KEGG   PATHWAY: myb04150
Entry
myb04150                    Pathway                                
Name
mTOR signaling pathway - Myotis brandtii (Brandt's bat)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
myb04150  mTOR signaling pathway
myb04150

Organism
Myotis brandtii (Brandt's bat) [GN:myb]
Gene
102246096  SLC7A5; solute carrier family 7 member 5 [KO:K13780]
102263968  SLC3A2; solute carrier family 3 member 2 [KO:K06519]
102253111  SLC38A9; solute carrier family 38 member 9 [KO:K14995]
102251036  ATP6V1A; ATPase H+ transporting V1 subunit A [KO:K02145] [EC:7.1.2.2]
102248043  ATP6V1B1; ATPase H+ transporting V1 subunit B1 [KO:K02147]
102246459  ATP6V1B2; ATPase H+ transporting V1 subunit B2 [KO:K02147]
102243269  ATP6V1C2; ATPase H+ transporting V1 subunit C2 [KO:K02148]
102241395  ATP6V1C1; ATPase H+ transporting V1 subunit C1 [KO:K02148]
102257344  ATP6V1D; ATPase H+ transporting V1 subunit D [KO:K02149]
102258315  ATP6V1E2; ATPase H+ transporting V1 subunit E2 [KO:K02150]
102240804  ATP6V1E1; ATPase H+ transporting V1 subunit E1 [KO:K02150]
102247074  ATP6V1F; ATPase H+ transporting V1 subunit F [KO:K02151]
102251184  ATP6V1G1; ATPase H+ transporting V1 subunit G1 [KO:K02152]
102249410  ATP6V1G3; ATPase H+ transporting V1 subunit G3 [KO:K02152]
102248687  ATP6V1G2; ATPase H+ transporting V1 subunit G2 [KO:K02152]
102250352  ATP6V1H; ATPase H+ transporting V1 subunit H [KO:K02144]
102256696  LAMTOR1; late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 [KO:K20397]
102261674  LAMTOR2; late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 [KO:K20398]
102241687  LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
102245972  LAMTOR4; late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 [KO:K20399]
102242320  LAMTOR5; late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 [KO:K16344]
102261787  FLCN; folliculin [KO:K09594]
102241536  FNIP1; folliculin interacting protein 1 [KO:K20400]
102244879  FNIP2; folliculin interacting protein 2 [KO:K20401]
102264019  RRAGB; Ras related GTP binding B [KO:K16185]
102258827  RRAGA; Ras related GTP binding A [KO:K16185]
102248433  RRAGC; Ras related GTP binding C [KO:K16186]
102250944  RRAGD; Ras related GTP binding D [KO:K16186]
102253520  SESN2; sestrin 2 [KO:K20394]
102253505  GATSL3; GATS protein like 3 [KO:K23080]
102257136  GATSL2; GATS protein like 2 [KO:K23081]
102244359  MIOS; meiosis regulator for oocyte development [KO:K20407]
102260107  SEH1L; SEH1 like nucleoporin [KO:K14299]
102255190  WDR24; WD repeat domain 24 [KO:K20408]
102256870  WDR59; WD repeat domain 59 [KO:K20409]
102261589  SEC13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004]
102257411  DEPDC5; DEP domain containing 5 [KO:K20404]
102253083  NPRL2; NPR2-like, GATOR1 complex subunit [KO:K20405]
102243642  NPRL3; NPR3 like, GATOR1 complex subunit [KO:K20406]
102262715  SKP2; S-phase kinase associated protein 2 [KO:K03875]
102244402  RNF152; ring finger protein 152 [KO:K15705] [EC:2.3.2.27]
102240594  RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
102243802  AKT1S1; AKT1 substrate 1 [KO:K16184]
102241670  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102250718  DEPTOR; DEP domain containing MTOR interacting protein [KO:K20402]
102255901  MLST8; MTOR associated protein, LST8 homolog [KO:K08266]
102253800  TELO2; telomere maintenance 2 [KO:K11137]
102258068  TTI1; TELO2 interacting protein 1 [KO:K20403]
102259036  CLIP1; CAP-Gly domain containing linker protein 1 [KO:K10421]
102242221  GRB10; growth factor receptor bound protein 10 [KO:K20064]
102254188  LPIN1; lipin 1 [KO:K15728] [EC:3.1.3.4]
102258431  LPIN2; lipin 2 [KO:K15728] [EC:3.1.3.4]
102247374  LPIN3; lipin 3 [KO:K15728] [EC:3.1.3.4]
102240341  ULK1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
102260328  ULK2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
102250463  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
102242528  EIF4E2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
102239076  EIF4E1B; eukaryotic translation initiation factor 4E family member 1B [KO:K03259]
102256842  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
102245108  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
102253735  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
102263110  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
102248482  RPS6; ribosomal protein S6 [KO:K02991]
102259132  40S ribosomal protein S6 [KO:K02991]
102246797  STRADA; STE20-related kinase adaptor alpha [KO:K08271]
102248563  STRADB; STE20-related kinase adaptor beta [KO:K17532]
102242649  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
102248912  CAB39; calcium binding protein 39 [KO:K08272]
102249113  CAB39L; calcium binding protein 39 like [KO:K08272]
102241697  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
102248668  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
102245381  TSC1; tuberous sclerosis 1 [KO:K07206]
102253389  TSC2; tuberous sclerosis 2 [KO:K07207]
102261918  TBC1D7; TBC1 domain family member 7 [KO:K20396]
102257160  RHEB; Ras homolog enriched in brain [KO:K07208]
102239480  DDIT4; DNA damage inducible transcript 4 [KO:K08270]
