KEGG   PATHWAY: gas04728
Entry
gas04728                    Pathway                                
Name
Dopaminergic synapse - Gracilinanus agilis (agile gracile opossum)
Description
Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning and memory, and endocrine regulation. Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. In addition, D1Rs and D2Rs modulate intracellular Ca2+ levels and a number of Ca2+ -dependent intracellular signaling processes. Through diverse cAMP- and Ca2+-dependent and - independent mechanisms, DA influences neuronal activity, synaptic plasticity, and behavior. Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system.
Class
Organismal Systems; Nervous system
Pathway map
gas04728  Dopaminergic synapse
gas04728

Other DBs
GO: 0001963
Organism
Gracilinanus agilis (agile gracile opossum) [GN:gas]
Gene
123248657  LOW QUALITY PROTEIN: tyrosine 3-monooxygenase-like [KO:K00501] [EC:1.14.16.2]
123243287  DDC; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
123238186  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
123234838  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
123235528  DRD1; D(1A) dopamine receptor [KO:K04144]
123252894  DRD5; D(1B) dopamine receptor [KO:K05840]
123236899  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
123233371  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
123234085  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
123252777  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
123247136  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
123250011  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
123246373  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
123236129  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
123242560  calmodulin-alpha-like [KO:K02183]
123236850  CALM2; calmodulin-2 [KO:K02183]
123256534  calmodulin-1-like [KO:K02183]
123256535  calmodulin-1-like [KO:K02183]
123243054  CALML6; calmodulin-like protein 6 [KO:K02183]
123237842  CALM1; calmodulin-1 isoform X1 [KO:K02183]
123250523  calmodulin-alpha-like [KO:K02183]
123237530  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
123232945  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
123233534  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
123252280  calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
123236954  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
123232952  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
123252235  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
123245333  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
123231861  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123254168  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
123255143  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
123237804  FOS; proto-oncogene c-Fos [KO:K04379]
123237154  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
123239631  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
123242354  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
123247653  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123254019  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
123232104  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
123242713  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
123242200  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
123250763  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
123247071  CREB3L4; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
123242984  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
123249476  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
123232395  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
123252575  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
123245162  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
123248655  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
123243860  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
123250672  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
123245414  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
123237465  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123238271  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
123251179  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123245445  PPP1R1B; protein phosphatase 1 regulatory subunit 1B [KO:K15494]
123237064  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
123244865  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
123252171  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
123252806  serine/threonine-protein phosphatase PP1-alpha catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
123241459  sodium channel protein type 1 subunit alpha [KO:K04833]
123250056  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
123246606  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
123256466  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
123233593  CACNA1B; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
123242254  KCNJ3; G protein-activated inward rectifier potassium channel 1 [KO:K04997]
123239630  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
123245454  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
123238916  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
123239489  DRD3; D(3) dopamine receptor [KO:K04146]
123248059  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
123244023  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
123250482  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
123237302  guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
123240150  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
123244840  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
123254622  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
123242834  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
123237937  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
123251886  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
123245546  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
123244419  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
123243826  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
123242968  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
123231222  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
123230621  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
123254868  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123232075  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
123230928  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
123230622  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
123245703  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
123239055  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
123244611  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
123240510  beta-arrestin-1 isoform X1 [KO:K04439]
123237637  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
123251011  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
123252361  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
123241835  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
123240795  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
123235614  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
123236652  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
123233025  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
123251504  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
123242326  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
123242569  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
123237685  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
123237600  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
123237748  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
123232498  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like [KO:K11584]
123245114  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
123245668  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
123247425  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123242998  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123237620  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123240804  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
123242376  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
123249044  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
123235591  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
123252946  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
123253484  glutamate receptor 3-like [KO:K05199]
123239011  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
123242267  KIF5C; kinesin heavy chain isoform X1 [KO:K10396]
123249552  KIF5B; kinesin-1 heavy chain [KO:K10396]
123250406  KIF5A; kinesin heavy chain [KO:K10396]
123252396  CLOCK; circadian locomoter output cycles protein kaput [KO:K02223] [EC:2.3.1.48]
123252161  ARNTL; aryl hydrocarbon receptor nuclear translocator-like protein 1 [KO:K02296]
123231574  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
123241625  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
123242437  amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
123240487  TOMT; transmembrane O-methyltransferase [KO:K00545] [EC:2.1.1.6]
Compound
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00238  Potassium cation
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C01161  3,4-Dihydroxyphenylacetate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C03758  Dopamine
C05582  Homovanillate
C05587  3-Methoxytyramine
Reference
PMID:21303898
  Authors
Beaulieu JM, Gainetdinov RR
  Title
The physiology, signaling, and pharmacology of dopamine receptors.
