KEGG   Homo sapiens (human): 2099
Entry
2099              CDS       T01001                                 
Symbol
ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1
Name
(RefSeq) estrogen receptor 1
  KO
K08550  estrogen receptor alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa04081  Hormone signaling
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04961  Endocrine and other factor-regulated calcium reabsorption
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05224  Breast cancer
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06227  Nuclear receptor signaling (cancer)
nt06270  Breast cancer
nt06323  KISS1-GnRH-LH/FSH-E2 signaling
  Element
N00286  Nuclear-initiated estrogen signaling pathway
N00287  ESR1-positive to nuclear-initiated estrogen signaling pathway
N01350  NNK/NNN to PI3K signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
N01352  BPA to RAS-ERK signaling pathway
N01353  E2 to RAS-ERK signaling pathway
N01364  E2 to nuclear-initiated estrogen signaling pathway
Disease
H00031  Breast cancer
H01730  Myocardial infarction
H02061  Estrogen resistance syndrome
Drug target
Acolbifene hydrochloride: D02758
Afimoxifene: D06551
Alfatradiol: D07121
Amcenestrant: D12145
Arzoxifene hydrochloride: D02993
Bazedoxifene: D03062<JP>
Brilanestrant: D11264
Camizestrant: D12049
Chlorotrianisene: D00269
Clometherone: D03551
Clomifene (DG00474): D00962<JP/US> D07726
Danazol: D00289<JP/US>
Delmadinone (DG02935): D07783
Desogestrel: D02367
Dienestrol: D00898
Diethylstilbestrol (DG00466): D00577 D00946 D07826
Droloxifene (DG01265): D03911 D03912
Elacestrant (DG03078): D11671 D11672<US>
Enclomiphene (DG01992): D08910 D10876
Epitiostanol: D01265
Equilin: D04041
Estetrol (DG03027): D11513 D11514
Estradiol (DG00462): D00105<JP/US> D01413<JP/US> D01617 D01953 D04061<US> D04063<US> D04064 D04065 D07918<US> D07919
Estriol (DG00463): D00185<JP> D01986 D01989 D07920 D07921
Estrogens, esterified: D04071<US>
Estrone (DG00464): D00067 D00312 D00948
Ethinylestradiol (DG00461): D00554<JP> D07928
Etonogestrel: D04104<US>
Etynodiol (DG00470): D01294 D07939
Fispemifene: D10008
Fluoroestradiol (18F): D11829<US>
Fulvestrant: D01161<JP/US>
Giredestrant (DG03318): D11961 D12943
Hexestrol (DG02847): D01641 D02018
Idoxifene: D04496
Lasofoxifene: D04672
Levormeloxifene fumarate: D09834
Mepitiostane: D01602
Mestranol: D00575
Miproxifene phosphate: D01853
Nafoxidine hydrochloride: D05106
Nitromifene citrate: D05192
Ormeloxifene: D08301
Ospemifene: D08958<US>
Palazestrant: D12827
Polyestradiol phosphate: D07434
Prasterone (DG00141): D01616 D08409<US>
Promestriene: D07221
Quinestrol: D00576
Raloxifene (DG00476): D02217<JP/US> D08465 D10606<JP>
Tamoxifen (DG00734): D00966<JP/US> D08559
Tibolone: D01639
Toremifene (DG00735): D00967<JP/US> D08620
Trioxifene mesylate: D06245
Vepdegestrant: D12628
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    2099 (ESR1)
 09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    2099 (ESR1)
   04917 Prolactin signaling pathway
    2099 (ESR1)
   04919 Thyroid hormone signaling pathway
    2099 (ESR1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    2099 (ESR1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2099 (ESR1)
   05205 Proteoglycans in cancer
    2099 (ESR1)
   05207 Chemical carcinogenesis - receptor activation
    2099 (ESR1)
  09162 Cancer: specific types
   05224 Breast cancer
