KEGG   PATHWAY: mjv04151
Entry
mjv04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Manis javanica (Malayan pangolin)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
mjv04151  PI3K-Akt signaling pathway
mjv04151

Other DBs
GO: 0043491
Organism
Manis javanica (Malayan pangolin) [GN:mjv]
Gene
108383249  LAMB2; laminin subunit beta-2 [KO:K06243]
108383338  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
108383561  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108383567  IL2; interleukin-2 [KO:K05429]
108383641  F2R; proteinase-activated receptor 1 isoform X2 [KO:K03914]
108383725  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X3 [KO:K03259]
108383914  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
108383974  FGF18; fibroblast growth factor 18 isoform X2 [KO:K04358]
108384043  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
108384371  VEGFD; vascular endothelial growth factor D [KO:K05449]
108384403  CHAD; chondroadherin [KO:K06248]
108384766  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
108384784  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
108384981  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
108385045  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
108385046  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X3 [KO:K04369] [EC:2.7.12.2]
108385122  ITGA3; integrin alpha-3 [KO:K06482]
108385124  COL1A1; collagen alpha-1(I) chain [KO:K06236]
108385153  CSF3; granulocyte colony-stimulating factor [KO:K05423]
108385222  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
108385232  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
108385338  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
108385396  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
108385397  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
108385498  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
108385648  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
108385741  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
108385913  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
108386004  TSC1; hamartin isoform X1 [KO:K07206]
108386081  NGF; beta-nerve growth factor [KO:K02582]
108386122  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X1 [KO:K04547]
108386296  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
108386548  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
108386580  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
108386659  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
108386709  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
108387268  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
108387546  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
108387620  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
108387631  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
108387768  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
108388002  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
108388205  PKN2; serine/threonine-protein kinase N2 isoform X2 [KO:K23691]
108388206  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
108388354  RBL2; retinoblastoma-like protein 2 [KO:K16332]
108388478  [KO:K03259]
108388480  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108388498  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
108389002  IL3RA; interleukin-3 receptor subunit alpha isoform X4 [KO:K04737]
108389097  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
108389506  FGF4; fibroblast growth factor 4 [KO:K04358]
108389785  MTCP1; protein p13 MTCP-1 [KO:K16837]
108390012  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
108390065  IL4; interleukin-4 [KO:K05430]
108390100  FOXO3; forkhead box protein O3 isoform X1 [KO:K09408]
108390154  PDGFD; platelet-derived growth factor D isoform X3 [KO:K05450]
108390365  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108390378  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
108390475  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
108390484  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108390634  TLR2; toll-like receptor 2 [KO:K10159]
108390684  ITGB6; integrin beta-6 [KO:K06589]
108390746  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
108390866  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
108390936  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
108391050  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X2 [KO:K04549]
108391063  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
108391324  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
108391341  FGF23; fibroblast growth factor 23 [KO:K22428]
108391456  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
108391499  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
108391501  VEGFC; vascular endothelial growth factor C isoform X2 [KO:K05449]
108391616  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
108391617  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
108391646  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
108391706  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
108391759  DDIT4; DNA damage-inducible transcript 4 protein isoform X2 [KO:K08270]
108391841  NOS3; nitric oxide synthase 3 isoform X2 [KO:K13242] [EC:1.14.13.39]
108391894  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
108391899  KIT; mast/stem cell growth factor receptor Kit isoform X5 [KO:K05091] [EC:2.7.10.1]
108391996  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
108392348  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
108392444  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
108392454  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
108392468  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
108392535  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
108392617  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
108392662  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
108392761  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X8 [KO:K05629]
108393043  FGF9; fibroblast growth factor 9 [KO:K04358]
108393091  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
108393161  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
108393230  ITGA9; integrin alpha-9 [KO:K06585]
108393262  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
108393279  FGF20; fibroblast growth factor 20 [KO:K04358]
108393303  YWHAG; 14-3-3 protein gamma [KO:K16198]
108393368  PDGFC; platelet-derived growth factor C isoform X5 [KO:K05450]
108393544  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3 [KO:K04354]
108393633  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
108393746  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
