KEGG   PATHWAY: arut04010
Entry
arut04010                   Pathway                                
Name
MAPK signaling pathway - Acipenser ruthenus (sterlet)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
arut04010  MAPK signaling pathway
arut04010

Other DBs
GO: 0000165
Organism
Acipenser ruthenus (sterlet) [GN:arut]
Gene
117971987  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
117402054  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like isoform X1 [KO:K04344]
117396785  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
117964688  voltage-dependent N-type calcium channel subunit alpha-1B-like isoform X1 [KO:K04849]
117415426  voltage-dependent L-type calcium channel subunit alpha-1C-like [KO:K04850]
117419745  voltage-dependent L-type calcium channel subunit alpha-1C-like isoform X1 [KO:K04850]
117413950  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
117412172  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
117406186  voltage-dependent R-type calcium channel subunit alpha-1E isoform X6 [KO:K04852]
117967960  voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
117423375  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
117418601  voltage-dependent T-type calcium channel subunit alpha-1H-like [KO:K04855]
117431071  voltage-dependent T-type calcium channel subunit alpha-1H-like isoform X1 [KO:K04855]
117430530  voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
117396463  voltage-dependent L-type calcium channel subunit alpha-1S-like [KO:K04857]
117419874  voltage-dependent calcium channel subunit alpha-2/delta-1-like isoform X1 [KO:K04858]
117415040  voltage-dependent calcium channel subunit alpha-2/delta-1-like [KO:K04858]
117412565  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
117963518  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a [KO:K04859]
117971351  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
117412410  voltage-dependent calcium channel subunit alpha-2/delta-3-like isoform X1 [KO:K04860]
117414667  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
117420037  voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861]
117971288  voltage-dependent L-type calcium channel subunit beta-1-like isoform X1 [KO:K04862]
117433454  voltage-dependent L-type calcium channel subunit beta-1-like isoform X1 [KO:K04862]
117434894  voltage-dependent L-type calcium channel subunit beta-1-like isoform X1 [KO:K04862]
117972344  voltage-dependent L-type calcium channel subunit beta-2-like [KO:K04863]
117394663  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-2-like [KO:K04863]
117400251  voltage-dependent L-type calcium channel subunit beta-2-like isoform X1 [KO:K04863]
117966893  voltage-dependent L-type calcium channel subunit beta-3-like isoform X1 [KO:K04864]
117400863  voltage-dependent L-type calcium channel subunit beta-3-like isoform X1 [KO:K04864]
117426960  voltage-dependent L-type calcium channel subunit beta-4-like isoform X2 [KO:K04865]
117410861  voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
117424644  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
117423498  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
117969738  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
117418851  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
117970379  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
117418498  voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
117431338  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
117424642  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
117423495  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
117974149  voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870]
117423497  LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
117424643  voltage-dependent calcium channel gamma-5 subunit-like isoform X1 [KO:K04870]
117409948  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
117409947  voltage-dependent calcium channel gamma-7 subunit-like isoform X1 [KO:K04872]
117409943  cacng8b; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
117417322  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
117402119  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
117962254  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
117413096  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
117424636  LOW QUALITY PROTEIN: protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
117423489  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117418057  LOW QUALITY PROTEIN: protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
117431125  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117409942  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
117966808  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
117418024  guanine nucleotide-binding protein subunit alpha-12-like [KO:K04346]
117431230  guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
117971992  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
117402097  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
117417334  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