    2099 (ESR1)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    2099 (ESR1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    2099 (ESR1)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    2099 (ESR1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 estrogen receptor-like
    2099 (ESR1)
Nuclear receptors [BR:hsa03310]
 3. Estrogen like
  3A. Estrogen receptor
   2099 (ESR1)
SSDB
Motif
Pfam: Oest_recep zf-C4 Hormone_recep ESR1_C
Other DBs
NCBI-GeneID: 2099
NCBI-ProteinID: NP_000116
OMIM: 133430
HGNC: 3467
Ensembl: ENSG00000091831
UniProt: P03372 G4XH65
Structure
LinkDB
Position
6:151656672..152129619
AA seq 595 aa
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
NT seq 1788 nt   +upstreamnt  +downstreamnt
atgaccatgaccctccacaccaaagcatctgggatggccctactgcatcagatccaaggg
aacgagctggagcccctgaaccgtccgcagctcaagatccccctggagcggcccctgggc
gaggtgtacctggacagcagcaagcccgccgtgtacaactaccccgagggcgccgcctac
gagttcaacgccgcggccgccgccaacgcgcaggtctacggtcagaccggcctcccctac
ggccccgggtctgaggctgcggcgttcggctccaacggcctggggggtttccccccactc
aacagcgtgtctccgagcccgctgatgctactgcacccgccgccgcagctgtcgcctttc
ctgcagccccacggccagcaggtgccctactacctggagaacgagcccagcggctacacg
gtgcgcgaggccggcccgccggcattctacaggccaaattcagataatcgacgccagggt
ggcagagaaagattggccagtaccaatgacaagggaagtatggctatggaatctgccaag
gagactcgctactgtgcagtgtgcaatgactatgcttcaggctaccattatggagtctgg
tcctgtgagggctgcaaggccttcttcaagagaagtattcaaggacataacgactatatg
tgtccagccaccaaccagtgcaccattgataaaaacaggaggaagagctgccaggcctgc
cggctccgtaaatgctacgaagtgggaatgatgaaaggtgggatacgaaaagaccgaaga
ggagggagaatgttgaaacacaagcgccagagagatgatggggagggcaggggtgaagtg
gggtctgctggagacatgagagctgccaacctttggccaagcccgctcatgatcaaacgc
tctaagaagaacagcctggccttgtccctgacggccgaccagatggtcagtgccttgttg
gatgctgagcccccgatactctattccgagtatgatcctaccagacccttcagtgaagct
tcgatgatgggcttactgaccaacctggcagacagggagctggttcacatgatcaactgg
gcgaagagggtgccaggctttgtggatttgaccctccatgatcaggtccaccttctagaa
tgtgcctggctagagatcctgatgattggtctcgtctggcgctccatggagcacccaggg
aagctactgtttgctcctaacttgctcttggacaggaaccagggaaaatgtgtagagggc
atggtggagatcttcgacatgctgctggctacatcatctcggttccgcatgatgaatctg
cagggagaggagtttgtgtgcctcaaatctattattttgcttaattctggagtgtacaca
tttctgtccagcaccctgaagtctctggaagagaaggaccatatccaccgagtcctggac
aagatcacagacactttgatccacctgatggccaaggcaggcctgaccctgcagcagcag
caccagcggctggcccagctcctcctcatcctctcccacatcaggcacatgagtaacaaa
ggcatggagcatctgtacagcatgaagtgcaagaacgtggtgcccctctatgacctgctg
ctggagatgctggacgcccaccgcctacatgcgcccactagccgtggaggggcatccgtg
gaggagacggaccaaagccacttggccactgcgggctctacttcatcgcattccttgcaa
aagtattacatcacgggggaggcagagggtttccctgccacggtctga

KEGG   Homo sapiens (human): 2100
Entry
2100              CDS       T01001                                 
Symbol
ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2, ODG8
Name
(RefSeq) estrogen receptor 2
  KO
K08551  estrogen receptor beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa04081  Hormone signaling
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04929  GnRH secretion
hsa05200  Pathways in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05224  Breast cancer
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06227  Nuclear receptor signaling (cancer)
nt06270  Breast cancer
nt06323  KISS1-GnRH-LH/FSH-E2 signaling
  Element
N00286  Nuclear-initiated estrogen signaling pathway
N01350  NNK/NNN to PI3K signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
N01352  BPA to RAS-ERK signaling pathway
N01353  E2 to RAS-ERK signaling pathway
N01364  E2 to nuclear-initiated estrogen signaling pathway
Disease
H00599  Ovarian dysgenesis
Drug target
Acolbifene hydrochloride: D02758
Afimoxifene: D06551
