KEGG   PATHWAY: cery04261
Entry
cery04261                   Pathway                                
Name
Adrenergic signaling in cardiomyocytes - Chanodichthys erythropterus (predatory carp)
Description
Cardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, and alpha-1C). In the human heart the beta-1-AR is the pre- dominate receptor. Acute sympathetic stimulation of cardiac beta-1-ARs induces positive inotropic and chronotropic effects, the most effective mechanism to acutely increase output of the heart, by coupling to Gs, formation of cAMP by adenylyl cyclase (AC), and PKA- dependent phosphorylation of various target proteins (e.g., ryanodine receptor [RyR]; phospholamban [PLB], troponin I [TnI], and the L-type Ca2+ channel [LTCC]). Chronic beta-1-AR stimulation is detrimental and induces cardiomyocyte hypertrophy and apoptosis. beta-2-AR coupled to Gs exerts a proapoptotic action as well as beta-1-AR, while beta-2-AR coupled to Gi exerts an antiapoptotic action.
Class
Organismal Systems; Circulatory system
Pathway map
cery04261  Adrenergic signaling in cardiomyocytes
cery04261

Other DBs
GO: 0001997
Organism
Chanodichthys erythropterus (predatory carp) [GN:cery]
Gene
137001994  tpm3; tropomyosin alpha-3 chain isoform X1 [KO:K10373]
137002017  creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
137002393  ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
137002428  agtr1a; type-1 angiotensin II receptor B [KO:K04166]
137002583  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
137002728  bcl2b; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
137002819  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
137002841  adcy1b; adenylate cyclase type 1b [KO:K08041] [EC:4.6.1.1]
137002847  tpm4b; tropomyosin 4b isoform X1 [KO:K10375]
137002903  atp1b3a; sodium/potassium-transporting ATPase subunit beta-3a [KO:K01540]
137002975  creb3l3b; cyclic AMP-responsive element-binding protein 3-like protein 3-B isoform X1 [KO:K09048]
137003182  scn12aa; sodium channel, voltage gated, type XII, alpha a [KO:K04838]
137003274  atp1a2a; sodium/potassium-transporting ATPase subunit alpha-2 isoform X1 [KO:K01539] [EC:7.2.2.13]
137003299  crema; cAMP-responsive element modulator isoform X1 [KO:K09052]
137004281  calm3a; calmodulin 3a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
137004423  slc8a2b; sodium/calcium exchanger 2b isoform X1 [KO:K05849]
137004772  atp1b3b; sodium/potassium-transporting ATPase subunit beta-3b [KO:K01540]
137004972  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
137005263  scn4ba; sodium channel, voltage-gated, type IV, beta a isoform X1 [KO:K04848]
137006127  slc8a1b; sodium/calcium exchanger 1b [KO:K05849]
137006149  actc1b; actin, alpha cardiac muscle 1b [KO:K12314]
137006192  si:ch211-132f19.7; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
137006209  ppp2r5ca; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
137006291  kcnk2a; potassium channel subfamily K member 2 [KO:K04913]
137006304  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
137006332  ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
137006461  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
137006570  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
137006597  calm1a; calmodulin-1a [KO:K02183]
137006666  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
137006951  [KO:K05852]
137007131  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
137007133  plcb4a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
137007165  ryr2b; ryanodine receptor 2 isoform X1 [KO:K04962]
137007341  camk2g1; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
137007441  zgc:163073; myosin light chain 4 isoform X1 [KO:K12750]
137007485  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like isoform X1 [KO:K05853] [EC:7.2.2.10]
137007654  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
137007693  adrb1; beta-1 adrenergic receptor [KO:K04141]
137007778  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
137008213  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
137008226  ryr2a; ryanodine receptor 2 [KO:K04962]
137008725  atp2b3b; plasma membrane calcium-transporting ATPase 3b isoform X1 [KO:K05850] [EC:7.2.2.10]
137008858  tnnt2a; troponin T type 2a (cardiac) [KO:K12045]
137008860  tnnc1a; troponin C type 1a (slow) [KO:K05865]
137008884  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a [KO:K04864]
137008930  adcy6b; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
137008938  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
137009009  tnnc1b; troponin C type 1b (slow) [KO:K05865]
137009084  atp1b2a; sodium/potassium-transporting ATPase subunit beta-2a [KO:K01540]
137009190  rapgef3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
137009503  ppp2r2cb; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
137009603  si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
137009875  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
137009886  adcy6a; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
137010445  atf4b; activating transcription factor 4b [KO:K04374]
137010533  atp1b1a; sodium/potassium-transporting ATPase subunit beta-1a [KO:K01540]
137010569  tnnt2b; troponin T, cardiac muscle isoforms [KO:K12045]
137010626  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
137010651  cacnb4b; voltage-dependent L-type calcium channel subunit beta-4b isoform X1 [KO:K04865]
137010696  myl4; myosin light chain 4 [KO:K12750]
137010730  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
137010830  [KO:K21290]
137010900  cacng5a; calcium channel, voltage-dependent, gamma subunit 5a [KO:K04870]
137010901  cacng1a; calcium channel, voltage-dependent, gamma subunit 1a isoform X1 [KO:K04866]
137010951  cacng4a; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
137011051  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
137011130  [KO:K04867]
137011139  pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
137011417  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
137011617  gnai2b; guanine nucleotide-binding protein G(i) subunit alpha-2b [KO:K04630]
137011695  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
137011736  rapgef4b; rap guanine nucleotide exchange factor 4-like [KO:K04351]
