PATHWAY: ko05130 Help
Entry Name Pathogenic Escherichia coli infection
Description Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:
H00278 H00277 ] is induction of attaching and effacing (A/E) lesions that damage intestinal epithelial cells. The capacity to form A/E lesions is encoded mainly by the locus of enterocyte effacement (LEE) pathogenicity island. Tir, Map, EspF, EspG are known LEE-encoded effector proteins secreted via the type III secretion system, which is also LEE-encoded, into the host cell. EPEC and EHEC Tir's link the extracellular bacterium to the cell cytoskeleton. Map and EspF are involved in mitochondrion membrane permeabilization. EspG interacts with tubulins and stimulates microtubule destabilization. LEE-encoded adhesin or intimin (Eae) is exported via the general secretory pathway to the periplasm, where it is inserted into the outer membrane. In addition to Tir, two potential host cell-carried intimin receptors, beta1 integrin (ITGB1) and nucleolin (NCL), have so far been identified. The distinguishing feature of EHEC is the elaboration of Shiga-like toxin (Stx). Stx cleaves ribosomal RNA, thereby disrupting protein synthesis and killing the intoxicated epithelial or endothelial cells.
Class Human Diseases; Infectious disease: bacterialBRITE hierarchy
Pathway map ko05130 Pathogenic Escherichia coli infection
Module M00542 EHEC/EPEC pathogenicity signature, T3SS and effectors [PATH:ko05130 ]
Disease H00277 Enterohemorrhagic Escherichia coli (EHEC) infection
H00278 Enteropathogenic Escherichia coli (EPEC) infection
Orthology K00134 GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12 ]
K02159 BAX; apoptosis regulator BAX
K02373 FADD; FAS-associated death domain protein
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K02581 NFKBIB; NF-kappa-B inhibitor beta
K02861 RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1 ]
K02985 RP-S3e, RPS3; small subunit ribosomal protein S3e
K03156 TNF, TNFA; tumor necrosis factor superfamily, member 2
K03158 TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
K03171 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K03221 yscF, sctF, ssaG, prgI; type III secretion protein F
K03914 F2R, PAR1; coagulation factor II (thrombin) receptor
K04275 LPAR4, GPR23; lysophosphatidic acid receptor 4
K04289 LPAR1, EDG2; lysophosphatidic acid receptor 1
K04291 LPAR2, EDG4; lysophosphatidic acid receptor 2
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
K04379 FOS; proto-oncogene protein c-fos
K04386 IL1R1, CD121a; interleukin 1 receptor type I
K04389 TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
K04390 TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K04393 CDC42; cell division control protein 42
K04403 MAP3K7IP1, TAB1; TAK1-binding protein 1
K04404 MAP3K7IP2, TAB2; TAK1-binding protein 2
K04427 MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25 ]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24 ]
K04448 JUN; transcription factor AP-1
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10 ]
K04513 RHOA; Ras homolog gene family, member A
K04519 IL1B; interleukin 1 beta
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
K04721 TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
K04722 TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
K04729 MYD88; myeloid differentiation primary response protein MyD88
K04730 IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1 ]
K04733 IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1 ]
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K04735 RELA; transcription factor p65
K05403 TIRAP; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
K05482 IL18, IL1F4; interleukin 18
K05627 BAIAP2, IRSP53; BAI1-associated protein 2
K05692 ACTB_G1; actin beta/gamma 1
K05697 PTPN6, SHP1; tyrosine-protein phosphatase non-receptor type 6 [EC:3.1.3.48 ]
K05701 TJP1, ZO1; tight junction protein 1
K05719 ITGB1, CD29; integrin beta 1
K05748 WASF2; WAS protein family, member 2
K05749 CYFIP; cytoplasmic FMR1 interacting protein
K05750 NCKAP1, NAP125; NCK-associated protein 1
K05752 C3ORF10, HSPC300; chromosome 3 open reading frame 10
K05753 WASF1; WAS protein family, member 1
K05754 ARPC5; actin related protein 2/3 complex, subunit 5
K05755 ARPC4; actin related protein 2/3 complex, subunit 4
K05756 ARPC3; actin related protein 2/3 complex, subunit 3
K05757 ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
K05758 ARPC2; actin related protein 2/3 complex, subunit 2
K06083 WASF3; WAS protein family, member 3
K06185 ABCF2; ATP-binding cassette, subfamily F, member 2
K06472 FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
K06856 IGH; immunoglobulin heavy chain