117413369  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
117431429  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
117397835  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
117415576  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
117409043  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
117418255  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
117413365  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
117421318  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117966432  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
117411317  calcineurin subunit B type 1 [KO:K06268]
117402840  calcineurin subunit B type 1 isoform X1 [KO:K06268]
117429881  ras-specific guanine nucleotide-releasing factor 1-like isoform X1 [KO:K04349]
117427608  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
117404117  ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
117403791  ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
117415502  RAS guanyl-releasing protein 1-like isoform X1 [KO:K04350]
117422022  LOW QUALITY PROTEIN: RAS guanyl-releasing protein 1-like [KO:K04350]
117422376  RAS guanyl-releasing protein 1-like isoform X1 [KO:K04350]
117394354  RAS guanyl-releasing protein 1-like [KO:K04350]
117967784  RAS guanyl-releasing protein 2-like [KO:K12361]
117398603  RAS guanyl-releasing protein 2-like [KO:K12361]
117411472  ras guanyl-releasing protein 3-like [KO:K12362]
117403108  ras guanyl-releasing protein 3-like [KO:K12362]
117420947  rap guanine nucleotide exchange factor 2-like [KO:K08018]
117408609  rap guanine nucleotide exchange factor 2-like isoform X1 [KO:K08018]
117429835  neurofibromin isoform X1 [KO:K08052]
117430678  neurofibromin isoform X6 [KO:K08052]
117403679  ras GTPase-activating protein 1-like isoform X1 [KO:K04352]
117403974  ras GTPase-activating protein 1 isoform X1 [KO:K04352]
117417435  ras GTPase-activating protein 2-like isoform X1 [KO:K08053]
117417594  ras-related protein Rap-1A [KO:K04353]
117431526  ras-related protein Rap-1A [KO:K04353]
117415871  ras-related protein Rap-1b [KO:K07836]
117419830  ras-related protein Rap-1b [KO:K07836]
117408408  pro-epidermal growth factor-like isoform X1 [KO:K04357]
117421414  pro-epidermal growth factor-like isoform X1 [KO:K04357]
117397813  protransforming growth factor alpha-like isoform X2 [KO:K08774]
117966142  protransforming growth factor alpha-like [KO:K08774]
117421107  proepiregulin-like [KO:K09784]
117962906  LOW QUALITY PROTEIN: fibroblast growth factor 1-like [KO:K18496]
117431342  fibroblast growth factor 1-like isoform X1 [KO:K18496]
117409611  fibroblast growth factor 2-like [KO:K18497]
117421144  fibroblast growth factor 2-like [KO:K18497]
117403589  fibroblast growth factor 5-like [KO:K04358]
117403875  fibroblast growth factor 5-like [KO:K04358]
117397764  fibroblast growth factor 17 [KO:K04358]
117418405  fgf8a; fibroblast growth factor 8 [KO:K04358]
117406602  fibroblast growth factor 9 isoform X1 [KO:K04358]
117408422  fibroblast growth factor 20 [KO:K04358]
117409574  fgf10a; LOW QUALITY PROTEIN: fibroblast growth factor 10a [KO:K04358]
117419425  fibroblast growth factor 4B-like [KO:K04358]
117429484  fgf7; fibroblast growth factor 7 [KO:K04358]
117420542  fibroblast growth factor 20-like [KO:K04358]
117430822  fibroblast growth factor 16 [KO:K04358]
117421539  fibroblast growth factor 18-like [KO:K04358]
117431408  fgf18a; fibroblast growth factor 18a isoform X2 [KO:K04358]
117431968  fgf4; fibroblast growth factor 4 [KO:K04358]
117432046  fgf3; fibroblast growth factor 3 [KO:K04358]
117966100  fibroblast growth factor 17-like [KO:K04358]
117428813  fibroblast growth factor 10 [KO:K04358]
117401204  fibroblast growth factor 10-like [KO:K04358]
117405205  fibroblast growth factor 9 isoform X1 [KO:K04358]
117415324  fibroblast growth factor 4B-like [KO:K04358]
117434549  fibroblast growth factor 4B-like [KO:K04358]
117434567  fibroblast growth factor 3-like [KO:K04358]
117963558  fibroblast growth factor 16 [KO:K04358]
117431959  fgf19; fibroblast growth factor 19 [KO:K22603]
117434863  fibroblast growth factor 19-like [KO:K22603]
117419709  fgf23; fibroblast growth factor 23 [KO:K22428]
117965946  venom nerve growth factor-like [KO:K02582]
117433907  venom nerve growth factor [KO:K02582]
117432421  brain-derived neurotrophic factor-like isoform X1 [KO:K04355]
117434831  brain-derived neurotrophic factor-like isoform X1 [KO:K04355]
117419343  neurotrophin-3-like [KO:K04356]
117415224  neurotrophin-3-like isoform X1 [KO:K04356]
117434440  insulin-like [KO:K04526]
117419510  insulin-like growth factor I isoform X1 [KO:K05459]
117414927  insulin-like growth factor I isoform X1 [KO:K05459]
117435150  insulin-like growth factor II [KO:K13769]
117431928  insulin-like growth factor II [KO:K13769]
117417838  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
117431157  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
117433133  platelet-derived growth factor subunit B-like isoform X1 [KO:K17386]
117965679  platelet-derived growth factor subunit B-like isoform X1 [KO:K17386]
