KEGG   PATHWAY: cery04625
Entry
cery04625                   Pathway                                
Name
C-type lectin receptor signaling pathway - Chanodichthys erythropterus (predatory carp)
Description
C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of one or more C-type lectin-like domains (CTLDs). CLRs function as pattern-recognition receptors (PRRs) for pathogen-derived ligands in dendric cells, macrophages, neutrophils, etc., such as Dectin-1 and Dectin-2 for recognition of fungi-derived B-glucan and high mannose-type carbohydrates. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
Class
Organismal Systems; Immune system
Pathway map
cery04625  C-type lectin receptor signaling pathway
cery04625

Organism
Chanodichthys erythropterus (predatory carp) [GN:cery]
Gene
137002101  il6; interleukin-6 [KO:K05405]
137002323  ptgs2a; prostaglandin G/H synthase 2a [KO:K11987] [EC:1.14.99.1]
137002346  bcl10; B-cell lymphoma/leukemia 10 isoform X1 [KO:K07368]
137002446  plk3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
137002940  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
137003113  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
137003705  fcer1gl; Fc receptor, IgE, high affinity I, gamma polypeptide like isoform X1 [KO:K07983]
137003712  zmp:0000001127; interleukin-12 subunit alpha [KO:K05406]
137004124  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
137004281  calm3a; calmodulin 3a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
137004468  il12a; interleukin-12 subunit alpha [KO:K05406]
137004506  arhgef12a; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
137004868  relb; transcription factor RelB [KO:K09253]
137005431  ksr1b; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
137006187  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
137006427  egr2a; E3 SUMO-protein ligase EGR2a [KO:K12496]
137006461  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
137006597  calm1a; calmodulin-1a [KO:K02183]
137007778  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
137007791  irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
137007922  egr2b; early growth response protein 2b [KO:K12496]
137008268  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
137008711  src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
137008719  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
137008876  ptpn11b; tyrosine-protein phosphatase non-receptor type 11b isoform X1 [KO:K07293] [EC:3.1.3.48]
137008942  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
137009531  ikbkg; NF-kappa-B essential modulator [KO:K07210]
137009724  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
137009787  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
137009798  rhoac; rho-related GTP-binding protein RhoA-C isoform X1 [KO:K04513]
137009875  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
137010734  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
137010794  itpr1a; inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 [KO:K04958]
137010908  cyldl; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
137011077  [KO:K04398] [EC:3.4.22.61]
137011206  casp8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
137011264  [KO:K17332]
137011268  casp8l1; caspase 8, apoptosis-related cysteine peptidase, like 1 [KO:K04398] [EC:3.4.22.61]
137011321  rhoca; ras homolog family member Ca [KO:K04513]
137011712  stat2; signal transducer and activator of transcription 2 [KO:K11221]
137011727  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
137012088  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
137012171  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
137012365  irf1b; interferon regulatory factor 1b isoform X1 [KO:K09444]
137012459  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
137012782  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
137013992  il12ba; interleukin 12Ba [KO:K05425]
137014323  [KO:K04466] [EC:2.7.11.25]
137014472  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
137014687  hrasa; HRas proto-oncogene, GTPase a isoform X1 [KO:K02833]
137015480  kras; GTPase KRas isoform X1 [KO:K07827]
137015576  calml4b; calmodulin-like protein 4 [KO:K02183]
137017475  zgc:55558; GTPase KRas [KO:K07827]
137017505  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
137017621  rras; ras-related protein R-Ras [KO:K07830]
137017738  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
137018454  ptgs2b; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
137018700  [KO:K04456] [EC:2.7.11.1]
137018733  nfkbiaa; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a [KO:K04734]
137019367  calm1b; calmodulin-1b [KO:K02183]
137019377  jun; transcription factor AP-1 [KO:K04448]
137020466  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
137020508  [KO:K04469]
137020554  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
137020639  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
137020809  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
137020876  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
137021108  il10; interleukin-10 [KO:K05443]