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10 ]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K07293 PTPN11, SHP2; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48 ]
K07365 NCK1; NCK adaptor protein 1
K07532 ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
K07874 RAB1A; Ras-related protein Rab-1A
K07937 ARF1_2; ADP-ribosylation factor 1/2
K07941 ARF6; ADP-ribosylation factor 6
K08390 LPAR5, GPR92; lysophosphatidic acid receptor 5
K10030 IL8, CXCL8; interleukin 8
K10160 TLR4, CD284; toll-like receptor 4
K10168 TLR5; toll-like receptor 5
K10352 MYH9s; myosin heavy chain 9/10/11/14
K11006 stxA; shiga toxin subunit A
K11007 stxB; shiga toxin subunit B
K12330 ARHGEF1; Rho guanine nucleotide exchange factor 1
K12331 ARHGEF11; Rho guanine nucleotide exchange factor 11
K12784 tir; translocated intimin receptor
K12785 espG, virA; LEE-encoded effector EspG
K12786 espF; LEE-encoded effector EspF
K12787 map; LEE-encoded effector Map
K12788 espH; LEE-encoded effector EspH
K12789 tccP; Tir-cytoskeleton coupling protein
K12791 ARHGEF2, GEF-H1; Rho guanine nucleotide exchange factor 2
K12793 MAP3K7IP3, TAB3; TAK1-binding protein 3
K12799 PYCARD, ASC; apoptosis-associated speck-like protein containing a CARD
K12800 NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
K12807 NAIP, BIRC1; baculoviral IAP repeat-containing protein 1
K12809 espG2; T3SS secreted effector EspG-like protein
K12810 bfpA; major structural subunit of bundle-forming pilus
K13365 SLC9A3R1, NHERF1; sodium/hydrogen exchange regulatory cofactor NHE-RF1
K14007 SEC24; protein transport protein SEC24
K14021 BAK, BAK1; Bcl-2 homologous antagonist/killer
K16041 nleA; non-LEE-encoded effector NleA
K16042 nleH; non-LEE-encoded effector NleH
K17260 ACTR2, ARP2; actin-related protein 2
K18584 ACTR3, ARP3; actin-related protein 3
K19475 WIPF; WAS/WASL-interacting protein
K19862 NCK2, GRB4; NCK adaptor protein 2
K20127 BAIAP2L1, IRTKS; BAI1-associated protein 2-like protein 1
K20352 TMED10, ERV25; p24 family protein delta-1
K21889 TMBIM6, BI1, TEGT; Bax inhibitor 1
K22265 NLRP4; NACHT, LRR and PYD domains-containing protein 4
K22487 prgJ; type III secretion system protein
K23612 WASL; neural Wiskott-Aldrich syndrome protein
K23648 espJ; T3SS secreted effector ADP-ribosyltransferase EspJ
K23650 espB; LEE-encoded effector EspB
K23651 espT; T3SS secreted effector EspT
K23652 espW; T3SS secreted effector EspW
K23653 espM; T3SS effector EspM
K23654 nleE, ospZ; T3SS secreted effector NleE
K23655 nleC; T3SS secreted effector NleC
K23656 nleD; T3SS secreted effector NleD
K23657 nleB; T3SS secreted effector NleB
K23658 nleF; T3SS secreted effector NleF
K23659 espZ; LEE-encoded effector EspZ
K23660 cif; cell inhibiting factor
K23661 escI; type III secretion system protein
Compound C00350 Phosphatidylethanolamine
C00681 1-Acyl-sn-glycerol 3-phosphate
Reference Authors Pinaud L, Sansonetti PJ, Phalipon A
Title Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal Reference Authors Santos AS, Finlay BB
Title Bringing down the host: enteropathogenic and enterohaemorrhagic Escherichia coli effector-mediated subversion of host innate immune pathways.
Journal Reference Authors Pearson JS, Hartland EL
Title The Inflammatory Response during Enterohemorrhagic Escherichia coli Infection.
Journal Reference Authors Wong AR, Pearson JS, Bright MD, Munera D, Robinson KS, Lee SF, Frankel G, Hartland EL
Title Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements.
Journal Reference Authors Lai Y, Rosenshine I, Leong JM, Frankel G
Title Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli.
Journal Reference Authors Ugalde-Silva P, Gonzalez-Lugo O, Navarro-Garcia F
Title Tight Junction Disruption Induced by Type 3 Secretion System Effectors Injected by Enteropathogenic and Enterohemorrhagic Escherichia coli.
Journal Reference Authors Yen H, Karino M, Tobe T
Title Modulation of the Inflammasome Signaling Pathway by Enteropathogenic and Enterohemorrhagic Escherichia coli.
Journal Reference Authors Humphreys D, Singh V, Koronakis V
Title Inhibition of WAVE Regulatory Complex Activation by a Bacterial Virulence Effector Counteracts Pathogen Phagocytosis.
Journal Reference Authors Dong N, Liu L, Shao F
Title A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis.
Journal Reference Authors Matsuzawa T, Kuwae A, Yoshida S, Sasakawa C, Abe A.
Title Enteropathogenic Escherichia coli activates the RhoA signaling pathway via the stimulation of GEF-H1.
Journal Related ko04064 NF-kappa B signaling pathway
ko04620 Toll-like receptor signaling pathway
ko04621 NOD-like receptor signaling pathway
ko04666 Fc gamma R-mediated phagocytosis
ko04810 Regulation of actin cytoskeleton