117972789  platelet-derived growth factor D-like isoform X1 [KO:K05450]
117407401  platelet-derived growth factor D-like isoform X1 [KO:K05450]
117408382  platelet-derived growth factor C-like [KO:K05450]
117964366  uncharacterized protein LOC117964366 [KO:K05450]
117420633  platelet-derived growth factor C-like [KO:K05450]
117964493  uncharacterized protein LOC117964493 isoform X1 [KO:K05453]
117432220  uncharacterized protein LOC117432220 isoform X1 [KO:K05453]
117419427  kit ligand-like [KO:K05461]
117414943  kit ligand-like [KO:K05461]
117969907  vascular endothelial growth factor A-like [KO:K05448]
117398638  vascular endothelial growth factor A-like [KO:K05448]
117410588  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
117403077  vascular endothelial growth factor A-like isoform X1 [KO:K05448]
117416693  placenta growth factor-like isoform X1 [KO:K16859]
117422031  placenta growth factor-like isoform X1 [KO:K16859]
117405792  vascular endothelial growth factor D-like [KO:K05449]
117406792  vegfd; vascular endothelial growth factor D [KO:K05449]
117409658  vegfc; vascular endothelial growth factor C [KO:K05449]
117420824  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
117431424  vascular endothelial growth factor C-like [KO:K05449]
117420010  hepatocyte growth factor-like [KO:K05460]
117415028  LOW QUALITY PROTEIN: hepatocyte growth factor-like [KO:K05460]
117424481  angiopoietin-1-like [KO:K05465]
117433653  angiopoietin-1-like [KO:K05465]
117399540  angiopoietin-1-like [KO:K05465]
117394235  angiopoietin-1-like [KO:K05465]
117402675  angiopoietin-2-like [KO:K05466]
117413599  angpt2b; angiopoietin-2b [KO:K05466]
117410619  angpt2a; angiopoietin-2a [KO:K05466]
117413274  angiopoietin-2-like [KO:K05466]
117973239  ephrin-A5 isoform X1 [KO:K05462]
117968857  ephrin-A5-like [KO:K05462]
117395435  ephrin-A3 [KO:K05462]
117970165  ephrin-A3-like [KO:K05462]
117409416  ephrin-A5 isoform X1 [KO:K05462]
117401230  ephrin-A2 [KO:K05462]
117966300  ephrin-A2-like [KO:K05462]
117395402  ephrin-A5-like [KO:K05462]
117395442  ephrin-A1-like [KO:K05462]
117409679  glial cell line-derived neurotrophic factor-like [KO:K05452]
117420977  glial cell line-derived neurotrophic factor-like [KO:K05452]
117401368  neurturin-like [KO:K25414]
117966293  neurturin-like [KO:K25414]
117416448  artemin-like [KO:K25415]
117411243  glial cell line-derived neurotrophic factor-like [KO:K25415]
117968844  persephin-like [KO:K25416]
117402008  persephin [KO:K25416]
117400452  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
117971274  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
117433463  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
117434964  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
117967077  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
117401044  receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
117427011  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
117411505  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
117397731  fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
117962604  fibroblast growth factor receptor 1-like isoform X1 [KO:K04362] [EC:2.7.10.1]
117418264  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
117421175  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
117968011  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
117409079  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
117431651  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
117413366  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
117399264  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
117400172  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
117394166  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
117433341  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
117434849  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
117970830  high affinity nerve growth factor receptor-like isoform X1 [KO:K03176] [EC:2.7.10.1]
117395629  high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
117408862  BDNF/NT-3 growth factors receptor-like isoform X1 [KO:K04360] [EC:2.7.10.1]
117421120  BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
117428863  LOW QUALITY PROTEIN: insulin receptor-like [KO:K04527] [EC:2.7.10.1]
117966207  LOW QUALITY PROTEIN: insulin receptor-like [KO:K04527] [EC:2.7.10.1]
117963120  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
117427860  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
117408343  platelet-derived growth factor receptor alpha-like [KO:K04363] [EC:2.7.10.1]
117420605  platelet-derived growth factor receptor alpha-like [KO:K04363] [EC:2.7.10.1]
117413283  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
117431496  csf1ra; macrophage colony-stimulating factor 1 receptor isoform X4 [KO:K05090] [EC:2.7.10.1]
117409565  mast/stem cell growth factor receptor kita-like [KO:K05091] [EC:2.7.10.1]
117420778  mast/stem cell growth factor receptor kita-like [KO:K05091] [EC:2.7.10.1]
117407344  receptor-type tyrosine-protein kinase FLT3-like [KO:K05092] [EC:2.7.10.1]
