Entry Name NF-kappa B signaling pathway
Description Nuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are several pathways leading to NF-kappa B-activation. The canonical pathway is induced by tumour necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) or byproducts of bacterial and viral infections. This pathway relies on IKK- mediated IkappaB-alpha phosphorylation on Ser32 and 36, leading to its degradation, which allows the p50/p65 NF-kappa B dimer to enter the nucleus and activate gene transcription. Atypical pathways are IKK-independent and rely on phosphorylation of IkappaB-alpha on Tyr42 or on Ser residues in IkappaB-alpha PEST domain. The non-canonical pathway is triggered by particular members of the TNFR superfamily, such as lymphotoxin-beta (LT-beta) or BAFF. It involves NIK and IKK-alpha-mediated p100 phosphorylation and processing to p52, resulting in nuclear translocation of p52/RelB heterodimers.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map ko04064 NF-kappa B signaling pathway
Ortholog table Orthology K10784 T cell receptor alpha chain V region
K10785 T-cell receptor beta chain V region
K07362 linker for activation of T cells family member 1
K06856 immunoglobulin heavy chain
K20912 caspase recruitment domain-containing protein 10
K07367 caspase recruitment domain-containing protein 11
K20913 caspase recruitment domain-containing protein 14
K07369 mucosa-associated lymphoid tissue lymphoma translocation protein 1 [EC:3.4.22.-]
K04386 interleukin 1 receptor type I
K04729 myeloid differentiation primary response protein MyD88
K03156 tumor necrosis factor superfamily, member 2
K03158 tumor necrosis factor receptor superfamily member 1A
K02861 receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1 ]
K03171 tumor necrosis factor receptor type 1-associated DEATH domain protein
K09849 TNF receptor-associated factor 5
K16060 baculoviral IAP repeat-containing protein 2/3
K05162 tumor necrosis factor receptor superfamily member EDAR
K23324 ectodysplasin-A receptor-associated adapter protein
K05163 tumor necrosis factor receptor superfamily member 27
K05399 lipopolysaccharide-binding protein
K04391 monocyte differentiation antigen CD14
K05403 toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
K05409 TRIF-related adaptor molecule
K05842 toll-like receptor adapter molecule 1
K03161 tumor necrosis factor ligand superfamily member 5
K03160 tumor necrosis factor receptor superfamily member 5
K03174 TNF receptor-associated factor 3
K05473 tumor necrosis factor ligand superfamily member 11
K05147 tumor necrosis factor receptor superfamily member 11A
K05468 lymphotoxin alpha (TNF superfamily, member 1)
K03157 lymphotoxin beta (TNF superfamily, member 3)
K05477 tumor necrosis factor ligand superfamily member 14
K03159 lymphotoxin beta receptor TNFR superfamily member 3
K05476 tumor necrosis factor ligand superfamily member 13B
K05151 tumor necrosis factor receptor superfamily member 13C
K07210 inhibitor of nuclear factor kappa-B kinase subunit gamma
K04467 inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10 ]
K07209 inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10 ]
K10577 ubiquitin-conjugating enzyme E2 I
K10130 leucine-rich repeats and death domain-containing protein
K16072 ELKS/RAB6-interacting/CAST family member 1
K04734 NF-kappa-B inhibitor alpha
K02580 nuclear factor NF-kappa-B p105 subunit
K04735 transcription factor p65
K27356 RelA-associated inhibitor
K04724 CASP8 and FADD-like apoptosis regulator
K04570 Bcl-2-like 1 (apoptosis regulator Bcl-X)
K02161 apoptosis regulator Bcl-2
K04402 growth arrest and DNA-damage-inducible protein
K03172 TNF receptor-associated factor 1
K02162 hematopoietic Bcl-2-related protein A1
K04469 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K05505 C-X-C motif chemokine 1/2/3
K06527 vascular cell adhesion molecule 1
K03115 casein kinase II subunit beta
K09253 transcription factor RelB
K10031 C-X-C motif chemokine 12
K06490 intercellular adhesion molecule 1
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Oeckinghaus A, Hayden MS, Ghosh S
Title Crosstalk in NF-kappaB signaling pathways.
Journal Reference Authors Gloire G, Piette J
Title Redox regulation of nuclear post-translational modifications during NF-kappaB activation.
Journal Reference Authors Perkins ND
Title Integrating cell-signalling pathways with NF-kappaB and IKK function.
Journal Reference Authors Lindstrom TM, Bennett PR
Title The role of nuclear factor kappa B in human labour.
Journal Reference Authors Razani B, Reichardt AD, Cheng G
Title Non-canonical NF-kappaB signaling activation and regulation: principles and perspectives.
