KEGG   PATHWAY: amj04150
Entry
amj04150                    Pathway                                
Name
mTOR signaling pathway - Alligator mississippiensis (American alligator)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
amj04150  mTOR signaling pathway
amj04150

Organism
Alligator mississippiensis (American alligator) [GN:amj]
Gene
102559512  SLC7A5; solute carrier family 7 member 5 [KO:K13780]
102558098  SLC3A2; 4F2 cell-surface antigen heavy chain [KO:K06519]
102557718  SLC38A9; solute carrier family 38 member 9 [KO:K14995]
102571000  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
102575551  ATP6V1A; ATPase H+ transporting V1 subunit A [KO:K02145] [EC:7.1.2.2]
102576299  ATP6V1B2; ATPase H+ transporting V1 subunit B2 [KO:K02147]
102567970  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
102572514  ATP6V1C2; ATPase H+ transporting V1 subunit C2 [KO:K02148]
106736871  ATP6V1C1; ATPase H+ transporting V1 subunit C1 [KO:K02148]
102566612  ATP6V1D; ATPase H+ transporting V1 subunit D [KO:K02149]
102574584  ATP6V1E1; ATPase H+ transporting V1 subunit E1 [KO:K02150]
102571919  ATP6V1F; ATPase H+ transporting V1 subunit F [KO:K02151]
102570417  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
102574731  ATP6V1G3; ATPase H+ transporting V1 subunit G3 [KO:K02152]
102563783  ATP6V1G1; ATPase H+ transporting V1 subunit G1 [KO:K02152]
102570066  ATP6V1H; ATPase H+ transporting V1 subunit H [KO:K02144]
102569510  LAMTOR1; late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 [KO:K20397]
102576838  LAMTOR2; late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 [KO:K20398]
102560921  LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
102560158  LAMTOR4; late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 [KO:K20399]
102570945  LAMTOR5; late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 [KO:K16344]
102561109  FLCN; folliculin [KO:K09594]
102558427  FNIP1; folliculin interacting protein 1 [KO:K20400]
102563331  FNIP2; folliculin interacting protein 2 [KO:K20401]
102564319  RRAGB; ras-related GTP-binding protein A [KO:K16185]
102572846  RRAGC; Ras related GTP binding C [KO:K16186]
102575182  RRAGD; Ras related GTP binding D [KO:K16186]
102563159  SESN2; sestrin 2 [KO:K20394]
102565452  GATSL3; GATS protein like 3 [KO:K23080]
102572351  GATSL2; GATS protein like 2 [KO:K23081]
102558302  MIOS; meiosis regulator for oocyte development [KO:K20407]
102567557  SEH1L; SEH1 like nucleoporin [KO:K14299]
102571323  WDR24; WD repeat domain 24 [KO:K20408]
102564649  WDR59; WD repeat domain 59 [KO:K20409]
102560870  SEC13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004]
102561090  DEPDC5; DEP domain containing 5 [KO:K20404]
102575991  NPRL2; NPR2-like, GATOR1 complex subunit [KO:K20405]
102558925  NPRL3; NPR3 like, GATOR1 complex subunit [KO:K20406]
102558881  SKP2; S-phase kinase associated protein 2 [KO:K03875]
102558912  RNF152; ring finger protein 152 [KO:K15705] [EC:2.3.2.27]
102566392  RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
102558199  AKT1S1; AKT1 substrate 1 [KO:K16184]
102574334  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102566837  DEP domain-containing mTOR-interacting protein [KO:K20402]
106736920  DEPTOR; DEP domain containing MTOR interacting protein [KO:K20402]
102559104  MLST8; MTOR associated protein, LST8 homolog [KO:K08266]
102575524  TELO2; telomere maintenance 2 [KO:K11137]
102568292  TTI1; TELO2 interacting protein 1 [KO:K20403]
102573382  CLIP1; CAP-Gly domain containing linker protein 1 [KO:K10421]
102567317  GRB10; growth factor receptor bound protein 10 [KO:K20064]
102564858  LPIN3; lipin 3 [KO:K15728] [EC:3.1.3.4]
102568253  LPIN2; lipin 2 [KO:K15728] [EC:3.1.3.4]
102571769  LPIN1; lipin 1 [KO:K15728] [EC:3.1.3.4]
102565589  ULK1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
102567608  ULK2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
102575532  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
102563175  EIF4E2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
102564304  EIF4E1B; eukaryotic translation initiation factor 4E [KO:K03259]
102557827  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
106736874  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
102571014  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
102570839  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
102562280  RPS6; ribosomal protein S6 [KO:K02991]
102571889  STRADA; STE20-related kinase adaptor alpha [KO:K08271]
102563368  STRADB; STE20-related kinase adaptor beta [KO:K17532]
102565922  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
102576111  CAB39L; calcium binding protein 39 like [KO:K08272]
102566906  CAB39; calcium binding protein 39 [KO:K08272]
102576605  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
102570371  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
102560300  TSC1; tuberous sclerosis 1 [KO:K07206]
102558178  TSC2; tuberous sclerosis 2 [KO:K07207]
102570540  TBC1D7; TBC1 domain family member 7 [KO:K20396]
102567948  RHEB; Ras homolog enriched in brain [KO:K07208]
102568463  DDIT4; DNA damage inducible transcript 4 [KO:K08270]
102559781  WNT1; Wnt family member 1 [KO:K03209]