117407053  vascular endothelial growth factor receptor 1-like isoform X1 [KO:K05096] [EC:2.7.10.1]
117405676  vascular endothelial growth factor receptor 1-like isoform X1 [KO:K05096] [EC:2.7.10.1]
117430671  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
117412244  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
117412879  vascular endothelial growth factor receptor 3-like isoform X1 [KO:K05097] [EC:2.7.10.1]
117431549  vascular endothelial growth factor receptor 3-like isoform X1 [KO:K05097] [EC:2.7.10.1]
117408570  vascular endothelial growth factor receptor 2-like isoform X1 [KO:K05098] [EC:2.7.10.1]
117420387  LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2-like [KO:K05098] [EC:2.7.10.1]
117415916  hepatocyte growth factor receptor-like isoform X1 [KO:K05099] [EC:2.7.10.1]
117420109  hepatocyte growth factor receptor-like isoform X2 [KO:K05099] [EC:2.7.10.1]
117408563  angiopoietin-1 receptor-like [KO:K05121] [EC:2.7.10.1]
117421531  angiopoietin-1 receptor-like [KO:K05121] [EC:2.7.10.1]
117425649  ephrin type-A receptor 2-like [KO:K05103] [EC:2.7.10.1]
117432300  ephrin type-A receptor 2-like [KO:K05103] [EC:2.7.10.1]
117417619  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
117422907  growth factor receptor-bound protein 2-like isoform X1 [KO:K04364]
117424057  growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
117973927  son of sevenless homolog 2-like [KO:K03099]
117421958  son of sevenless homolog 2-like [KO:K03099]
117410672  son of sevenless homolog 1-like [KO:K03099]
117402902  son of sevenless homolog 1 isoform X1 [KO:K03099]
117431924  GTPase HRas [KO:K02833]
117434435  GTPase HRas [KO:K02833]
117419957  GTPase KRas isoform X1 [KO:K07827]
117962512  GTPase HRas-like [KO:K07827]
117415640  GTPase KRas isoform X1 [KO:K07827]
117407743  GTPase HRas-like [KO:K07827]
117428047  GTPase NRas [KO:K07828]
117962404  GTPase NRas [KO:K07828]
117435061  ras-related protein R-Ras2 [KO:K07830]
117431956  ras-related protein R-Ras2 [KO:K07830]
117968182  ras-related protein M-Ras-like [KO:K07831]
117427088  ras-related protein M-Ras-like [KO:K07831]
117412466  ras-related protein M-Ras [KO:K07831]
117967710  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
117401630  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
117419793  serine/threonine-protein kinase B-raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
117415020  serine/threonine-protein kinase B-raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
117414023  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
117412241  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
117428255  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117964269  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117401470  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117966151  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117408786  ragulator complex protein LAMTOR3-like [KO:K04370]
117421364  ragulator complex protein LAMTOR3 [KO:K04370]
117973328  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117398123  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117426782  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117417206  MAP kinase-interacting serine/threonine-protein kinase 1-like [KO:K04372] [EC:2.7.11.1]
117401391  MAP kinase-interacting serine/threonine-protein kinase 2-like [KO:K04372] [EC:2.7.11.1]
117413045  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
117428888  MAP kinase-interacting serine/threonine-protein kinase 2-like [KO:K04372] [EC:2.7.11.1]
117406561  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
117971026  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
117414028  ribosomal protein S6 kinase alpha-1-like isoform X1 [KO:K04373] [EC:2.7.11.1]
117410726  ribosomal protein S6 kinase alpha-2-like isoform X1 [KO:K04373] [EC:2.7.11.1]
117430634  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
117402628  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
117413281  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
117412331  ribosomal protein S6 kinase alpha-6-like isoform X1 [KO:K04373] [EC:2.7.11.1]
117401627  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
117404275  ETS domain-containing protein Elk-1-like [KO:K04375]
117435094  ETS domain-containing protein Elk-4-like [KO:K04376]
117434093  LOW QUALITY PROTEIN: ETS domain-containing protein Elk-4-like [KO:K04376]
117394278  mycb; transcriptional regulator Myc-B [KO:K04377]
117409784  transcriptional regulator Myc-B-like [KO:K04377]
117428910  transcriptional regulator Myc-B-like [KO:K04377]
117410718  srfb; serum response factor b isoform X1 [KO:K04378]
117402353  serum response factor-like isoform X1 [KO:K04378]
117422116  proto-oncogene c-Fos-like isoform X1 [KO:K04379]
117417438  proto-oncogene c-Fos-like isoform X1 [KO:K04379]
117409032  proto-oncogene c-Fos-like [KO:K04379]
117422027  proto-oncogene c-Fos-like [KO:K04379]
117433252  microtubule-associated protein 2-like isoform X1 [KO:K04380]
117434430  maptb; microtubule-associated protein 2 isoform X1 [KO:K04380]
117412761  stathmin-like [KO:K04381]
