KEGG   PATHWAY: mmf04010
Entry
mmf04010                    Pathway                                
Name
MAPK signaling pathway - Molossus molossus (Pallas's mastiff bat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mmf04010  MAPK signaling pathway
mmf04010

Other DBs
GO: 0000165
Organism
Molossus molossus (Pallas's mastiff bat) [GN:mmf]
Gene
118615122  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118615134  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
118615155  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
118615237  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
118615300  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
118615316  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
118615385  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
118615386  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
118615449  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
118615452  PSPN; persephin [KO:K25416]
118615490  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
118615560  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118615605  CD14; monocyte differentiation antigen CD14 [KO:K04391]
118615652  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
118615777  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
118615793  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118615867  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
118615941  FGF18; fibroblast growth factor 18 [KO:K04358]
118616022  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
118616042  FGF2; fibroblast growth factor 2 [KO:K18497]
118616081  FGF1; fibroblast growth factor 1 [KO:K18496]
118616113  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
118616115  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
118616286  NRTN; neurturin [KO:K25414]
118616426  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
118616461  JUND; transcription factor jun-D [KO:K04449]
118616505  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
118616519  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
118616546  FGF22; fibroblast growth factor 22 [KO:K04358]
118616724  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
118617067  [KO:K04723]
118617285  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
118617309  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
118617882  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
118618281  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
118618599  FOS; proto-oncogene c-Fos [KO:K04379]
118618649  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
118618755  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
118618819  ANGPT4; angiopoietin-4 [KO:K05467]
118619242  EREG; proepiregulin [KO:K09784]
118619570  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118619617  [KO:K04456] [EC:2.7.11.1]
118619859  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
118619881  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
118620077  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118620125  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
118620202  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
118620253  AREG; amphiregulin [KO:K09782]
118620717  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
118620813  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
118620900  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
118621004  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118621005  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
118621036  HSPA1B; heat shock 70 kDa protein 1B [KO:K03283]
118621078  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
118621083  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
118621085  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
118621222  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
118621339  [KO:K03283]
118621340  HSPA1A; heat shock 70 kDa protein 1A [KO:K03283]
118621587  SRF; serum response factor [KO:K04378]
118621647  TNF; tumor necrosis factor [KO:K03156]
118621904  DAXX; death domain-associated protein 6 [KO:K02308]
118622259  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
118622317  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118622697  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
118622705  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
118622757  FGF20; fibroblast growth factor 20 [KO:K04358]
118622788  VEGFC; vascular endothelial growth factor C [KO:K05449]
118622845  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118623190  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118623396  CACNA2D4; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
118623440  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
118623445  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
118623513  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
118623538  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
118623804  FGF23; fibroblast growth factor 23 [KO:K22428]
118623887  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
118623904  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
118623918  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
118623942  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
118623957  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
118624003  KITLG; kit ligand [KO:K05461]
118624040  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
118624097  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
118624129  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
118624132  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
118624180  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
118624255  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
118624257  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
118624294  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
118624301  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
118624310  FGF9; fibroblast growth factor 9 [KO:K04358]
118624365  NTF3; neurotrophin-3 [KO:K04356]
118624477  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
118624552  FGF6; fibroblast growth factor 6 [KO:K04358]
118624619  KRAS; GTPase KRas isoform X1 [KO:K07827]
118624675  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
118624733  RAP1B; ras-related protein Rap-1b [KO:K07836]
118624789  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118625175  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
118625188  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
118625204  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
118625225  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
118625228  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
118625398  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
118626070  CDC42; cell division control protein 42 homolog [KO:K04393]
118626130  FGF7; fibroblast growth factor 7 [KO:K04358]
118626166  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
118626296  ARTN; artemin [KO:K25415]
118626350  STMN1; stathmin [KO:K04381]
118626673  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
118626713  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
118626884  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
118627104  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
118627118  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
118627217  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
118627223  JUN; transcription factor AP-1 [KO:K04448]
118627541  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
118627562  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
118627946  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
118627949  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
118628000  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
118628014  RRAS2; ras-related protein R-Ras2 [KO:K07830]
118628029  IGF2; insulin-like growth factor II [KO:K13769]
118628031  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
118628048  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
118628151  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
118628259  FGF19; fibroblast growth factor 19 [KO:K22603]
118628260  FGF4; fibroblast growth factor 4 [KO:K04358]
118628283  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
118628367  RELA; transcription factor p65 [KO:K04735]
118628434  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118628462  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
118628517  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
118628632  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
118628761  FGF3; fibroblast growth factor 3 [KO:K04358]
118628856  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
118628933  INS; insulin [KO:K04526]
118629069  PDGFD; platelet-derived growth factor D [KO:K05450]
118629292  MAX; protein max isoform X1 [KO:K04453]
118629403  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
118629453  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
118629607  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
118629754  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
118629846  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
118630299  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118630446  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
118630520  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
118630633  MAP4K4; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
118630701  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