102245856  WNT1; Wnt family member 1 [KO:K03209]
102261227  WNT2; Wnt family member 2 [KO:K00182]
102255951  WNT2B; Wnt family member 2B [KO:K00182]
102244362  WNT3A; Wnt family member 3A [KO:K00312]
102240785  WNT3; Wnt family member 3 [KO:K00312]
102240589  WNT4; Wnt family member 4 [KO:K00408]
102241642  WNT5B; Wnt family member 5B [KO:K00444]
102240132  WNT5A; Wnt family member 5A [KO:K00444]
102256374  WNT6; Wnt family member 6 [KO:K00445]
102249626  WNT7A; Wnt family member 7A [KO:K00572]
102257706  WNT7B; Wnt family member 7B [KO:K00572]
102260194  WNT8B; Wnt family member 8B [KO:K00714]
102255244  WNT8A; Wnt family member 8A [KO:K00714]
102244068  WNT9A; Wnt family member 9A [KO:K01064]
102240485  WNT9B; Wnt family member 9B [KO:K01064]
102256067  WNT10A; Wnt family member 10A [KO:K01357]
102245559  WNT10B; Wnt family member 10B [KO:K01357]
102243634  WNT11; Wnt family member 11 [KO:K01384]
102247057  WNT16; Wnt family member 16 [KO:K01558]
102255722  FZD1; frizzled class receptor 1 [KO:K02432]
102254143  FZD7; frizzled class receptor 7 [KO:K02432]
102240100  FZD2; frizzled class receptor 2 [KO:K02235]
102250456  FZD3; frizzled class receptor 3 [KO:K02329]
102238804  FZD4; frizzled class receptor 4 [KO:K02354]
102261392  FZD5; frizzled class receptor 5 [KO:K02375]
102254257  FZD8; frizzled class receptor 8 [KO:K02375]
102241703  FZD6; frizzled class receptor 6 [KO:K02376]
102255327  FZD9; frizzled class receptor 9 [KO:K02842]
102243449  FZD10; frizzled class receptor 10 [KO:K02842]
102258692  LRP5; LDL receptor related protein 5 [KO:K03068]
102238882  LRP6; LDL receptor related protein 6 [KO:K03068]
102247666  DVL3; dishevelled segment polarity protein 3 [KO:K02353]
102263975  DVL2; dishevelled segment polarity protein 2 [KO:K02353]
102242768  DVL1; dishevelled segment polarity protein 1 [KO:K02353]
102248758  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102246703  TNF; tumor necrosis factor [KO:K03156]
102251038  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102261405  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102254396  insulin [KO:K04526]
102252071  IGF1; insulin like growth factor 1 [KO:K05459]
102252005  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102253516  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102241832  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102252301  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102259408  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102263667  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102244940  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102247606  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102260644  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102254003  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102240696  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102245571  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102255250  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102245641  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102245651  RPS6KA2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
102263950  RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
102247755  RPS6KA3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
102248542  RPS6KA6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
102247525  IRS1; insulin receptor substrate 1 [KO:K16172]
102258430  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102253405  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102242302  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102260487  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102252921  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102239669  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102257838  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102262391  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102254864  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102254191  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102251050  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102261467  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102248900  MAPKAP1; mitogen-activated protein kinase associated protein 1 [KO:K20410]
102256407  RICTOR; RPTOR independent companion of MTOR complex 2 [KO:K08267]
102246600  PRR5; proline rich 5 [KO:K20411]
102248843  PRR5L; proline rich 5 like [KO:K20411]
102244315  RHOA; ras homolog family member A [KO:K04513]
102260557  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102243136  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102249897  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102250674  SGK1; serum/glucocorticoid regulated kinase 1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
myb00561  Glycerolipid metabolism
myb04010  MAPK signaling pathway
myb04140  Autophagy - animal
myb04151  PI3K-Akt signaling pathway
myb04152  AMPK signaling pathway
myb04810  Regulation of actin cytoskeleton
myb04910  Insulin signaling pathway
KO pathway
ko04150   
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