117413719  stmn1b; stathmin 1b [KO:K04381]
117422516  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
117421957  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
117413188  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
117416518  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
117410163  cytosolic phospholipase A2-like isoform X1 [KO:K16342] [EC:3.1.1.4]
117965004  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
117433977  lymphotoxin-alpha-like isoform X1 [KO:K03156]
117433981  tumor necrosis factor-like [KO:K03156]
117969121  interleukin-1 beta-like [KO:K04519]
117397957  interleukin-1 beta-like [KO:K04519]
117397782  interleukin-1 beta-like [KO:K04519]
117397956  interleukin-1 beta-like [KO:K04519]
117397798  interleukin-1 beta-like [KO:K04519]
117970734  interleukin-1 beta-like [KO:K04519]
117397953  interleukin-1 beta-like [KO:K04519]
117397955  interleukin-1 beta-like [KO:K04519]
117394578  transforming growth factor beta-1 proprotein-like [KO:K13375]
117962646  transforming growth factor beta-2 proprotein-like isoform X1 [KO:K13376]
117398621  transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
117410435  transforming growth factor beta-2 proprotein-like [KO:K13376]
117402519  transforming growth factor beta-2 proprotein-like [KO:K13376]
117963928  transforming growth factor beta-3 proprotein-like [KO:K13377]
117422235  transforming growth factor beta-3 proprotein [KO:K13377]
117425211  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117405220  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
117416597  interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
117423775  interleukin-1 receptor accessory protein-like [KO:K04723]
117400416  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
117394350  TGF-beta receptor type-1-like isoform X1 [KO:K04674] [EC:2.7.11.30]
117426292  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
117400383  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
117394619  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
117411359  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
117417998  fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
117415262  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
117418183  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
117431016  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
117432597  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117968020  ras-related C3 botulinum toxin substrate 2-like [KO:K07860]
117423588  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
117424197  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
117424587  cell division control protein 42 homolog [KO:K04393]
117425264  cell division control protein 42 homolog [KO:K04393]
117432225  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
117425088  tumor necrosis factor receptor type 1-associated DEATH domain protein-like [KO:K03171]
117424274  tumor necrosis factor receptor type 1-associated DEATH domain protein-like [KO:K03171]
117409020  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
117420645  caspase-3-like [KO:K02187] [EC:3.4.22.56]
117420663  caspase-3-like [KO:K02187] [EC:3.4.22.56]
117962289  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
117962309  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
117396690  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
117396934  TNF receptor-associated factor 2-like isoform X2 [KO:K03173] [EC:2.3.2.27]
117434177  death domain-associated protein 6 [KO:K02308]
117964846  death domain-associated protein 6-like [KO:K02308]
117435484  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
117399595  LOW QUALITY PROTEIN: myeloid differentiation primary response protein MyD88-like [KO:K04729]
117404204  LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
117419673  irak4; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
117435117  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
117432247  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
117400851  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117971933  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117971936  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117971940  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117416935  LOW QUALITY PROTEIN: growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
117408484  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117400855  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117400856  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117409183  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117409625  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117409629  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117428915  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
117401312  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
117404259  growth arrest and DNA damage-inducible protein GADD45 alpha-like isoform X1 [KO:K04402]
117403068  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like [KO:K04404]
