KEGG   PATHWAY: mbez04350
Entry
mbez04350                   Pathway                                
Name
TGF-beta signaling pathway - Moschus berezovskii (Chinese forest musk deer)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
mbez04350  TGF-beta signaling pathway
mbez04350

Other DBs
GO: 0007179
Organism
Moschus berezovskii (Chinese forest musk deer) [GN:mbez]
Gene
129535634  LEMD3; inner nuclear membrane protein Man1 [KO:K19410]
129535642  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
129535728  INHBC; inhibin beta C chain [KO:K22688]
129535762  ACVR1B; activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
129535764  SP1; transcription factor Sp1 [KO:K04684]
129536188  DCN; decorin [KO:K04660]
129536424  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
129536465  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
129536468  IFNG; interferon gamma [KO:K04687]
129536488  [KO:K04673] [EC:2.7.11.30]
129536506  NOG; noggin [KO:K04658]
129536817  INHBE; inhibin beta E chain [KO:K22689]
129537898  NBL1; neuroblastoma suppressor of tumorigenicity 1 isoform X1 [KO:K19558]
129537916  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
129537933  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
129538180  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
129538336  INHBB; inhibin beta B chain [KO:K22687]
129538385  [KO:K03094]
129538494  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
129538665  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
129539208  [KO:K04382] [EC:3.1.3.16]
129539357  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
129539448  [KO:K04513]
129539566  GDF7; growth/differentiation factor 7 [KO:K20013]
129539629  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
129539880  LTBP1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
129540331  ZFYVE9; zinc finger FYVE domain-containing protein 9 [KO:K04679]
129540337  TFRC; transferrin receptor protein 1 [KO:K06503]
129540659  HJV; hemojuvelin isoform X1 [KO:K23100]
129540795  [KO:K06067] [EC:3.5.1.98]
129540874  [KO:K16622]
129541464  [KO:K16622]
129541526  TMEM53; transmembrane protein 53 [KO:K28359]
129542180  NRROS; transforming growth factor beta activator LRRC33 isoform X1 [KO:K26317]
129542187  SMAD1; mothers against decapentaplegic homolog 1 isoform X1 [KO:K04676]
129542485  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129543262  TNF; tumor necrosis factor isoform X1 [KO:K03156]
129543595  BMP5; bone morphogenetic protein 5 [KO:K04663]
129543640  ID4; DNA-binding protein inhibitor ID-4 [KO:K17695]
129543700  HFE; hereditary hemochromatosis protein isoform X1 [KO:K26535]
129543830  BMP6; bone morphogenetic protein 6 isoform X1 [KO:K16620]
129544181  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
129544554  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
129545115  CHRD; chordin isoform X1 [KO:K04657]
129545322  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
129545501  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129545612  SKIL; ski-like protein [KO:K18499]
129545677  TFR2; transferrin receptor protein 2 isoform X1 [KO:K23910]
129545732  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
129546146  HAMP; hepcidin [KO:K23106]
129546445  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
129546604  EMP3; epithelial membrane protein 3 [KO:K26257]
129546785  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
129547015  E2F4; transcription factor E2F4 [KO:K04682]
129547056  [KO:K06067] [EC:3.5.1.98]
129547692  [KO:K14736]
129547838  RHOA; transforming protein RhoA [KO:K04513]
129548139  ACVR2B; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
129548192  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
129548695  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
129549379  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
129549466  [KO:K03094]
129549745  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
129549764  TGIF1; homeobox protein TGIF1 isoform X1 [KO:K19383]
129549831  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
129549837  SMAD7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
129549854  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
129550240  RGMA; repulsive guidance molecule A [KO:K23096]
129550441  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
129551108  [KO:K04668]
129551439  SKI; ski oncogene [KO:K26503]
129551635  [KO:K04668]
129551685  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
129551788  FMOD; fibromodulin [KO:K08121]
129552056  [KO:K03347]
129552231  [KO:K14736]
129552578  INHBA; inhibin beta A chain [KO:K04667]
129552744  CUL1; cullin-1 isoform X1 [KO:K03347]
129553267  FST; follistatin isoform X1 [KO:K04661]
129554318  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
129554506  [KO:K06067] [EC:3.5.1.98]
129554699  LRRC32; transforming growth factor beta activator LRRC32 [KO:K26316]
129555646  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
129555685  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
129555754  NODAL; nodal homolog [KO:K04666]
129555784  GDF5; growth/differentiation factor 5 [KO:K04664]
129555979  [KO:K06067] [EC:3.5.1.98]
129556323  SMAD9; mothers against decapentaplegic homolog 9 [KO:K16791]
129556533  TFDP1; transcription factor Dp-1 [KO:K04683]
129556858  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
129557537  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
129558058  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
129558295  SMAD5; mothers against decapentaplegic homolog 5 [KO:K16790]
129558297  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
129558414  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
129558505  RGMB; repulsive guidance molecule B [KO:K06847]
129558697  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
129559599  AMH; muellerian-inhibiting factor [KO:K04665]
129559907  E2F5; transcription factor E2F5 [KO:K04682]
129560159  BMP2; bone morphogenetic protein 2 [KO:K21283]
129560340  MYC; myc proto-oncogene protein [KO:K04377]
129560389  GDF6; growth/differentiation factor 6 [KO:K20012]
129560927  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
129561454  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
129561674  BMP7; bone morphogenetic protein 7 [KO:K16621]
129561844  PITX2; pituitary homeobox 2 isoform X1 [KO:K04686]
129562363  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
129562431  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
129562470  SMAD6; mothers against decapentaplegic homolog 6 isoform X1 [KO:K04677]
129562707  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
129562784  THSD4; thrombospondin type-1 domain-containing protein 4 [KO:K23377]
129562955  GREM1; gremlin-1 [KO:K23318]
129563140  TGIF2; homeobox protein TGIF2 [KO:K19553]
129563163  FBN1; fibrillin-1 [KO:K06825]
129563172  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
129563231  RBL1; retinoblastoma-like protein 1 [KO:K04681]
129563241  [KO:K06067] [EC:3.5.1.98]
129563289  NEO1; neogenin isoform X1 [KO:K06766]
129563803  [KO:K03456]
129563804  [KO:K03456]
129564222  [KO:K04382] [EC:3.1.3.16]
129564481  IGSF1; immunoglobulin superfamily member 1 [KO:K26168]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Reference
PMID:38267638
  Authors
Wu M, Wu S, Chen W, Li YP
  Title
The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease.
  Journal
Cell Res 34:101-123 (2024)
DOI:10.1038/s41422-023-00918-9
Related
pathway
mbez04010  MAPK signaling pathway
mbez04110  Cell cycle
mbez04120  Ubiquitin mediated proteolysis
mbez04210  Apoptosis
KO pathway
ko04350   

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