KEGG   PATHWAY: myb04151
Entry
myb04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Myotis brandtii (Brandt's bat)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
myb04151  PI3K-Akt signaling pathway
myb04151

Other DBs
GO: 0043491
Organism
Myotis brandtii (Brandt's bat) [GN:myb]
Gene
102264252  EGF; epidermal growth factor [KO:K04357]
102262078  TGFA; transforming growth factor alpha [KO:K08774]
102240761  EREG; epiregulin [KO:K09784]
102240463  AREG; amphiregulin [KO:K09782]
102256157  FGF1; fibroblast growth factor 1 [KO:K18496]
102246008  FGF2; fibroblast growth factor 2 [KO:K18497]
102250520  FGF3; fibroblast growth factor 3 [KO:K04358]
102260092  FGF17; fibroblast growth factor 17 [KO:K04358]
102254187  FGF22; fibroblast growth factor 22 [KO:K04358]
102255119  FGF6; fibroblast growth factor 6 [KO:K04358]
102251158  FGF16; fibroblast growth factor 16 [KO:K04358]
102250238  FGF10; fibroblast growth factor 10 [KO:K04358]
102259056  FGF8; fibroblast growth factor 8 [KO:K04358]
102262222  FGF18; fibroblast growth factor 18 [KO:K04358]
102261041  FGF9; fibroblast growth factor 9 [KO:K04358]
102260244  FGF5; fibroblast growth factor 5 [KO:K04358]
102259580  FGF20; fibroblast growth factor 20 [KO:K04358]
102261751  FGF7; fibroblast growth factor 7 [KO:K04358]
102249614  FGF19; fibroblast growth factor 19 [KO:K22603]
102260667  FGF21; fibroblast growth factor 21 [KO:K22429]
102240867  FGF23; fibroblast growth factor 23 [KO:K22428]
102245962  NGF; nerve growth factor [KO:K02582]
102247090  BDNF; brain derived neurotrophic factor [KO:K04355]
102244296  NTF3; neurotrophin 3 [KO:K04356]
102260565  NTF4; neurotrophin 4 [KO:K12457]
102254396  insulin [KO:K04526]
102252071  IGF1; insulin like growth factor 1 [KO:K05459]
102247355  IGF2; insulin like growth factor 2 [KO:K13769]
102253551  PDGFA; platelet derived growth factor subunit A [KO:K04359]
102239511  PDGFB; platelet derived growth factor subunit B [KO:K17386]
102248385  PDGFC; platelet derived growth factor C [KO:K05450]
102240259  PDGFD; platelet derived growth factor D [KO:K05450]
102263365  CSF1; colony stimulating factor 1 [KO:K05453]
102250743  KITLG; KIT ligand [KO:K05461]
102264081  FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454]
102254357  VEGFA; vascular endothelial growth factor A [KO:K05448]
102257492  VEGFB; vascular endothelial growth factor B [KO:K16858]
102243042  PGF; placental growth factor [KO:K16859]
102252136  VEGFC; vascular endothelial growth factor C [KO:K05449]
102260639  VEGFD; vascular endothelial growth factor D [KO:K05449]
102259449  HGF; hepatocyte growth factor [KO:K05460]
102248939  ANGPT1; angiopoietin 1 [KO:K05465]
102260431  ANGPT4; angiopoietin 4 [KO:K05467]
102238988  EFNA5; ephrin A5 [KO:K05462]
102249824  EFNA1; ephrin A1 [KO:K05462]
102258114  EFNA2; ephrin A2 [KO:K05462]
102253384  EFNA4; ephrin A4 [KO:K05462]
102253687  EFNA3; ephrin A3 [KO:K05462]
102258925  GDNF; glial cell derived neurotrophic factor [KO:K05452]
102255572  NRTN; neurturin [KO:K25414]
102251006  PSPN; persephin [KO:K25416]
102257758  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102243033  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
102248465  ERBB3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
102241613  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
102253832  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
102254053  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
102258015  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102244827  NGFR; nerve growth factor receptor [KO:K02583]
102238774  NTRK2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
102252005  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102253516  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102255326  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102241145  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102256301  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102263655  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
102244263  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
102247542  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
102244559  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
102244912  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
102256532  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
102263347  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
102241735  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
102250877  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
102238841  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
