KEGG   PATHWAY: ecoh05130
Entry
ecoh05130                   Pathway                                
Name
Pathogenic Escherichia coli infection - Escherichia coli O145:H28 RM13516 (EHEC)
Description
Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction of attaching and effacing (A/E) lesions that damage intestinal epithelial cells. The capacity to form A/E lesions is encoded mainly by the locus of enterocyte effacement (LEE) pathogenicity island. Tir, Map, EspF, EspG are known LEE-encoded effector proteins secreted via the type III secretion system, which is also LEE-encoded, into the host cell. EPEC and EHEC Tir's link the extracellular bacterium to the cell cytoskeleton. Map and EspF are involved in mitochondrion membrane permeabilization. EspG interacts with tubulins and stimulates microtubule destabilization. LEE-encoded adhesin or intimin (Eae) is exported via the general secretory pathway to the periplasm, where it is inserted into the outer membrane. In addition to Tir, two potential host cell-carried intimin receptors, beta1 integrin (ITGB1) and nucleolin (NCL), have so far been identified. The distinguishing feature of EHEC is the elaboration of Shiga-like toxin (Stx). Stx cleaves ribosomal RNA, thereby disrupting protein synthesis and killing the intoxicated epithelial or endothelial cells.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
ecoh05130  Pathogenic Escherichia coli infection
ecoh05130

Module
ecoh_M00363  EHEC pathogenicity signature, Shiga toxin [PATH:ecoh05130]
Organism
Escherichia coli O145:H28 RM13516 (EHEC) [GN:ecoh]
Gene
ECRM13516_2316  stx2A; Shiga-like toxin II subunit A precursor [KO:K11006]
ECRM13516_2315  stx2B; Shiga-like toxin II subunit B precursor [KO:K11007]
ECRM13516_0802  espJ; T3SS effector protein EspJ [KO:K23648]
ECRM13516_4503  espG; T3SS secreted effector protein EspG [KO:K12785]
ECRM13516_4481  espH; EspH [KO:K12788]
ECRM13516_4471  espB; T3SS secreted effector protein EspB [KO:K23650]
ECRM13516_4479  map_2; T3SS secreted effector protein Map [KO:K12787]
ECRM13516_1636  espM; T3SS secreted effector protein EspM [KO:K23653]
ECRM13516_4476  eae; intimin adherence protein [KO:K12790]
ECRM13516_4478  tir; translocated intimin receptor Tir [KO:K12784]
ECRM13516_1074  tccP; T3SS secreted effector TccP [KO:K12789]
ECRM13516_1778  gapC; NAD-dependent glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
ECRM13516_2183  gapA; NAD-dependent glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
ECRM13516_5228  nleE; T3SS secreted effector protein NleE [KO:K23654]
ECRM13516_0797  nleH; T3SS secreted effector NleH [KO:K16042]
ECRM13516_2458  nleH_2; T3SS secreted effector protein NleH [KO:K16042]
ECRM13516_1911  nleC; T3SS secreted effector protein NleC [KO:K23655]
ECRM13516_2281  nleC_2; T3SS secreted effector protein NleC [KO:K23655]
ECRM13516_5227  nleB_3; T3SS secreted effector protein NleB [KO:K23657]
ECRM13516_2459  nleB_2; T3SS secreted effector protein NleB [KO:K23657]
ECRM13516_2457  nleF; T3SS secreted effector protein NleF [KO:K23658]
ECRM13516_4487  espZ; T3SS secreted effector protein EspZ [KO:K23659]
ECRM13516_0799  cif; Cell Inhibiting Factor (Cif) [KO:K23660]
ECRM13516_4467  espF; T3SS secreted effector protein EspF [KO:K12786]
ECRM13516_4469  ssaG; Type III secretion protein SsaG [KO:K03221]
ECRM13516_2757  nleA; T3SS secreted effector protein NleA [KO:K16041]
Compound
C00338  Lipopolysaccharide
C00350  Phosphatidylethanolamine
C00681  1-Acyl-sn-glycerol 3-phosphate
Reference
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
  Authors
Santos AS, Finlay BB
  Title
Bringing down the host: enteropathogenic and enterohaemorrhagic Escherichia coli effector-mediated subversion of host innate immune pathways.
  Journal
Cell Microbiol 17:318-32 (2015)
DOI:10.1111/cmi.12412
Reference
  Authors
Pearson JS, Hartland EL
  Title
The Inflammatory Response during Enterohemorrhagic Escherichia coli Infection.
  Journal
Microbiol Spectr 2:EHEC-0012-2013 (2014)
DOI:10.1128/microbiolspec.EHEC-0012-2013
Reference
  Authors
Wong AR, Pearson JS, Bright MD, Munera D, Robinson KS, Lee SF, Frankel G, Hartland EL
  Title
Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements.
  Journal
Mol Microbiol 80:1420-38 (2011)
DOI:10.1111/j.1365-2958.2011.07661.x
Reference
  Authors
Lai Y, Rosenshine I, Leong JM, Frankel G
  Title
Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli.
  Journal
Cell Microbiol 15:1796-808 (2013)
DOI:10.1111/cmi.12179
Reference
  Authors
Ugalde-Silva P, Gonzalez-Lugo O, Navarro-Garcia F
  Title
Tight Junction Disruption Induced by Type 3 Secretion System Effectors Injected by Enteropathogenic and Enterohemorrhagic Escherichia coli.
  Journal
Front Cell Infect Microbiol 6:87 (2016)
DOI:10.3389/fcimb.2016.00087
Reference
  Authors
Yen H, Karino M, Tobe T
  Title
Modulation of the Inflammasome Signaling Pathway by Enteropathogenic and Enterohemorrhagic Escherichia coli.
  Journal
Front Cell Infect Microbiol 6:89 (2016)
DOI:10.3389/fcimb.2016.00089
Reference
  Authors
Humphreys D, Singh V, Koronakis V
  Title
Inhibition of WAVE Regulatory Complex Activation by a Bacterial Virulence Effector Counteracts Pathogen Phagocytosis.
  Journal
Cell Rep 17:697-707 (2016)
DOI:10.1016/j.celrep.2016.09.039
Reference
  Authors
Dong N, Liu L, Shao F
  Title
A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis.
  Journal
EMBO J 29:1363-76 (2010)
DOI:10.1038/emboj.2010.33
Reference
  Authors
Matsuzawa T, Kuwae A, Yoshida S, Sasakawa C, Abe A.
  Title
Enteropathogenic Escherichia coli activates the RhoA signaling pathway via the stimulation of GEF-H1.
  Journal
EMBO J 23:3570-82 (2004)
DOI:10.1038/sj.emboj.7600359
Related
pathway
ecoh02040  Flagellar assembly
ecoh03070  Bacterial secretion system
KO pathway
ko05130   
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