KEGG   PATHWAY: cqu03040
Entry
cqu03040                    Pathway                                
Name
Spliceosome - Culex quinquefasciatus (southern house mosquito)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
cqu03040  Spliceosome
cqu03040

Other DBs
GO: 0005681
Organism
Culex quinquefasciatus (southern house mosquito) [GN:cqu]
Gene
CpipJ_CPIJ005545  conserved hypothetical protein [KO:K12811] [EC:5.6.2.7]
CpipJ_CPIJ014241  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
CpipJ_CPIJ003520  pre-mRNA-splicing factor ATP-dependent RNA helicase prp22 [KO:K12813] [EC:5.6.2.6]
CpipJ_CPIJ003160  pre-mRNA splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
CpipJ_CPIJ015768  pre-mRNA-processing factor 17 [KO:K12816]
CpipJ_CPIJ009867  pre-mRNA splicing factor prp17 [KO:K12816]
CpipJ_CPIJ018613  pre-mRNA splicing factor [KO:K12816]
CpipJ_CPIJ013694  pre-mRNA splicing factor prp17 [KO:K12816]
CpipJ_CPIJ005083  pre-mRNA-splicing factor 18 [KO:K12817]
CpipJ_CPIJ011263  ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
CpipJ_CPIJ010870  pre-mRNA-splicing factor SLU7 [KO:K12819]
CpipJ_CPIJ008192  ATP-dependent RNA helicase [KO:K12820] [EC:5.6.2.6]
CpipJ_CPIJ006616  small nuclear ribonucleoprotein-associated protein B [KO:K11086]
CpipJ_CPIJ016511  small nuclear ribonucleoprotein Sm D1 [KO:K11087]
CpipJ_CPIJ001706  small nuclear ribonucleoprotein sm d2 [KO:K11096]
CpipJ_CPIJ005588  small nuclear ribonucleoprotein SM D3 [KO:K11088]
CpipJ_CPIJ017424  small nuclear ribonucleoprotein E [KO:K11097]
CpipJ_CPIJ002691  small nuclear ribonucleoprotein F [KO:K11098]
CpipJ_CPIJ002885  conserved hypothetical protein [KO:K11099]
CpipJ_CPIJ019181  U1 small nuclear ribonucleoprotein C [KO:K11095]
CpipJ_CPIJ003277  U1 small nuclear ribonucleoprotein C [KO:K11095]
CpipJ_CPIJ015884  conserved hypothetical protein [KO:K12821]
CpipJ_CPIJ008698  rbm25 protein [KO:K12822]
CpipJ_CPIJ014935  DEAD box ATP-dependent RNA helicase [KO:K12823] [EC:5.6.2.7]
CpipJ_CPIJ016569  ATP-dependent RNA helicase p62 [KO:K12823] [EC:5.6.2.7]
CpipJ_CPIJ012512  ATP-dependent RNA helicase p62 [KO:K12823] [EC:5.6.2.7]
CpipJ_CPIJ009445  DEAD box ATP-dependent RNA helicase [KO:K12823] [EC:5.6.2.7]
CpipJ_CPIJ009446  DEAD box ATP-dependent RNA helicase [KO:K12823] [EC:5.6.2.7]
CpipJ_CPIJ006155  transcription elongation regulator 1 [KO:K12824]
CpipJ_CPIJ002677  transcription elongation regulator 1 [KO:K12824]
CpipJ_CPIJ006342  conserved hypothetical protein [KO:K13098]
CpipJ_CPIJ000188  U2 small nuclear ribonucleoprotein A [KO:K11092]
CpipJ_CPIJ019134  U1 small nuclear ribonucleoprotein A [KO:K11094]
CpipJ_CPIJ015416  splicing factor 3 subunit 1 [KO:K12825]
CpipJ_CPIJ003364  splicing factor 3A subunit 2 [KO:K12826]
CpipJ_CPIJ002728  splicing factor 3A subunit 3 [KO:K12827]
CpipJ_CPIJ009000  U2 small nuclear ribonucleoprotein [KO:K12828]
CpipJ_CPIJ010596  splicing factor 3B subunit 2 [KO:K12829]
CpipJ_CPIJ007014  splicing factor 3B subunit 3 [KO:K12830]
CpipJ_CPIJ014149  splicing factor 3B subunit 4 [KO:K12831]
CpipJ_CPIJ018072  splicing factor 3B subunit 5 [KO:K12832]
CpipJ_CPIJ008576  pre-mRNA branch site protein p14 [KO:K12833]
