KEGG   PATHWAY: mmu04070
Entry
mmu04070                    Pathway                                
Name
Phosphatidylinositol signaling system - Mus musculus (house mouse)
Class
Environmental Information Processing; Signal transduction
Pathway map
mmu04070  Phosphatidylinositol signaling system
mmu04070

Organism
Mus musculus (house mouse) [GN:mmu]
Gene
101490  Inpp5f; inositol polyphosphate-5-phosphatase F [KO:K21798] [EC:3.1.3.-]
104015  Synj1; synaptojanin 1 [KO:K20279] [EC:3.1.3.36]
104418  Dgkz; diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
107650  Pi4kb; phosphatidylinositol 4-kinase beta [KO:K19801] [EC:2.7.1.67]
108083  Pip4k2b; phosphatidylinositol-5-phosphate 4-kinase, type II, beta [KO:K00920] [EC:2.7.1.149]
110197  Dgkg; diacylglycerol kinase, gamma [KO:K00901] [EC:2.7.1.107]
110524  Dgkq; diacylglycerol kinase, theta [KO:K00901] [EC:2.7.1.107]
110911  Cds2; CDP-diacylglycerol synthase 2 [KO:K00981] [EC:2.7.7.41]
114663  Impa2; inositol monophosphatase 2 [KO:K01092] [EC:3.1.3.25]
114875  Plcz1; phospholipase C, zeta 1 [KO:K05861] [EC:3.1.4.11]
117150  Pip4k2c; phosphatidylinositol-5-phosphate 4-kinase, type II, gamma [KO:K00920] [EC:2.7.1.149]
12313  Calm1; calmodulin 1 [KO:K02183]
12314  Calm2; calmodulin 2 [KO:K02183]
12315  Calm3; calmodulin 3 [KO:K02183]
13139  Dgka; diacylglycerol kinase, alpha [KO:K00901] [EC:2.7.1.107]
16329  Inpp1; inositol polyphosphate-1-phosphatase [KO:K01107] [EC:3.1.3.57]
16330  Inpp5b; inositol polyphosphate-5-phosphatase B [KO:K01099] [EC:3.1.3.36]
16331  Inpp5d; inositol polyphosphate-5-phosphatase D [KO:K03084] [EC:3.1.3.86]
16332  Inppl1; inositol polyphosphate phosphatase-like 1 [KO:K15909] [EC:3.1.3.86]
16438  Itpr1; inositol 1,4,5-trisphosphate receptor 1 [KO:K04958]
16439  Itpr2; inositol 1,4,5-triphosphate receptor 2 [KO:K04959]
16440  Itpr3; inositol 1,4,5-triphosphate receptor 3 [KO:K04960]
170749  Mtmr4; myotubularin related protein 4 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
17772  Mtm1; X-linked myotubular myopathy gene 1 [KO:K01108] [EC:3.1.3.64 3.1.3.95]
18704  Pik3c2a; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha [KO:K00923] [EC:2.7.1.154]
18705  Pik3c2g; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma [KO:K00923] [EC:2.7.1.154]
18706  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
18707  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
18708  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
18709  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
18710  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
18711  Pikfyve; phosphoinositide kinase, FYVE type zinc finger containing [KO:K00921] [EC:2.7.1.150]
18717  Pip5k1c; phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma [KO:K00889] [EC:2.7.1.68]
18718  Pip4k2a; phosphatidylinositol-5-phosphate 4-kinase, type II, alpha [KO:K00920] [EC:2.7.1.149]
18719  Pip5k1b; phosphatidylinositol-4-phosphate 5-kinase, type 1 beta [KO:K00889] [EC:2.7.1.68]
18720  Pip5k1a; phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha [KO:K00889] [EC:2.7.1.68]
18750  Prkca; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
18751  Prkcb; protein kinase C, beta [KO:K19662] [EC:2.7.11.13]
18752  Prkcg; protein kinase C, gamma [KO:K19663] [EC:2.7.11.13]
18795  Plcb1; phospholipase C, beta 1 [KO:K05858] [EC:3.1.4.11]
18796  Plcb2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
18797  Plcb3; phospholipase C, beta 3 [KO:K05858] [EC:3.1.4.11]
18798  Plcb4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
18799  Plcd1; phospholipase C, delta 1 [KO:K05857] [EC:3.1.4.11]
18802  Plcd4; phospholipase C, delta 4 [KO:K05857] [EC:3.1.4.11]
18803  Plcg1; phospholipase C, gamma 1 [KO:K01116] [EC:3.1.4.11]
19211  Pten; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
20975  Synj2; synaptojanin 2 [KO:K20279] [EC:3.1.3.36]
212111  Inpp5a; inositol polyphosphate-5-phosphatase A [KO:K01106] [EC:3.1.3.56]
217480  Dgkb; diacylglycerol kinase, beta [KO:K00901] [EC:2.7.1.107]
217837  Itpk1; inositol 1,3,4-triphosphate 5/6 kinase [KO:K00913] [EC:2.7.1.159 2.7.1.134]
219024  Pip4p1; phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 [KO:K13084] [EC:3.1.3.78]
