KEGG   PATHWAY: cata04514
Entry
cata04514                   Pathway                                
Name
Cell adhesion molecule (CAM) interaction - Cygnus atratus (black swan)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
cata04514  Cell adhesion molecule (CAM) interaction
cata04514

Other DBs
GO: 0050839
Organism
Cygnus atratus (black swan) [GN:cata]
Gene
118243260  PTPRF; receptor-type tyrosine-protein phosphatase F [KO:K05695] [EC:3.1.3.48]
118243302  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
118243371  SELP; P-selectin isoform X1 [KO:K06496]
118243409  SELE; LOW QUALITY PROTEIN: E-selectin [KO:K06496]
118243496  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
118243715  NTNG1; netrin-G1 isoform X1 [KO:K07522]
118244095  CLDN20; claudin-20 [KO:K06087]
118244311  CD6; T-cell differentiation antigen CD6 [KO:K06456]
118244753  NRXN3; neurexin 3 isoform X1 [KO:K07377]
118244904  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
118244911  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
118244971  ALCAM; CD166 antigen isoform X2 [KO:K06547]
118244987  NECTIN3; nectin-3 isoform X1 [KO:K06592]
118244996  VTCN1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747]
118245048  CD2; LOW QUALITY PROTEIN: T-cell surface antigen CD2 [KO:K06449]
118245051  IGSF11; immunoglobulin superfamily member 11 isoform X1 [KO:K06791]
118245244  CD99L2; CD99 antigen-like protein 2 [KO:K06520]
118245460  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
118245502  CD40LG; CD40 ligand [KO:K03161]
118245514  SLITRK4; SLIT and NTRK-like protein 4 [KO:K25835]
118245515  CLDN2; claudin-2 isoform X1 [KO:K06087]
118245600  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
118245669  CLDN34; claudin-34 [KO:K06087]
118245785  NLGN4X; neuroligin-4, X-linked isoform X1 [KO:K07378]
118245816  CD99; CD99 antigen isoform X1 [KO:K06520]
118245818  XG; glycoprotein Xg [KO:K06520]
118246310  GLG1; Golgi apparatus protein 1 [KO:K06816]
118246331  CLDN23; claudin-23 [KO:K06087]
118246375  CDH5; cadherin-5 [KO:K06533]
118246661  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
118246820  CNTN1; contactin-1 [KO:K06759]
118247030  CLDN1; claudin-1 [KO:K06087]
118247048  [KO:K06087]
118247132  CLDN18; claudin-18 isoform X1 [KO:K06087]
118247197  CLDN16; claudin-16 [KO:K06087]
118247253  PDCD1; programmed cell death protein 1 [KO:K06744]
118247363  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
118247524  ITGB1; integrin beta-1 [KO:K05719]
118247526  CLDN12; claudin-12 [KO:K06087]
118247535  ICOSLG; LOW QUALITY PROTEIN: ICOS ligand [KO:K06710]
118247566  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
118247575  CD4; LOW QUALITY PROTEIN: T-cell surface glycoprotein CD4 [KO:K06454]
118247621  CXADR; coxsackievirus and adenovirus receptor isoform X1 [KO:K06788]
118247642  NCAM2; neural cell adhesion molecule 2 [KO:K06491]
118247712  [KO:K06087]
118247715  CLDN14; claudin-14 [KO:K06087]
118247716  [KO:K06087]
118247849  SDC2; syndecan-2 [KO:K16336]
118248380  [KO:K06459]
118248381  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
118248810  CDH4; cadherin-4 isoform X1 [KO:K06797]
118248889  SDC4; syndecan-4 [KO:K16338]
118250020  CD226; CD226 antigen [KO:K06567]
118250804  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
118250922  CNTNAP2; contactin-associated protein-like 2 [KO:K07380]
118250954  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
118252262  NTNG2; netrin-G2 isoform X2 [KO:K16359]
118252367  CADM1; cell adhesion molecule 1 [KO:K06781]
118252417  JAM3; junctional adhesion molecule C [KO:K06785]
118252430  NCAM1; neural cell adhesion molecule 1 isoform X2 [KO:K06491]
118252452  CLDN25; putative claudin-25 [KO:K06087]
