KEGG   PATHWAY: cery03013
Entry
cery03013                   Pathway                                
Name
Nucleocytoplasmic transport - Chanodichthys erythropterus (predatory carp)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
cery03013  Nucleocytoplasmic transport
cery03013

Other DBs
GO: 0050658
Organism
Chanodichthys erythropterus (predatory carp) [GN:cery]
Gene
137002410  thoc1; THO complex subunit 1 isoform X1 [KO:K12878]
137002601  tpra; nucleoprotein TPR isoform X1 [KO:K09291]
137002692  ndc1; nucleoporin NDC1 isoform X1 [KO:K14315]
137002870  upf1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
137003476  ipo13a; importin-13 [KO:K25202]
137003713  acin1a; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
137005001  nmd3; 60S ribosomal export protein NMD3 [KO:K07562]
137005432  kpna4; importin subunit alpha-3 [KO:K23583]
137006044  thoc3; THO complex subunit 3 [KO:K12880]
137006114  xpo1b; exportin-1 isoform X1 [KO:K14290]
137006221  ahctf1; protein ELYS isoform X1 [KO:K25129]
137006362  pnn; pinin [KO:K13114]
137007139  srrm1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
137007683  rangap1b; ran GTPase-activating protein 1b [KO:K14319]
137008712  nup210; nuclear pore membrane glycoprotein 210 [KO:K14314]
137008847  eef1a2; elongation factor 1-alpha 2 [KO:K03231]
137009088  nup85; nuclear pore complex protein Nup85 [KO:K14304]
137009540  ddx19a; ATP-dependent RNA helicase DDX19A isoform X1 [KO:K18655] [EC:5.6.2.7]
137010270  kpna2; importin subunit alpha-1 [KO:K15043]
137010620  sumo3a; small ubiquitin-related modifier 3-like isoform X1 [KO:K12160]
137010922  sumo2a; small ubiquitin like modifier 2a [KO:K12160]
137011050  sumo1; small ubiquitin-related modifier 1 [KO:K12160]
137011215  senp2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
137011403  rae1; mRNA export factor isoform X1 [KO:K14298]
137011793  upf3b; regulator of nonsense transcripts 3B [KO:K14328]
137012057  nup54; nucleoporin p54 isoform X1 [KO:K14308]
137012879  nup188; nucleoporin NUP188 isoform X1 [KO:K14311]
137013221  nxf1b; nuclear RNA export factor 1 [KO:K14284]
137013289  nup98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
137013461  eef1a1l3; elongation factor 1-alpha-like isoform X1 [KO:K03231]
137013601  kpna1; importin subunit alpha-5 isoform X1 [KO:K23940]
137013893  ube2ib; SUMO-conjugating enzyme UBC9-A [KO:K10577]
137013945  nup58; nucleoporin p58/p45 isoform X1 [KO:K14307]
137014071  ipo4; importin-4 isoform X1 [KO:K20221]
137014494  thoc5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
137014917  snupn; snurportin-1 [KO:K13151]
137015092  [KO:K03345] [EC:3.4.22.68]
137015551  nup160; nuclear pore complex protein Nup160 isoform X1 [KO:K14303]
137015702  [KO:K03345] [EC:3.4.22.68]
137016141  [KO:K03345] [EC:3.4.22.68]
137017162  rangap1a; ran GTPase-activating protein 1a [KO:K14319]
137017201  sumo2b; small ubiquitin-related modifier 2 [KO:K12160]
137017258  xpo6; exportin-6 [KO:K25204]
137017275  [KO:K14325]
137017342  tnpo2a; transportin-2 [KO:K18727]
137017368  [KO:K10577]
137017406  casc3; protein CASC3 isoform X1 [KO:K14323]
137017610  thoc6; THO complex subunit 6 homolog [KO:K13175]
137017821  ube2ia; SUMO-conjugating enzyme UBC9-B [KO:K10577]
137017944  alyref; THO complex subunit 4 isoform X1 [KO:K12881]
137017972  nup62l; nucleoporin 62 like isoform X1 [KO:K14306]
137018116  ran; GTP-binding nuclear protein Ran [KO:K07936]
137018503  nxf1a; nuclear RNA export factor 1 [KO:K14284]
137018843  nup43; nucleoporin Nup43 [KO:K14305]
137019071  tprb; translocated promoter region b, nuclear basket protein isoform X1 [KO:K09291]