102241832  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102252301  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102259408  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102263667  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102244940  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102247606  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102254003  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102240696  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102245571  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102255250  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102245641  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102247525  IRS1; insulin receptor substrate 1 [KO:K16172]
102256005  TLR2; toll like receptor 2 [KO:K10159]
102253644  TLR4; toll like receptor 4 [KO:K10160]
102259160  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102253571  uncharacterized LOC102253571 [KO:K06856]
106724953  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
106725568  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
106725385  uncharacterized LOC106725385 [KO:K06856]
106726103  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
106726515  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
106726783  uncharacterized LOC106726783 [KO:K06856]
102251188  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
102243247  SYK; spleen associated tyrosine kinase [KO:K05855] [EC:2.7.10.2]
102260921  CD19; CD19 molecule [KO:K06465]
102264118  PIK3AP1; phosphoinositide-3-kinase adaptor protein 1 [KO:K12230]
102242921  somatotropin [KO:K05438]
102261680  PRL; prolactin [KO:K05439]
102259125  OSM; oncostatin M [KO:K05418]
102246940  IL2; interleukin 2 [KO:K05429]
102243367  IL6; interleukin 6 [KO:K05405]
102243627  IL4; interleukin 4 [KO:K05430]
102263096  IL7; interleukin 7 [KO:K05431]
106724769  interferon alpha-8-like [KO:K05414]
102261905  IFNB1; interferon beta 1 [KO:K05415]
102247780  EPO; erythropoietin [KO:K05437]
102248205  CSF3; colony stimulating factor 3 [KO:K05423]
102252226  GHR; growth hormone receptor [KO:K05080]
102245033  PRLR; prolactin receptor [KO:K05081]
102257110  OSMR; oncostatin M receptor [KO:K05057]
102249529  IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
102241115  IL2RB; interleukin 2 receptor subunit beta [KO:K05069]
102241164  IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
102242151  IL6R; interleukin 6 receptor [KO:K05055]
102243995  interleukin-4 receptor subunit alpha [KO:K05071]
102264253  IL7R; interleukin 7 receptor [KO:K05072]
102245971  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
102259457  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
102240499  EPOR; erythropoietin receptor [KO:K05079]
102241961  CSF3R; colony stimulating factor 3 receptor [KO:K05061]
102260801  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
102253056  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
102241153  JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
102259707  COL1A1; collagen type I alpha 1 chain [KO:K06236]
102253918  COL1A2; collagen type I alpha 2 chain [KO:K06236]
102254069  filaggrin-2-like [KO:K06236]
102248763  collagen alpha-1(II) chain [KO:K19719]
102254720  COL2A1; collagen type II alpha 1 chain [KO:K19719]
102256779  COL4A5; collagen type IV alpha 5 chain [KO:K06237]
102242641  COL4A6; collagen type IV alpha 6 chain [KO:K06237]
102249508  COL4A1; collagen type IV alpha 1 chain [KO:K06237]
102248314  COL4A3; collagen type IV alpha 3 chain [KO:K06237]
102249405  COL4A4; collagen type IV alpha 4 chain [KO:K06237]
102243536  COL4A2; collagen type IV alpha 2 chain [KO:K06237]
102255770  COL6A5; collagen type VI alpha 5 chain [KO:K06238]
102257789  COL6A3; collagen type VI alpha 3 chain [KO:K06238]
102254080  COL6A6; collagen type VI alpha 6 chain [KO:K06238]
102256069  collagen alpha-4(VI) chain [KO:K06238]
102245872  COL6A2; collagen type VI alpha 2 chain [KO:K06238]
102251267  COL6A1; collagen type VI alpha 1 chain [KO:K06238]
102243552  COL9A2; collagen type IX alpha 2 chain [KO:K08131]
102251306  COL9A3; collagen type IX alpha 3 chain [KO:K08131]
102258848  COL9A1; collagen type IX alpha 1 chain [KO:K08131]
102261526  LAMA2; laminin subunit alpha 2 [KO:K05637]
102256202  LAMA1; laminin subunit alpha 1 [KO:K05637]
102263709  LAMA5; laminin subunit alpha 5 [KO:K06240]
102255410  LAMA3; laminin subunit alpha 3 [KO:K06240]
102256520  laminin subunit alpha-3 [KO:K06240]
102244301  LAMA4; laminin subunit alpha 4 [KO:K06241]
102250973  LAMB1; laminin subunit beta 1 [KO:K05636]
102258809  LAMB2; laminin subunit beta 2 [KO:K06243]
102258165  LAMB3; laminin subunit beta 3 [KO:K06244]
102251547  LAMB4; laminin subunit beta 4 [KO:K06245]
102240493  LAMC1; laminin subunit gamma 1 [KO:K05635]