108393793  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
108393890  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
108393946  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
108393980  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
108393998  TNXB; tenascin-X isoform X1 [KO:K06252]
108394031  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
108394274  TNR; tenascin-R isoform X3 [KO:K06252]
108394280  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
108394341  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108394467  YWHAH; 14-3-3 protein eta isoform X1 [KO:K16198]
108394490  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
108394547  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
108394606  G6PC1; glucose-6-phosphatase catalytic subunit 1 isoform X1 [KO:K01084] [EC:3.1.3.9]
108394626  FGF3; fibroblast growth factor 3 [KO:K04358]
108394828  BCL2L11; bcl-2-like protein 11 isoform X7 [KO:K16341]
108395051  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
108395105  NTF3; neurotrophin-3 isoform X2 [KO:K04356]
108395182  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
108395217  HSP90B1; endoplasmin [KO:K09487]
108395258  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
108395333  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
108395520  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
108395842  KRAS; GTPase KRas isoform X1 [KO:K07827]
108395918  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
108395928  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
108395975  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
108396147  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
108396160  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
108396268  KITLG; kit ligand isoform X1 [KO:K05461]
108396343  FGF5; fibroblast growth factor 5 [KO:K04358]
108396377  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
108396432  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
108396573  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
108396879  OSM; oncostatin-M isoform X1 [KO:K05418]
108396937  VTN; vitronectin [KO:K06251]
108397005  RELA; transcription factor p65 isoform X1 [KO:K04735]
108397051  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
108397112  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
108397161  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
108397189  IRS1; insulin receptor substrate 1 [KO:K16172]
108397219  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
108397227  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
108397237  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
108397295  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
108397360  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
108397369  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
108397409  [KO:K05414]
108397433  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108397450  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108397568  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
108397792  FGF10; fibroblast growth factor 10 [KO:K04358]
108397962  EGFR; epidermal growth factor receptor isoform X6 [KO:K04361] [EC:2.7.10.1]
108398047  NRAS; GTPase NRas [KO:K07828]
108398121  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
108398133  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
108398173  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
108398257  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
108398275  NR4A1; nuclear receptor subfamily 4immunitygroup A member 1 isoform X4 [KO:K04465]
108398366  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
108398401  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
108398403  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
108398405  COL1A2; collagen alpha-2(I) chain [KO:K06236]
108398432  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
108398454  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108398622  IL6; interleukin-6 [KO:K05405]
108398654  YWHAQ; 14-3-3 protein theta [KO:K16197]
108398892  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
108398928  IL7; interleukin-7 isoform X1 [KO:K05431]
108398989  EPOR; erythropoietin receptor [KO:K05079]
108399089  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
108399156  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
108399163  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
108399212  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
108399226  PGF; placenta growth factor isoform X1 [KO:K16859]
108399322  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
108399430  STK11; serine/threonine-protein kinase STK11 isoform X4 [KO:K07298] [EC:2.7.11.1]
108399547  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
108399649  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
108399658  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
108399795  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
108399811  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X4 [KO:K06276] [EC:2.7.11.1]
108399832  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
108399942  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
108399996  MYC; myc proto-oncogene protein [KO:K04377]
108400302  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
108400332  FGF21; fibroblast growth factor 21 isoform X2 [KO:K22429]
108400338  NTF4; neurotrophin-4 [KO:K12457]
108400389  ITGA10; integrin alpha-10 isoform X3 [KO:K06586]
108400412  RPS6; small ribosomal subunit protein eS6 [KO:K02991]
108400418  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
108400452  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
108400493  GHR; growth hormone receptor isoform X1 [KO:K05080]
108400639  ITGB4; integrin beta-4 [KO:K06525]
108400653  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
108400663  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
108400680  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
108400781  KDR; vascular endothelial growth factor receptor 2 isoform X6 [KO:K05098] [EC:2.7.10.1]
108400786  ITGA1; integrin alpha-1 isoform X2 [KO:K06480]
108400801  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
108400819  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
108400921  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
108400987  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
108401015  TNC; tenascin isoform X2 [KO:K06252]
108401068  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
108401199  ITGA11; integrin alpha-11 [KO:K06587]
108401268  IBSP; integrin-binding sialoprotein [KO:K06253]
108401269  SPP1; osteopontin isoform X2 [KO:K06250]
