KEGG   PATHWAY: dsp04350
Entry
dsp04350                    Pathway                                
Name
TGF-beta signaling pathway - Dipodomys spectabilis (banner-tailed kangaroo rat)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
dsp04350  TGF-beta signaling pathway
dsp04350

Other DBs
GO: 0007179
Organism
Dipodomys spectabilis (banner-tailed kangaroo rat) [GN:dsp]
Gene
122098357  Chrd; chordin isoform X1 [KO:K04657]
122103433  Nog; noggin [KO:K04658]
122115329  Nbl1; neuroblastoma suppressor of tumorigenicity 1 isoform X1 [KO:K19558]
122103857  Grem2; gremlin-2 [KO:K23318]
122114679  Grem1; gremlin-1 isoform X1 [KO:K23318]
122114333  Thbs1; thrombospondin-1 [KO:K16857]
122119196  Dcn; decorin [KO:K04660]
122109747  Fmod; fibromodulin [KO:K08121]
122126732  LOW QUALITY PROTEIN: left-right determination factor 2-like [KO:K04668]
122116963  Fst; follistatin isoform X1 [KO:K04661]
122120543  Bmp2; bone morphogenetic protein 2 [KO:K21283]
122110043  Bmp4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
122114027  Bmp6; bone morphogenetic protein 6 [KO:K16620]
122112415  Inhbb; inhibin beta B chain [KO:K22687]
122095610  inhibitor of carbonic anhydrase-like [KO:K14736]
122095611  serotransferrin-like [KO:K14736]
122122641  Bmp5; bone morphogenetic protein 5 [KO:K04663]
122124577  Bmp7; bone morphogenetic protein 7 [KO:K16621]
122108913  Bmp8a; bone morphogenetic protein 8A [KO:K16622]
122109159  bone morphogenetic protein 8A-like [KO:K16622]
122120484  Gdf5; growth/differentiation factor 5 [KO:K04664]
122102373  Gdf6; growth/differentiation factor 6 [KO:K20012]
122108838  Gdf7; growth/differentiation factor 7 [KO:K20013]
122122865  Amh; muellerian-inhibiting factor [KO:K04665]
122124303  Ifng; interferon gamma [KO:K04687]
122111281  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
122122940  Thsd4; thrombospondin type-1 domain-containing protein 4 [KO:K23377]
122114357  Fbn1; fibrillin-1 [KO:K06825]
122122436  Ltbp1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
122097410  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
122109464  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
122118877  Tgfb3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
122120886  Inhba; LOW QUALITY PROTEIN: inhibin beta A chain [KO:K04667]
122124021  Inhbc; inhibin beta C chain [KO:K22688]
122124343  Inhbe; inhibin beta E chain [KO:K22689]
122122223  Nodal; nodal homolog [KO:K04666]
122116497  Bmpr1a; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
122127136  Bmpr1b; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
122110801  Acvr1; LOW QUALITY PROTEIN: activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
122096406  Bmpr2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
122110790  Acvr2a; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
122112352  Hjv; hemojuvelin [KO:K23100]
122122937  Neo1; neogenin [KO:K06766]
122111269  LOW QUALITY PROTEIN: hereditary hemochromatosis protein homolog [KO:K26535]
122113676  Tfr2; transferrin receptor protein 2 isoform X1 [KO:K23910]
122096941  Tfrc; transferrin receptor protein 1 isoform X1 [KO:K06503]
122123963  Rgma; LOW QUALITY PROTEIN: repulsive guidance molecule A [KO:K23096]
122117274  Rgmb; repulsive guidance molecule B isoform X1 [KO:K06847]
122124339  Amhr2; anti-Muellerian hormone type-2 receptor isoform X1 [KO:K04672] [EC:2.7.11.30]
122121204  Tgfbr1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
122096026  Tgfbr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
122125810  Emp3; epithelial membrane protein 3 [KO:K26257]
122116047  Lrrc32; transforming growth factor beta activator LRRC32 [KO:K26316]
122099309  Nrros; transforming growth factor beta activator LRRC33 isoform X1 [KO:K26317]
122098383  Acvr1b; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
122096745  Acvr2b; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
122110815  Acvr1c; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
122109955  Igsf1; immunoglobulin superfamily member 1 [KO:K26168]
122113303  Bambi; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
122127188  Smad1; mothers against decapentaplegic homolog 1 [KO:K04676]
122100913  Smad5; mothers against decapentaplegic homolog 5 [KO:K16790]
122112702  Smad9; mothers against decapentaplegic homolog 9 [KO:K16791]
122104270  Smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
122114693  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
122104309  Smad4; mothers against decapentaplegic homolog 4 [KO:K04501]
122114482  Smad6; mothers against decapentaplegic homolog 6 [KO:K04677]
122104365  Smad7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
122128374  Smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
122113841  Smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
122107631  Zfyve9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
122117128  Zfyve16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
122123619  Rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
122105888  Cul1; cullin-1 [KO:K03347]
122112677  S-phase kinase-associated protein 1-like [KO:K03094]
122115441  Skp1; S-phase kinase-associated protein 1 [KO:K03094]
122095844  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122096287  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122095683  Rhoa; transforming protein RhoA [KO:K04513]
122115017  transforming protein RhoA-like [KO:K04513]
122104238  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
122110678  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
122125515  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
122125518  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
122125535  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
122125543  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
122125547  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
122110283  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
122106294  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
122106295  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
122115382  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
122126971  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
122105362  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
122117335  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
122097526  hepcidin [KO:K23106]
122120303  Id1; DNA-binding protein inhibitor ID-1 [KO:K04680]
122108785  Id2; DNA-binding protein inhibitor ID-2 [KO:K17693]
122115201  Id3; DNA-binding protein inhibitor ID-3 [KO:K17694]
122107002  Id4; DNA-binding protein inhibitor ID-4 [KO:K17695]
122120249  Rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
122096720  E2f5; transcription factor E2F5 isoform X1 [KO:K04682]
122126204  E2f4; transcription factor E2F4 [KO:K04682]
122122679  Tfdp1; transcription factor Dp-1 isoform X1 [KO:K04683]
122123534  Ep300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
122123684  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
122124412  Sp1; transcription factor Sp1 isoform X1 [KO:K04684]
122107235  Skil; ski-like protein [KO:K18499]
122127319  Ski; ski oncogene [KO:K26503]
122098426  Sin3a; paired amphipathic helix protein Sin3a [KO:K11644]
122121563  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
122109561  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
122101531  Ncor1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
122104381  Tgif1; homeobox protein TGIF1 isoform X1 [KO:K19383]
122120219  Tgif2; homeobox protein TGIF2 [KO:K19553]
122102408  Myc; myc proto-oncogene protein [KO:K04377]
122118978  Cdkn2b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
122127058  Pitx2; pituitary homeobox 2 [KO:K04686]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Related
pathway
dsp04010  MAPK signaling pathway
dsp04110  Cell cycle
dsp04120  Ubiquitin mediated proteolysis
dsp04210  Apoptosis
KO pathway
ko04350   
LinkDB

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