102569359  WNT2; Wnt family member 2 [KO:K00182]
102575620  WNT2B; Wnt family member 2B [KO:K00182]
106736642  WNT3; Wnt family member 3 [KO:K00312]
102563237  WNT3A; Wnt family member 3A [KO:K00312]
102561676  WNT4; Wnt family member 4 [KO:K00408]
102573669  protein Wnt-4 [KO:K00408]
102568211  WNT5B; Wnt family member 5B [KO:K00444]
102574844  WNT5A; Wnt family member 5A [KO:K00444]
106737397  WNT6; Wnt family member 6 [KO:K00445]
102568312  WNT7B; Wnt family member 7B [KO:K00572]
102575772  WNT7A; Wnt family member 7A [KO:K00572]
102576973  WNT8B; Wnt family member 8B [KO:K00714]
102564241  WNT8A; Wnt family member 8A [KO:K00714]
102567669  WNT9B; Wnt family member 9B [KO:K01064]
102569365  WNT9A; Wnt family member 9A [KO:K01064]
102563189  WNT10A; protein Wnt-10a [KO:K01357]
102558673  WNT11B; protein Wnt-11b [KO:K01384]
102569158  WNT11; Wnt family member 11 [KO:K01384]
102559691  WNT16; Wnt family member 16 [KO:K01558]
102566978  FZD1; frizzled class receptor 1 [KO:K02432]
106737147  FZD7; frizzled class receptor 7 [KO:K02432]
102570331  FZD2; frizzled class receptor 2 [KO:K02235]
102573694  FZD3; frizzled class receptor 3 [KO:K02329]
102558838  FZD4; frizzled class receptor 4 [KO:K02354]
102558031  FZD8; frizzled class receptor 8 [KO:K02375]
102565515  FZD5; frizzled class receptor 5 [KO:K02375]
106737187  FZD6; frizzled class receptor 6 [KO:K02376]
102559669  FZD10; frizzled class receptor 10 [KO:K02842]
102572450  FZD9; frizzled class receptor 9 [KO:K02842]
106736807  LRP6; LDL receptor related protein 6 [KO:K03068]
102565598  LRP5; LDL receptor related protein 5 [KO:K03068]
106736875  DVL3; dishevelled segment polarity protein 3 [KO:K02353]
102570134  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
102577127  DVL1; dishevelled segment polarity protein 1 [KO:K02353]
106737044  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102569751  TNF; tumor necrosis factor [KO:K03156]
102560352  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102561936  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102565762  INS; insulin [KO:K04526]
102559209  IGF1; insulin like growth factor 1 [KO:K05459]
102558884  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
106736787  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102564907  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102576889  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102572638  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102562157  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102574430  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102575936  GTPase HRas [KO:K07827]
102566357  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
106737102  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102576986  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102563228  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
106736997  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106737342  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102561718  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109282845  mitogen-activated protein kinase 3-like [KO:K04371] [EC:2.7.11.24]
102563194  RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
102574678  RPS6KA3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
102561736  RPS6KA6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
102571036  RPS6KA2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
102574179  IRS1; insulin receptor substrate 1 [KO:K16172]
106737141  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102567863  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102570922  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102564312  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
106737094  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102571877  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102558284  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102575851  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102574794  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102558879  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102564996  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
106736873  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102558437  MAPKAP1; mitogen-activated protein kinase associated protein 1 [KO:K20410]
102557894  RICTOR; RPTOR independent companion of MTOR complex 2 [KO:K08267]
102573541  PRR5; proline rich 5 [KO:K20411]
102571582  PRR5L; proline rich 5 like [KO:K20411]
102560127  transforming protein RhoA-like [KO:K04513]
102563558  RHOA; ras homolog family member A [KO:K04513]
102572836  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102572486  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102574559  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102576261  SGK1; serum/glucocorticoid regulated kinase 1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
amj00561  Glycerolipid metabolism
amj04010  MAPK signaling pathway
amj04140  Autophagy - animal
amj04810  Regulation of actin cytoskeleton
amj04910  Insulin signaling pathway
KO pathway
ko04150   
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