CpipJ_CPIJ011447  pre-mRNA-splicing factor ini1 [KO:K12834]
CpipJ_CPIJ019196  DEAD box ATP-dependent RNA helicase [KO:K12835] [EC:5.6.2.7]
CpipJ_CPIJ016711  splicing factor U2af 38 kDa subunit [KO:K12836]
CpipJ_CPIJ003901  splicing factor U2af 38 kDa subunit [KO:K12836]
CpipJ_CPIJ012850  splicing factor u2af large subunit [KO:K12837]
CpipJ_CPIJ011203  splicing factor U2AF 50 kDa subunit [KO:K12837]
CpipJ_CPIJ014506  fuse-binding protein-interacting repressor siahbp1 [KO:K12838]
CpipJ_CPIJ004934  survival motor neuron protein [KO:K12839]
CpipJ_CPIJ012520  splicing factor 45 [KO:K12840]
CpipJ_CPIJ008957  conserved hypothetical protein [KO:K12841]
CpipJ_CPIJ014539  U2-associated SR140 protein [KO:K12842]
CpipJ_CPIJ016060  gar2 [KO:K12842]
CpipJ_CPIJ001194  snrnp sm protein [KO:K12622]
CpipJ_CPIJ006842  small nuclear ribonucleoprotein sm [KO:K12623]
CpipJ_CPIJ013501  Lsm5 protein [KO:K12624]
CpipJ_CPIJ015157  Lsm6 protein [KO:K12625]
CpipJ_CPIJ005288  SM protein G [KO:K12626]
CpipJ_CPIJ014618  LSM8 protein [KO:K12627]
CpipJ_CPIJ006451  conserved hypothetical protein [KO:K12627]
CpipJ_CPIJ006146  Trisn small nuclear ribonucleoprotein [KO:K12843]
CpipJ_CPIJ012025  U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
CpipJ_CPIJ010561  peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
CpipJ_CPIJ002179  U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
CpipJ_CPIJ005818  13 kDa ribonucleoprotein-associated protein [KO:K12845]
CpipJ_CPIJ009185  conserved hypothetical protein [KO:K12846]
CpipJ_CPIJ001879  conserved hypothetical protein [KO:K12847]
CpipJ_CPIJ008849  U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
CpipJ_CPIJ009914  zinc finger matrin-type protein 2 [KO:K12848]
CpipJ_CPIJ008907  PRP38 pre-mRNA processing factor 38 domain containing A [KO:K12849]
CpipJ_CPIJ004500  PRP38 pre-mRNA processing factor 38 domain containing B [KO:K12850]
CpipJ_CPIJ004501  conserved hypothetical protein [KO:K12850]
CpipJ_CPIJ011526  elongation factor 2 [KO:K12852]
CpipJ_CPIJ018280  conserved hypothetical protein [KO:K12852]
CpipJ_CPIJ013238  Eftud2 protein [KO:K12852]
CpipJ_CPIJ013409  Eftud2 protein [KO:K12852]
CpipJ_CPIJ005029  U5 snRNP-specific protein [KO:K12852]
CpipJ_CPIJ018470  target of rapamycin [KO:K12852]
CpipJ_CPIJ013674  conserved hypothetical protein [KO:K12852]
CpipJ_CPIJ007995  Eftud2 protein [KO:K12852]
CpipJ_CPIJ002586  U5 snRNP-specific protein [KO:K12852]
CpipJ_CPIJ011675  elongation factor Tu GTP binding domain containing 2 [KO:K12852]
CpipJ_CPIJ016776  conserved hypothetical protein [KO:K12852]
CpipJ_CPIJ007405  conserved hypothetical protein [KO:K12852]
CpipJ_CPIJ013139  pre-mRNA-splicing helicase BRR2 [KO:K12854] [EC:5.6.2.6]
CpipJ_CPIJ014611  activating signal cointegrator 1 complex subunit 3 [KO:K12854] [EC:5.6.2.6]
CpipJ_CPIJ016208  pre-mRNA-splicing helicase BRR2 [KO:K12854] [EC:5.6.2.6]
CpipJ_CPIJ018359  activating signal cointegrator 1 complex subunit 3 [KO:K12854] [EC:5.6.2.6]
CpipJ_CPIJ016885  pre-mRNA-splicing factor prp1 [KO:K12855]
CpipJ_CPIJ016636  pre-mRNA-processing-splicing factor 8 [KO:K12856]
CpipJ_CPIJ002451  WD repeat protein 57 [KO:K12857]
CpipJ_CPIJ014426  wd-repeat protein [KO:K12857]