118630740  IL1B; interleukin-1 beta [KO:K04519]
118630745  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
118630768  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
118630811  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118630966  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
118630999  IL1A; interleukin-1 alpha [KO:K04383]
118631025  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
118631516  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
118631560  MYC; myc proto-oncogene protein [KO:K04377]
118631699  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
118632005  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
118632108  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
118632179  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118632260  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
118632312  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118632350  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
118632384  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
118632456  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118632575  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
118632576  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118632910  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
118632928  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
118633017  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
118633152  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
118633198  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
118633307  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
118633334  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
118633343  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118633354  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
118633491  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
118633604  MRAS; ras-related protein M-Ras [KO:K07831]
118633605  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118633768  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
118633806  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
118633856  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
118633861  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
118633872  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118633888  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
118633933  CRK; adapter molecule crk [KO:K04438]
118633936  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
118634043  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
118634096  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
118634140  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
118634183  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
118634211  NF1; neurofibromin isoform X1 [KO:K08052]
118634237  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
118634439  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
118634493  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
118634494  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
118634552  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
118634578  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
118634585  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
118634685  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118634773  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
118634813  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
118634916  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
118634976  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
118635035  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
118635608  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
118635619  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118635666  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
118635671  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
118635717  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
118635912  [KO:K05096] [EC:2.7.10.1]
118636328  VEGFD; vascular endothelial growth factor D [KO:K05449]
118636423  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
118636442  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
118636475  FGF16; fibroblast growth factor 16 [KO:K04358]
118636593  FLNA; filamin-A isoform X1 [KO:K04437]
118636653  ELK1; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1 [KO:K04375]
118637043  RAP1A; ras-related protein Rap-1A [KO:K04353]
118637108  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
118637109  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
118637117  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
118637179  PGF; placenta growth factor [KO:K16859]
118637205  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
118637506  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
118637533  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
118637549  EFNA1; ephrin-A1 [KO:K05462]
118637611  [KO:K05461]
118637658  EFNA4; ephrin-A4 [KO:K05462]
118637713  NGF; beta-nerve growth factor [KO:K02582]
118637733  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
118637768  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118637822  NRAS; GTPase NRas [KO:K07828]
118638018  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
118638191  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
118638192  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
118638195  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
118638196  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
118638405  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118638486  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
118638912  [KO:K04393]
118639002  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
118639068  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
118639212  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
118639287  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
118639314  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
118639385  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
118639436  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
118639443  PPP5C; serine/threonine-protein phosphatase 5 isoform X1 [KO:K04460] [EC:3.1.3.16]
118639454  NTF4; neurotrophin-4 [KO:K12457]
118639558  RELB; transcription factor RelB [KO:K09253]
118639620  FGF21; fibroblast growth factor 21 [KO:K22429]
118639624  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
118639914  CRKL; crk-like protein [KO:K04438]
118639959  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X5 [KO:K04445] [EC:2.7.11.1]
118639973  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
118640017  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
118640121  FGF5; fibroblast growth factor 5 [KO:K04358]
118640210  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118640254  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
118640533  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
118640543  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
118640620  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118640657  PTPN7; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
118640680  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
118640736  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
118640813  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
118640888  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
118641149  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
118641186  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
118641187  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
118641262  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
118641275  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
118641294  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
118641370  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118641386  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
118641408  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
118642157  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118642159  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
118642231  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
118642277  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
118642307  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
118642367  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
118642448  FGF10; fibroblast growth factor 10 [KO:K04358]
118642468  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
118642477  HSPB1; heat shock protein beta-1 [KO:K04455]
118642548  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
118642864  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
118642904  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
118643162  HRAS; GTPase HRas isoform X1 [KO:K02833]
118643185  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
118643440  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
118643595  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118643683  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
118643768  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
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Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mmf04070  Phosphatidylinositol signaling system
mmf04110  Cell cycle
mmf04115  p53 signaling pathway
mmf04210  Apoptosis
mmf04310  Wnt signaling pathway
mmf04668  TNF signaling pathway
KO pathway
ko04010   

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