KEGG   PATHWAY: afb00260
Entry
afb00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Anoplopoma fimbria (sablefish)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
afb00260  Glycine, serine and threonine metabolism
afb00260

Module
afb_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:afb00260]
afb_M00047  Creatine pathway [PATH:afb00260]
afb_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:afb00260]
afb_M00555  Betaine biosynthesis, choline => betaine [PATH:afb00260]
afb_M00621  Glycine cleavage system [PATH:afb00260]
afb_M00974  Betaine metabolism, animals, betaine => glycine [PATH:afb00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Anoplopoma fimbria (sablefish) [GN:afb]
Gene
129091517  uncharacterized protein LOC129091517 [KO:K01620] [EC:4.1.2.48]
129091714  uncharacterized protein LOC129091714 [KO:K01620] [EC:4.1.2.48]
129091835  uncharacterized protein LOC129091835 [KO:K01620] [EC:4.1.2.48]
129099570  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
129105421  shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
129098772  shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
129112547  agxtb; alanine--glyoxylate and serine--pyruvate aminotransferase b [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
129094234  agxta; alanine--glyoxylate and serine--pyruvate aminotransferase a [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
129090042  grhpra; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
129096044  grhprb; glyoxylate reductase/hydroxypyruvate reductase b [KO:K00049] [EC:1.1.1.79 1.1.1.81]
129105520  glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
129095693  pgam1b; phosphoglycerate mutase 1b [KO:K01834] [EC:5.4.2.11]
129102643  pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
129092143  LOW QUALITY PROTEIN: phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
129108357  bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
129104764  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
129101423  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
129095495  psph; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
129098356  gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
129111871  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
129107040  tdh; L-threonine dehydrogenase [KO:K15789] [EC:1.1.1.103]
129103513  tdh2; L-threonine dehydrogenase 2 isoform X1 [KO:K15789] [EC:1.1.1.103]
129099551  alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
129100082  5-aminolevulinate synthase, non-specific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]
129105655  alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
129104820  mao; amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
129102531  si:ch211-127i16.2; probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
129098952  aoc2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
129100721  gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
129099254  amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
129108186  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
129102724  gcshb; glycine cleavage system protein H (aminomethyl carrier), b [KO:K02437]
129108404  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
129101197  D-amino-acid oxidase-like [KO:K00273] [EC:1.4.3.3]
129102107  alanine--glyoxylate aminotransferase 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
129102201  alanine--glyoxylate aminotransferase 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
129106525  gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
129094519  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
129099768  chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
129094493  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
129100666  betaine--homocysteine S-methyltransferase 1-like isoform X1 [KO:K00544] [EC:2.1.1.5]
129100667  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
129100923  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
129100924  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
129102188  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
129102455  dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
129095378  pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
129115748  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
129102463  sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
129103685  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
129111678  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
129094530  cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
129092806  L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
129101703  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
129103384  sdsl; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
129089091  zgc:162816; D-threo-3-hydroxyaspartate dehydratase [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
afb00010  Glycolysis / Gluconeogenesis
afb00020  Citrate cycle (TCA cycle)
afb00230  Purine metabolism
afb00250  Alanine, aspartate and glutamate metabolism
afb00270  Cysteine and methionine metabolism
afb00290  Valine, leucine and isoleucine biosynthesis
afb00330  Arginine and proline metabolism
afb00470  D-Amino acid metabolism
afb00564  Glycerophospholipid metabolism
afb00600  Sphingolipid metabolism
afb00620  Pyruvate metabolism
afb00630  Glyoxylate and dicarboxylate metabolism
afb00640  Propanoate metabolism
afb00860  Porphyrin metabolism
afb00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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