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Entry
Name
Endocytosis - Mus musculus (house mouse)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Mus musculus (house mouse) [GN:
mmu ]
Gene
18717 Pip5k1c; phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma [KO:K00889 ] [EC:2.7.1.68 ]
18719 Pip5k1b; phosphatidylinositol-4-phosphate 5-kinase, type 1 beta [KO:K00889 ] [EC:2.7.1.68 ]
18720 Pip5k1a; phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha [KO:K00889 ] [EC:2.7.1.68 ]
11772 Ap2a2; adaptor-related protein complex 2, alpha 2 subunit [KO:K11824 ]
11771 Ap2a1; adaptor-related protein complex 2, alpha 1 subunit [KO:K11824 ]
71770 Ap2b1; adaptor-related protein complex 2, beta 1 subunit [KO:K11825 ]
11773 Ap2m1; adaptor-related protein complex 2, mu 1 subunit [KO:K11826 ]
232910 Ap2s1; adaptor-related protein complex 2, sigma 1 subunit [KO:K11827 ]
218441 Zfyve16; zinc finger, FYVE domain containing 16 [KO:K04679 ]
230597 Zfyve9; zinc finger, FYVE domain containing 9 [KO:K04679 ]
18854 Pml; promyelocytic leukemia [KO:K10054 ] [EC:2.3.2.-]
18595 Pdgfra; platelet derived growth factor receptor, alpha polypeptide [KO:K04363 ] [EC:2.7.10.1 ]
58194 Sh3kbp1; SH3-domain kinase binding protein 1 [KO:K12470 ]
54673 Sh3glb1; SH3-domain GRB2-like B1 (endophilin) [KO:K11248 ]
227700 Sh3glb2; SH3-domain GRB2-like endophilin B2 [KO:K21269 ]
13858 Eps15; epidermal growth factor receptor pathway substrate 15 [KO:K12472 ]
13859 Eps15l1; epidermal growth factor receptor pathway substrate 15-like 1 [KO:K12472 ]
17999 Nedd4; neural precursor cell expressed, developmentally down-regulated 4 [KO:K10591 ] [EC:2.3.2.26 ]
83814 Nedd4l; neural precursor cell expressed, developmentally down-regulated gene 4-like [KO:K13305 ] [EC:2.3.2.26 ]
16835 Ldlr; low density lipoprotein receptor [KO:K12473 ]
100017 Ldlrap1; low density lipoprotein receptor adaptor protein 1 [KO:K12474 ]
13132 Dab2; disabled 2, mitogen-responsive phosphoprotein [KO:K12475 ]
12765 Cxcr2; C-X-C motif chemokine receptor 2 [KO:K05050 ]
12767 Cxcr4; C-X-C motif chemokine receptor 4 [KO:K04189 ]
73178 Wasl; WASP like actin nucleation promoting factor [KO:K23612 ]
11867 Arpc1b; actin related protein 2/3 complex, subunit 1B [KO:K05757 ]
56443 Arpc1a; actin related protein 2/3 complex, subunit 1A [KO:K05757 ]
76709 Arpc2; actin related protein 2/3 complex, subunit 2 [KO:K05758 ]
56378 Arpc3; actin related protein 2/3 complex, subunit 3 [KO:K05756 ]
68089 Arpc4; actin related protein 2/3 complex, subunit 4 [KO:K05755 ]
67771 Arpc5; actin related protein 2/3 complex, subunit 5 [KO:K05754 ]
74192 Arpc5l; actin related protein 2/3 complex, subunit 5-like [KO:K05754 ]
215280 Wipf1; WAS/WASL interacting protein family, member 1 [KO:K19475 ]
68524 Wipf2; WAS/WASL interacting protein family, member 2 [KO:K19475 ]
330319 Wipf3; WAS/WASL interacting protein family, member 3 [KO:K19475 ]
72685 Dnajc6; DnaJ heat shock protein family (Hsp40) member C6 [KO:K09526 ]
12340 Capza1; capping actin protein of muscle Z-line subunit alpha 1 [KO:K10364 ]
12343 Capza2; capping actin protein of muscle Z-line subunit alpha 2 [KO:K10364 ]
12344 Capza3; capping actin protein of muscle Z-line subunit alpha 3 [KO:K10364 ]
12345 Capzb; capping actin protein of muscle Z-line subunit beta [KO:K10365 ]
56433 Vps29; VPS29 retromer complex component [KO:K18467 ]
30930 Vps26a; VPS26 retromer complex component A [KO:K18466 ]
69091 Vps26b; VPS26 retromer complex component B [KO:K18466 ]
65114 Vps35; VPS35 retromer complex component [KO:K18468 ]
19349 Rab7; RAB7, member RAS oncogene family [KO:K07897 ]
15239 Hgs; HGF-regulated tyrosine kinase substrate [KO:K12182 ]
20844 Stam; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [KO:K04705 ]
56324 Stam2; signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 [KO:K04705 ]
22088 Tsg101; tumor susceptibility gene 101 [KO:K12183 ]
73711 Mvb12a; multivesicular body subunit 12A [KO:K12186 ]
72543 Mvb12b; multivesicular body subunit 12B [KO:K12186 ]