137012019  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
137012047  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
137012294  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
137012430  slc8a4a; solute carrier family 8 member 4a isoform X1 [KO:K05849]
137012506  ppp2r2bb; protein phosphatase 2, regulatory subunit B, beta b isoform X1 [KO:K04354]
137012518  adrb2b; adrenoceptor beta 2, surface b [KO:K04142]
137012773  adra1ba; alpha-1A adrenergic receptor [KO:K04136]
137012782  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
137013247  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
137013322  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
137013330  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
137013439  [KO:K17751]
137013441  [KO:K17751]
137013442  [KO:K17751]
137013443  [KO:K17751]
137013444  [KO:K17751]
137013661  [KO:K17751]
137013662  [KO:K17751]
137013667  scn5lab; sodium channel, voltage gated, type V-like, alpha b isoform X1 [KO:K04838]
137014046  bcl2a; apoptosis regulator Bcl-2a isoform X1 [KO:K02161]
137014328  agtr1b; type-1 angiotensin II receptor A [KO:K04166]
137014500  atp2b1b; plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
137014705  tpm1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
137014784  tnnt2d; troponin T2d, cardiac [KO:K12045]
137015079  cacna2d4b; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
137015190  acte1; beta-actin-like protein 2 [KO:K12314]
137015570  gnaia; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a [KO:K04630]
137015576  calml4b; calmodulin-like protein 4 [KO:K02183]
137015580  kcnq1.2; potassium voltage-gated channel subfamily KQT member 1 [KO:K04926]
137017251  [KO:K08049] [EC:4.6.1.1]
137017306  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345] [EC:2.7.11.11]
137017357  pik3r6b; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
137017468  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
137017500  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
137017505  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
137017563  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
137017598  ppp2r2ba; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
137017999  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
137018000  prkcab; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
137018332  kcnk2b; potassium channel subfamily K member 2b [KO:K04913]
137018534  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
137018599  [KO:K08043] [EC:4.6.1.1]
137018700  [KO:K04456] [EC:2.7.11.1]
137018759  adcy1a; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
137018851  ppp2r5ea; protein phosphatase 2, regulatory subunit B', epsilon isoform X1 [KO:K11584]
137019011  actc1a; actin, alpha cardiac muscle 1a [KO:K12314]
137019160  pln1; cardiac phospholamban [KO:K05852]
137019266  myh6; myosin-6 [KO:K17751]
137019272  ppp2r5cb; protein phosphatase 2, regulatory subunit B', gamma b isoform X1 [KO:K11584]
137019294  plcb4b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
137019295  plcb1l; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
137019302  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
137019361  actc2; actin, alpha, cardiac muscle 2 [KO:K12314]
137019367  calm1b; calmodulin-1b [KO:K02183]
137019441  [KO:K06269] [EC:3.1.3.16]
137020165  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
137020466  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
137020496  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
137020525  agt; angiotensinogen [KO:K09821]
137020530  acta1b; actin alpha 1, skeletal muscle b [KO:K12314]
137020763  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
137020844  ppp2r5eb; protein phosphatase 2, regulatory subunit B', epsilon isoform X1 [KO:K11584]
137020876  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
137020991  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
137021205  atp1b4; protein ATP1B4 isoform X1 [KO:K01540]
137021360  adrb2a; adrenoceptor beta 2, surface a [KO:K04142]
137021437  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
137021457  gnai2a; guanine nucleotide-binding protein G(i) subunit alpha-2a isoform X1 [KO:K04630]
137021480  slc8a1a; sodium/calcium exchanger 1a isoform X1 [KO:K05849]
137021568  atp2b4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
137021706  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
137021723  adra1bb; adrenoceptor alpha 1Bb [KO:K04136]
137021750  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
137021806  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
137022548  ppp2caa; protein phosphatase 2 catalytic subunit alpha a [KO:K04382] [EC:3.1.3.16]
137022777  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
137022919  [KO:K04858]
137023110  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
137023797  creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
137024184  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
137024287  tnnt2e; troponin T2e, cardiac isoform X1 [KO:K12045]
137024298  mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
137024299  mapk12b; mitogen-activated protein kinase 12b isoform X1 [KO:K04441] [EC:2.7.11.24]
137024358  tnnt2c; troponin T2c, cardiac isoform X1 [KO:K12045]
137024415  atp2b1a; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
137024487  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a [KO:K04858]
137024507  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
137024555  gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
137024601  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
137024677  adcy2a; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
137025093  creb5b; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
137025686  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
137025702  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
137026229  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
137026279  atp2b3a; plasma membrane calcium-transporting ATPase 3a isoform X1 [KO:K05850] [EC:7.2.2.10]
137026362  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
137026394  creb3l3l; cAMP responsive element binding protein 3-like 3 like [KO:K09048]