219135  Mtmr6; myotubularin related protein 6 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
224020  Pi4ka; phosphatidylinositol 4-kinase alpha [KO:K00888] [EC:2.7.1.67]
225326  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
227333  Dgkd; diacylglycerol kinase, delta [KO:K00901] [EC:2.7.1.107]
227399  Ppip5k2; diphosphoinositol pentakisphosphate kinase 2 [KO:K13024] [EC:2.7.4.24]
228550  Itpka; inositol 1,4,5-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
233011  Itpkc; inositol 1,4,5-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
234515  Inpp4b; inositol polyphosphate-4-phosphatase, type II [KO:K01109] [EC:3.1.3.66]
234779  Plcg2; phospholipase C, gamma 2 [KO:K05859] [EC:3.1.4.11]
240752  Pik3c2b; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta [KO:K00923] [EC:2.7.1.154]
242291  Bpnt2; 3'(2'), 5'-bisphosphate nucleotidase 2 [KO:K15759] [EC:3.1.3.7]
269180  Inpp4a; inositol polyphosphate-4-phosphatase, type I [KO:K01109] [EC:3.1.3.66]
271424  Ip6k3; inositol hexaphosphate kinase 3 [KO:K07756] [EC:2.7.4.21]
27399  Ip6k1; inositol hexaphosphate kinase 1 [KO:K07756] [EC:2.7.4.21]
320127  Dgki; diacylglycerol kinase, iota [KO:K00901] [EC:2.7.1.107]
320404  Itpkb; inositol 1,4,5-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
320634  Ocrl; OCRL, inositol polyphosphate-5-phosphatase [KO:K01099] [EC:3.1.3.36]
327655  Ppip5k1; diphosphoinositol pentakisphosphate kinase 1 [KO:K13024] [EC:2.7.4.24]
331374  Dgkk; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
380921  Dgkh; diacylglycerol kinase, eta [KO:K00901] [EC:2.7.1.107]
494124  Calm5; calmodulin 5 [KO:K02183]
52858  Cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
53332  Mtmr1; myotubularin related protein 1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
54384  Mtmr7; myotubularin related protein 7 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
55980  Impa1; inositol (myo)-1(or 4)-monophosphatase 1 [KO:K01092] [EC:3.1.3.25]
56077  Dgke; diacylglycerol kinase, epsilon [KO:K00901] [EC:2.7.1.107]
64436  Inpp5e; inositol polyphosphate-5-phosphatase E [KO:K20278] [EC:3.1.3.36]
67073  Pi4k2b; phosphatidylinositol 4-kinase type 2 beta [KO:K13711] [EC:2.7.1.67]
69718  Ipmk; inositol polyphosphate multikinase [KO:K00915] [EC:2.7.1.140 2.7.1.151]
70405  Calml3; calmodulin-like 3 [KO:K02183]
72469  Plcd3; phospholipase C, delta 3 [KO:K05857] [EC:3.1.4.11]
72519  Pip4p2; phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 [KO:K13084] [EC:3.1.3.78]
74055  Plce1; phospholipase C, epsilon 1 [KO:K05860] [EC:3.1.4.11]
74302  Mtmr3; myotubularin related protein 3 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
74596  Cds1; CDP-diacylglycerol synthase 1 [KO:K00981] [EC:2.7.7.41]
74769  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
75600  Calml4; calmodulin-like 4 [KO:K02183]
75678  Ippk; inositol 1,3,4,5,6-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
76500  Ip6k2; inositol hexaphosphate kinase 2 [KO:K07756] [EC:2.7.4.21]
77116  Mtmr2; myotubularin related protein 2 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
80796  Calm4; calmodulin 4 [KO:K02183]
83493  Sacm1l; SAC1 suppressor of actin mutations 1-like (yeast) [KO:K21797] [EC:3.1.3.-]
84095  Pi4k2a; phosphatidylinositol 4-kinase type 2 alpha [KO:K13711] [EC:2.7.1.67]
97287  Mtmr14; myotubularin related protein 14 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
Compound
C00076  Calcium cation
C00137  myo-Inositol
C00269  CDP-diacylglycerol
C00416  Phosphatidate
C00641  1,2-Diacyl-sn-glycerol
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11174  1-Diphosinositol pentakisphosphate
C11526  5-PP-InsP5
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
PMID:19580826
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
DOI:10.1016/j.plipres.2009.06.001
Reference
PMID:19439500
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
DOI:10.1124/mol.109.055897
Related
pathway
mmu04020  Calcium signaling pathway
mmu04144  Endocytosis
mmu04151  PI3K-Akt signaling pathway
mmu04510  Focal adhesion
KO pathway
ko04070   

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