KEGG   PATHWAY: arut04310
Entry
arut04310                   Pathway                                
Name
Wnt signaling pathway - Acipenser ruthenus (sterlet)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
arut04310  Wnt signaling pathway
arut04310

Other DBs
GO: 0016055
Organism
Acipenser ruthenus (sterlet) [GN:arut]
Gene
117404205  protein-serine O-palmitoleoyltransferase porcupine-like isoform X1 [KO:K00181] [EC:2.3.1.250]
117967005  protein Wnt-1 [KO:K03209]
117401155  protein Wnt-1 [KO:K03209]
117415953  protein Wnt-2-like isoform X2 [KO:K00182]
117428861  protein Wnt-2b-A [KO:K00182]
117964431  protein Wnt-2b-A-like [KO:K00182]
117420007  protein Wnt-2-like [KO:K00182]
117400591  wnt3a; protein Wnt-3a [KO:K00312]
117435784  protein Wnt-3a isoform X1 [KO:K00312]
117433499  wnt3; proto-oncogene Wnt-3 [KO:K00312]
117425047  wnt4; LOW QUALITY PROTEIN: protein Wnt-4a [KO:K00408]
117425216  wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408]
117415732  protein Wnt-5b isoform X1 [KO:K00444]
117419878  protein Wnt-5b-like [KO:K00444]
117412611  protein Wnt-5a [KO:K00444]
117420386  protein Wnt-5a [KO:K00444]
117426563  protein Wnt-6-like isoform X1 [KO:K00445]
117413004  protein Wnt-6-like [KO:K00445]
117419949  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
117411890  protein Wnt-7a-like [KO:K00572]
117413752  protein Wnt-7a [KO:K00572]
117973633  protein Wnt-8-like [KO:K00714]
117417691  protein Wnt-8b-like [KO:K00714]
117412759  protein Wnt-8-like [KO:K00714]
117412800  protein Wnt-8a-like [KO:K00714]
117431763  protein Wnt-8-like [KO:K00714]
117414647  protein Wnt-8b [KO:K00714]
117400589  wnt9a; protein Wnt-9a [KO:K01064]
117433367  wnt9b; protein Wnt-9b [KO:K01064]
117395067  protein Wnt-9a [KO:K01064]
117967014  protein Wnt-10b-like [KO:K01357]
117427102  protein Wnt-10a [KO:K01357]
117401158  protein Wnt-10b [KO:K01357]
117413378  protein Wnt-10a-like [KO:K01357]
117972819  protein Wnt-11 isoform X1 [KO:K01384]
117407537  protein Wnt-11 isoform X1 [KO:K01384]
117430858  protein Wnt-11b-like [KO:K01384]
117412458  protein Wnt-11b-like [KO:K01384]
117419393  protein Wnt-16-like [KO:K01558]
117414657  protein Wnt-16-like [KO:K01558]
117408407  cerberus-like [KO:K01645]
117424421  palmitoleoyl-protein carboxylesterase notum1a-like isoform X1 [KO:K19882] [EC:3.1.1.98]
117417758  carboxylesterase notum2 [KO:K19882] [EC:3.1.1.98]
117431092  carboxylesterase notum2-like [KO:K19882] [EC:3.1.1.98]
117423787  notum1b; inactive palmitoleoyl-protein carboxylesterase notum1b [KO:K19882] [EC:3.1.1.98]
117419628  wnt inhibitory factor 1-like [KO:K01691]
117415357  wnt inhibitory factor 1-like [KO:K01691]
117434974  sost; sclerostin [KO:K16834]
117409013  dkk2; dickkopf-related protein 2 [KO:K02165]
117416217  dickkopf-related protein 1 [KO:K02165]
117417640  dkk1b; dickkopf-related protein 1b [KO:K02165]
117421493  dickkopf-related protein 2-like [KO:K02165]
117397689  dickkopf-related protein 4-like isoform X1 [KO:K02165]
117429123  pigment epithelium-derived factor-like [KO:K19614]
117430289  pigment epithelium-derived factor-like [KO:K19614]
117971672  secreted frizzled-related protein 1-like [KO:K02166]
117397745  secreted frizzled-related protein 1 [KO:K02166]
117973035  secreted frizzled-related protein 2-like [KO:K02176]
117405880  secreted frizzled-related protein 2-like [KO:K02176]
117408307  sfrp2; secreted frizzled-related protein 2 [KO:K02176]
117426207  secreted frizzled-related protein 3-like [KO:K25481]
117403865  secreted frizzled-related protein 3-like isoform X1 [KO:K25481]
117399416  secreted frizzled-related sequence protein 4-like [KO:K02185]
117395055  secreted frizzled-related sequence protein 4-like [KO:K02185]
117416140  secreted frizzled-related protein 5-like [KO:K02222]
117418262  secreted frizzled-related protein 5-like [KO:K02222]
117964595  R-spondin-1-like [KO:K19471]
117413940  R-spondin-1 [KO:K19471]
117425591  R-spondin-2 [KO:K23097]
117400667  R-spondin-2-like isoform X1 [KO:K23097]
117424502  R-spondin-2-like [KO:K23097]
117394283  R-spondin-2-like [KO:K23097]
117410496  R-spondin-3-like [KO:K23098]
117402498  rspo3; R-spondin-3 [KO:K23098]
117434997  leucine-rich repeat-containing G-protein coupled receptor 4-like [KO:K04309]