CpipJ_CPIJ000951  pre-mRNA-splicing ATP-dependent RNA helicase PRP28 [KO:K12858] [EC:5.6.2.7]
CpipJ_CPIJ006204  DEAD box ATP-dependent RNA helicase [KO:K12858] [EC:5.6.2.7]
CpipJ_CPIJ007068  mitosis protein dim1 [KO:K12859]
CpipJ_CPIJ011261  cell cycle control protein cwf8 [KO:K10599] [EC:2.3.2.27]
CpipJ_CPIJ005780  pre-mRNA-splicing factor cef-1 [KO:K12860]
CpipJ_CPIJ003889  breast carcinoma amplified sequence 2 [KO:K12861]
CpipJ_CPIJ004561  pleiotropic regulator 1 [KO:K12862]
CpipJ_CPIJ014049  pre-mRNA-splicing factor cwc15 [KO:K12863]
CpipJ_CPIJ006035  nuclear protein NAP [KO:K12864]
CpipJ_CPIJ006534  conserved hypothetical protein [KO:K03283]
CpipJ_CPIJ014564  heat shock protein 70 B2 [KO:K03283]
CpipJ_CPIJ011083  heat shock protein 70 B2 [KO:K03283]
CpipJ_CPIJ011082  heat shock protein 70 B2 [KO:K03283]
CpipJ_CPIJ014283  heat shock protein 70 B2 [KO:K03283]
CpipJ_CPIJ011081  heat shock protein 70 B2 [KO:K03283]
CpipJ_CPIJ008915  heat shock 70 kDa protein cognate 4 [KO:K03283]
CpipJ_CPIJ002807  conserved hypothetical protein [KO:K12865]
CpipJ_CPIJ008086  conserved hypothetical protein [KO:K12866]
CpipJ_CPIJ008316  puff-specific protein Bx42 [KO:K06063]
CpipJ_CPIJ005885  XPA-binding protein 2 [KO:K12867]
CpipJ_CPIJ008327  pre-mRNA-splicing factor Syf2 [KO:K12868]
CpipJ_CPIJ008391  crooked neck [KO:K12869]
CpipJ_CPIJ016037  pre-mRNA-splicing factor ISY1 [KO:K12870]
CpipJ_CPIJ014089  cyclophilin [KO:K12733] [EC:5.2.1.8]
CpipJ_CPIJ008841  peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
CpipJ_CPIJ001031  coiled-coil domain-containing protein 12 [KO:K12871]
CpipJ_CPIJ014747  pre-mRNA-splicing factor RBM22 [KO:K12872]
CpipJ_CPIJ008029  cell cycle control protein cwf14 [KO:K12873]
CpipJ_CPIJ003439  intron-binding protein aquarius [KO:K12874]
CpipJ_CPIJ004841  conserved hypothetical protein [KO:K12875]
CpipJ_CPIJ019131  DEAD box ATP-dependent RNA helicase [KO:K13025] [EC:5.6.2.7]
CpipJ_CPIJ007339  RNA-binding protein 8A [KO:K12876]
CpipJ_CPIJ002949  mago nashi [KO:K12877]
CpipJ_CPIJ004005  THO complex subunit 1 [KO:K12878]
CpipJ_CPIJ019403  THO complex subunit 2 [KO:K12879]
CpipJ_CPIJ003676  THO complex subunit 3 [KO:K12880]
CpipJ_CPIJ007834  RNA and export factor binding protein [KO:K12881]
CpipJ_CPIJ013054  nuclear cap-binding protein subunit 1 [KO:K12882]
CpipJ_CPIJ013057  conserved hypothetical protein [KO:K12882]
CpipJ_CPIJ003555  nuclear cap-binding protein subunit 2 [KO:K12883]
CpipJ_CPIJ001612  heterogeneous nuclear ribonucleoprotein [KO:K12741]
CpipJ_CPIJ000130  heterogeneous nuclear ribonucleoprotein k [KO:K12886]
CpipJ_CPIJ008786  arginine/serine-rich splicing factor [KO:K12890]
CpipJ_CPIJ007047  serine/arginine rich splicing factor [KO:K12891]
CpipJ_CPIJ003074  conserved hypothetical protein [KO:K12892]
CpipJ_CPIJ008634  52K active chromatin boundary protein [KO:K12893]
CpipJ_CPIJ013237  conserved hypothetical protein [KO:K12896]
CpipJ_CPIJ016646  transformer-2 sex-determining protein [KO:K12897]
CpipJ_CPIJ004538  conserved hypothetical protein [KO:K12897]
CpipJ_CPIJ001852  conserved hypothetical protein [KO:K12897]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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