Alfatradiol: D07121
Arzoxifene hydrochloride: D02993
Bazedoxifene: D03062<JP>
Brilanestrant: D11264
Chlorotrianisene: D00269
Clometherone: D03551
Clomifene (DG00474): D00962<JP/US> D07726
Delmadinone (DG02935): D07783
Dienestrol: D00898
Diethylstilbestrol (DG00466): D00577 D00946 D07826
Droloxifene (DG01265): D03911 D03912
Enclomiphene (DG01992): D08910 D10876
Epitiostanol: D01265
Equilin: D04041
Erteberel: D09899
Estetrol (DG03027): D11513 D11514
Estradiol (DG00462): D00105<JP/US> D01413<JP/US> D01617 D01953 D04061<US> D04063<US> D04064 D04065 D07918<US> D07919
Estriol (DG00463): D00185<JP> D01986 D01989 D07920 D07921
Estrogens, esterified: D04071<US>
Estrone (DG00464): D00067 D00312 D00948
Fispemifene: D10008
Fluoroestradiol (18F): D11829<US>
Fulvestrant: D01161<JP/US>
Hexestrol (DG02847): D01641 D02018
Idoxifene: D04496
Lasofoxifene: D04672
Levormeloxifene fumarate: D09834
Mepitiostane: D01602
Mestranol: D00575
Miproxifene phosphate: D01853
Nafoxidine hydrochloride: D05106
Nitromifene citrate: D05192
Ormeloxifene: D08301
Prasterone (DG00141): D01616 D08409<US>
Prinaberel: D06631
Promestriene: D07221
Raloxifene (DG00476): D02217<JP/US> D08465 D10606<JP>
Tamoxifen (DG00734): D00966<JP/US> D08559
Toremifene (DG00735): D00967<JP/US> D08620
Trioxifene mesylate: D06245
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    2100 (ESR2)
 09150 Organismal Systems
  09152 Endocrine system
   04929 GnRH secretion
    2100 (ESR2)
   04915 Estrogen signaling pathway
    2100 (ESR2)
   04917 Prolactin signaling pathway
    2100 (ESR2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2100 (ESR2)
   05207 Chemical carcinogenesis - receptor activation
    2100 (ESR2)
  09162 Cancer: specific types
   05224 Breast cancer
    2100 (ESR2)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    2100 (ESR2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    2100 (ESR2)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    2100 (ESR2)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 estrogen receptor-like
    2100 (ESR2)
Nuclear receptors [BR:hsa03310]
 3. Estrogen like
  3A. Estrogen receptor
   2100 (ESR2)
SSDB
Motif
Pfam: ERbeta_N zf-C4 Hormone_recep
Other DBs
NCBI-GeneID: 2100
NCBI-ProteinID: NP_001428
OMIM: 601663
HGNC: 3468
Ensembl: ENSG00000140009
UniProt: Q92731 Q7LCB3
Structure
LinkDB
Position
14:complement(64226707..64338613)
AA seq 530 aa
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
NT seq 1593 nt   +upstreamnt  +downstreamnt
atggatataaaaaactcaccatctagccttaattctccttcctcctacaactgcagtcaa
tccatcttacccctggagcacggctccatatacataccttcctcctatgtagacagccac
catgaatatccagccatgacattctatagccctgctgtgatgaattacagcattcccagc
aatgtcactaacttggaaggtgggcctggtcggcagaccacaagcccaaatgtgttgtgg
ccaacacctgggcacctttctcctttagtggtccatcgccagttatcacatctgtatgcg
gaacctcaaaagagtccctggtgtgaagcaagatcgctagaacacaccttacctgtaaac
agagagacactgaaaaggaaggttagtgggaaccgttgcgccagccctgttactggtcca
ggttcaaagagggatgctcacttctgcgctgtctgcagcgattacgcatcgggatatcac
tatggagtctggtcgtgtgaaggatgtaaggccttttttaaaagaagcattcaaggacat
aatgattatatttgtccagctacaaatcagtgtacaatcgataaaaaccggcgcaagagc
tgccaggcctgccgacttcggaagtgttacgaagtgggaatggtgaagtgtggctcccgg
agagagagatgtgggtaccgccttgtgcggagacagagaagtgccgacgagcagctgcac
tgtgccggcaaggccaagagaagtggcggccacgcgccccgagtgcgggagctgctgctg
gacgccctgagccccgagcagctagtgctcaccctcctggaggctgagccgccccatgtg
ctgatcagccgccccagtgcgcccttcaccgaggcctccatgatgatgtccctgaccaag
ttggccgacaaggagttggtacacatgatcagctgggccaagaagattcccggctttgtg
gagctcagcctgttcgaccaagtgcggctcttggagagctgttggatggaggtgttaatg