102256358  LAMC2; laminin subunit gamma 2 [KO:K06246]
102256058  LAMC3; laminin subunit gamma 3 [KO:K06247]
102241550  CHAD; chondroadherin [KO:K06248]
102252569  RELN; reelin [KO:K06249] [EC:3.4.21.-]
102250983  THBS1; thrombospondin 1 [KO:K16857]
102242389  THBS2; thrombospondin 2 [KO:K04659]
102248184  THBS4; thrombospondin 4 [KO:K04659]
102249845  COMP; cartilage oligomeric matrix protein [KO:K04659]
102250634  THBS3; thrombospondin 3 [KO:K04659]
102244892  FN1; fibronectin 1 [KO:K05717]
102245794  SPP1; secreted phosphoprotein 1 [KO:K06250]
102244665  VTN; vitronectin [KO:K06251]
102253855  TNXB; tenascin XB [KO:K06252]
102261192  TNN; tenascin N [KO:K06252]
102252550  TNC; tenascin C [KO:K06252]
102245416  TNR; tenascin R [KO:K06252]
102248658  VWF; von Willebrand factor [KO:K03900]
102256918  IBSP; integrin binding sialoprotein [KO:K06253]
102244635  ITGA1; integrin subunit alpha 1 [KO:K06480]
102244336  ITGA2; integrin subunit alpha 2 [KO:K06481]
102252761  ITGA2B; integrin subunit alpha 2b [KO:K06476]
102245715  ITGA3; integrin subunit alpha 3 [KO:K06482]
102259547  ITGA4; integrin subunit alpha 4 [KO:K06483]
102255900  ITGA5; integrin subunit alpha 5 [KO:K06484]
102261916  ITGA6; integrin subunit alpha 6 [KO:K06485]
102249761  ITGA7; integrin subunit alpha 7 [KO:K06583]
102253526  ITGA8; integrin subunit alpha 8 [KO:K06584]
102248306  integrin alpha-9 [KO:K06585]
102260193  ITGA10; integrin subunit alpha 10 [KO:K06586]
102242832  ITGA11; integrin subunit alpha 11 [KO:K06587]
102260401  ITGAV; integrin subunit alpha V [KO:K06487]
102260978  ITGB1; integrin subunit beta 1 [KO:K05719]
102242014  ITGB3; integrin subunit beta 3 [KO:K06493]
102260390  ITGB4; integrin subunit beta 4 [KO:K06525]
102262191  ITGB5; integrin subunit beta 5 [KO:K06588]
102249275  ITGB6; integrin subunit beta 6 [KO:K06589]
102258333  integrin beta-7 [KO:K06590]
102258028  integrin beta-7-like [KO:K06590]
102246659  ITGB8; integrin subunit beta 8 [KO:K06591]
102245460  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
102260487  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102252921  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102239669  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102258430  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102253405  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102242302  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102249171  F2R; coagulation factor II thrombin receptor [KO:K03914]
102238610  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
102244198  CHRM2; cholinergic receptor muscarinic 2 [KO:K04130]
102258769  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
102246865  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102242469  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
102246973  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
102250139  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102251488  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
102257321  GNB1; G protein subunit beta 1 [KO:K04536]
102257762  GNB2; G protein subunit beta 2 [KO:K04537]
102262102  GNB3; G protein subunit beta 3 [KO:K07825]
102263696  GNB4; G protein subunit beta 4 [KO:K04538]
102252218  guanine nucleotide-binding protein subunit beta-4-like [KO:K04538]
102242731  GNB5; G protein subunit beta 5 [KO:K04539]
102253997  GNG2; G protein subunit gamma 2 [KO:K07826]
102259768  GNG4; G protein subunit gamma 4 [KO:K04541]
102250530  GNG5; G protein subunit gamma 5 [KO:K04542]
102258952  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102263275  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102238618  GNG7; G protein subunit gamma 7 [KO:K04543]
102250013  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102263426  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102254808  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102242875  GNG12; G protein subunit gamma 12 [KO:K04347]
102240295  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
102257413  GNG13; G protein subunit gamma 13 [KO:K04547]
102252604  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
102241723  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K21289] [EC:2.7.1.153]
102246489  PIK3R5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K21290]
102246179  PIK3R6; phosphoinositide-3-kinase regulatory subunit 6 [KO:K21290]
102262391  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102242649  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
102241697  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
102248668  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
102239480  DDIT4; DNA damage inducible transcript 4 [KO:K08270]
