KEGG   PATHWAY: clum04070
Entry
clum04070                   Pathway                                
Name
Phosphatidylinositol signaling system - Cyclopterus lumpus (lumpfish)
Class
Environmental Information Processing; Signal transduction
Pathway map
clum04070  Phosphatidylinositol signaling system
clum04070

Organism
Cyclopterus lumpus (lumpfish) [GN:clum]
Gene
117725449  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
117725978  dgki; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
117726294  calml4a; calmodulin-like protein 4a [KO:K02183]
117727166  calm1b; calmodulin-1b [KO:K02183]
117727266  [KO:K05858] [EC:3.1.4.11]
117727496  itpkb; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
117727721  [KO:K05858] [EC:3.1.4.11]
117728012  sacm1lb; phosphatidylinositide phosphatase SAC1-B [KO:K21797] [EC:3.1.3.-]
117728904  ppip5k1a; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1 [KO:K13024] [EC:2.7.4.24]
117729144  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117729209  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
117729261  inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
117729444  [KO:K01116] [EC:3.1.4.11]
117729683  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
117729698  [KO:K02649]
117730022  pi4k2b; phosphatidylinositol 4-kinase type 2-beta isoform X1 [KO:K13711] [EC:2.7.1.67]
117730310  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
117730314  ip6k1; inositol hexakisphosphate kinase 1 isoform X1 [KO:K07756] [EC:2.7.4.21]
117730321  mtmr14; myotubularin-related protein 14 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
117730401  pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923] [EC:2.7.1.154]
117730495  [KO:K02183]
117730782  [KO:K07756] [EC:2.7.4.21]
117730952  dgkab; diacylglycerol kinase, alpha b isoform X1 [KO:K00901] [EC:2.7.1.107]
117730966  inpp1; inositol polyphosphate 1-phosphatase [KO:K01107] [EC:3.1.3.57]
117731062  [KO:K00920] [EC:2.7.1.149]
117731168  [KO:K04958]
117731234  [KO:K07756] [EC:2.7.4.21]
117731505  inpp4b; type II inositol 3,4-bisphosphate 4-phosphatase isoform X1 [KO:K01109] [EC:3.1.3.66]
117731512  ippk; inositol-pentakisphosphate 2-kinase isoform X1 [KO:K10572] [EC:2.7.1.158]
117731766  pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923] [EC:2.7.1.154]
117731808  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
117731812  [KO:K13024] [EC:2.7.4.24]
117731905  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
117732410  [KO:K05861] [EC:3.1.4.11]
117732599  dgkzb; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
117732901  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
117732996  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117733021  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
117733504  pip4k2ca; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
117733655  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
117733717  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
117733760  dgkaa; diacylglycerol kinase, alpha a isoform X1 [KO:K00901] [EC:2.7.1.107]
117734359  mtmr7b; myotubularin-related protein 7b [KO:K18083] [EC:3.1.3.64 3.1.3.95]
117734944  [KO:K19662] [EC:2.7.11.13]
117735288  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117735390  cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
117735628  plcd3a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A [KO:K05857] [EC:3.1.4.11]
117735894  cds2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
117735974  pi4kab; LOW QUALITY PROTEIN: phosphatidylinositol 4-kinase, catalytic, alpha b [KO:K00888] [EC:2.7.1.67]
117736025  [KO:K02649]
117736088  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
117736166  cds1; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
117736353  [KO:K00920] [EC:2.7.1.149]
117736732  mtmr3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
117736764  inpp5l; inositol polyphosphate-5-phosphatase A [KO:K01106] [EC:3.1.3.56]
117737186  ocrl; LOW QUALITY PROTEIN: inositol polyphosphate 5-phosphatase OCRL [KO:K01099] [EC:3.1.3.36]
117737654  inppl1b; inositol polyphosphate phosphatase-like 1b [KO:K15909] [EC:3.1.3.86]
117737775  mtmr7a; myotubularin-related protein 7a [KO:K18083] [EC:3.1.3.64 3.1.3.95]
117737786  [KO:K00901] [EC:2.7.1.107]
117738684  sacm1la; phosphatidylinositide phosphatase SAC1-A [KO:K21797] [EC:3.1.3.-]
117738890  [KO:K00889] [EC:2.7.1.68]
117739301  [KO:K19801] [EC:2.7.1.67]
117739500  pip4p2; type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1 [KO:K13084] [EC:3.1.3.78]
117740185  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117740385  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