118252481  [KO:K06081]
118252489  JAML; junctional adhesion molecule-like isoform X1 [KO:K28137]
118252505  ESAM; endothelial cell-selective adhesion molecule isoform X2 [KO:K06787]
118252981  CLDN5; claudin-5 [KO:K06087]
118253085  CLDN10; claudin-10 isoform X1 [KO:K06087]
118253117  SLITRK3; SLIT and NTRK-like protein 3 [KO:K25834]
118253177  NLGN1; neuroligin-1 isoform X2 [KO:K07378]
118253189  CLDN11; claudin-11 [KO:K06087]
118253500  [KO:K06087]
118253510  [KO:K06087]
118254007  PECAM1; platelet endothelial cell adhesion molecule isoform X4 [KO:K06471]
118254143  CLDN3; claudin-3 [KO:K06087]
118254145  [KO:K06087]
118254152  [KO:K06087]
118254680  SDC1; syndecan-1 [KO:K06257]
118255344  NFASC; LOW QUALITY PROTEIN: neurofascin [KO:K06757]
118255345  CNTN2; contactin-2 [KO:K06760]
118255418  CD34; hematopoietic progenitor cell antigen CD34 [KO:K06474]
118255665  [KO:K06087]
118255689  NRXN1; neurexin-1 isoform X2 [KO:K07377]
118255920  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
118256341  VCAN; versican core protein isoform X1 [KO:K06793]
118256835  PTPRM; receptor-type tyrosine-protein phosphatase mu isoform X3 [KO:K05693] [EC:3.1.3.48]
118256970  NEGR1; neuronal growth regulator 1 isoform X1 [KO:K06775]
118257300  SDC3; syndecan-3 [KO:K16337]
118257572  SELPLG; LOW QUALITY PROTEIN: P-selectin glycoprotein ligand 1 [KO:K06544]
118257836  [KO:K05689]
118257840  CDH15; LOW QUALITY PROTEIN: cadherin-15 [KO:K06809]
118257859  CDH1; cadherin-1 [KO:K05689]
118257860  [KO:K06796]
118258129  NEO1; neogenin isoform X1 [KO:K06766]
118258151  CD276; CD276 antigen [KO:K06746]
118258277  [KO:K10784]
118258403  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
118258706  CD274; programmed cell death 1 ligand 1 isoform X1 [KO:K06745]
118258720  [KO:K06708]
118258758  PTPRS; receptor-type tyrosine-protein phosphatase S isoform X2 [KO:K06778] [EC:3.1.3.48]
118258808  CLDN19; claudin-19 [KO:K06087]
118258818  [KO:K06087]
118258934  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
118258938  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
118259150  CNTNAP1; contactin-associated protein 1 [KO:K07379]
118259181  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
118259253  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
118259648  LRRC4; LOW QUALITY PROTEIN: leucine-rich repeat-containing protein 4 [KO:K16351]
118259680  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
118259798  ITGA4; integrin alpha-4 [KO:K06483]
118259820  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
118259826  SLITRK5; SLIT and NTRK-like protein 5 [KO:K25836]
118259892  PTPRD; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase delta [KO:K06777] [EC:3.1.3.48]
118259920  [KO:K06713]
118259930  OCLN; occludin [KO:K06088]
118260059  MADCAM1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
118260273  [KO:K06752]
118260274  [KO:K06752]
118260299  [KO:K06751]
118260399  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
118260459  F11R; junctional adhesion molecule A [KO:K06089]
118260773  CTLA4; cytotoxic T-lymphocyte protein 4 [KO:K06538]
118260779  CDH2; cadherin-2 isoform X1 [KO:K06736]
118261042  MPZ; LOW QUALITY PROTEIN: myelin protein P0 [KO:K06770]
118261047  CADM3; cell adhesion molecule 3 [KO:K06780]
118261099  SIGLEC1; sialoadhesin [KO:K06548]
118261529  [KO:K06752]
118261531  [KO:K06752]
118261532  [KO:K06752]
118261633  MAG; myelin-associated glycoprotein [KO:K06771]
126913365  VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation isoform X1 [KO:K23268]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
cata04520  Adherens junction
cata04530  Tight junction
KO pathway
ko04514   

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