137026591  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
137026710  cacna1db; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
137026819  ppp2r2aa; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
137026821  adra1aa; adrenoceptor alpha 1Aa isoform X1 [KO:K04135]
137026877  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
137026894  atp2a2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
137027121  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
137027133  gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
137027151  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
137027389  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
137027681  tpm4a; tropomyosin 4a isoform X1 [KO:K10375]
137027768  gna11a; guanine nucleotide-binding protein subunit alpha-11a isoform X1 [KO:K04634]
137027785  scn1ba; sodium channel, voltage-gated, type I, beta a [KO:K04845]
137027823  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
137028262  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
137028389  adra1ab; alpha-1A adrenergic receptor [KO:K04135]
137028469  akt2l; v-akt murine thymoma viral oncogene homolog 2, like [KO:K04456] [EC:2.7.11.1]
137028537  [KO:K04515] [EC:2.7.11.17]
137028821  ppp2r2ab; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
137028947  tpm2; tropomyosin beta chain isoform X1 [KO:K10374]
137028965  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
137029151  creb3l3a; cyclic AMP-responsive element-binding protein 3-like protein 3-A [KO:K09048]
137029249  cacna2d2b; voltage-dependent calcium channel subunit alpha-2/delta-2b isoform X1 [KO:K04859]
137029846  tpma; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
137029919  bves; blood vessel epicardial substance isoform X1 [KO:K21108]
137029926  popdc3; popeye domain-containing protein 3 [KO:K26207]
137029986  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
137030029  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
137030139  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
137030143  [KO:K06269] [EC:3.1.3.16]
137030218  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
137030341  kcnq1.1; potassium voltage-gated channel subfamily KQT member 1.1 [KO:K04926]
137030385  creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
137031153  slc8a4b; solute carrier family 8 member 4b [KO:K05849]
137031154  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
137031340  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
137031374  calml4a; calmodulin-like protein 4a [KO:K02183]
137031545  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
137031660  [KO:K01539] [EC:7.2.2.13]
137031767  atp1a1a.4; sodium/potassium-transporting ATPase subunit alpha-1a.4 isoform X1 [KO:K01539] [EC:7.2.2.13]
137031822  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
137031987  ppp2r2ca; protein phosphatase 2, regulatory subunit B, gamma a [KO:K04354]
137032154  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
137032252  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
137032283  atp1a3b; sodium/potassium-transporting ATPase subunit alpha-3b [KO:K01539] [EC:7.2.2.13]
137032528  creb1a; cyclic AMP-responsive element-binding protein 1a [KO:K05870]
137032538  cacng3a; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
137032560  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
137032672  atp1b1b; sodium/potassium-transporting ATPase subunit beta-1b [KO:K01540]
137032899  adra1d; alpha-1A adrenergic receptor [KO:K04137]
137032928  [KO:K01539] [EC:7.2.2.13]
137032930  [KO:K01539] [EC:7.2.2.13]
137032994  acta1a; actin alpha 1, skeletal muscle a [KO:K12314]
137033586  mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
137033588  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
137033643  gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
137033712  myl2a; myosin regulatory light chain 2a [KO:K10351]
137033721  cmlc1; cardiac myosin light chain-1 [KO:K12750]
137033820  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
137034061  fxyd2; sodium/potassium-transporting ATPase subunit gamma [KO:K01538]
137034064  scn4bb; sodium channel, voltage-gated, type IV, beta b [KO:K04848]
137034238  ppp2r1ba; protein phosphatase 2, regulatory subunit A, beta a [KO:K03456]
137034415  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
137034444  atp1b2b; sodium/potassium-transporting ATPase subunit beta-2b isoform X1 [KO:K01540]
137034654  slc8a2a; sodium/calcium exchanger 2a isoform X1 [KO:K05849]
137034977  agtr2; type-2 angiotensin II receptor [KO:K04167]
137035387  adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
137035408  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
137035568  rapgef4a; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
137035708  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
137035824  ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
137035994  atp1a1b; sodium/potassium-transporting ATPase subunit alpha-1b isoform X1 [KO:K01539] [EC:7.2.2.13]
137036017  creb1b; cyclic AMP-responsive element-binding protein 1b [KO:K05870]
137036086  si:ch211-225p5.8; sodium channel subunit beta-1 [KO:K04845]
137036340  popdc2; popeye domain-containing 2 isoform X1 [KO:K26206]
137037216  slc9a1b; sodium/hydrogen exchanger 1b isoform X1 [KO:K05742]
137037474  scn1bb; sodium channel, voltage-gated, type I, beta b [KO:K04845]
137037579  slc9a1a; sodium/hydrogen exchanger 1 [KO:K05742]
137037630  cacng8a; calcium channel, voltage-dependent, gamma subunit 8a [KO:K04873]
137037709  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
137037761  creb5a; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
137037858  cacng6a; calcium channel, voltage-dependent, gamma subunit 6a [KO:K04871]
137037908  atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
137037915  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a isoform X1 [KO:K04872]
137037954  atp1a3a; sodium/potassium-transporting ATPase subunit alpha-3a isoform X1 [KO:K01539] [EC:7.2.2.13]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00788  L-Adrenaline
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C07056  Isoproterenol
Reference
PMID:19883653
  Authors
Grimm M, Brown JH
  Title
Beta-adrenergic receptor signaling in the heart: role of CaMKII.
