Entry
Name
B cell receptor signaling pathway - Molossus molossus (Pallas's mastiff bat)
Description
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
mmf04662 B cell receptor signaling pathway
Ortholog table
Other DBs
Organism
Molossus molossus (Pallas's mastiff bat) [GN:
mmf ]
Gene
118639019 CD79A; B-cell antigen receptor complex-associated protein alpha chain isoform X1 [KO:K06506 ]
118634264 CD79B; B-cell antigen receptor complex-associated protein beta chain [KO:K06507 ]
118636120 DAPP1; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide [KO:K12229 ]
118637802 VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730 ]
118634237 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
118634685 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
118643595 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
118632179 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
118618649 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
118618225 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
118639385 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
118616108 CARD11; caspase recruitment domain-containing protein 11 [KO:K07367 ]
118618613 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369 ] [EC:3.4.22.-]
118624789 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
118626685 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
118642883 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
118616460 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
118632927 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
118626944 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
118617106 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
118637095 FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560 ]
118618083 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
118618085 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
118618086 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
118618087 leukocyte immunoglobulin-like receptor subfamily A member 2 [KO:K06512 ]
118618089 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
118638726 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
118638728 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
118638812 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
118638813 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
118638815 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
118638818 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
118638819 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 4 [KO:K06512 ]
118638822 leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
118632013 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
118632014 leukocyte immunoglobulin-like receptor subfamily A member 3 [KO:K06512 ]
118632015 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
118638941 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
118639291 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
118639292 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
118639294 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
118639324 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
118639325 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
118639326 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
118639327 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
118639328 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
118639329 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
118639334 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
118639336 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
118639337 leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X1 [KO:K06512 ]
118639345 leukocyte immunoglobulin-like receptor subfamily A member 3 [KO:K06512 ]
118632219 PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Niiro H, Clark EA.
Title
Regulation of B-cell fate by antigen-receptor signals.
Journal
Reference
Authors
Kurosaki T.
Title
Genetic analysis of B cell antigen receptor signaling.
Journal
Reference
Authors
Nitschke L.
Title
The role of CD22 and other inhibitory co-receptors in B-cell activation.
Journal
Reference
Authors
Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
Title
Complement: central to innate immunity and bridging to adaptive responses.
Journal
Reference
Authors
Kurosaki T.
Title
Regulation of B-cell signal transduction by adaptor proteins.
Journal
Reference
Authors
Nitschke L, Tsubata T.
Title
Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
Journal
Reference
Authors
Jumaa H, Hendriks RW, Reth M.
Title
B cell signaling and tumorigenesis.
Journal
Reference
Authors
Rickert RC.
Title
Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
Journal
Reference
Authors
Zouali M, Sarmay G
Title
B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
Journal
Reference
Authors
Chiles TC.
Title
Regulation and function of cyclin D2 in B lymphocyte subsets.
Journal
Reference
Authors
Allam A, Marshall AJ
Title
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Journal
Reference
Authors
Gold MR
Title
To make antibodies or not: signaling by the B-cell antigen receptor.
Journal
Reference
Authors
Fu C, Turck CW, Kurosaki T, Chan AC
Title
BLNK: a central linker protein in B cell activation.
Journal
Reference
Authors
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
Title
BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Journal
Reference
Authors
Shinohara H, Maeda S, Watarai H, Kurosaki T
Title
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
Journal
Related pathway
mmf04610 Complement and coagulation cascades
mmf04810 Regulation of actin cytoskeleton
KO pathway
LinkDB
All DBs