137021452  itpr1b; inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X1 [KO:K04958]
137021461  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
137021579  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
137021582  mapkapk2a; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
137021605  prkcdb; protein kinase C, delta b [KO:K06068] [EC:2.7.11.13]
137021750  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
137021787  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
137022705  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
137022777  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
137023028  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
137023110  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
137023276  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
137023308  itpr2; inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 isoform X1 [KO:K04959]
137023419  malt3; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369] [EC:3.4.22.-]
137023504  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
137024298  mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
137024299  mapk12b; mitogen-activated protein kinase 12b isoform X1 [KO:K04441] [EC:2.7.11.24]
137024559  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
137026469  mapkapk2b; MAP kinase-activated protein kinase 2b [KO:K04443] [EC:2.7.11.1]
137026659  [KO:K12799]
137026791  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
137026877  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
137026886  nras; GTPase NRas [KO:K07828]
137026918  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
137027010  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
137027114  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
137027121  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
137027153  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
137027341  egr3; early growth response protein 3 isoform X1 [KO:K12497]
137027661  stat1a; signal transducer and activator of transcription 1a isoform X1 [KO:K11220]
137027832  mrasb; ras-related protein M-Ras [KO:K07831]
137028439  [KO:K04513]
137028469  akt2l; v-akt murine thymoma viral oncogene homolog 2, like [KO:K04456] [EC:2.7.11.1]
137028492  ptpn11a; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
137028548  [KO:K04519]
137028631  ksr1a; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
137028712  cblb; E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]
137028810  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
137029097  malt2; MALT paracaspase 2 [KO:K07369] [EC:3.4.22.-]
137029421  [KO:K04519]
137029422  [KO:K04519]
137029423  [KO:K04519]
137029424  [KO:K04519]
137029905  fcer1g; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
137030508  rela; transcription factor p65 [KO:K04735]
137030523  rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
137030555  cyld3; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
137031141  [KO:K04348] [EC:3.1.3.16]
137031219  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
137031343  cyld; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
137031362  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
137031374  calml4a; calmodulin-like protein 4a [KO:K02183]
137031545  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
137031784  [KO:K01370] [EC:3.4.22.36]
137031788  [KO:K12799]
137031842  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
137032780  [KO:K01370] [EC:3.4.22.36]
137033557  arhgef12b; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
137033586  mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
137034610  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
137034726  malt1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369] [EC:3.4.22.-]
137034769  card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
137034884  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
137034980  casp22; LOW QUALITY PROTEIN: caspase-22 [KO:K04398] [EC:3.4.22.61]
137035124  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
137035360  casp10; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
137035384  bcl3; B-cell lymphoma 3 protein homolog [KO:K09258]
137035719  mrasa; ras-related protein M-Ras isoform X1 [KO:K07831]
137035818  il17d; interleukin-17D [KO:K05492]
137036066  caspa; caspase a [KO:K01370] [EC:3.4.22.36]
137036098  pycard; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
137037220  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
137037257  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00159  D-Mannose
C00165  Diacylglycerol
C00584  Prostaglandin E2
C00965  1,3-beta-D-Glucan
C01019  L-Fucose
C01245  D-myo-Inositol 1,4,5-trisphosphate
C16844  Hydroxyl radical
C21790  Mycobacterial trehalose dimycolate
C21791  Rhodocytin
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:27291962
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
C-type lectin receptors in the control of T helper cell differentiation.
  Journal
Nat Rev Immunol 16:433-48 (2016)
DOI:10.1038/nri.2016.55
Reference
PMID:21350579
  Authors
Hajishengallis G, Lambris JD
  Title
Microbial manipulation of receptor crosstalk in innate immunity.