108401312  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
108401438  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
108401571  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
108401589  BDNF; neurotrophic factor BDNF precursor form isoform X1 [KO:K04355]
108401935  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
108402196  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
108402426  [KO:K06238]
108402439  FGF16; fibroblast growth factor 16 [KO:K04358]
108402531  IFNB1; interferon beta [KO:K05415]
108402612  IGF2; insulin-like growth factor 2 isoform X1 [KO:K13769]
108402614  INS; insulin [KO:K04526]
108402987  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
108403050  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
108403155  [KO:K05438]
108403236  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
108403309  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
108403551  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
108403691  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
108403785  LPAR3; lysophosphatidic acid receptor 3 isoform X2 [KO:K04294]
108403976  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
108404266  TP53; cellular tumor antigen p53 [KO:K04451]
108404453  ARTN; artemin [KO:K25415]
108404459  VWF; von Willebrand factor isoform X1 [KO:K03900]
108404568  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
108404581  LAMB1; laminin subunit beta-1 [KO:K05636]
108404652  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
108404891  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
108405132  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X3 [KO:K09047]
108405149  IL4R; interleukin-4 receptor subunit alpha isoform X4 [KO:K05071]
108405281  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
108405384  ITGB7; integrin beta-7 isoform X2 [KO:K06590]
108405577  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
108405702  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X2 [KO:K03456]
108405848  PRLR; prolactin receptor isoform X2 [KO:K05081]
108405988  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
108405993  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
108406027  COMP; cartilage oligomeric matrix protein [KO:K04659]
108406080  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
108406100  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
108406129  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
108406417  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X3 [KO:K11583]
108406673  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
108406777  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
108406785  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
108406808  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X2 [KO:K09048]
108406858  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
108406985  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
108407058  FN1; fibronectin isoform X1 [KO:K05717]
108407135  VEGFA; vascular endothelial growth factor A, long form [KO:K05448]
108407139  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
108407285  EFNA3; ephrin-A3 isoform X2 [KO:K05462]
108407292  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
108407453  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
108407456  RELN; reelin isoform X2 [KO:K06249] [EC:3.4.21.-]
108407563  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
108407564  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
108407571  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
108407595  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
108407758  SGK3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
108408073  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
108408192  LAMC3; laminin subunit gamma-3 [KO:K06247]
108408207  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
108408210  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
108408223  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X3 [KO:K07198] [EC:2.7.11.31]
108408507  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
108408568  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
108408598  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
108408627  HRAS; GTPase HRas isoform X1 [KO:K02833]
108408755  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
108408944  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
108409106  AREG; amphiregulin [KO:K09782]
108409141  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
108409197  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
108409214  NRTN; neurturin [KO:K25414]
108409505  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
108409537  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
108409560  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
108409564  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
108409586  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
108409661  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
108409759  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
108410004  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
108410024  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
108410039  LAMC1; laminin subunit gamma-1 [KO:K05635]
108410040  LAMC2; laminin subunit gamma-2 [KO:K06246]
108410138  ANGPT2; angiopoietin-2 isoform X3 [KO:K05466]
108410150  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
108410254  TSC2; tuberin isoform X9 [KO:K07207]
108410331  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2 [KO:K11583]
108410340  IGF1; insulin-like growth factor 1 isoform X2 [KO:K05459]
118967667  [KO:K02833]
118967966  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
118970652  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
118970663  FGF6; fibroblast growth factor 6 [KO:K04358]
118971119  FGF19; fibroblast growth factor 19 [KO:K22603]
118973114  FGF7; fibroblast growth factor 7 [KO:K04358]
140842982  [KO:K02833]
140843067  [KO:K02833]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
mjv00010  Glycolysis / Gluconeogenesis
mjv04010  MAPK signaling pathway
mjv04012  ErbB signaling pathway
mjv04062  Chemokine signaling pathway
mjv04064  NF-kappa B signaling pathway
mjv04068  FoxO signaling pathway
mjv04110  Cell cycle
mjv04115  p53 signaling pathway
mjv04150  mTOR signaling pathway
mjv04210  Apoptosis
mjv04370  VEGF signaling pathway
mjv04510  Focal adhesion
mjv04620  Toll-like receptor signaling pathway
mjv04630  JAK-STAT signaling pathway
mjv04662  B cell receptor signaling pathway
mjv04910  Insulin signaling pathway
KO pathway
ko04151   

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