  Journal
J Mol Cell Cardiol 48:322-30 (2010)
DOI:10.1016/j.yjmcc.2009.10.016
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:17988210
  Authors
Bers DM
  Title
Calcium cycling and signaling in cardiac myocytes.
  Journal
Annu Rev Physiol 70:23-49 (2008)
DOI:10.1146/annurev.physiol.70.113006.100455
Reference
PMID:20923637
  Authors
Soltis AR, Saucerman JJ
  Title
Synergy between CaMKII substrates and beta-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling.
  Journal
Biophys J 99:2038-47 (2010)
DOI:10.1016/j.bpj.2010.08.016
Reference
PMID:12439640
  Authors
Wallukat G
  Title
The beta-adrenergic receptors.
  Journal
Herz 27:683-90 (2002)
DOI:10.1007/s00059-002-2434-z
Reference
PMID:11604549
  Authors
Xiao RP
  Title
Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins.
  Journal
Sci STKE 2001:re15 (2001)
DOI:10.1126/stke.2001.104.re15
Reference
PMID:10571541
  Authors
Xiao RP, Cheng H, Zhou YY, Kuschel M, Lakatta EG
  Title
Recent advances in cardiac beta(2)-adrenergic signal transduction.
  Journal
Circ Res 85:1092-100 (1999)
DOI:10.1161/01.RES.85.11.1092
Reference
PMID:15979723
  Authors
Zheng M, Zhu W, Han Q, Xiao RP
  Title
Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling.
  Journal
Pharmacol Ther 108:257-68 (2005)
DOI:10.1016/j.pharmthera.2005.04.006
Reference
PMID:17826821
  Authors
Kuzumoto M, Takeuchi A, Nakai H, Oka C, Noma A, Matsuoka S
  Title
Simulation analysis of intracellular Na+ and Cl- homeostasis during beta 1-adrenergic stimulation of cardiac myocyte.
  Journal
Prog Biophys Mol Biol 96:171-86 (2008)
DOI:10.1016/j.pbiomolbio.2007.07.005
Reference
PMID:11805843
  Authors
Bers DM
  Title
Cardiac excitation-contraction coupling.
  Journal
Nature 415:198-205 (2002)
DOI:10.1038/415198a
Reference
PMID:20658186
  Authors
Ho D, Yan L, Iwatsubo K, Vatner DE, Vatner SF
  Title
Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.
  Journal
Heart Fail Rev 15:495-512 (2010)
DOI:10.1007/s10741-010-9183-5
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:15765137
  Authors
Yano M, Ikeda Y, Matsuzaki M
  Title
Altered intracellular Ca2+ handling in heart failure.
  Journal
J Clin Invest 115:556-64 (2005)
DOI:10.1172/JCI24159
Reference
PMID:15232578
  Authors
Wehrens XH, Marks AR
  Title
Novel therapeutic approaches for heart failure by normalizing calcium cycling.
  Journal
Nat Rev Drug Discov 3:565-73 (2004)
DOI:10.1038/nrd1440
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:18407781
  Authors
Barry SP, Davidson SM, Townsend PA
  Title
Molecular regulation of cardiac hypertrophy.
  Journal
Int J Biochem Cell Biol 40:2023-39 (2008)
DOI:10.1016/j.biocel.2008.02.020
Related
pathway
cery04020  Calcium signaling pathway
cery04260  Cardiac muscle contraction
KO pathway
ko04261   

DBGET integrated database retrieval system