27681 Snf8; SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) [KO:K12188 ]
208092 Chmp6; charged multivesicular body protein 6 [KO:K12195 ]
75608 Chmp4b; charged multivesicular body protein 4B [KO:K12194 ]
66371 Chmp4c; charged multivesicular body protein 4C [KO:K24782 ]
66700 Chmp3; charged multivesicular body protein 3 [KO:K12193 ]
68953 Chmp2a; charged multivesicular body protein 2A [KO:K12191 ]
68942 Chmp2b; charged multivesicular body protein 2B [KO:K12192 ]
105513 Chmp7; charged multivesicular body protein 7 [KO:K15053 ]
66201 Vta1; vesicle (multivesicular body) trafficking 1 [KO:K12199 ]
67028 Chmp1b2; charged multivesicular body protein 1B2 [KO:K12197 ]
67064 Chmp1b; charged multivesicular body protein 1B [KO:K12197 ]
234852 Chmp1a; charged multivesicular body protein 1A [KO:K12197 ]
76959 Chmp5; charged multivesicular body protein 5 [KO:K12198 ]
71955 Ist1; increased sodium tolerance 1 homolog (yeast) [KO:K19476 ]
18571 Pdcd6ip; programmed cell death 6 interacting protein [KO:K12200 ]
16004 Igf2r; insulin-like growth factor 2 receptor [KO:K06564 ]
15461 Hras; Harvey rat sarcoma virus oncogene [KO:K02833 ]
16184 Il2ra; interleukin 2 receptor, alpha chain [KO:K05068 ]
16185 Il2rb; interleukin 2 receptor, beta chain [KO:K05069 ]
16186 Il2rg; interleukin 2 receptor, gamma chain [KO:K05070 ]
67653 4930544G11Rik; RIKEN cDNA 4930544G11 gene [KO:K04513 ]
14990 H2-M2; histocompatibility 2, M region locus 2 [KO:K06751 ]
14991 H2-M3; histocompatibility 2, M region locus 3 [KO:K06751 ]
14997 H2-M9; histocompatibility 2, M region locus 9 [KO:K06751 ]
15006 H2-Q1; histocompatibility 2, Q region locus 1 [KO:K06751 ]
15007 H2-Q10; histocompatibility 2, Q region locus 10 [KO:K06751 ]
15013 H2-Q2; histocompatibility 2, Q region locus 2 [KO:K06751 ]
15018 H2-Q7; histocompatibility 2, Q region locus 7 [KO:K06751 ]
15039 H2-T22; histocompatibility 2, T region locus 22 [KO:K06751 ]
15040 H2-T23; histocompatibility 2, T region locus 23 [KO:K06751 ]
15042 H2-T24; histocompatibility 2, T region locus 24 [KO:K06751 ]
15043 H2-T3; histocompatibility 2, T region locus 3 [KO:K06751 ]
224753 H2-M10.4; histocompatibility 2, M region locus 10.4 [KO:K06751 ]
224754 H2-M11; histocompatibility 2, M region locus 11 [KO:K06751 ]
224756 H2-M1; histocompatibility 2, M region locus 1 [KO:K06751 ]
224761 H2-M10.5; histocompatibility 2, M region locus 10.5 [KO:K06751 ]
333715 H2-M10.2; histocompatibility 2, M region locus 10.2 [KO:K06751 ]
399549 H2-M10.6; histocompatibility 2, M region locus 10.6 [KO:K06751 ]
15024 H2-T10; histocompatibility 2, T region locus 10 [KO:K06751 ]
110557 H2-Q6; histocompatibility 2, Q region locus 6 [KO:K06751 ]
110696 H2-M10.3; histocompatibility 2, M region locus 10.3 [KO:K06751 ]
14963 H2-Bl; histocompatibility 2, blastocyst [KO:K06751 ]
14964 H2-D1; histocompatibility 2, D region locus 1 [KO:K06751 ]
14972 H2-K1; histocompatibility 2, K1, K region [KO:K06751 ]
14985 H2-M10.1; histocompatibility 2, M region locus 10.1 [KO:K06751 ]
110558 H2-Q9; histocompatibility 2, Q region locus 9 [KO:K06751 ]
667977 H2-T26; histocompatibility 2, T region locus 26 [KO:K06751 ]
14980 H2-L; histocompatibility 2, D region locus L [KO:K06751 ]
15015 H2-Q4; histocompatibility 2, Q region locus 4 [KO:K06751 ]
240095 H2-M5; histocompatibility 2, M region locus 5 [KO:K06751 ]
630294 H2-T25; histocompatibility-2, T region locus 25 [KO:K06751 ]
19344 Rab5b; RAB5B, member RAS oncogene family [KO:K07888 ]
19345 Rab5c; RAB5C, member RAS oncogene family [KO:K07889 ]
54189 Rabep1; rabaptin, RAB GTPase binding effector protein 1 [KO:K12480 ]
19341 Rab4a; RAB4A, member RAS oncogene family [KO:K07879 ]
70432 Rufy2; RUN and FYVE domain-containing 2 [KO:K12482 ]
19334 Rab22a; RAB22A, member RAS oncogene family [KO:K07891 ]
19325 Rab10; RAB10, member RAS oncogene family [KO:K07903 ]
17274 Rab8a; RAB8A, member RAS oncogene family [KO:K07901 ]
77407 Rab35; RAB35, member RAS oncogene family [KO:K07876 ]
