KEGG   PATHWAY: arut04350
Entry
arut04350                   Pathway                                
Name
TGF-beta signaling pathway - Acipenser ruthenus (sterlet)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
arut04350  TGF-beta signaling pathway
arut04350

Other DBs
GO: 0007179
Organism
Acipenser ruthenus (sterlet) [GN:arut]
Gene
117417168  chordin-like [KO:K04657]
117423731  chordin-like isoform X1 [KO:K04657]
117424747  nog3; noggin-3 [KO:K04658]
117418114  noggin-2-like [KO:K04658]
117431422  noggin-2-like [KO:K04658]
117423738  noggin-like [KO:K04658]
117411664  neuroblastoma suppressor of tumorigenicity 1 [KO:K19558]
117968616  neuroblastoma suppressor of tumorigenicity 1-like [KO:K19558]
117415525  gremlin-1-like [KO:K23318]
117400142  gremlin-1-like [KO:K23318]
117410820  grem2b; gremlin-2b [KO:K23318]
117402186  gremlin-2-like [KO:K23318]
117422307  gremlin-1-like [KO:K23318]
117421302  thbs1b; LOW QUALITY PROTEIN: thrombospondin-1 [KO:K16857]
117415452  dcn; decorin [KO:K04660]
117420002  decorin-like [KO:K04660]
117395498  fibromodulin-like [KO:K08121]
117434131  fibromodulin-like [KO:K08121]
117410616  left-right determination factor 2-like [KO:K04668]
117402489  left-right determination factor 1-like [KO:K04668]
117973329  follistatin-A isoform X1 [KO:K04661]
117403607  follistatin-A isoform X1 [KO:K04661]
117966292  bone morphogenetic protein 2-like [KO:K21283]
117401277  bone morphogenetic protein 2 [KO:K21283]
117415773  bone morphogenetic protein 2-like [KO:K21283]
117417752  bone morphogenetic protein 2-like [KO:K21283]
117410840  bmp2a; bone morphogenetic protein 2 [KO:K21283]
117402384  bone morphogenetic protein 2-like [KO:K21283]
117395390  LOW QUALITY PROTEIN: bone morphogenetic protein 2 [KO:K21283]
117421860  bone morphogenetic protein 4-like [KO:K04662]
117395489  bone morphogenetic protein 4-like [KO:K04662]
117400219  bone morphogenetic protein 7-like [KO:K16620]
117394425  bone morphogenetic protein 7-like isoform X2 [KO:K16620]
117972128  inhibin beta B chain-like [KO:K22687]
117967108  inhibin beta B chain-like [KO:K22687]
117426331  inhibin beta B chain-like [KO:K22687]
117401154  inhibin beta B chain [KO:K22687]
117403990  inhibin beta B chain-like [KO:K22687]
117417370  serotransferrin-2 [KO:K14736]
117423387  serotransferrin-2 [KO:K14736]
117410640  bmp5; bone morphogenetic protein 5 [KO:K04663]
117402601  bone morphogenetic protein 5-like [KO:K04663]
117963959  bone morphogenetic protein 7-like [KO:K16621]
117426719  bone morphogenetic protein 7-like [KO:K16621]
117414038  bone morphogenetic protein 8A [KO:K16622]
117413352  bone morphogenetic protein 8A-like [KO:K16622]
117424672  growth/differentiation factor 5-like [KO:K04664]
117430283  growth/differentiation factor 5-like [KO:K04664]
117435297  growth/differentiation factor 6-A-like [KO:K20012]
117399372  growth/differentiation factor 6-A-like [KO:K20012]
117410576  growth/differentiation factor 6-A-like [KO:K20013]
117402548  growth/differentiation factor 6-A-like [KO:K20013]
117401371  muellerian-inhibiting factor-like [KO:K04665]
117428873  muellerian-inhibiting factor-like [KO:K04665]
117419385  ifng1; interferon gamma 1 [KO:K04687]
117415132  interferon gamma 1-like [KO:K04687]
117965004  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
117433977  lymphotoxin-alpha-like isoform X1 [KO:K03156]
117433981  tumor necrosis factor-like [KO:K03156]
117421530  thrombospondin type-1 domain-containing protein 4-like [KO:K23377]
117408863  thrombospondin type-1 domain-containing protein 4-like [KO:K23377]
117429867  thrombospondin type-1 domain-containing protein 4-like isoform X2 [KO:K23377]
117428027  fibrillin-1-like [KO:K06825]
117429415  fbn1; fibrillin-1 [KO:K06825]
117411023  ltbp1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
117402566  latent-transforming growth factor beta-binding protein 1-like isoform X1 [KO:K19559]
117394578  transforming growth factor beta-1 proprotein-like [KO:K13375]
117962646  transforming growth factor beta-2 proprotein-like isoform X1 [KO:K13376]
117398621  transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
117410435  transforming growth factor beta-2 proprotein-like [KO:K13376]
117402519  transforming growth factor beta-2 proprotein-like [KO:K13376]
117963928  transforming growth factor beta-3 proprotein-like [KO:K13377]
117422235  transforming growth factor beta-3 proprotein [KO:K13377]
117399556  inhibin beta A chain-like [KO:K04667]
117394899  inhibin beta A chain-like [KO:K04667]
117397871  nodal homolog 2-A-like [KO:K04666]
117415811  nodal homolog [KO:K04666]
117417866  nodal homolog [KO:K04666]
117966455  nodal homolog 2-A-like [KO:K04666]
117417723  bone morphogenetic protein receptor type-1A-like isoform X1 [KO:K04673] [EC:2.7.11.30]
117414699  bone morphogenetic protein receptor type-1A-like [KO:K04673] [EC:2.7.11.30]
117408649  bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
