KEGG   PATHWAY: cmao03420
Entry
cmao03420                   Pathway                                
Name
Nucleotide excision repair - Colossoma macropomum (tambaqui)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
cmao03420  Nucleotide excision repair
cmao03420

Other DBs
GO: 0006289
Organism
Colossoma macropomum (tambaqui) [GN:cmao]
Gene
118797382  polr2ea; DNA-directed RNA polymerases I, II, and III subunit RPABC1 [KO:K03013]
118797851  ercc5; DNA repair protein complementing XP-G cells homolog [KO:K10846]
118798123  cul4a; cullin-4A [KO:K10609]
118800160  rad23aa; RAD23 homolog A, nucleotide excision repair protein a [KO:K10839]
118801166  ercc2; general transcription and DNA repair factor IIH helicase subunit XPD [KO:K10844] [EC:5.6.2.3]
118801706  rpa1; replication protein A 70 kDa DNA-binding subunit isoform X1 [KO:K07466]
118802106  [KO:K10739]
118802397  pole3; DNA polymerase epsilon subunit 3 [KO:K02326] [EC:2.7.7.7]
118803121  lig1; DNA ligase 1 isoform X1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
118804544  polr2f; DNA-directed RNA polymerases I, II, and III subunit RPABC2 [KO:K03014]
118805005  rpa3; replication protein A 14 kDa subunit [KO:K10740]
118805224  polr2k; DNA-directed RNA polymerases I, II, and III subunit RPABC4 [KO:K03009]
118805387  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
118805408  gtf2h4; general transcription factor IIH subunit 4 [KO:K03144]
118806609  polr2c; DNA-directed RNA polymerase II subunit RPB3 [KO:K03011]
118806884  polr2g; DNA-directed RNA polymerase II subunit RPB7 [KO:K03015]
118807154  cul4b; cullin-4B [KO:K10609]
118807330  uvssa; UV-stimulated scaffold protein A [KO:K23720]
118807334  cetn2; centrin-2 [KO:K10840]
118807843  ercc3; general transcription and DNA repair factor IIH helicase subunit XPB [KO:K10843] [EC:5.6.2.4]
118809230  polr2a; DNA-directed RNA polymerase II subunit RPB1 [KO:K03006] [EC:2.7.7.6]
118809621  ercc4; DNA repair endonuclease XPF [KO:K10848] [EC:3.1.-.-]
118810422  ercc6; DNA excision repair protein ERCC-6 [KO:K10841]
118810539  ercc1; DNA excision repair protein ERCC-1 [KO:K10849]
118810557  pold4; DNA polymerase delta subunit 4 [KO:K03505]
118811030  mnat1; CDK-activating kinase assembly factor MAT1 [KO:K10842]
118811503  cetn4; caltractin [KO:K10840]
118811867  gtf2h1; general transcription factor IIH subunit 1 [KO:K03141]
118813057  pold2; DNA polymerase delta subunit 2 [KO:K02328]
118813653  xpc; DNA repair protein complementing XP-C cells isoform X1 [KO:K10838]
118813856  ercc8; DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
118814332  polr2j; DNA-directed RNA polymerase II subunit RPB11-a [KO:K03008]
118815710  gtf2h5; general transcription factor IIH subunit 5 [KO:K10845]
118816596  rfc1; replication factor C subunit 1 [KO:K10754]
118816981  xpa; DNA repair protein complementing XP-A cells [KO:K10847]
118817571  polr2m; protein GRINL1A [KO:K21987]
118817876  ddb1; DNA damage-binding protein 1 [KO:K10610]
118817897  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
118818344  polr2i; DNA-directed RNA polymerase II subunit RPB9 [KO:K03017]
118818865  polr2l; DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007]
118818968  rpa2; replication protein A 32 kDa subunit [KO:K10739]
118819047  rad23ab; RAD23 homolog A, nucleotide excision repair protein b [KO:K10839]
118819068  pole4; DNA polymerase epsilon subunit 4 [KO:K03506] [EC:2.7.7.7]
118819094  polr2h; DNA-directed RNA polymerases I, II, and III subunit RPABC3 [KO:K03016]
118819350  rfc4; replication factor C subunit 4 [KO:K10755]
118819399  polr2eb; DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X1 [KO:K03013]
118819922  rad23b; UV excision repair protein RAD23 homolog B [KO:K10839]
118820407  rfc2; replication factor C subunit 2 [KO:K10755]
118820575  pold3; DNA polymerase delta subunit 3 [KO:K03504]
118820887  polr2b; DNA-directed RNA polymerase II subunit RPB2 [KO:K03010] [EC:2.7.7.6]
118821266  pold1; DNA polymerase delta catalytic subunit isoform X1 [KO:K02327] [EC:2.7.7.7]
118823481  pole2; DNA polymerase epsilon subunit 2 isoform X1 [KO:K02325] [EC:2.7.7.7]
118824925  pcna; proliferating cell nuclear antigen [KO:K04802]
118825163  rfc3; replication factor C subunit 3 [KO:K10756]
118826724  polr2d; DNA-directed RNA polymerase II subunit RPB4 [KO:K03012]
118826843  ccnh; cyclin-H isoform X1 [KO:K06634]
118826902  gtf2h3; general transcription factor IIH subunit 3 [KO:K03143]
118827334  gtf2h2; general transcription factor IIH subunit 2 [KO:K03142]
118827397  cdk7; cyclin-dependent kinase 7 isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
118827446  rfc5; replication factor C subunit 5 [KO:K10756]
118827600  pole; DNA polymerase epsilon catalytic subunit A [KO:K02324] [EC:2.7.7.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
cmao03020  RNA polymerase
cmao04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

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