53869 Rab11a; RAB11A, member RAS oncogene family [KO:K07904 ]
19326 Rab11b; RAB11B, member RAS oncogene family [KO:K07905 ]
74998 Rab11fip2; RAB11 family interacting protein 2 (class I) [KO:K12484 ]
75767 Rab11fip1; RAB11 family interacting protein 1 (class I) [KO:K12484 ]
52055 Rab11fip5; RAB11 family interacting protein 5 (class I) [KO:K12484 ]
319740 Zfyve27; zinc finger, FYVE domain containing 27 [KO:K19368 ]
268451 Rab11fip4; RAB11 family interacting protein 4 (class II) [KO:K12485 ]
215445 Rab11fip3; RAB11 family interacting protein 3 (class II) [KO:K12485 ]
93742 Pard3; par-3 family cell polarity regulator [KO:K04237 ]
56513 Pard6a; par-6 family cell polarity regulator alpha [KO:K06093 ]
58220 Pard6b; par-6 family cell polarity regulator beta [KO:K06093 ]
93737 Pard6g; par-6 family cell polarity regulator gamma [KO:K06093 ]
230837 Asap3; ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [KO:K12488 ]
211914 Asap2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 [KO:K12488 ]
13196 Asap1; ArfGAP with SH3 domain, ankyrin repeat and PH domain1 [KO:K12488 ]
140500 Acap3; ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 [KO:K12489 ]
216859 Acap1; ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 [KO:K12489 ]
78618 Acap2; ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [KO:K12489 ]
69710 Arap1; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 [KO:K18439 ]
212285 Arap2; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 [KO:K18440 ]
106952 Arap3; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [KO:K12490 ]
213990 Agap3; ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 [KO:K12491 ]
347722 Agap1; ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 [KO:K12491 ]
216439 Agap2; ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 [KO:K17848 ]
228998 Arfgap1; ADP-ribosylation factor GTPase activating protein 1 [KO:K12492 ]
66251 Arfgap3; ADP-ribosylation factor GTPase activating protein 3 [KO:K12493 ]
77038 Arfgap2; ADP-ribosylation factor GTPase activating protein 2 [KO:K12493 ]
215632 Psd4; pleckstrin and Sec7 domain containing 4 [KO:K12494 ]
234353 Psd3; pleckstrin and Sec7 domain containing 3 [KO:K12494 ]
73728 Psd; pleckstrin and Sec7 domain containing [KO:K12494 ]
74002 Psd2; pleckstrin and Sec7 domain containing 2 [KO:K12494 ]
211673 Arfgef1; ADP ribosylation factor guanine nucleotide exchange factor 1 [KO:K18442 ]
99371 Arfgef2; ADP ribosylation factor guanine nucleotide exchange factor 2 [KO:K18442 ]
107338 Gbf1; golgi-specific brefeldin A-resistance factor 1 [KO:K18443 ]
Compound
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11556 1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
Authors
Acconcia F, Sigismund S, Polo S
Title
Ubiquitin in trafficking: the network at work.
Journal
Reference
Authors
Donaldson JG, Porat-Shliom N, Cohen LA
Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
Journal
Reference
Authors
Sorkin A
Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
Journal
Reference
Authors
Raiborg C, Stenmark H
Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
Journal
Reference
Authors
Scita G, Di Fiore PP
Title
The endocytic matrix.
Journal
Reference
Authors
Le Roy C, Wrana JL
Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
Journal
Reference
Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
Title
The early endosome: a busy sorting station for proteins at the crossroads.
Journal
Reference
Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
Title
Viral entry, lipid rafts and caveosomes.
Journal
Reference
Authors
Grant BD, Donaldson JG
Title
Pathways and mechanisms of endocytic recycling.
Journal
Reference
Authors
Cullen PJ, Korswagen HC
Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
Journal
Related pathway
mmu04060 Cytokine-cytokine receptor interaction
mmu04070 Phosphatidylinositol signaling system
mmu04130 SNARE interactions in vesicular transport
KO pathway
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