117432064  leucine-rich repeat-containing G-protein coupled receptor 4-like [KO:K04309]
117419431  leucine-rich repeat-containing G-protein coupled receptor 5-like isoform X6 [KO:K04308]
117414733  leucine-rich repeat-containing G-protein coupled receptor 5-like isoform X1 [KO:K04308]
117428816  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1 [KO:K08399]
117417592  leucine-rich repeat-containing G-protein coupled receptor 6-like [KO:K08399]
117430302  E3 ubiquitin-protein ligase RNF43 isoform X1 [KO:K15694] [EC:2.3.2.27]
117962671  E3 ubiquitin-protein ligase znrf3-like [KO:K16273] [EC:2.3.2.27]
117426168  E3 ubiquitin-protein ligase znrf3-like isoform X2 [KO:K16273] [EC:2.3.2.27]
117399646  frizzled-1-like [KO:K02432]
117426363  frizzled-7 [KO:K02432]
117401055  frizzled-7-A-like [KO:K02432]
117394842  frizzled-1-like [KO:K02432]
117433330  frizzled-2-like [KO:K02235]
117434598  frizzled-2 [KO:K02235]
117402412  frizzled-3 isoform X1 [KO:K02329]
117972853  frizzled-4-like [KO:K02354]
117405189  frizzled-4 [KO:K02354]
117399763  frizzled-8-like [KO:K02375]
117435710  frizzled-8-like [KO:K02375]
117427085  frizzled-5-like [KO:K02375]
117403465  frizzled-5-like [KO:K02375]
117435612  frizzled-6-like [KO:K02376]
117400571  frizzled-6-like [KO:K02376]
117973370  frizzled-10-B-like [KO:K02842]
117427738  frizzled-10-B-like [KO:K02842]
117429126  frizzled-9 [KO:K02842]
117430303  frizzled-9 [KO:K02842]
117435003  low-density lipoprotein receptor-related protein 5-like [KO:K03068]
117419896  lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
117432307  low-density lipoprotein receptor-related protein 5-like [KO:K03068]
117399519  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
117968185  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
117394158  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
117394164  LOW QUALITY PROTEIN: protein APCDD1-like [KO:K25812]
117399872  protein APCDD1-like [KO:K25812]
117417383  protein APCDD1-like [KO:K25812]
117429412  protein APCDD1-like [KO:K25812]
117971138  casein kinase I [KO:K08960] [EC:2.7.11.1]
117433034  casein kinase I [KO:K08960] [EC:2.7.11.1]
117418631  LOW QUALITY PROTEIN: protein Daple-like [KO:K25811]
117421940  LOW QUALITY PROTEIN: protein Daple-like [KO:K25811]
117431902  segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
117967650  segment polarity protein dishevelled homolog DVL-2-like isoform X1 [KO:K02353]
117416997  segment polarity protein dishevelled homolog DVL-3 isoform X2 [KO:K02353]
117404623  segment polarity protein dishevelled homolog DVL-2 isoform X2 [KO:K02353]
117423415  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
117400567  GSK-3-binding protein-like [KO:K03096]
117394953  GSK-3-binding protein-like [KO:K03096]
117431472  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
117968459  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
117970024  casein kinase II subunit alpha-like isoform X1 [KO:K03097] [EC:2.7.11.1]
117425150  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
117400491  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
117394445  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
117424124  csnk2a2b; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
117971090  casein kinase II subunit beta [KO:K03115]
117433984  casein kinase II subunit beta [KO:K03115]
117425048  protein naked cuticle homolog 1-like isoform X1 [KO:K03213]
117400662  nkd2b; protein naked cuticle homolog 2-like [KO:K03213]
117394197  protein naked cuticle homolog 2-like isoform X1 [KO:K03213]
117424069  protein naked cuticle homolog 1-like isoform X1 [KO:K03213]
117408981  CXXC-type zinc finger protein 4 [KO:K03344]
117421072  CXXC-type zinc finger protein 4-like [KO:K03344]
117426309  senp2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
117405839  LOW QUALITY PROTEIN: glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
117407370  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117435320  catenin beta-1-like isoform X1 [KO:K02105]
117400133  catenin beta-1 [KO:K02105]
117962440  axin-1-like isoform X1 [KO:K02157]
117418194  axin-1 isoform X1 [KO:K02157]
117423538  axin2; LOW QUALITY PROTEIN: axin-2 [KO:K04385]
117424758  axin-2-like isoform X1 [KO:K04385]
