KEGG   PATHWAY: cfr04972
Entry
cfr04972                    Pathway                                
Name
Pancreatic secretion - Camelus ferus (Wild Bactrian camel)
Description
The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion.
Class
Organismal Systems; Digestive system
Pathway map
cfr04972  Pancreatic secretion
cfr04972

Other DBs
GO: 0030157
Organism
Camelus ferus (Wild Bactrian camel) [GN:cfr]
Gene
102503785  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
102504585  [KO:K14075] [EC:3.1.1.3]
102504846  [KO:K14073] [EC:3.1.1.3]
102505197  CEL; bile salt-activated lipase [KO:K12298] [EC:3.1.1.3 3.1.1.13]
102505216  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
102505261  ADCY9; LOW QUALITY PROTEIN: adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102505338  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
102505598  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
102506121  ATP2A2; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
102506233  PRSS2; trypsin-2 [KO:K01312] [EC:3.4.21.4]
102506813  CPA2; LOW QUALITY PROTEIN: carboxypeptidase A2 [KO:K01298] [EC:3.4.17.15]
102506872  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
102507440  ATP2A1; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
102507832  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
102507993  RHOA; transforming protein RhoA [KO:K04513]
102508026  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
102508164  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
102508209  CPA3; LOW QUALITY PROTEIN: mast cell carboxypeptidase A [KO:K08780] [EC:3.4.17.1]
102508256  BST1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X1 [KO:K18152] [EC:3.2.2.6 2.4.99.20]
102508460  CPB1; carboxypeptidase B [KO:K01291] [EC:3.4.17.2]
102508487  KCNQ1; potassium voltage-gated channel subfamily KQT member 1 isoform X1 [KO:K04926]
102508526  RAB3D; ras-related protein Rab-3D [KO:K07884]
102508547  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
102508872  PLA2G2E; group IIE secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
102509058  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3 [KO:K05858] [EC:3.1.4.11]
102509111  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
102509333  RAB27B; ras-related protein Rab-27B [KO:K07886]
102509654  KCNMA1; calcium-activated potassium channel subunit alpha-1 isoform X1 [KO:K04936]
102509736  ATP1A1; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
102509764  CPB2; carboxypeptidase B2 [KO:K01300] [EC:3.4.17.20]
102509921  [KO:K04632]
102510957  TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964]
102510993  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
102511780  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
102511859  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
102511904  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
102512064  [KO:K05030]
102512302  CLCA4; LOW QUALITY PROTEIN: calcium-activated chloride channel regulator 4 [KO:K05030]
102512347  CA2; carbonic anhydrase 2 [KO:K18245] [EC:4.2.1.1]
102512950  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
102513364  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
102513431  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
102513516  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102513676  CCKAR; cholecystokinin receptor type A [KO:K04194]
102513869  [KO:K04632]
102513958  [KO:K01047] [EC:3.1.1.4]
102513996  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
102514000  [KO:K01345] [EC:3.4.21.70]
102514596  SLC12A2; solute carrier family 12 member 2 isoform X1 [KO:K10951]
102514641  [KO:K14074] [EC:3.1.1.3]
102514915  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
102515084  RAB11A; ras-related protein Rab-11A [KO:K07904]
102515090  [KO:K01312] [EC:3.4.21.4]
102515349  [KO:K01312] [EC:3.4.21.4]
102515667  CTRL; LOW QUALITY PROTEIN: chymotrypsin-like protease CTRL-1 [KO:K09632] [EC:3.4.21.-]
102516053  ATP1A2; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
102516450  RAP1A; ras-related protein Rap-1A [KO:K04353]
102516646  ATP1A4; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
102516893  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102517295  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102517343  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102517415  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
102517882  ADCY1; LOW QUALITY PROTEIN: adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102517893  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
102517974  RAB8A; ras-related protein Rab-8A [KO:K07901]
102517975  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
102519577  [KO:K01346] [EC:3.4.21.71]
102519611  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
102519924  ATP2B3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
102520380  PLA2G5; calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102520577  ATP1B4; protein ATP1B4 isoform X3 [KO:K01540]
102520584  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
102520622  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102520853  PLA2G2F; LOW QUALITY PROTEIN: group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102521097  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102521109  CLCA1; calcium-activated chloride channel regulator 1 [KO:K05027]
102521259  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
102521349  CLCA2; calcium-activated chloride channel regulator 2 [KO:K05028]
102521432  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
102521486  CCK; cholecystokinin [KO:K05226]
102521639  [KO:K01310] [EC:3.4.21.1]
102521660  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102521814  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
102521880  [KO:K01310] [EC:3.4.21.1]
102522344  SCTR; secretin receptor isoform X1 [KO:K04588]
102522746  SLC26A3; chloride anion exchanger [KO:K14078]
102523015  PLA2G12A; LOW QUALITY PROTEIN: group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102523025  SLC4A2; anion exchange protein 2 isoform X1 [KO:K13855]
102523222  RYR2; ryanodine receptor 2 [KO:K04962]
102523392  CPA1; carboxypeptidase A1 [KO:K08779] [EC:3.4.17.1]
102523470  [KO:K01176] [EC:3.2.1.1]
102524031  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
102524037  RAP1B; ras-related protein Rap-1b [KO:K07836]
102524078  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
102524246  [KO:K01310] [EC:3.4.21.1]
102524365  SLC4A4; electrogenic sodium bicarbonate cotransporter 1 isoform X1 [KO:K13575]
102524614  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
Compound
C00001  H2O
C00011  CO2
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00288  HCO3-
C00575  3',5'-Cyclic AMP
C00698  Cl-
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01353  Carbonic acid
C01996  Acetylcholine
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:17850212
  Authors
Petersen OH, Tepikin AV
  Title
Polarized calcium signaling in exocrine gland cells.
