KEGG   PATHWAY: mcal04530
Entry
mcal04530                   Pathway                                
Name
Tight junction - Mus caroli (Ryukyu mouse)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mcal04530  Tight junction
mcal04530

Other DBs
GO: 0005923
Organism
Mus caroli (Ryukyu mouse) [GN:mcal]
Gene
110284212  Crb3; protein crumbs homolog 3 [KO:K06090]
110287318  claudin-34-like [KO:K06087]
110287448  claudin-34-like [KO:K06087]
110300932  Cldn22; claudin-22 [KO:K06087]
110302086  Cldn18; claudin-18 isoform X1 [KO:K06087]
110293468  Cldn19; claudin-19 [KO:K06087]
110311494  Cldn14; claudin-14 [KO:K06087]
110284203  Cldn9; claudin-9 [KO:K06087]
110312074  Cldn8; claudin-8 [KO:K06087]
110294968  Cldn15; claudin-15 [KO:K06087]
110286648  Cldn2; claudin-2 isoform X1 [KO:K06087]
110294482  Cldn3; claudin-3 [KO:K06087]
110300765  Cldn23; claudin-23 [KO:K06087]
110309436  Cldn10; claudin-10 isoform X1 [KO:K06087]
110287314  claudin-34-like [KO:K06087]
110311408  Cldn1; claudin-1 [KO:K06087]
110311649  Cldn5; claudin-5 [KO:K06087]
110304873  Cldn7; claudin-7 [KO:K06087]
110295257  Cldn4; claudin-4 [KO:K06087]
110311875  Cldn16; claudin-16 [KO:K06087]
110284121  Cldn6; claudin-6 [KO:K06087]
110312490  Cldn20; claudin-20 [KO:K06087]
110312097  Cldn17; claudin-17 [KO:K06087]
110300977  Cldn25; putative claudin-25 [KO:K06087]
110291258  Cldn11; claudin-11 [KO:K06087]
110293857  claudin-13 [KO:K06087]
110295032  Cldn12; claudin-12 [KO:K06087]
110308396  Ocln; occludin isoform X1 [KO:K06088]
110302693  F11r; junctional adhesion molecule A [KO:K06089]
110311766  Jam2; junctional adhesion molecule B [KO:K06735]
110301490  Jam3; junctional adhesion molecule C [KO:K06785]
110303903  Bves; blood vessel epicardial substance [KO:K21108]
110292517  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
110287295  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
110299798  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
110284823  Pard6g; partitioning defective 6 homolog gamma isoform X1 [KO:K06093]
110306904  Mpp5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
110296195  Mpp4; MAGUK p55 subfamily member 4 [KO:K21109]
110302904  Tjp3; tight junction protein ZO-3 isoform X1 [KO:K06097]
110292253  Patj; inaD-like protein isoform X1 [KO:K06092]
110293269  Mpdz; multiple PDZ domain protein isoform X1 [KO:K06095]
110292460  Prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
110290944  Prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
110286729  Amot; angiomotin isoform X1 [KO:K16819]
110301904  Amotl2; angiomotin-like protein 2 isoform X2 [KO:K06104]
110301205  Amotl1; angiomotin-like protein 1 isoform X4 [KO:K06104]
110297627  Arhgap17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
110293965  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
110306166  Nf2; merlin isoform X1 [KO:K16684]
110305811  Llgl1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
110304844  Llgl2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
110311707  Dlg1; disks large homolog 1 isoform X4 [KO:K12076]
110310223  Scrib; protein scribble homolog isoform X1 [KO:K16175]
110305092  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
110299736  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
110302129  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
110312643  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
110298725  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
110309355  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
110284493  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2 [KO:K04354]
110294530  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X3 [KO:K04354]
110300435  Pard3; partitioning defective 3 homolog isoform X7 [KO:K04237]
110311394  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
110297425  Tjp1; tight junction protein ZO-1 isoform X6 [KO:K05701]
110312634  Tjap1; tight junction-associated protein 1 isoform X1 [KO:K06105]
110299456  Dlg2; disks large homolog 2 isoform X6 [KO:K12075]
110302744  disks large homolog 2-like [KO:K12075]
110286480  Dlg3; disks large homolog 3 isoform X1 [KO:K21098]
110300972  Nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
110285033  Nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X6 [KO:K13305] [EC:2.3.2.26]
110291104  Cgn; cingulin isoform X1 [KO:K06102]
110301137  Cgnl1; cingulin-like protein 1 [KO:K21110]
110290909  Arhgef2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
110292411  transforming protein RhoA [KO:K04513]
110302438  Rhoa; transforming protein RhoA [KO:K04513]
110309538  Gata4; transcription factor GATA-4 [KO:K09183]
110300538  Marveld3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
110307741  Map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
110294148  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110308920  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110304169  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110292423  Jun; transcription factor AP-1 [KO:K04448]
110290701  Cd1d; antigen-presenting glycoprotein CD1d [KO:K06448]
110290702  antigen-presenting glycoprotein CD1d1-like [KO:K06448]
110296314  Cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
110303132  Cdk4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
