KEGG   PATHWAY: cjc04640
Entry
cjc04640                    Pathway                                
Name
Hematopoietic cell lineage - Callithrix jacchus (white-tufted-ear marmoset)
Description
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Class
Organismal Systems; Immune system
Pathway map
cjc04640  Hematopoietic cell lineage
cjc04640

Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100410844  KITLG; kit ligand isoform X1 [KO:K05461]
103790554  kit ligand-like [KO:K05461]
100387798  IL7; interleukin-7 [KO:K05431]
100406536  IL4; interleukin-4 precursor [KO:K05430]
100410164  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
100411269  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X11 [KO:K05454]
100407630  IL5; interleukin-5 precursor [KO:K05428]
100411779  LOW QUALITY PROTEIN: granulocyte colony-stimulating factor [KO:K05423]
100408545  CSF3; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor [KO:K05423]
100393440  IL6; interleukin-6 precursor [KO:K05405]
100390490  IL11; interleukin-11 [KO:K05417]
100406401  IL1A; interleukin-1 alpha [KO:K04383]
100406769  IL1B; interleukin-1 beta isoform X1 [KO:K04519]
100397484  TNF; tumor necrosis factor [KO:K03156]
100386071  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
100394313  EPO; erythropoietin [KO:K05437]
103795045  THPO; LOW QUALITY PROTEIN: thrombopoietin [KO:K06854]
100397598  CD34; hematopoietic progenitor cell antigen CD34 precursor [KO:K06474]
100413316  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
100397804  DNTT; DNA nucleotidylexotransferase isoform X1 [KO:K00977] [EC:2.7.7.31]
100386155  CAJA-DRB1; HLA class II histocompatibility antigen, DRB1-13 beta chain-like precursor [KO:K06752]
100397732  HLA class II histocompatibility antigen, DR beta 5 chain [KO:K06752]
100386865  HLA class II histocompatibility antigen, DQ beta 1 chain [KO:K06752]
100387227  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
100405222  HLA class II histocompatibility antigen, DQ beta 2 chain isoform X1 [KO:K06752]
100411388  HLA class II histocompatibility antigen, DQ alpha 1 chain [KO:K06752]
100412691  CAJA-DMB; HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
100408132  CAJA-DOA; HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
100408503  CAJA-DPB1; HLA class II histocompatibility antigen, DP beta 1 chain isoform X3 [KO:K06752]
100407771  CAJA-DMA; HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
100413648  CAJA-DPA1; HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
100385427  CAJA-DRA; HLA class II histocompatibility antigen, DR alpha chain precursor [KO:K06752]
128931734  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
100390910  CD44; CD44 antigen isoform X17 [KO:K06256]
100411615  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
100412016  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
100397720  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
100407510  TFRC; transferrin receptor protein 1 [KO:K06503]
100387937  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
100404041  CD7; uncharacterized protein CD7 isoform X1 [KO:K06457]
100395235  CD2; T-cell surface antigen CD2 precursor [KO:K06449]
103796343  CD5; T-cell surface glycoprotein CD5 [KO:K06455]
100396420  T-cell surface glycoprotein CD1a-like [KO:K06448]
100393854  CD1B; T-cell surface glycoprotein CD1b [KO:K06448]
100394213  T-cell surface glycoprotein CD1e, membrane-associated [KO:K06448]
100393492  CD1D; antigen-presenting glycoprotein CD1d isoform X1 [KO:K06448]
100392273  CD1C; T-cell surface glycoprotein CD1c [KO:K06448]
100398240  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
100385000  CD4; T-cell surface glycoprotein CD4 precursor [KO:K06454]
100387674  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
100413968  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
100404313  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X2 [KO:K06450]
100403944  CD3E; T-cell surface glycoprotein CD3 epsilon chain precursor [KO:K06451]
100404679  T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
100387438  MME; neprilysin isoform X1 [KO:K01389] [EC:3.4.24.11]
100397045  CD9; CD9 antigen [KO:K06460]
100402637  CD19; B-lymphocyte antigen CD19 precursor [KO:K06465]
100894712  CD22; B-cell receptor CD22 isoform X1 [KO:K06467]
100404018  CD24; signal transducer CD24 isoform X1 [KO:K06469]
100403725  MS4A1; B-lymphocyte antigen CD20 [KO:K06466]
108587696  CR2; complement receptor type 2 isoform X2 [KO:K04012]
100394586  CD37; leukocyte antigen CD37 isoform X1 [KO:K06475]
103793556  immunoglobulin heavy variable 1-18 [KO:K06856]
