KEGG   PATHWAY: mjv04070
Entry
mjv04070                    Pathway                                
Name
Phosphatidylinositol signaling system - Manis javanica (Malayan pangolin)
Class
Environmental Information Processing; Signal transduction
Pathway map
mjv04070  Phosphatidylinositol signaling system
mjv04070

Organism
Manis javanica (Malayan pangolin) [GN:mjv]
Gene
108383411  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
108383561  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108384280  MTMR6; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 isoform X1 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
108384332  PIK3C2G; phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923] [EC:2.7.1.154]
108384333  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
108384525  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
108384746  SYNJ1; synaptojanin-1 isoform X1 [KO:K20279] [EC:3.1.3.36]
108385036  MTMR3; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
108385300  DGKI; LOW QUALITY PROTEIN: diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
108385666  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
108385696  INPP5D; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
108386713  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
108387536  DGKD; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
108387578  SYNJ2; synaptojanin-2 isoform X1 [KO:K20279] [EC:3.1.3.36]
108387655  INPP5E; phosphatidylinositol polyphosphate 5-phosphatase type IV isoform X1 [KO:K20278] [EC:3.1.3.36]
108387665  PIP4P2; type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase [KO:K13084] [EC:3.1.3.78]
108387768  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
108388410  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
108388426  INPP5B; type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [KO:K01099] [EC:3.1.3.36]
108389026  CALM1; calmodulin-1 [KO:K02183]
108390106  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
108390365  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108390475  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
108390511  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
108391137  INPP4B; inositol polyphosphate 4-phosphatase type II isoform X1 [KO:K01109] [EC:3.1.3.66]
108391461  CALM2; calmodulin-2 [KO:K02183]
108391662  CDS1; phosphatidate cytidylyltransferase 1 isoform X2 [KO:K00981] [EC:2.7.7.41]
108391700  PPIP5K2; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X2 [KO:K13024] [EC:2.7.4.24]
108393051  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X4 [KO:K00889] [EC:2.7.1.68]
108393271  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
108393278  MTMR7; phosphatidylinositol-3-phosphate phosphatase MTMR7 isoform X1 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
108393342  IP6K1; inositol hexakisphosphate kinase 1 isoform X1 [KO:K07756] [EC:2.7.4.21]
108393532  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2 [KO:K05860] [EC:3.1.4.11]
108393869  DGKE; diacylglycerol kinase epsilon isoform X2 [KO:K00901] [EC:2.7.1.107]
108393904  PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X3 [KO:K00923] [EC:2.7.1.154]
108394158  IPMK; inositol polyphosphate multikinase isoform X4 [KO:K00915] [EC:2.7.1.140 2.7.1.151]
108394257  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X5 [KO:K05858] [EC:3.1.4.11]
108394259  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
108394360  MTMR2; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2 isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
108395733  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
108395919  DGKA; diacylglycerol kinase alpha isoform X1 [KO:K00901] [EC:2.7.1.107]
108395952  ITPR1; inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 [KO:K04958]
108395975  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
108396137  SACM1L; phosphatidylinositol-3-phosphatase SAC1 [KO:K21797] [EC:3.1.3.-]
108396216  ITPKB; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
108396232  MTMR8; LOW QUALITY PROTEIN: phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
108396424  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
108396814  INPP4A; inositol polyphosphate-4-phosphatase type I A isoform X1 [KO:K01109] [EC:3.1.3.66]
108396822  INPP5A; inositol polyphosphate-5-phosphatase A isoform X2 [KO:K01106] [EC:3.1.3.56]
108396919  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
108396948  DGKQ; diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
108397169  MTMR4; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
108397450  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108397822  IMPA1; inositol monophosphatase 1 isoform X1 [KO:K01092] [EC:3.1.3.25]
108398374  CDS2; phosphatidate cytidylyltransferase 2 isoform X1 [KO:K00981] [EC:2.7.7.41]
108398904  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
108399741  PI4K2A; phosphatidylinositol 4-kinase type 2-alpha isoform X1 [KO:K13711] [EC:2.7.1.67]
108400047  PPIP5K1; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X17 [KO:K13024] [EC:2.7.4.24]
108400388  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
108400464  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
108400467  IMPA2; inositol monophosphatase 2 isoform X2 [KO:K01092] [EC:3.1.3.25]
108400775  MTM1; myotubularin isoform X1 [KO:K01108] [EC:3.1.3.64 3.1.3.95]
108401653  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
108402009  INPP1; inositol polyphosphate 1-phosphatase [KO:K01107] [EC:3.1.3.57]
108402517  MTMR1; phosphatidylinositol-3-phosphate phosphatase MTMR1 isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
108402934  IP6K3; inositol hexakisphosphate kinase 3 [KO:K07756] [EC:2.7.4.21]
108402938  ITPR3; inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 isoform X2 [KO:K04960]
108403281  PIP4P1; type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1 [KO:K13084] [EC:3.1.3.78]
108403293  ITPR2; inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 isoform X1 [KO:K04959]
108403623  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
108403685  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X2 [KO:K05857] [EC:3.1.4.11]
108403742  PI4K2B; phosphatidylinositol 4-kinase type 2-beta isoform X1 [KO:K13711] [EC:2.7.1.67]
108404008  IPPK; inositol-pentakisphosphate 2-kinase isoform X1 [KO:K10572] [EC:2.7.1.158]
108405095  INPPL1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X2 [KO:K15909] [EC:3.1.3.86]
108406136  CALM3; calmodulin-3 [KO:K02183]
108406306  PI4KB; phosphatidylinositol 4-kinase beta isoform X2 [KO:K19801] [EC:2.7.1.67]
108406544  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108406654  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
108406695  INPP5F; phosphatidylinositide phosphatase SAC2 isoform X1 [KO:K21798] [EC:3.1.3.-]
108406804  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
108407248  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3 [KO:K01116] [EC:3.1.4.11]
108407518  DGKB; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
108407569  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
108407974  MTMR14; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
108407983  OCRL; inositol polyphosphate 5-phosphatase OCRL isoform X1 [KO:K01099] [EC:3.1.3.36]
108408436  BPNT2; Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase [KO:K15759] [EC:3.1.3.7]
108408664  PIK3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923] [EC:2.7.1.154]
108408978  PI4KA; phosphatidylinositol 4-kinase alpha isoform X2 [KO:K00888] [EC:2.7.1.67]
108409266  IP6K2; inositol hexakisphosphate kinase 2 [KO:K07756] [EC:2.7.4.21]
108409752  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
108409820  ITPK1; inositol-tetrakisphosphate 1-kinase isoform X2 [KO:K00913] [EC:2.7.1.159 2.7.1.134]
108409981  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
118972461  ITPKA; inositol-trisphosphate 3-kinase A isoform X1 [KO:K00911] [EC:2.7.1.127]
140847875  [KO:K02183]
140847877  [KO:K02183]
Compound
C00076  Calcium cation
C00137  myo-Inositol
C00269  CDP-diacylglycerol
C00416  Phosphatidate
C00641  1,2-Diacyl-sn-glycerol
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11174  1-Diphosinositol pentakisphosphate
C11526  5-PP-InsP5
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
PMID:19580826
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
DOI:10.1016/j.plipres.2009.06.001
Reference
PMID:19439500
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
DOI:10.1124/mol.109.055897
Related
pathway
mjv04020  Calcium signaling pathway
mjv04144  Endocytosis
mjv04151  PI3K-Akt signaling pathway
mjv04510  Focal adhesion
KO pathway
ko04070   

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