atggggctgatgtggcgctcaattgaccaccccggcaagctcatctttgctccagatctt
gttctggacagggatgaggggaaatgcgtagaaggaattctggaaatctttgacatgctc
ctggcaactacttcaaggtttcgagagttaaaactccaacacaaagaatatctctgtgtc
aaggccatgatcctgctcaattccagtatgtaccctctggtcacagcgacccaggatgct
gacagcagccggaagctggctcacttgctgaacgccgtgaccgatgctttggtttgggtg
attgccaagagcggcatctcctcccagcagcaatccatgcgcctggctaacctcctgatg
ctcctgtcccacgtcaggcatgcgagtaacaagggcatggaacatctgctcaacatgaag
tgcaaaaatgtggtcccagtgtatgacctgctgctggagatgctgaatgcccacgtgctt
cgcgggtgcaagtcctccatcacggggtccgagtgcagcccggcagaggacagtaaaagc
aaagagggctcccagaacccacagtctcagtga

KEGG   Homo sapiens (human): 2353
Entry
2353              CDS       T01001                                 
Symbol
FOS, AP-1, C-FOS, p55
Name
(RefSeq) Fos proto-oncogene, AP-1 transcription factor subunit
  KO
K04379  proto-oncogene protein c-fos
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa04010  MAPK signaling pathway
hsa04024  cAMP signaling pathway
hsa04210  Apoptosis
hsa04380  Osteoclast differentiation
hsa04620  Toll-like receptor signaling pathway
hsa04657  IL-17 signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04668  TNF signaling pathway
hsa04713  Circadian entrainment
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04932  Non-alcoholic fatty liver disease
hsa04935  Growth hormone synthesis, secretion and action
hsa05031  Amphetamine addiction
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
hsa05133  Pertussis
hsa05135  Yersinia infection
hsa05140  Leishmaniasis
hsa05142  Chagas disease
hsa05161  Hepatitis B
hsa05162  Measles
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05224  Breast cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05323  Rheumatoid arthritis
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
nt06210  ERK signaling (cancer)
nt06211  Other MAPK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06223  TNF signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06461  Huntington disease
nt06516  TNF signaling
nt06517  TLR signaling
nt06526  MAPK signaling
  Element
N00188  IL1-IL1R-JNK signaling pathway
N00438  TLR2/4-MAPK signaling pathway
N00446  TNF-JNK signaling pathway
N00447  HIV Vpr/Tat to TNF-JNK signaling pathway
N00509  HTLV-1 Tax to SRF-mediated transcription
N00545  HBV HBx to ERK signaling pathway
N01344  NNK/NNN to RAS-ERK signaling pathway
N01350  NNK/NNN to PI3K signaling pathway
N01353  E2 to RAS-ERK signaling pathway
N01407  Metals to JNK signaling pathway
N01408  Metals to RAS-ERK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    2353 (FOS)
   04668 TNF signaling pathway
    2353 (FOS)
   04024 cAMP signaling pathway
    2353 (FOS)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    2353 (FOS)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    2353 (FOS)
   04660 T cell receptor signaling pathway
    2353 (FOS)
   04658 Th1 and Th2 cell differentiation
    2353 (FOS)
   04659 Th17 cell differentiation
    2353 (FOS)
   04657 IL-17 signaling pathway
    2353 (FOS)
   04662 B cell receptor signaling pathway
    2353 (FOS)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    2353 (FOS)
   04917 Prolactin signaling pathway
    2353 (FOS)
   04921 Oxytocin signaling pathway
    2353 (FOS)
   04926 Relaxin signaling pathway
    2353 (FOS)
   04935 Growth hormone synthesis, secretion and action
    2353 (FOS)
   04928 Parathyroid hormone synthesis, secretion and action
    2353 (FOS)
  09156 Nervous system
   04725 Cholinergic synapse
    2353 (FOS)