117420858  LOW QUALITY PROTEIN: bone morphogenetic protein receptor type-1B-like [KO:K13578] [EC:2.7.11.30]
117423648  activin receptor type-1-like [KO:K04675] [EC:2.7.11.30]
117969899  activin receptor type-1-like [KO:K04675] [EC:2.7.11.30]
117962743  activin receptor type-1-like [KO:K04675] [EC:2.7.11.30]
117426847  activin receptor type-1-like [KO:K04675] [EC:2.7.11.30]
117401043  activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
117410035  activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
117407627  bone morphogenetic protein receptor type-2-like isoform X1 [KO:K04671] [EC:2.7.11.30]
117426670  bone morphogenetic protein receptor type-2-like isoform X1 [KO:K04671] [EC:2.7.11.30]
117427134  activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
117410738  activin receptor type-2A-like isoform X1 [KO:K04670] [EC:2.7.11.30]
117962364  hemojuvelin-like isoform X1 [KO:K23100]
117395560  hemojuvelin isoform X1 [KO:K23100]
117429513  neogenin-like [KO:K06766]
117428130  neogenin-like [KO:K06766]
117404556  tfr2; transferrin receptor protein 2 [KO:K23910]
117423218  transferrin receptor protein 1-like isoform X1 [KO:K06503]
117417093  tfr1a; transferrin receptor 1a [KO:K06503]
117401298  repulsive guidance molecule A-like isoform X1 [KO:K23096]
117415203  repulsive guidance molecule A-like isoform X1 [KO:K23096]
117963122  repulsive guidance molecule A-like [KO:K23096]
117429536  repulsive guidance molecule A-like [KO:K23096]
117963069  RGM domain family member B-like [KO:K06847]
117404140  RGM domain family member B [KO:K06847]
117400416  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
117394350  TGF-beta receptor type-1-like isoform X1 [KO:K04674] [EC:2.7.11.30]
117426292  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
117400383  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
117394619  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
117409932  epithelial membrane protein 3-like [KO:K26257]
117406980  transforming growth factor beta activator LRRC32-like isoform X1 [KO:K26316]
117405547  transforming growth factor beta activator LRRC32-like isoform X2 [KO:K26316]
117430849  transforming growth factor beta activator LRRC32-like [KO:K26316]
117412209  transforming growth factor beta activator LRRC32-like [KO:K26316]
117421633  nrros; transforming growth factor beta activator LRRC33 [KO:K26317]
117962264  activin receptor type-1B-like isoform X1 [KO:K13567] [EC:2.7.11.30]
117401025  activin receptor type-1B-like isoform X1 [KO:K13567] [EC:2.7.11.30]
117394817  activin receptor type-2B-like [KO:K13596] [EC:2.7.11.30]
117400503  activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
117426977  activin receptor type-1C-like [KO:K13568] [EC:2.7.11.30]
117411948  activin receptor type-1C-like [KO:K13568] [EC:2.7.11.30]
117399519  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
117968185  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
117394158  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
117409514  mothers against decapentaplegic homolog 1-like isoform X1 [KO:K04676]
117421397  mothers against decapentaplegic homolog 1 [KO:K04676]
117431188  LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 5-like [KO:K16790]
117412980  LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 5 [KO:K16790]
117406046  mothers against decapentaplegic homolog 9 [KO:K16791]
117406637  smad9; mothers against decapentaplegic homolog 9 [KO:K16791]
117421319  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
117428208  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
117429671  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
117968709  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
117962470  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
117409333  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
117421209  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
117395592  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
117427922  mothers against decapentaplegic homolog 6-like [KO:K04677]
117429381  mothers against decapentaplegic homolog 6-like [KO:K04677]
117421258  smad7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
117424634  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
117417617  E3 ubiquitin-protein ligase SMURF1-like isoform X1 [KO:K04678] [EC:2.3.2.26]
117431517  E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
117423487  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
117403989  zinc finger FYVE domain-containing protein 16-like isoform X1 [KO:K04679]
117416927  zinc finger FYVE domain-containing protein 9-like isoform X1 [KO:K04679]
117403667  zinc finger FYVE domain-containing protein 16-like isoform X1 [KO:K04679]
117405350  zinc finger FYVE domain-containing protein 9-like isoform X1 [KO:K04679]
117400297  cullin-1-like isoform X1 [KO:K03347]
117394620  cullin-1 isoform X1 [KO:K03347]
117431303  S-phase kinase-associated protein 1 [KO:K03094]
117413036  S-phase kinase-associated protein 1 [KO:K03094]