117411419  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like isoform X1 [KO:K04404]
117962334  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial-like [KO:K04405]
117401947  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
117411124  map4k3a; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
117402962  map4k3b; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
117406164  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
117406910  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
117412303  mitogen-activated protein kinase kinase kinase kinase 4-like isoform X1 [KO:K04407] [EC:2.7.11.1]
117430660  mitogen-activated protein kinase kinase kinase kinase 4-like isoform X1 [KO:K04407] [EC:2.7.11.1]
117973040  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
117405978  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
117423416  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
117432045  serine/threonine-protein kinase 4-like [KO:K04411]
117423476  serine/threonine-protein kinase 4-like [KO:K04411]
117435557  serine/threonine-protein kinase 3-like [KO:K04412]
117400326  serine/threonine-protein kinase 3 [KO:K04412]
117398661  mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
117967868  mitogen-activated protein kinase kinase kinase kinase 2-like isoform X1 [KO:K04414] [EC:2.7.11.1]
117435608  mitogen-activated protein kinase kinase kinase 8-like [KO:K04415] [EC:2.7.11.25]
117399861  mitogen-activated protein kinase kinase kinase 8-like [KO:K04415] [EC:2.7.11.25]
117963658  mitogen-activated protein kinase kinase kinase 1-like isoform X1 [KO:K04416] [EC:2.7.11.25]
117425788  mitogen-activated protein kinase kinase kinase 1 isoform X3 [KO:K04416] [EC:2.7.11.25]
117398668  mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
117967786  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 11-like [KO:K04419] [EC:2.7.11.25]
117414908  mitogen-activated protein kinase kinase kinase 2-like [KO:K04420] [EC:2.7.11.25]
117409171  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
117435074  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
117416421  mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
117400396  mitogen-activated protein kinase kinase kinase 3-like isoform X1 [KO:K04421] [EC:2.7.11.25]
117394816  map3k22; mitogen-activated protein kinase kinase kinase 22 isoform X1 [KO:K04421] [EC:2.7.11.25]
117424577  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9-like [KO:K04417] [EC:2.7.11.25]
117422669  mitogen-activated protein kinase kinase kinase 9-like isoform X1 [KO:K04417] [EC:2.7.11.25]
117416186  mitogen-activated protein kinase kinase kinase 10-like [KO:K04418] [EC:2.7.11.25]
117394801  mitogen-activated protein kinase kinase kinase 10-like [KO:K04418] [EC:2.7.11.25]
117410614  mitogen-activated protein kinase kinase kinase 21-like isoform X1 [KO:K17534] [EC:2.7.11.25]
117402997  mitogen-activated protein kinase kinase kinase 21-like isoform X1 [KO:K17534] [EC:2.7.11.25]
117966950  mitogen-activated protein kinase kinase kinase 12-like [KO:K04423] [EC:2.7.11.25]
117400879  mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
117426139  mitogen-activated protein kinase kinase kinase 13-like [KO:K04422] [EC:2.7.11.25]
117404502  mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
117406331  mitogen-activated protein kinase kinase kinase 20-like isoform X1 [KO:K04424] [EC:2.7.11.25]
117427031  mitogen-activated protein kinase kinase kinase 20-like isoform X1 [KO:K04424] [EC:2.7.11.25]
117410928  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
117402892  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
117413367  mitogen-activated protein kinase kinase kinase 5-like isoform X1 [KO:K04426] [EC:2.7.11.25]
117414092  mitogen-activated protein kinase kinase kinase 5-like isoform X1 [KO:K04426] [EC:2.7.11.25]
117411069  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117402843  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
117411192  mitogen-activated protein kinase kinase kinase 4-like isoform X1 [KO:K04428] [EC:2.7.11.25]
117402821  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
117426274  serine/threonine-protein kinase TAO3-like isoform X1 [KO:K04429] [EC:2.7.11.1]
117399038  serine/threonine-protein kinase TAO2-like isoform X1 [KO:K04429] [EC:2.7.11.1]
117428114  serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
117429567  serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
117430541  serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
117424541  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
117423548  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
117968273  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
117401995  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
117418403  dual specificity mitogen-activated protein kinase kinase 3-like isoform X1 [KO:K04432] [EC:2.7.12.2]
117431675  dual specificity mitogen-activated protein kinase kinase 3-like isoform X1 [KO:K04432] [EC:2.7.12.2]
117424624  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
117422947  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