   04728 Dopaminergic synapse
    2353 (FOS)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    2353 (FOS)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2353 (FOS)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2353 (FOS)
   05207 Chemical carcinogenesis - receptor activation
    2353 (FOS)
   05208 Chemical carcinogenesis - reactive oxygen species
    2353 (FOS)
   05231 Choline metabolism in cancer
    2353 (FOS)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    2353 (FOS)
  09162 Cancer: specific types
   05210 Colorectal cancer
    2353 (FOS)
   05224 Breast cancer
    2353 (FOS)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    2353 (FOS)
   05170 Human immunodeficiency virus 1 infection
    2353 (FOS)
   05161 Hepatitis B
    2353 (FOS)
   05171 Coronavirus disease - COVID-19
    2353 (FOS)
   05162 Measles
    2353 (FOS)
   05167 Kaposi sarcoma-associated herpesvirus infection
    2353 (FOS)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    2353 (FOS)
   05132 Salmonella infection
    2353 (FOS)
   05135 Yersinia infection
    2353 (FOS)
   05133 Pertussis
    2353 (FOS)
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    2353 (FOS)
   05142 Chagas disease
    2353 (FOS)
  09163 Immune disease
   05323 Rheumatoid arthritis
    2353 (FOS)
  09165 Substance dependence
   05031 Amphetamine addiction
    2353 (FOS)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    2353 (FOS)
   05418 Fluid shear stress and atherosclerosis
    2353 (FOS)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    2353 (FOS)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    2353 (FOS)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    2353 (FOS)
   04131 Membrane trafficking [BR:hsa04131]
    2353 (FOS)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, Fos
    2353 (FOS)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Chaperone mediated autophagy (CMA)
   Selective cargos
    2353 (FOS)
SSDB
Motif
Pfam: bZIP_1 bZIP_2 bZIP_Maf MIC19_MIC25 DUF3450 HALZ Macoilin
Other DBs
NCBI-GeneID: 2353
NCBI-ProteinID: NP_005243
OMIM: 164810
HGNC: 3796
Ensembl: ENSG00000170345
UniProt: P01100 Q6FG41
Structure
LinkDB
Position
14:75278828..75282230
AA seq 380 aa
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANF
IPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRA
QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ
TEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFT
LPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYA
ADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRK
GSSSNEPSSDSLSSPTLLAL
NT seq 1143 nt   +upstreamnt  +downstreamnt
atgatgttctcgggcttcaacgcagactacgaggcgtcatcctcccgctgcagcagcgcg
tccccggccggggatagcctctcttactaccactcacccgcagactccttctccagcatg
ggctcgcctgtcaacgcgcaggacttctgcacggacctggccgtctccagtgccaacttc
attcccacggtcactgccatctcgaccagtccggacctgcagtggctggtgcagcccgcc
ctcgtctcctccgtggccccatcgcagaccagagcccctcaccctttcggagtccccgcc
ccctccgctggggcttactccagggctggcgttgtgaagaccatgacaggaggccgagcg
cagagcattggcaggaggggcaaggtggaacagttatctccagaagaagaagagaaaagg
agaatccgaagggaaaggaataagatggctgcagccaaatgccgcaaccggaggagggag
ctgactgatacactccaagcggagacagaccaactagaagatgagaagtctgctttgcag
accgagattgccaacctgctgaaggagaaggaaaaactagagttcatcctggcagctcac
cgacctgcctgcaagatccctgatgacctgggcttcccagaagagatgtctgtggcttcc
cttgatctgactgggggcctgccagaggttgccaccccggagtctgaggaggccttcacc
ctgcctctcctcaatgaccctgagcccaagccctcagtggaacctgtcaagagcatcagc
agcatggagctgaagaccgagccctttgatgacttcctgttcccagcatcatccaggccc