117973328  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117398123  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117426782  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117971333  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
117404314  rho-related GTP-binding protein RhoA-C [KO:K04513]
117429429  rho-related GTP-binding protein RhoA-D [KO:K04513]
117401697  rho-related GTP-binding protein RhoA-C [KO:K04513]
117412320  transforming protein RhoA [KO:K04513]
117962391  rho-related GTP-binding protein RhoA-D [KO:K04513]
117963525  transforming protein RhoA [KO:K04513]
117400355  rho-associated protein kinase 1-like [KO:K04514] [EC:2.7.11.39]
117394747  rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
117433644  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
117434266  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
117966538  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456]
117397413  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
117970742  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
117409015  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
117431670  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
117413387  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
117970725  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
117410109  LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
117430235  ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
117963246  ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
117433660  hepcidin-like [KO:K23106]
117434269  hepcidin-like [KO:K23106]
117417627  DNA-binding protein inhibitor ID-1-like [KO:K04680]
117429566  DNA-binding protein inhibitor ID-1-like [KO:K04680]
117410545  DNA-binding protein inhibitor ID-2-like [KO:K17693]
117402271  DNA-binding protein inhibitor ID-2-like [KO:K17693]
117413919  id3; DNA-binding protein inhibitor ID-3 [KO:K17694]
117427793  retinoblastoma-like protein 1 [KO:K04681]
117434860  retinoblastoma-like protein 1 [KO:K04681]
117424822  e2f4; transcription factor E2F4 [KO:K04682]
117399799  transcription factor E2F5-like isoform X1 [KO:K04682]
117394950  transcription factor E2F5-like [KO:K04682]
117425373  transcription factor E2F4-like [KO:K04682]
117406482  transcription factor Dp-1-like isoform X1 [KO:K04683]
117405225  transcription factor Dp-1-like isoform X1 [KO:K04683]
117432515  LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
117968047  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
117417994  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
117431768  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
117966968  transcription factor Sp1-like isoform X1 [KO:K04684]
117401144  transcription factor Sp1 isoform X1 [KO:K04684]
117417141  ski-like protein [KO:K18499]
117423248  ski-like protein [KO:K18499]
117963646  ski oncogene-like [KO:K26503]
117425070  ski oncogene [KO:K26503]
117428402  paired amphipathic helix protein Sin3a-like isoform X1 [KO:K11644]
117429630  paired amphipathic helix protein Sin3a-like isoform X3 [KO:K11644]
117413759  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
117411603  histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
117403307  histone deacetylase 2-like [KO:K06067] [EC:3.5.1.98]
117412982  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
117429646  ncor1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
117430661  nuclear receptor corepressor 1-like isoform X1 [KO:K04650]
117400598  homeobox protein AKR-like [KO:K19383]
117394201  homeobox protein AKR-like [KO:K19383]
117424849  homeobox protein TGIF2-like isoform X1 [KO:K19553]
117430183  homeobox protein TGIF2-like [KO:K19553]
117394278  mycb; transcriptional regulator Myc-B [KO:K04377]
117409784  transcriptional regulator Myc-B-like [KO:K04377]
117428910  transcriptional regulator Myc-B-like [KO:K04377]
117970487  cyclin-dependent kinase inhibitor 2A-like [KO:K04685]
117409583  cyclin-dependent kinase inhibitor 2A-like [KO:K04685]
117421214  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
117409613  pituitary homeobox 2-like [KO:K04686]
117421498  pituitary homeobox 2 [KO:K04686]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
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J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
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Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
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Int J Mol Sci 22:ijms22094591 (2021)
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PMID:20495575
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Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
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Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Related
pathway
arut04010  MAPK signaling pathway
arut04110  Cell cycle
arut04120  Ubiquitin mediated proteolysis
arut04210  Apoptosis
KO pathway
ko04350   
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