110296844  Ybx3; Y-box-binding protein 3 isoform X1 [KO:K06099]
110299508  Sympk; symplekin isoform X1 [KO:K06100]
110310774  proliferating cell nuclear antigen-like [KO:K04802]
110285987  Pcna; proliferating cell nuclear antigen [KO:K04802]
110298189  Ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
110304771  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
110311558  Runx1; runt-related transcription factor 1 isoform X1 [KO:K08367]
110306022  Hspa4; heat shock 70 kDa protein 4 [KO:K09489]
110305683  Slc9a3r1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
110312486  Ezr; ezrin [KO:K08007]
110300986  Rdx; radixin isoform X1 [KO:K05762]
110286791  Msn; moesin [KO:K05763]
110312510  Prkce; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
110304283  Actg1; actin, cytoplasmic 2 [KO:K05692]
110295381  Actb; actin, cytoplasmic 1 [KO:K05692]
110309492  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
110303338  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
110299603  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
110310031  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
110311663  Hcls1; hematopoietic lineage cell-specific protein [KO:K06106]
110297817  Cttn; src substrate cortactin isoform X1 [KO:K06106]
110305500  Actr2; actin-related protein 2 isoform X2 [KO:K17260]
110290273  Actr3; actin-related protein 3 [KO:K18584]
110294128  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
110294284  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
110290663  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
110294933  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
110295988  Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
110288098  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
110289494  Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
110299011  Whamm; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
110287161  Was; wiskott-Aldrich syndrome protein [KO:K05747]
110297879  Vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
110290795  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
110300173  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110291138  Rab13; ras-related protein Rab-13 isoform X1 [KO:K06109]
110299665  Arhgef18; rho guanine nucleotide exchange factor 18 isoform X3 [KO:K21066]
110284478  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
110306686  Rock2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.1]
110294798  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
110292730  Epb41l4b; band 4.1-like protein 4B isoform X2 [KO:K21111]
110303223  Stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
110310318  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
110292593  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
110290879  Prkab2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
110295068  Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
110310242  Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
110293866  Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
110297812  Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
110297781  Myh14; myosin-14 isoform X1 [KO:K10352]
110304509  Myh10; myosin-10 [KO:K10352]
110310114  Myh9; myosin-9 [KO:K10352]
110311849  Myh11; myosin-11 isoform X2 [KO:K10352]
110293161  myosin light polypeptide 6-like [KO:K12751]
110302967  Myl6; myosin light polypeptide 6 isoform X1 [KO:K12751]
110303150  Myl6b; myosin light chain 6B [KO:K12751]
110285279  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
110312338  myosin regulatory light chain RLC-A isoform X1 [KO:K12757]
110312339  Myl12b; myosin regulatory light chain 12B [KO:K12757]
110311879  Igsf5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
110295719  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
110285046  Synpo; synaptopodin isoform X3 [KO:K21112]
110298906  Actn4; alpha-actinin-4 isoform X1 [KO:K05699]
110306555  Actn1; alpha-actinin-1 [KO:K05699]
110294833  Micall2; MICAL-like protein 2 isoform X1 [KO:K21068]
110299787  Rab8a; ras-related protein Rab-8A [KO:K07901]
110302358  Rab8b; ras-related protein Rab-8B [KO:K07902]
110304183  Rapgef6; rap guanine nucleotide exchange factor 6 isoform X4 [KO:K08020]
110290796  Rap1a; ras-related protein Rap-1A [KO:K04353]
110299930  Itgb1; integrin beta-1 isoform X2 [KO:K05719]
110284326  Afdn; afadin isoform X17 [KO:K05702]
110285404  Tjp2; tight junction protein ZO-2 isoform X2 [KO:K06098]
110290848  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
110287207  Rap2c; ras-related protein Rap-2c [KO:K07839]
110307901  Marveld2; MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
110296015  tubulin alpha-3 chain [KO:K07374]
110308300  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
110304519  Tuba4a; tubulin alpha-4A chain isoform X1 [KO:K07374]
110310101  tubulin alpha-1C chain-like [KO:K07374]
110288534  tubulin alpha-1 chain-like [KO:K07374]
110297783  tubulin alpha-1C chain-like [KO:K07374]
110295773  Tuba8; tubulin alpha-8 chain [KO:K07374]
110291381  tubulin alpha-1B chain [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
mcal04520  Adherens junction
mcal04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
LinkDB

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