  Journal
Annu Rev Physiol 70:273-99 (2008)
DOI:10.1146/annurev.physiol.70.113006.100618
Reference
PMID:20625287
  Authors
Williams JA
  Title
Regulation of acinar cell function in the pancreas.
  Journal
Curr Opin Gastroenterol 26:478-83 (2010)
DOI:10.1097/MOG.0b013e32833d11c6
Reference
PMID:16891880
  Authors
Williams JA
  Title
Regulation of pancreatic acinar cell function.
  Journal
Curr Opin Gastroenterol 22:498-504 (2006)
DOI:10.1097/01.mog.0000239863.96833.c0
Reference
PMID:15689674
  Authors
Bi Y, Williams JA
  Title
Receptor biology and signal transduction in pancreatic acinar cells.
  Journal
Curr Opin Gastroenterol 20:427-34 (2004)
DOI:10.1097/00001574-200409000-00002
Reference
PMID:14660554
  Authors
Yamasaki M, Masgrau R, Morgan AJ, Churchill GC, Patel S, Ashcroft SJ, Galione A
  Title
Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.
  Journal
J Biol Chem 279:7234-40 (2004)
DOI:10.1074/jbc.M311088200
Reference
PMID:9548666
  Authors
Kanno T
  Title
Ca2+ signaling in the pancreatic acinus.
  Journal
Pancreas 16:273-6 (1998)
Reference
PMID:18626068
  Authors
Heitzmann D, Warth R
  Title
Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
  Journal
Physiol Rev 88:1119-82 (2008)
DOI:10.1152/physrev.00020.2007
Reference
PMID:14637169
  Authors
Konturek SJ, Zabielski R, Konturek JW, Czarnecki J
  Title
Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion.
  Journal
Eur J Pharmacol 481:1-14 (2003)
DOI:10.1016/j.ejphar.2003.08.042
Reference
PMID:16888148
  Authors
Chu JY, Yung WH, Chow BK
  Title
Secretin: a pleiotrophic hormone.
  Journal
Ann N Y Acad Sci 1070:27-50 (2006)
DOI:10.1196/annals.1317.013
Reference
PMID:16930743
  Authors
Siu FK, Lam IP, Chu JY, Chow BK
  Title
Signaling mechanisms of secretin receptor.
  Journal
Regul Pept 137:95-104 (2006)
DOI:10.1016/j.regpep.2006.02.011
Reference
PMID:15709963
  Authors
Steward MC, Ishiguro H, Case RM
  Title
Mechanisms of bicarbonate secretion in the pancreatic duct.
  Journal
Annu Rev Physiol 67:377-409 (2005)
DOI:10.1146/annurev.physiol.67.031103.153247
Reference
PMID:20224219
  Authors
Kim D, Steward MC
  Title
The role of CFTR in bicarbonate secretion by pancreatic duct and airway epithelia.
  Journal
J Med Invest 56 Suppl:336-42 (2009)
DOI:10.2152/jmi.56.336
Reference
PMID:17205399
  Authors
Whitcomb DC, Lowe ME
  Title
Human pancreatic digestive enzymes.
  Journal
Dig Dis Sci 52:1-17 (2007)
DOI:10.1007/s10620-006-9589-z
Reference
PMID:10835353
  Authors
Cancela JM, Gerasimenko OV, Gerasimenko JV, Tepikin AV, Petersen OH
  Title
Two different but converging messenger pathways to intracellular Ca(2+) release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate.
  Journal
EMBO J 19:2549-57 (2000)
DOI:10.1093/emboj/19.11.2549
Reference
PMID:10078532
  Authors
Cancela JM, Churchill GC, Galione A
  Title
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.
  Journal
Nature 398:74-6 (1999)
DOI:10.1038/18032
Reference
PMID:11087843
  Authors
Parekh AB
  Title
Calcium signaling and acute pancreatitis: specific response to a promiscuous messenger.
  Journal
Proc Natl Acad Sci U S A 97:12933-4 (2000)
DOI:10.1073/pnas.97.24.12933
Reference
PMID:19088252
  Authors
Williams JA, Chen X, Sabbatini ME
  Title
Small G proteins as key regulators of pancreatic digestive enzyme secretion.
  Journal
Am J Physiol Endocrinol Metab 296:E405-14 (2009)
DOI:10.1152/ajpendo.90874.2008
Related
pathway
cfr04020  Calcium signaling pathway
cfr04530  Tight junction
cfr04973  Carbohydrate digestion and absorption
cfr04974  Protein digestion and absorption
cfr04975  Fat digestion and absorption
cfr04977  Vitamin digestion and absorption
KO pathway
ko04972   

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