102245381  TSC1; tuberous sclerosis 1 [KO:K07206]
102253389  TSC2; tuberous sclerosis 2 [KO:K07207]
102257160  RHEB; Ras homolog enriched in brain [KO:K07208]
102255901  MLST8; MTOR associated protein, LST8 homolog [KO:K08266]
102241670  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102240594  RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
102250463  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
102242528  EIF4E2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
102239076  EIF4E1B; eukaryotic translation initiation factor 4E family member 1B [KO:K03259]
102256842  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
102245108  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
102253735  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
102263110  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
102248482  RPS6; ribosomal protein S6 [KO:K02991]
102259132  40S ribosomal protein S6 [KO:K02991]
102260557  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102261179  PKN1; protein kinase N1 [KO:K06071] [EC:2.7.11.13]
102247536  PKN2; protein kinase N2 [KO:K23691] [EC:2.7.11.13]
102249689  PKN3; protein kinase N3 [KO:K23692] [EC:2.7.11.13]
102250674  SGK1; serum/glucocorticoid regulated kinase 1 [KO:K13302] [EC:2.7.11.1]
102251712  SGK3; serum/glucocorticoid regulated kinase family member 3 [KO:K13304] [EC:2.7.11.1]
102254864  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102254191  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102251050  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102263994  MAGI1; membrane associated guanylate kinase, WW and PDZ domain containing 1 [KO:K05631]
102255256  MAGI2; membrane associated guanylate kinase, WW and PDZ domain containing 2 [KO:K05629]
102257838  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102245884  acyl-coenzyme A thioesterase THEM4-like [KO:K16339] [EC:3.1.2.2]
102254099  acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
102249483  acyl-coenzyme A thioesterase THEM4-like [KO:K16339] [EC:3.1.2.2]
102246010  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
102255371  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
102262643  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
102254517  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
102243537  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
102240425  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
102238990  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
102254637  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
102248512  PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
106725200  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like [KO:K11583]
102240816  PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583]
102241218  PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584]
102242374  PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584]
102239026  PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584]
102249194  PPP2R5D; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
102244211  PPP2R5B; protein phosphatase 2 regulatory subunit B'beta [KO:K11584]
102263971  HSP90AA1; heat shock protein 90 alpha family class A member 1 [KO:K04079]
102261247  HSP90AB1; heat shock protein 90 alpha family class B member 1 [KO:K04079]
102244916  HSP90B1; heat shock protein 90 beta family member 1 [KO:K09487]
102246274  CDC37; cell division cycle 37 [KO:K09554]
102257000  CRTC2; CREB regulated transcription coactivator 2 [KO:K16333]
102255957  PHLPP2; PH domain and leucine rich repeat protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
102242412  PHLPP1; PH domain and leucine rich repeat protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
102256387  protein p13 MTCP-1 [KO:K10167]
102256692  protein p13 MTCP-1-like [KO:K10167]
102241031  protein p13 MTCP-1-like [KO:K10167]
102241644  T-cell leukemia/lymphoma protein 1A [KO:K10167]
106726048  protein p13 MTCP-1-like [KO:K10167]
106726049  protein p13 MTCP-1-like [KO:K10167]
102241953  T-cell leukemia/lymphoma protein 1A-like [KO:K10167]
102241131  protein p13 MTCP-1 [KO:K10167]
102241434  T-cell leukemia/lymphoma protein 1A [KO:K10167]
106726011  protein p13 MTCP-1-like [KO:K10167]
102241742  T-cell leukemia/lymphoma protein 1A [KO:K10167]
102256721  T-cell leukemia/lymphoma protein 1A [KO:K10167]
102243319  T-cell leukemia/lymphoma protein 1A [KO:K10167]
102259829  protein p13 MTCP-1 [KO:K10167]
102251432  T-cell leukemia/lymphoma protein 1A [KO:K10167]
102251732  protein p13 MTCP-1 [KO:K10167]
102245866  protein TCL1B1-like [KO:K10167]
102246176  protein p13 MTCP-1 [KO:K10167]
102263109  protein p13 MTCP-1 [KO:K10167]