  Journal
Pharmacol Rev 63:182-217 (2011)
DOI:10.1124/pr.110.002642
Reference
PMID:15521361
  Authors
Neve KA, Seamans JK, Trantham-Davidson H
  Title
Dopamine receptor signaling.
  Journal
J Recept Signal Transduct Res 24:165-205 (2004)
DOI:10.1081/RRS-200029981
Reference
PMID:17408758
  Authors
Surmeier DJ, Ding J, Day M, Wang Z, Shen W
  Title
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.
  Journal
Trends Neurosci 30:228-35 (2007)
DOI:10.1016/j.tins.2007.03.008
Reference
PMID:20224735
  Authors
Knab AM, Lightfoot JT
  Title
Does the difference between physically active and couch potato lie in the dopamine system?
  Journal
Int J Biol Sci 6:133-50 (2010)
DOI:10.7150/ijbs.6.133
Reference
PMID:10433257
  Authors
Greengard P, Allen PB, Nairn AC
  Title
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.
  Journal
Neuron 23:435-47 (1999)
DOI:10.1016/S0896-6273(00)80798-9
Reference
PMID:15590733
  Authors
Hu XT, Dong Y, Zhang XF, White FJ
  Title
Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons.
  Journal
J Neurophysiol 93:1406-17 (2005)
DOI:10.1152/jn.00771.2004
Reference
PMID:17349698
  Authors
Beaulieu JM, Gainetdinov RR, Caron MG
  Title
The Akt-GSK-3 signaling cascade in the actions of dopamine.
  Journal
Trends Pharmacol Sci 28:166-72 (2007)
DOI:10.1016/j.tips.2007.02.006
Reference
PMID:19138563
  Authors
De Mei C, Ramos M, Iitaka C, Borrelli E
  Title
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.
  Journal
Curr Opin Pharmacol 9:53-8 (2009)
DOI:10.1016/j.coph.2008.12.002
Reference
PMID:15381316
  Authors
Seamans JK, Yang CR
  Title
The principal features and mechanisms of dopamine modulation in the prefrontal cortex.
  Journal
Prog Neurobiol 74:1-58 (2004)
DOI:10.1016/j.pneurobio.2004.05.006
Reference
PMID:18353279
  Authors
Yao WD, Spealman RD, Zhang J
  Title
Dopaminergic signaling in dendritic spines.
  Journal
Biochem Pharmacol 75:2055-69 (2008)
DOI:10.1016/j.bcp.2008.01.018
Reference
PMID:20727368
  Authors
Li YC, Gao WJ
  Title
GSK-3beta activity and hyperdopamine-dependent behaviors.
  Journal
Neurosci Biobehav Rev 35:645-54 (2011)
DOI:10.1016/j.neubiorev.2010.08.001
Reference
PMID:15292232
  Authors
Tang TS, Bezprozvanny I
  Title
Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons.
  Journal
J Biol Chem 279:42082-94 (2004)
DOI:10.1074/jbc.M407389200
Reference
PMID:12967774
  Authors
Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS
  Title
Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.
  Journal
Trends Pharmacol Sci 24:486-92 (2003)
DOI:10.1016/S0165-6147(03)00232-3
Reference
PMID:9457173
  Authors
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG
  Title
Dopamine receptors: from structure to function.
  Journal
Physiol Rev 78:189-225 (1998)
DOI:10.1152/physrev.1998.78.1.189
Reference
PMID:19251795
  Authors
Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ
  Title
Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?
  Journal
Eur Respir J 33:468-80 (2009)
DOI:10.1183/09031936.00056908
Related
pathway
gas00350  Tyrosine metabolism
gas04020  Calcium signaling pathway
gas04721  Synaptic vesicle cycle
gas04724  Glutamatergic synapse
gas05012  Parkinson disease
KO pathway
ko04728   
LinkDB

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