117740557  plcd4a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
117740583  pi4kaa; phosphatidylinositol 4-kinase alpha [KO:K00888] [EC:2.7.1.67]
117740593  dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
117740797  [KO:K01109] [EC:3.1.3.66]
117741125  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117741237  calm3a; calmodulin 3a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
117741240  [KO:K00901] [EC:2.7.1.107]
117741329  inppl1a; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A isoform X1 [KO:K15909] [EC:3.1.3.86]
117741358  itpkcb; inositol-trisphosphate 3-kinase Cb isoform X1 [KO:K00911] [EC:2.7.1.127]
117741434  [KO:K00901] [EC:2.7.1.107]
117741987  [KO:K00913] [EC:2.7.1.159 2.7.1.134]
117742262  synj1; synaptojanin-1 isoform X1 [KO:K20279] [EC:3.1.3.36]
117742437  mtmr4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
117742447  pi4k2a; phosphatidylinositol 4-kinase type 2-alpha [KO:K13711] [EC:2.7.1.67]
117743027  itpkca; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
117743142  mtmr2; myotubularin-related protein 2 isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
117743829  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117743862  [KO:K01106] [EC:3.1.3.56]
117743966  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
117743969  inpp5f; phosphatidylinositide phosphatase SAC2 isoform X1 [KO:K21798] [EC:3.1.3.-]
117743988  [KO:K05858] [EC:3.1.4.11]
117745114  [KO:K00889] [EC:2.7.1.68]
117745270  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
117745576  pi4kb; LOW QUALITY PROTEIN: phosphatidylinositol 4-kinase beta [KO:K19801] [EC:2.7.1.67]
117745660  inpp5b; type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [KO:K01099] [EC:3.1.3.36]
117745756  dgkb; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
117746072  pip4p1a; type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-A [KO:K13084] [EC:3.1.3.78]
117746145  impa1; inositol monophosphatase 1 isoform X1 [KO:K01092] [EC:3.1.3.25]
117746485  [KO:K00889] [EC:2.7.1.68]
117746514  [KO:K00922] [EC:2.7.1.153]
117746515  [KO:K02649]
117746600  bpnt2; inositol monophosphatase 3 [KO:K15759] [EC:3.1.3.7]
117746960  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117747077  [KO:K05857] [EC:3.1.4.11]
117747448  mtm1; myotubularin isoform X1 [KO:K01108] [EC:3.1.3.64 3.1.3.95]
117747495  si:dkey-172j4.3; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
117747576  [KO:K13084] [EC:3.1.3.78]
117747650  [KO:K00922] [EC:2.7.1.153]
117747790  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
117747934  mtmr1a; myotubularin-related protein 1a isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
117748011  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
117748096  [KO:K01109] [EC:3.1.3.66]
117748371  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117748676  [KO:K05857] [EC:3.1.4.11]
117748994  ipmkb; inositol polyphosphate multikinase [KO:K00915] [EC:2.7.1.140 2.7.1.151]
117749046  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
117749285  mtmr6; myotubularin-related protein 6 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
117749433  [KO:K19662] [EC:2.7.11.13]
117749606  [KO:K01092] [EC:3.1.3.25]
117749647  [KO:K01092] [EC:3.1.3.25]
117749665  plcd1a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1a isoform X1 [KO:K05857] [EC:3.1.4.11]
117749861  pip4k2aa; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
117750096  pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
117750156  plcd4b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
117750788  dgkh; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
117750846  inpp4aa; inositol polyphosphate-4-phosphatase type I A [KO:K01109] [EC:3.1.3.66]
117751024  [KO:K00901] [EC:2.7.1.107]
117751154  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
117751166  itpk1b; inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.159 2.7.1.134]
117751249  calm1a; calmodulin-1a isoform X1 [KO:K02183]
Compound
C00076  Calcium cation
C00137  myo-Inositol
C00269  CDP-diacylglycerol
C00416  Phosphatidate
C00641  1,2-Diacyl-sn-glycerol
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11174  1-Diphosinositol pentakisphosphate
C11526  5-PP-InsP5
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
PMID:19580826
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
DOI:10.1016/j.plipres.2009.06.001
Reference
PMID:19439500
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
DOI:10.1124/mol.109.055897
Related
pathway
clum04020  Calcium signaling pathway
clum04144  Endocytosis
clum04510  Focal adhesion
KO pathway
ko04070   

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