  Journal
Nat Rev Immunol 11:187-200 (2011)
DOI:10.1038/nri2918
Reference
PMID:28604735
  Authors
Iliev ID, Leonardi I
  Title
Fungal dysbiosis: immunity and interactions at mucosal barriers.
  Journal
Nat Rev Immunol 17:635-646 (2017)
DOI:10.1038/nri.2017.55
Reference
PMID:25002863
  Authors
Richardson MB, Williams SJ
  Title
MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
  Journal
Front Immunol 5:288 (2014)
DOI:10.3389/fimmu.2014.00288
Reference
PMID:21924922
  Authors
Vautier S, MacCallum DM, Brown GD
  Title
C-type lectin receptors and cytokines in fungal immunity.
  Journal
Cytokine 58:89-99 (2012)
DOI:10.1016/j.cyto.2011.08.031
Reference
PMID:22170181
  Authors
Gauglitz GG, Callenberg H, Weindl G, Korting HC
  Title
Host defence against Candida albicans and the role of pattern-recognition receptors.
  Journal
Acta Derm Venereol 92:291-8 (2012)
DOI:10.2340/00015555-1250
Reference
PMID:22973279
  Authors
Cunha C, Carvalho A, Esposito A, Bistoni F, Romani L
  Title
DAMP signaling in fungal infections and diseases.
  Journal
Front Immunol 3:286 (2012)
DOI:10.3389/fimmu.2012.00286
Reference
PMID:29449845
  Authors
Tang J, Lin G, Langdon WY, Tao L, Zhang J
  Title
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.
  Journal
Front Immunol 9:123 (2018)
DOI:10.3389/fimmu.2018.00123
Reference
PMID:27999992
  Authors
Mayer S, Raulf MK, Lepenies B
  Title
C-type lectins: their network and roles in pathogen recognition and immunity.
  Journal
Histochem Cell Biol 147:223-237 (2017)
DOI:10.1007/s00418-016-1523-7
Reference
PMID:23570314
  Authors
Plato A, Willment JA, Brown GD
  Title
C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.
  Journal
Int Rev Immunol 32:134-56 (2013)
DOI:10.3109/08830185.2013.777065
Reference
PMID:22344277
  Authors
Dupaul-Chicoine J, Saleh M
  Title
A new path to IL-1beta production controlled by caspase-8.
  Journal
Nat Immunol 13:211-2 (2012)
DOI:10.1038/ni.2241
Reference
PMID:24009832
  Authors
Batbayar S, Lee DH, Kim HW
  Title
Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.
  Journal
Biomol Ther (Seoul) 20:433-45 (2012)
DOI:10.4062/biomolther.2012.20.5.433
Reference
PMID:28606994
  Authors
Bendickova K, Tidu F, Fric J
  Title
Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.
  Journal
EMBO Mol Med 9:990-999 (2017)
DOI:10.15252/emmm.201707698
Reference
PMID:18998127
  Authors
den Dunnen J, Gringhuis SI, Geijtenbeek TB
  Title
Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
  Journal
Cancer Immunol Immunother 58:1149-57 (2009)
DOI:10.1007/s00262-008-0615-1
Reference
PMID:28640912
  Authors
Marakalala MJ, Ndlovu H
  Title
Signaling C-type lectin receptors in antimycobacterial immunity.
  Journal
PLoS Pathog 13:e1006333 (2017)
DOI:10.1371/journal.ppat.1006333
Reference
PMID:24867235
  Authors
Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TB
  Title
Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation.
  Journal
Nat Commun 5:3898 (2014)
DOI:10.1038/ncomms4898
Reference
PMID:19521399
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
Signalling through C-type lectin receptors: shaping immune responses.
  Journal
Nat Rev Immunol 9:465-79 (2009)
DOI:10.1038/nri2569
Reference
PMID:19122653
  Authors
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB
  Title
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.
  Journal
Nat Immunol 10:203-13 (2009)
DOI:10.1038/ni.1692
KO pathway
ko04625   

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