117973183  adenomatous polyposis coli protein-like isoform X1 [KO:K02085]
117409398  adenomatous polyposis coli protein isoform X2 [KO:K02085]
117401442  adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
117966228  adenomatous polyposis coli protein 2-like isoform X1 [KO:K02085]
117431427  casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
117413150  casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
117431552  lymphoid enhancer-binding factor 1-like isoform X1 [KO:K02620]
117413262  lymphoid enhancer-binding factor 1-like isoform X1 [KO:K02620]
117397962  transcription factor 7-like 1-A isoform X1 [KO:K04490]
117962397  transcription factor 7-like 1-A isoform X1 [KO:K04490]
117418190  transcription factor 7-like 2 isoform X2 [KO:K04491]
117415317  transcription factor 7-like 2 isoform X1 [KO:K04491]
117408361  lymphoid enhancer-binding factor 1-like isoform X1 [KO:K04492]
117420543  lymphoid enhancer-binding factor 1-like isoform X1 [KO:K04492]
117417798  leucine zipper putative tumor suppressor 2 homolog [KO:K26471]
117415464  leucine zipper putative tumor suppressor 2 homolog [KO:K26471]
117963598  beta-catenin-interacting protein 1 [KO:K04493]
117432061  beta-catenin-interacting protein 1 [KO:K04493]
117433098  cby1; protein chibby homolog 1 [KO:K23402]
117398828  chd8; LOW QUALITY PROTEIN: chromodomain-helicase-DNA-binding protein 8 [KO:K04494] [EC:5.6.2.-]
117409395  LOW QUALITY PROTEIN: colorectal mutant cancer protein-like [KO:K26734]
117424174  LOW QUALITY PROTEIN: colorectal mutant cancer protein [KO:K26734]
117397762  cell cycle and apoptosis regulator protein 2 [KO:K25816]
117966426  cell cycle and apoptosis regulator protein 2-like [KO:K25816]
117973487  NAD-dependent protein deacetylase sirtuin-1-like [KO:K11411] [EC:2.3.1.286]
117418272  NAD-dependent protein deacetylase sirtuin-1-like isoform X1 [KO:K11411] [EC:2.3.1.286]
117414652  NAD-dependent protein deacetylase sirtuin-1-like [KO:K11411] [EC:2.3.1.286]
117399943  transcription factor Sox-17-alpha-like [KO:K04495]
117394216  transcription factor Sox-17-alpha-A [KO:K04495]
117431305  C-terminal-binding protein 2-like isoform X1 [KO:K04496] [EC:1.1.1.428]
117415855  uncharacterized protein LOC117415855 isoform X1 [KO:K04496] [EC:1.1.1.428]
117409559  C-terminal-binding protein 1-like isoform X1 [KO:K04496] [EC:1.1.1.428]
117418299  uncharacterized protein LOC117418299 isoform X1 [KO:K04496] [EC:1.1.1.428]
117421205  C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
117413343  C-terminal-binding protein 2-like isoform X1 [KO:K04496] [EC:1.1.1.428]
117409221  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
117409426  transducin-like enhancer protein 4 isoform X1 [KO:K04497]
117428159  transducin-like enhancer protein 3 isoform X1 [KO:K04497]
117964265  transducin-like enhancer protein 3 isoform X1 [KO:K04497]
117401467  transducin-like enhancer protein 1 isoform X7 [KO:K04497]
117401468  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
117421089  transducin-like enhancer protein 4 isoform X1 [KO:K04497]
117421237  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
117962920  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
117962278  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
117400196  catenin delta-2-like isoform X1 [KO:K23491]
117394476  ctnnd2a; catenin delta-2 isoform X1 [KO:K23491]
117432515  LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
117968047  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
117417994  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
117431768  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
117964080  ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
117411776  ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
117968709  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
117962470  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
117409333  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
117421209  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
117395592  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
117428208  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
117429671  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