agtggctctgagacagcccgctccgtgccagacatggacctatctgggtccttctatgca
gcagactgggagcctctgcacagtggctccctggggatggggcccatggccacagagctg
gagcccctgtgcactccggtggtcacctgtactcccagctgcactgcttacacgtcttcc
ttcgtcttcacctaccccgaggctgactccttccccagctgtgcagctgcccaccgcaag
ggcagcagcagcaatgagccttcctctgactcgctcagctcacccacgctgctggccctg
tga

KEGG   Homo sapiens (human): 3725
Entry
3725              CDS       T01001                                 
Symbol
JUN, AP-1, AP1, c-Jun, cJUN, p39
Name
(RefSeq) Jun proto-oncogene, AP-1 transcription factor subunit
  KO
K04448  transcription factor AP-1
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04024  cAMP signaling pathway
hsa04137  Mitophagy - animal
hsa04210  Apoptosis
hsa04310  Wnt signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04530  Tight junction
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04657  IL-17 signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04668  TNF signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa04912  GnRH signaling pathway
hsa04915  Estrogen signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05133  Pertussis
hsa05135  Yersinia infection
hsa05140  Leishmaniasis
hsa05142  Chagas disease
hsa05161  Hepatitis B
hsa05162  Measles
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05224  Breast cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05321  Inflammatory bowel disease
hsa05323  Rheumatoid arthritis
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
nt06210  ERK signaling (cancer)
nt06211  Other MAPK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06223  TNF signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06461  Huntington disease
nt06516  TNF signaling
nt06517  TLR signaling
nt06526  MAPK signaling
  Element
N00188  IL1-IL1R-JNK signaling pathway
N00438  TLR2/4-MAPK signaling pathway
N00446  TNF-JNK signaling pathway
N00447  HIV Vpr/Tat to TNF-JNK signaling pathway
N00503  HTLV-1 Tax to TNF-JNK signaling pathway
N00543  HBV HBx to JNK signaling pathway
N00545  HBV HBx to ERK signaling pathway
N01344  NNK/NNN to RAS-ERK signaling pathway
N01350  NNK/NNN to PI3K signaling pathway
N01353  E2 to RAS-ERK signaling pathway
N01407  Metals to JNK signaling pathway
N01408  Metals to RAS-ERK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    3725 (JUN)
   04012 ErbB signaling pathway
    3725 (JUN)
   04310 Wnt signaling pathway
    3725 (JUN)
   04668 TNF signaling pathway
    3725 (JUN)
   04024 cAMP signaling pathway
    3725 (JUN)
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    3725 (JUN)
  09143 Cell growth and death
   04210 Apoptosis
    3725 (JUN)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    3725 (JUN)
   04530 Tight junction
    3725 (JUN)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    3725 (JUN)
   04621 NOD-like receptor signaling pathway
    3725 (JUN)
   04625 C-type lectin receptor signaling pathway
    3725 (JUN)
   04660 T cell receptor signaling pathway
    3725 (JUN)
   04658 Th1 and Th2 cell differentiation
    3725 (JUN)
   04659 Th17 cell differentiation
    3725 (JUN)
   04657 IL-17 signaling pathway
    3725 (JUN)
   04662 B cell receptor signaling pathway
    3725 (JUN)
  09152 Endocrine system
   04912 GnRH signaling pathway
    3725 (JUN)
   04915 Estrogen signaling pathway
    3725 (JUN)
   04921 Oxytocin signaling pathway
    3725 (JUN)
   04926 Relaxin signaling pathway
    3725 (JUN)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    3725 (JUN)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    3725 (JUN)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3725 (JUN)