Journal Reference Authors Sun SC
Title Non-canonical NF-kappaB signaling pathway.
Journal Reference Authors Neumann M, Naumann M
Title Beyond IkappaBs: alternative regulation of NF-kappaB activity.
Journal Reference Authors Verhelst K, Carpentier I, Beyaert R
Title Regulation of TNF-induced NF-kappaB activation by different cytoplasmic ubiquitination events.
Journal Reference Authors Rickert RC, Jellusova J, Miletic AV
Title Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease.
Journal Reference Authors Naude PJ, den Boer JA, Luiten PG, Eisel UL
Title Tumor necrosis factor receptor cross-talk.
Journal Reference Authors Grivennikov SI, Kuprash DV, Liu ZG, Nedospasov SA
Title Intracellular signals and events activated by cytokines of the tumor necrosis factor superfamily: From simple paradigms to complex mechanisms.
Journal Reference Authors Wada T, Nakashima T, Hiroshi N, Penninger JM
Title RANKL-RANK signaling in osteoclastogenesis and bone disease.
Journal Reference Authors Schulze-Luehrmann J, Ghosh S
Title Antigen-receptor signaling to nuclear factor kappa B.
Journal Reference Authors Weil R, Israel A
Title T-cell-receptor- and B-cell-receptor-mediated activation of NF-kappaB in lymphocytes.
Journal Reference Authors Siebenlist U, Brown K, Claudio E
Title Control of lymphocyte development by nuclear factor-kappaB.
Journal Reference Authors Lucas PC, McAllister-Lucas LM, Nunez G
Title NF-kappaB signaling in lymphocytes: a new cast of characters.
Journal Reference Authors Khan WN
Title B cell receptor and BAFF receptor signaling regulation of B cell homeostasis.
Journal Reference Authors Vallabhapurapu S, Karin M
Title Regulation and function of NF-kappaB transcription factors in the immune system.
Journal Reference Authors Hacker H, Karin M
Title Regulation and function of IKK and IKK-related kinases.
Journal Reference Authors Sabatel H, Pirlot C, Piette J, Habraken Y
Title Importance of PIKKs in NF-kappaB activation by genotoxic stress.
Journal Reference Authors Miyamoto S
Title Nuclear initiated NF-kappaB signaling: NEMO and ATM take center stage.
Journal Reference Authors Brzoska K, Szumiel I
Title Signalling loops and linear pathways: NF-kappaB activation in response to genotoxic stress.
Journal Reference Authors Wu ZH, Miyamoto S
Title Many faces of NF-kappaB signaling induced by genotoxic stress.
Journal Reference Authors Maelfait J, Beyaert R
Title Emerging role of ubiquitination in antiviral RIG-I signaling.
Journal Reference Authors Ware CF
Title Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways.
Journal Reference Authors Schneider K, Potter KG, Ware CF
Title Lymphotoxin and LIGHT signaling pathways and target genes.
Journal Reference Authors Remouchamps C, Boutaffala L, Ganeff C, Dejardin E
Title Biology and signal transduction pathways of the Lymphotoxin-alphabeta/LTbetaR system.
Journal Reference Authors Liu S, Chen ZJ
Title Expanding role of ubiquitination in NF-kappaB signaling.
Journal Reference Authors Skaug B, Jiang X, Chen ZJ
Title The role of ubiquitin in NF-kappaB regulatory pathways.
Journal Reference Authors Wertz IE, Dixit VM
Title Signaling to NF-kappaB: regulation by ubiquitination.
Journal Reference Authors Karin M, Lin A
Title NF-kappaB at the crossroads of life and death.
Journal Reference Authors Lin A, Karin M
Title NF-kappaB in cancer: a marked target.
Journal Reference Authors Morlon A, Munnich A, Smahi A
Title TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd.
Journal Reference Authors Sadier A, Viriot L, Pantalacci S, Laudet V
Title The ectodysplasin pathway: from diseases to adaptations.
Journal Reference Authors Verhelst K, Gardam S, Borghi A, Kreike M, Carpentier I, Beyaert R
Title XEDAR activates the non-canonical NF-kappaB pathway.
Journal Reference Authors McDaniel DK, Eden K, Ringel VM, Allen IC
Title Emerging Roles for Noncanonical NF-kappaB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology.
Journal Reference Authors Mikkola ML, Thesleff I
Title Ectodysplasin signaling in development.
Journal Reference Authors Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
Title Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
Journal Related ko04060 Cytokine-cytokine receptor interaction
ko04120 Ubiquitin mediated proteolysis
ko04620 Toll-like receptor signaling pathway
ko04622 RIG-I-like receptor signaling pathway
ko04660 T cell receptor signaling pathway
ko04662 B cell receptor signaling pathway
LinkDB All DBs