117411069  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117402843  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
117398968  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
117429770  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
117430731  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
117394278  mycb; transcriptional regulator Myc-B [KO:K04377]
117409784  transcriptional regulator Myc-B-like [KO:K04377]
117428910  transcriptional regulator Myc-B-like [KO:K04377]
117963780  transcription factor AP-1-like [KO:K04448]
117421449  transcription factor AP-1-like [KO:K04448]
117416589  transcription factor AP-1-like [KO:K04448]
117401403  transcription factor AP-1 [KO:K04448]
117435119  G1/S-specific cyclin-D1-like [KO:K04503]
117432035  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
117398003  G1/S-specific cyclin-D2-like [KO:K10151]
117419684  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
117433893  G1/S-specific cyclin-D2-like [KO:K10151]
117415323  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
117400296  CCN family member 4-like [KO:K22471]
117394918  CCN family member 4-like [KO:K22471]
117964477  peroxisome proliferator-activated receptor delta-like [KO:K04504]
117431393  peroxisome proliferator-activated receptor delta-like [KO:K04504]
117422675  presenilin-1-like [KO:K04505] [EC:3.4.23.-]
117433704  psen1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
117417322  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
117402119  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
117962254  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
117413096  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
117970978  cellular tumor antigen p53-like isoform X1 [KO:K04451]
117404615  cellular tumor antigen p53 [KO:K04451]
117424847  siah1; E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
117425774  E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
117416726  calcyclin-binding protein [KO:K04507]
117411193  calcyclin-binding protein-like [KO:K04507]
117431303  S-phase kinase-associated protein 1 [KO:K03094]
117413036  S-phase kinase-associated protein 1 [KO:K03094]
117417136  F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
117407411  F-box-like/WD repeat-containing protein TBL1X isoform X1 [KO:K04508]
117423350  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1 [KO:K04508]
117405693  F-box-like/WD repeat-containing protein TBL1X isoform X1 [KO:K04508]
117413404  F-box/WD repeat-containing protein 11 [KO:K03362]
117415480  beta-TrCP isoform X1 [KO:K03362]
117418534  beta-TrCP-like isoform X3 [KO:K03362]
117431581  F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
117400297  cullin-1-like isoform X1 [KO:K03347]
117394620  cullin-1 isoform X1 [KO:K03347]
117430229  glypican-4-like [KO:K08110]
117411778  gpc4; glypican-4 [KO:K08110]
117416903  inactive tyrosine-protein kinase transmembrane receptor ROR1-like [KO:K05122] [EC:2.7.10.1]
117404965  inactive tyrosine-protein kinase transmembrane receptor ROR1-like [KO:K05122] [EC:2.7.10.1]
117971931  tyrosine-protein kinase transmembrane receptor ROR2-like isoform X1 [KO:K05123] [EC:2.7.10.1]
117408835  tyrosine-protein kinase transmembrane receptor ROR2 isoform X1 [KO:K05123] [EC:2.7.10.1]
117423051  ryk; tyrosine-protein kinase RYK isoform X1 [KO:K05128] [EC:2.7.10.1]
117405819  vang-like protein 1 [KO:K04510]
117406661  vang-like protein 1 [KO:K04510]
117411849  prickle-like protein 2 isoform X1 [KO:K04511]
117416188  prickle-like protein 1 [KO:K04511]
117413733  prickle-like protein 2 isoform X1 [KO:K04511]
117401634  prickle3; prickle planar cell polarity protein 3 [KO:K04511]
117404199  prickle-like protein 2 [KO:K04511]
117419390  prickle-like protein 1 [KO:K04511]
117394706  invs; inversin isoform X1 [KO:K19626]
117421241  LOW QUALITY PROTEIN: disheveled-associated activator of morphogenesis 1-like [KO:K04512]
117422280  daam1a; LOW QUALITY PROTEIN: disheveled-associated activator of morphogenesis 1 [KO:K04512]
117411099  disheveled-associated activator of morphogenesis 2-like isoform X1 [KO:K04512]
117402611  disheveled-associated activator of morphogenesis 2-like isoform X1 [KO:K04512]
117971333  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