100409349  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
100396861  complement receptor type 1 isoform X1 [KO:K04011]
103790668  complement receptor type 1 [KO:K04011]
100413917  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066]
100405472  interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
100405713  myeloid cell surface antigen CD33-like [KO:K06473]
100406082  myeloid cell surface antigen CD33 isoform X1 [KO:K06473]
100411874  myeloid cell surface antigen CD33-like [KO:K06473]
100412639  IL4R; interleukin-4 receptor subunit alpha precursor [KO:K05071]
100385661  IL6R; interleukin-6 receptor subunit alpha precursor [KO:K05055]
100393738  FCGR1A; high affinity immunoglobulin gamma Fc receptor I isoform X2 [KO:K06498]
100406047  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
100406342  ANPEP; aminopeptidase N [KO:K11140] [EC:3.4.11.2]
100389341  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
100895453  CD14; monocyte differentiation antigen CD14 [KO:K04391]
100408034  IL9R; interleukin-9 receptor [KO:K05073]
100393945  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
100393582  IL1R2; LOW QUALITY PROTEIN: interleukin-1 receptor type 2 [KO:K04387]
100393434  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
100414222  IL5RA; interleukin-5 receptor subunit alpha precursor [KO:K05067]
100389634  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
100387385  CD36; platelet glycoprotein 4 [KO:K06259]
100894608  GYPA; glycophorin-A isoform X1 [KO:K06575]
100396134  CD55; complement decay-accelerating factor isoform X3 [KO:K04006]
100386445  CD59; CD59 glycoprotein [KO:K04008]
100894787  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
100386042  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
100408748  ITGA2B; integrin alpha-IIb [KO:K06476]
100398063  GP9; platelet glycoprotein IX [KO:K06263]
100393767  GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261]
100896512  GP5; platelet glycoprotein V [KO:K06260]
100404358  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
100403636  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
100386753  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
100389291  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
100386674  ITGA5; integrin alpha-5 [KO:K06484]
100403557  ITGA6; integrin alpha-6 isoform X7 [KO:K06485]
Reference
  Authors
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ
  Title
Immunobiology - International editon: The immune system in health and disease
  Journal
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)
Reference
  Authors
Abe T
  Title
[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (In Japanese)
  Journal
Nihonijishinhousya (2000)
Reference
PMID:15771582
  Authors
Rothenberg EV, Taghon T.
  Title
Molecular genetics of T cell development.
  Journal
Annu Rev Immunol 23:601-49 (2005)
DOI:10.1146/annurev.immunol.23.021704.115737
Reference
PMID:12415312
  Authors
Ceredig R, Rolink T.
  Title
A positive look at double-negative thymocytes.
  Journal
Nat Rev Immunol 2:888-97 (2002)
DOI:10.1038/nri937
Reference
PMID:15156179
  Authors
de Bruijn MF, Speck NA.
  Title
Core-binding factors in hematopoiesis and immune function.
  Journal
Oncogene 23:4238-48 (2004)
DOI:10.1038/sj.onc.1207763
Reference
PMID:14985712
  Authors
Radtke F, Wilson A, Mancini SJ, MacDonald HR.
  Title
Notch regulation of lymphocyte development and function.
  Journal
Nat Immunol 5:247-53 (2004)
DOI:10.1038/ni1045
Reference
PMID:12360214
  Authors
Spits H.
  Title
Development of alphabeta T cells in the human thymus.
  Journal
Nat Rev Immunol 2:760-72 (2002)
DOI:10.1038/nri913
Reference
PMID:9927518
  Authors
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.
  Title
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
  Journal
J Exp Med 189:563-74 (1999)
DOI:10.1084/jem.189.3.563
Reference
PMID:11905810
  Authors
Mak TW, Penninger JM, Ohashi PS.
  Title
Knockout mice: a paradigm shift in modern immunology.
  Journal
Nat Rev Immunol 1:11-9 (2001)
DOI:10.1038/35095551
Reference
PMID:15738953
  Authors
Shapiro-Shelef M, Calame K.
  Title
Regulation of plasma-cell development.
  Journal
Nat Rev Immunol 5:230-42 (2005)
DOI:10.1038/nri1572
Reference
PMID:14670296
  Authors
Maillard I, Adler SH, Pear WS.
  Title
Notch and the immune system.
  Journal
Immunity 19:781-91 (2003)
DOI:10.1016/S1074-7613(03)00325-X
Reference
PMID:15629410
  Authors
Alpdogan O, van den Brink MR.
  Title
IL-7 and IL-15: therapeutic cytokines for immunodeficiency.
  Journal
Trends Immunol 26:56-64 (2005)
DOI:10.1016/j.it.2004.11.002
KO pathway
ko04640   
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