Entry
Name
Renal cell carcinoma - Cricetulus griseus (Chinese hamster)
Description
Renal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal cancer accounts for 1-4% of cases. RCC is not a single disease, it has several morphological subtypes. Conventional RCC (clear cell RCC) accounts for ~80% of cases, followed by papillary RCC (10-15%), chromophobe RCC (5%), and collecting duct RCC (<1%). Genes potentially involved in sporadic neoplasms of each particular type are VHL, MET, BHD, and FH respectively. In the absence of VHL, hypoxia-inducible factor alpha (HIF-alpha) accumulates, leading to production of several growth factors, including vascular endothelial growth factor and platelet-derived growth factor. Activated MET mediates a number of biological effects including motility, invasion of extracellular matrix, cellular transformation, prevention of apoptosis and metastasis formation. Loss of functional FH leads to accumulation of fumarate in the cell, triggering inhibition of HPH and preventing targeted pVHL-mediated degradation of HIF-alpha. BHD mutations cause the Birt-Hogg-Dube syndrome and its associated chromophobe, hybrid oncocytic, and conventional (clear cell) RCC.
Class
Human Diseases; Cancer: specific types
BRITE hierarchy
Pathway map
Ortholog table
Organism
Cricetulus griseus (Chinese hamster) [GN:
cge ]
Gene
100771160 Epas1; endothelial PAS domain-containing protein 1 isoform X2 [KO:K09095 ]
100751916 Vhl; von Hippel-Lindau disease tumor suppressor isoform X2 [KO:K03871 ]
100752106 Arnt; aryl hydrocarbon receptor nuclear translocator isoform X8 [KO:K09097 ]
100773566 Arnt2; aryl hydrocarbon receptor nuclear translocator 2 isoform X2 [KO:K15589 ]
100753506 Slc2a1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299 ]
100755957 Vegfa; LOW QUALITY PROTEIN: vascular endothelial growth factor A isoform X2 [KO:K05448 ]
100773359 Tgfb1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375 ]
100774918 Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
100756831 Tgfb3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377 ]
100774990 Pdgfb; platelet-derived growth factor subunit B isoform X2 [KO:K17386 ]
100754730 Tgfa; LOW QUALITY PROTEIN: protransforming growth factor alpha isoform X2 [KO:K08774 ]
100689251 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100769225 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922 ] [EC:2.7.1.153 ]
100689252 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922 ] [EC:2.7.1.153 ]
100771181 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649 ]
100750761 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
100774067 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
100760426 Bad; bcl2-associated agonist of cell death isoform X2 [KO:K02158 ]
100764804 Rapgef1; rap guanine nucleotide exchange factor 1 isoform X2 [KO:K06277 ]
100769627 Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
100756792 Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
103160601 Cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625 ]
Compound
Reference
Authors
Cohen HT, McGovern FJ.
Title
Renal-cell carcinoma.
Journal
Reference
Authors
Pavlovich CP, Schmidt LS.
Title
Searching for the hereditary causes of renal-cell carcinoma.
Journal
Reference
Authors
Linehan WM, Walther MM, Zbar B.
Title
The genetic basis of cancer of the kidney.
Journal
Reference
Authors
Kim WY, Kaelin WG.
Title
Role of VHL gene mutation in human cancer.
Journal
Reference
Authors
Sudarshan S, Linehan WM, Neckers L.
Title
HIF and fumarate hydratase in renal cancer.
Journal
Reference
Authors
Sudarshan S, Pinto PA, Neckers L, Linehan WM.
Title
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer.
Journal
Reference
Authors
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF.
Title
Met, metastasis, motility and more.
Journal
Reference
Authors
Muller-Hocker J, Babaryka G, Schmid I, Jung A
Title
Overexpression of cyclin D1, D3, and p21 in an infantile renal carcinoma with Xp11.2 TFE3-gene fusion.
Journal
Reference
Authors
Bodmer D, van den Hurk W, van Groningen JJ, Eleveld MJ, Martens GJ, Weterman MA, van Kessel AG.
Title
Understanding familial and non-familial renal cell cancer.
Journal
Reference
Authors
Kauffman EC, Ricketts CJ, Rais-Bahrami S, Yang Y, Merino MJ, Bottaro DP, Srinivasan R, Linehan WM
Title
Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers.
Journal
Reference
Authors
Skalsky YM, Ajuh PM, Parker C, Lamond AI, Goodwin G, Cooper CS
Title
PRCC, the commonest TFE3 fusion partner in papillary renal carcinoma is associated with pre-mRNA splicing factors.
Journal
Reference
Authors
Medendorp K, van Groningen JJ, Vreede L, Hetterschijt L, Brugmans L, van den Hurk WH, van Kessel AG
Title
The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay.
Journal
Related pathway
KO pathway
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