
Peinado H, Quintanilla M, Cano A.
  Title
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.
  Journal
J Biol Chem 278:21113-23 (2003)
DOI:10.1074/jbc.M211304200
Reference
PMID:10890911
  Authors
Labbe E, Letamendia A, Attisano L.
  Title
Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways.
  Journal
Proc Natl Acad Sci U S A 97:8358-63 (2000)
DOI:10.1073/pnas.150152697
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Related
pathway
arut04010  MAPK signaling pathway
arut04060  Cytokine-cytokine receptor interaction
arut04310  Wnt signaling pathway
arut04350  TGF-beta signaling pathway
arut04530  Tight junction
arut04810  Regulation of actin cytoskeleton
KO pathway
ko04520   
LinkDB

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