137019210  ipo13b; importin-13 [KO:K25202]
137020353  nxt2; NTF2-related export protein 2 isoform X1 [KO:K14285]
137020583  eef1a1a; elongation factor 1-alpha 1a [KO:K03231]
137020787  [KO:K14289]
137020910  eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
137021121  thoc7; THO complex subunit 7 homolog [KO:K13176]
137021215  cse1l; exportin-2 [KO:K18423]
137021227  ddx19b; ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
137021257  thoc2; THO complex subunit 2 isoform X1 [KO:K12879]
137021547  ipo9; importin-9 isoform X1 [KO:K20224]
137022082  tmem33; transmembrane protein 33 [KO:K20724]
137022806  nup93; nuclear pore complex protein Nup93 [KO:K14309]
137023204  [KO:K12882]
137023260  nup205; nuclear pore complex protein Nup205 [KO:K14310]
137023928  nup37; nucleoporin Nup37 [KO:K14302]
137023964  nup107; nuclear pore complex protein Nup107 [KO:K14301]
137024150  xpot; exportin-T isoform X1 [KO:K14288]
137024152  upf2; regulator of nonsense transcripts 2 [KO:K14327]
137024236  ipo8; importin-8 isoform X1 [KO:K18755]
137024382  tnpo3; transportin-3 isoform X1 [KO:K15436]
137024643  nup50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
137025108  [KO:K03345] [EC:3.4.22.68]
137026166  pym1; partner of Y14 and mago [KO:K14294]
137026202  gle1; mRNA export factor GLE1 [KO:K18723]
137027004  magoh; protein mago nashi homolog [KO:K12877]
137027060  ipo11; importin-11 [KO:K25201]
137027554  phax; phosphorylated adapter RNA export protein [KO:K14291]
137027636  sec13; protein SEC13 homolog [KO:K14004]
137028159  rbm8a; RNA-binding protein 8A [KO:K12876]
137028359  kpna7; importin subunit alpha-8 [KO:K15043]
137028660  pom121; nuclear envelope pore membrane protein POM 121 [KO:K14316]
137028812  xpo7; exportin-7 isoform X1 [KO:K18460]
137028985  ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
137029344  nup155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
137029447  [KO:K14314]
137030086  ipo7; importin-7 isoform X1 [KO:K20223]
137030829  [KO:K14299]
137030943  acin1b; apoptotic chromatin condensation inducer 1b [KO:K12875]
137031900  nup133; nuclear pore complex protein Nup133 [KO:K14300]
137032025  tnpo2b; transportin-2 isoform X1 [KO:K18727]
137032096  xpo1a; exportin-1 [KO:K14290]
137032514  kpnb3; importin-5 [KO:K20222]
137032519  eef1a1b; elongation factor 1-alpha 1b [KO:K03231]
137033163  kpna3; importin subunit alpha-4 [KO:K23583]
137033590  tnpo1; transportin-1 isoform X1 [KO:K18752]
137033653  nup214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
137033821  kpna5; importin subunit alpha-6 [KO:K15042]
137033912  nup88; nucleoporin 88 [KO:K14318]
137035669  nup35; nucleoporin NUP35 isoform X1 [KO:K14313]
137035674  sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
137035861  upf3a; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
137035873  xpo4; exportin-4 [KO:K25203]
137035983  sumo3b; small ubiquitin-related modifier 3 [KO:K12160]
137036377  ranbp2; E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
137036518  aaas; aladin [KO:K14320]
137037072  [KO:K03231]
137037073  [KO:K03231]
137037298  kpna6; importin subunit alpha-7 isoform X1 [KO:K15042]
137037305  ddx39b; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B [KO:K12812] [EC:5.6.2.7]
137037563  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
137037568  nup153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
137037582  kpnb1; importin subunit beta-1 [KO:K14293]
137037847  nup42; nucleoporin NUP42 [KO:K14321]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
cery03015  mRNA surveillance pathway
KO pathway
ko03013   

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