   05207 Chemical carcinogenesis - receptor activation
    3725 (JUN)
   05208 Chemical carcinogenesis - reactive oxygen species
    3725 (JUN)
   05203 Viral carcinogenesis
    3725 (JUN)
   05231 Choline metabolism in cancer
    3725 (JUN)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    3725 (JUN)
  09162 Cancer: specific types
   05210 Colorectal cancer
    3725 (JUN)
   05211 Renal cell carcinoma
    3725 (JUN)
   05224 Breast cancer
    3725 (JUN)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    3725 (JUN)
   05170 Human immunodeficiency virus 1 infection
    3725 (JUN)
   05161 Hepatitis B
    3725 (JUN)
   05171 Coronavirus disease - COVID-19
    3725 (JUN)
   05162 Measles
    3725 (JUN)
   05167 Kaposi sarcoma-associated herpesvirus infection
    3725 (JUN)
   05169 Epstein-Barr virus infection
    3725 (JUN)
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    3725 (JUN)
   05130 Pathogenic Escherichia coli infection
    3725 (JUN)
   05132 Salmonella infection
    3725 (JUN)
   05131 Shigellosis
    3725 (JUN)
   05135 Yersinia infection
    3725 (JUN)
   05133 Pertussis
    3725 (JUN)
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    3725 (JUN)
   05142 Chagas disease
    3725 (JUN)
  09163 Immune disease
   05323 Rheumatoid arthritis
    3725 (JUN)
   05321 Inflammatory bowel disease
    3725 (JUN)
  09165 Substance dependence
   05030 Cocaine addiction
    3725 (JUN)
   05031 Amphetamine addiction
    3725 (JUN)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    3725 (JUN)
   05418 Fluid shear stress and atherosclerosis
    3725 (JUN)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    3725 (JUN)
   04933 AGE-RAGE signaling pathway in diabetic complications
    3725 (JUN)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    3725 (JUN)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    3725 (JUN)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, Jun
    3725 (JUN)
SSDB
Motif
Pfam: Jun bZIP_1 bZIP_2 bZIP_Maf ZapB PspA_IM30 Fib_alpha DUF3450 TFIIA FlaC_arch
Other DBs
NCBI-GeneID: 3725
NCBI-ProteinID: NP_002219
OMIM: 165160
HGNC: 6204
Ensembl: ENSG00000177606
UniProt: P05412
Structure
LinkDB
Position
1:complement(58780791..58784047)
AA seq 331 aa
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
NT seq 996 nt   +upstreamnt  +downstreamnt
atgactgcaaagatggaaacgaccttctatgacgatgccctcaacgcctcgttcctcccg
tccgagagcggaccttatggctacagtaaccccaagatcctgaaacagagcatgaccctg
aacctggccgacccagtggggagcctgaagccgcacctccgcgccaagaactcggacctc
ctcacctcgcccgacgtggggctgctcaagctggcgtcgcccgagctggagcgcctgata
atccagtccagcaacgggcacatcaccaccacgccgacccccacccagttcctgtgcccc
aagaacgtgacagatgagcaggagggcttcgccgagggcttcgtgcgcgccctggccgaa
ctgcacagccagaacacgctgcccagcgtcacgtcggcggcgcagccggtcaacggggca
ggcatggtggctcccgcggtagcctcggtggcagggggcagcggcagcggcggcttcagc
gccagcctgcacagcgagccgccggtctacgcaaacctcagcaacttcaacccaggcgcg
ctgagcagcggcggcggggcgccctcctacggcgcggccggcctggcctttcccgcgcaa
ccccagcagcagcagcagccgccgcaccacctgccccagcagatgcccgtgcagcacccg
cggctgcaggccctgaaggaggagcctcagacagtgcccgagatgcccggcgagacaccg
cccctgtcccccatcgacatggagtcccaggagcggatcaaggcggagaggaagcgcatg
aggaaccgcatcgctgcctccaagtgccgaaaaaggaagctggagagaatcgcccggctg
gaggaaaaagtgaaaaccttgaaagctcagaactcggagctggcgtccacggccaacatg
ctcagggaacaggtggcacagcttaaacagaaagtcatgaaccacgttaacagtgggtgc
caactcatgctaacgcagcagttgcaaacattttga

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