117432373  C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434]
117434568  C-Jun-amino-terminal kinase-interacting protein 1-like isoform X1 [KO:K04434]
117415656  C-Jun-amino-terminal kinase-interacting protein 2-like isoform X1 [KO:K04435]
117419860  C-Jun-amino-terminal kinase-interacting protein 2-like isoform X1 [KO:K04435]
117417980  C-Jun-amino-terminal kinase-interacting protein 3-like [KO:K04436]
117431353  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
117401729  filamin-A-like [KO:K04437]
117404347  LOW QUALITY PROTEIN: filamin-A [KO:K04437]
117427125  crk-like protein [KO:K04438]
117964278  adapter molecule crk-like isoform X1 [KO:K04438]
117428561  crk-like protein [KO:K04438]
117430672  adapter molecule crk-like isoform X1 [KO:K04438]
117972795  beta-arrestin-1 isoform X1 [KO:K04439]
117962496  arrestin red cell isoform X1 [KO:K04439]
117419327  arrestin red cell isoform X1 [KO:K04439]
117405967  beta-arrestin-1 isoform X1 [KO:K04439]
117409061  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117415548  LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
117962527  mitogen-activated protein kinase 10 isoform X7 [KO:K04440] [EC:2.7.11.24]
117418084  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117431535  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
117413208  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
117414718  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
117973539  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
117414715  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
117413780  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
117428934  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
117430486  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
117419844  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
117411959  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
117963411  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
117427196  MAP kinase-activated protein kinase 5-like isoform X1 [KO:K04442] [EC:2.7.11.1]
117428474  MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
117394845  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
117428195  mapkapk2a; LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
117411920  MAP kinase-activated protein kinase 2 [KO:K04444] [EC:2.7.11.1]
117963486  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
117963531  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
117421844  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-5-like [KO:K04445] [EC:2.7.11.1]
117423432  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-5-like [KO:K04445] [EC:2.7.11.1]
117408742  M-phase inducer phosphatase 1-like [KO:K05866] [EC:3.1.3.48]
117420909  M-phase inducer phosphatase 1-like [KO:K05866] [EC:3.1.3.48]
117399482  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
117394763  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
117425595  nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333]
117424146  nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333]
117963780  transcription factor AP-1-like [KO:K04448]
117421449  transcription factor AP-1-like [KO:K04448]
117416589  transcription factor AP-1-like [KO:K04448]
117401403  transcription factor AP-1 [KO:K04448]
117428835  transcription factor jun-D-like [KO:K04449]
117966277  transcription factor jun-D-like [KO:K04449]
117426833  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
117409383  cyclic AMP-dependent transcription factor ATF-2-like [KO:K04450]
117970978  cellular tumor antigen p53-like isoform X1 [KO:K04451]
117404615  cellular tumor antigen p53 [KO:K04451]
117966972  DNA damage-inducible transcript 3 protein-like isoform X1 [KO:K04452]
117401063  DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
117421915  protein max [KO:K04453]
117419511  protein max isoform X1 [KO:K04453]
117403767  myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
117404115  myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
117426970  heat shock protein beta-1-like isoform X1 [KO:K04455]
117428083  heat shock protein beta-1-like isoform X1 [KO:K04455]
117429340  heat shock protein beta-1-like [KO:K04455]
117430658  heat shock protein beta-1-like [KO:K04455]
117416317  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
117398601  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
117423438  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117415905  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117400209  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117411324  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
117403056  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117412568  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
117414362  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117422488  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
117397139  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117419962  protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
117422308  protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