117404314  rho-related GTP-binding protein RhoA-C [KO:K04513]
117429429  rho-related GTP-binding protein RhoA-D [KO:K04513]
117401697  rho-related GTP-binding protein RhoA-C [KO:K04513]
117412320  transforming protein RhoA [KO:K04513]
117962391  rho-related GTP-binding protein RhoA-D [KO:K04513]
117963525  transforming protein RhoA [KO:K04513]
117410455  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
117402932  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
117418183  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
117431016  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
117432597  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117968020  ras-related C3 botulinum toxin substrate 2-like [KO:K07860]
117423588  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
117424197  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
117409061  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117415548  LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
117962527  mitogen-activated protein kinase 10 isoform X7 [KO:K04440] [EC:2.7.11.24]
117418084  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117431535  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
117413208  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
117402733  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
117422522  plcb2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
117398658  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
117967866  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
117410730  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
117411059  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
117402388  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
117417715  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
117409482  calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
117413376  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
117421196  calcium/calmodulin-dependent protein kinase type II delta chain isoform X1 [KO:K04515] [EC:2.7.11.17]
117415406  calcium/calmodulin-dependent protein kinase type II delta chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
117431429  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
117397835  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
117415576  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
117409043  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
117418255  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
117413365  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
117421318  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117966432  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
117411317  calcineurin subunit B type 1 [KO:K06268]
117402840  calcineurin subunit B type 1 isoform X1 [KO:K06268]
117424636  LOW QUALITY PROTEIN: protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
117423489  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117418057  LOW QUALITY PROTEIN: protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
117431125  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117409942  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
117966808  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
117399482  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
117394763  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
117963955  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
117433202  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
117425595  nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333]
117424146  nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333]
117398127  nuclear factor of activated T-cells, cytoplasmic 4-like [KO:K17334]
117398848  nuclear factor of activated T-cells, cytoplasmic 4-like isoform X2 [KO:K17334]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
PMID:28242765
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
arut04010  MAPK signaling pathway
arut04110  Cell cycle
arut04115  p53 signaling pathway
arut04120  Ubiquitin mediated proteolysis
arut04350  TGF-beta signaling pathway
arut04510  Focal adhesion
arut04520  Adherens junction
KO pathway
ko04310   
LinkDB

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