102263719  protein p13 MTCP-1 [KO:K10167]
102255568  T-cell leukemia/lymphoma protein 1A [KO:K10167]
106727262  T-cell leukemia/lymphoma protein 1A-like [KO:K10167]
106726914  TCL1A; T-cell leukemia/lymphoma 1A [KO:K10167]
106728206  protein p13 MTCP-1-like [KO:K10167]
102248529  protein p13 MTCP-1 [KO:K10167]
102241333  protein p13 MTCP-1 [KO:K10167]
102246486  protein p13 MTCP-1-like [KO:K10167]
102256987  MTCP1; mature T-cell proliferation 1 [KO:K16837]
102256555  NOS3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
102250563  BRCA1; BRCA1, DNA repair associated [KO:K10605] [EC:2.3.2.27]
102248758  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102262755  GYS1; glycogen synthase 1 [KO:K00693] [EC:2.4.1.11]
102251419  GYS2; glycogen synthase 2 [KO:K00693] [EC:2.4.1.11]
102262025  PCK1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
102256852  PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
102253613  G6PC; glucose-6-phosphatase catalytic subunit [KO:K01084] [EC:3.1.3.9]
102248370  G6PC2; glucose-6-phosphatase catalytic subunit 2 [KO:K01084] [EC:3.1.3.9]
102247442  G6PC3; glucose-6-phosphatase catalytic subunit 3 [KO:K01084] [EC:3.1.3.9]
102257498  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
102263484  CCND1; cyclin D1 [KO:K04503]
102245891  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
102252017  CDKN1B; cyclin dependent kinase inhibitor 1B [KO:K06624]
102256122  CDK2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
102261527  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102258140  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102254218  CCND2; cyclin D2 [KO:K10151]
102252389  CCND3; cyclin D3 [KO:K10152]
102248984  CCNE2; cyclin E2 [KO:K06626]
102246728  FOXO3; forkhead box O3 [KO:K09408]
102251179  RBL2; RB transcriptional corepressor like 2 [KO:K16332]
102262076  FASLG; Fas ligand [KO:K04389]
102257135  BCL2L11; BCL2 like 11 [KO:K16341]
102246440  YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta [KO:K16197]
102261683  YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [KO:K16197]
102261238  YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [KO:K16197]
102256309  14-3-3 protein zeta/delta-like [KO:K16197]
102253232  YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon [KO:K06630]
102244681  YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma [KO:K16198]
102242657  YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta [KO:K16198]
102239479  BAD; BCL2 associated agonist of cell death [KO:K02158]
102260460  BCL2L1; BCL2 like 1 [KO:K04570]
102248597  BCL2; BCL2, apoptosis regulator [KO:K02161]
102254877  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
102246867  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
102241887  ATF2; activating transcription factor 2 [KO:K04450]
102238786  ATF4; activating transcription factor 4 [KO:K04374]
102258024  CREB3L4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
102241829  CREB3; cAMP responsive element binding protein 3 [KO:K09048]
102244833  CREB3L1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
102245296  CREB3L2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
102251355  CREB3L3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
102240701  CREB5; cAMP responsive element binding protein 5 [KO:K09047]
102261840  ATF6B; activating transcription factor 6 beta [KO:K09049]
102262272  MCL1; BCL2 family apoptosis regulator [KO:K02539]
102262918  RXRA; retinoid X receptor alpha [KO:K08524]
102245718  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102252013  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
102261467  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102261405  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102263790  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102255251  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102256546  MYB; MYB proto-oncogene, transcription factor [KO:K09420]
102256024  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
102244768  TP53; tumor protein p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
myb00010  Glycolysis / Gluconeogenesis
myb04010  MAPK signaling pathway
myb04012  ErbB signaling pathway
myb04062  Chemokine signaling pathway
myb04064  NF-kappa B signaling pathway
myb04068  FoxO signaling pathway
myb04110  Cell cycle
myb04115  p53 signaling pathway
myb04150  mTOR signaling pathway
myb04210  Apoptosis
myb04370  VEGF signaling pathway
myb04510  Focal adhesion
myb04620  Toll-like receptor signaling pathway
myb04630  JAK-STAT signaling pathway
myb04662  B cell receptor signaling pathway
myb04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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