117395444  protein phosphatase 1B-like [KO:K04457] [EC:3.1.3.16]
117415951  LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase R-like [KO:K04458] [EC:3.1.3.48]
117969233  tyrosine-protein phosphatase non-receptor type 5-like [KO:K18018] [EC:3.1.3.48]
117431960  tyrosine-protein phosphatase non-receptor type 5-like [KO:K18018] [EC:3.1.3.48]
117434719  tyrosine-protein phosphatase non-receptor type 5-like [KO:K18018] [EC:3.1.3.48]
117426814  tyrosine-protein phosphatase non-receptor type 7-like [KO:K18019] [EC:3.1.3.48]
117965948  tyrosine-protein phosphatase non-receptor type 7-like [KO:K18019] [EC:3.1.3.48]
117394765  tyrosine-protein phosphatase non-receptor type 7-like [KO:K18019] [EC:3.1.3.48]
117431064  dual specificity protein phosphatase 1-like [KO:K21278] [EC:3.1.3.16 3.1.3.48]
117412756  dual specificity protein phosphatase 1-like [KO:K21278] [EC:3.1.3.16 3.1.3.48]
117969113  dual specificity protein phosphatase 8-like isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117397926  dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117418029  dual specificity protein phosphatase 5-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117419542  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117420916  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117412431  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117432351  dual specificity protein phosphatase 8-like isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117414165  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117434453  dual specificity protein phosphatase 8-like isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117966492  dual specificity protein phosphatase 2-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117415313  dual specificity protein phosphatase 5-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117419496  dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
117414898  dual specificity protein phosphatase 6-like [KO:K21946] [EC:3.1.3.16 3.1.3.48]
117410800  dual specificity protein phosphatase 10-like [KO:K20216] [EC:3.1.3.16 3.1.3.48]
117402687  dual specificity protein phosphatase 10-like [KO:K20216] [EC:3.1.3.16 3.1.3.48]
117434976  dusp3a; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
117435358  serine/threonine-protein phosphatase 5-like [KO:K04460] [EC:3.1.3.16]
117416070  serine/threonine-protein phosphatase 5-like [KO:K04460] [EC:3.1.3.16]
117402298  protein phosphatase 1B-like isoform X1 [KO:K04461] [EC:3.1.3.16]
117411164  protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
117434053  heat shock cognate 71 kDa protein [KO:K03283]
117397288  heat shock cognate 71 kDa protein [KO:K03283]
117419854  heat shock 70 kDa protein-like [KO:K03283]
117429554  LOW QUALITY PROTEIN: heat shock 70 kDa protein-like [KO:K03283]
117430501  LOW QUALITY PROTEIN: heat shock 70 kDa protein [KO:K03283]
117962896  heat shock cognate 71 kDa protein-like [KO:K03283]
117431908  heat shock 70 kDa protein-like [KO:K03283]
117397052  heat shock cognate 70 kDa protein [KO:K03283]
117417159  histone-lysine N-methyltransferase MECOM-like isoform X1 [KO:K04462] [EC:2.1.1.367]
117423468  histone-lysine N-methyltransferase MECOM-like isoform X1 [KO:K04462] [EC:2.1.1.367]
117428339  dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
117429614  dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
117967103  nuclear receptor subfamily 4 group A member 1-like isoform X1 [KO:K04465]
117401111  nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
117427187  mitogen-activated protein kinase kinase kinase 14-like isoform X1 [KO:K04466] [EC:2.7.11.25]
117433487  map3k14a; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
117416037  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
117397678  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
117962689  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
117404249  NF-kappa-B essential modulator [KO:K07210]
117401606  NF-kappa-B essential modulator-like [KO:K07210]
117398968  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
117429770  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
117430731  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
117408542  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
117421210  nuclear factor NF-kappa-B p105 subunit-like isoform X1 [KO:K02580]
117415750  uncharacterized protein LOC117415750 [KO:K04469]
117417705  nuclear factor NF-kappa-B p100 subunit-like isoform X2 [KO:K04469]
117962714  putative transcription factor p65 homolog isoform X1 [KO:K04735]
117967842  putative transcription factor p65 homolog [KO:K04735]
117398684  putative transcription factor p65 homolog isoform X1 [KO:K04735]
117435067  embryonic polarity protein dorsal-like isoform X1 [KO:K09253]
117414737  transcription factor RelB homolog isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
arut04070  Phosphatidylinositol signaling system
arut04110  Cell cycle
arut04115  p53 signaling pathway
arut04210  Apoptosis
arut04310  Wnt signaling pathway
KO pathway
ko04010   
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