KEGG   PATHWAY: amj04810
Entry
amj04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Alligator mississippiensis (American alligator)
Class
Cellular Processes; Cell motility
Pathway map
amj04810  Regulation of actin cytoskeleton
amj04810

Other DBs
GO: 0030036
Organism
Alligator mississippiensis (American alligator) [GN:amj]
Gene
102557881  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
102557891  [KO:K05765]
102557905  [KO:K00907] [EC:2.7.11.18]
102558298  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.39]
102558358  C9; complement C9 [KO:K04000]
102558369  CFL2; cofilin 2 [KO:K05765]
102558433  PAK5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
102558748  CDC42; cell division cycle 42 [KO:K04393]
102558879  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102559004  C5; complement C5 [KO:K03994]
102559171  F2R; coagulation factor II thrombin receptor [KO:K03914]
102559298  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
102559319  FAM49B; family with sequence similarity 49 member B [KO:K27976]
102559351  PXN; paxillin [KO:K05760]
102559388  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
102559452  NCKAP1; NCK associated protein 1 [KO:K05750]
102559625  IQGAP3; IQ motif containing GTPase activating protein 3 [KO:K05767]
102559664  MYH10; myosin heavy chain 10 [KO:K10352]
102559708  MYL10; myosin light chain 10 [KO:K12756]
102559732  ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
102559993  GNA12; G protein subunit alpha 12 [KO:K04346]
102560042  MYH9; myosin heavy chain 9 [KO:K10352]
102560127  [KO:K04513]
102560150  ARHGEF7; Rho guanine nucleotide exchange factor 7 [KO:K13710]
102560233  EGF; epidermal growth factor [KO:K04357]
102560494  [KO:K12757]
102560726  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07830]
102560817  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
102561475  PPP1R12B; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
102561509  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102561520  MYLK; myosin light chain kinase [KO:K00907] [EC:2.7.11.18]
102561718  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102561800  [KO:K05692]
102562157  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102562210  BDKRB2; bradykinin receptor B2 [KO:K03916]
102562216  NCKAP1L; nck-associated protein 1-like [KO:K05750]
102562234  PDGFB; platelet derived growth factor subunit B [KO:K17386]
102562278  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
102562442  MYL7; myosin light chain 7 [KO:K12754]
102562446  BDKRB1; bradykinin receptor B1 [KO:K03915]
102562456  ENAH; enabled homolog (Drosophila) [KO:K05746]
102562542  GSN; gelsolin [KO:K05768]
102562789  ITGA2; integrin subunit alpha 2 [KO:K06481]
102562790  VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
102562806  ITGB4; integrin subunit beta 4 [KO:K06525]
102563000  FGF4; fibroblast growth factor 4 [KO:K04358]
102563136  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
102563228  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102563235  FGF19; fibroblast growth factor 19 [KO:K22603]
102563393  ITGA5; integrin subunit alpha 5 [KO:K06484]
102563449  ITGAE; integrin subunit alpha E [KO:K06524]
102563468  PFN2; profilin 2 [KO:K05759]
102563470  ITGB5; integrin subunit beta 5 [KO:K06588]
102563558  RHOA; ras homolog family member A [KO:K04513]
102563754  PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
102563758  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
102563759  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
102563829  MYL2; myosin light chain 2 [KO:K10351]
102563842  ITGB8; integrin subunit beta 8 [KO:K06591]
102563942  ITGB2; integrin subunit beta 2 [KO:K06464]
102563948  FGF3; fibroblast growth factor 3 [KO:K04358]
102564037  KNG1; kininogen 1 [KO:K03898]
102564093  ACTR3B; ARP3 actin related protein 3 homolog B [KO:K18584]
102564109  FGF6; fibroblast growth factor 6 [KO:K04358]
102564142  ITGA4; integrin subunit alpha 4 [KO:K06483]
102564190  FGF18; fibroblast growth factor 18 [KO:K04358]
102564312  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102564332  MYL5; myosin light chain 5 [KO:K12753]
102564417  ARHGAP35; Rho GTPase activating protein 35 [KO:K05732]
102564466  TMSB10; thymosin beta-11 [KO:K05764]
102564560  BRK1; BRICK1, SCAR/WAVE actin nucleating complex subunit [KO:K05752]
102564591  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
102564693  ARHGEF4; Rho guanine nucleotide exchange factor 4 [KO:K05769]
102564750  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
102564803  FGF23; fibroblast growth factor 23 [KO:K22428]
102564820  C8G; complement C8 gamma chain [KO:K03999]
102564996  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
102565155  IQGAP2; IQ motif containing GTPase activating protein 2 [KO:K05767]
102565209  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102565264  VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730]
102565268  BCAR1; BCAR1, Cas family scaffolding protein [KO:K05726]
102565419  PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
102565552  FGF21; fibroblast growth factor 21 [KO:K22429]
102565628  SPATA13; spermatogenesis associated 13 [KO:K05769]
102565683  ACTB; actin, cytoplasmic 2 [KO:K05692]
102565756  SSH2; slingshot protein phosphatase 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102565762  INS; insulin [KO:K04526]
102565915  BAIAP2; BAI1 associated protein 2 [KO:K05627]
102565962  ITGA6; integrin subunit alpha 6 [KO:K06485]
102566037  SSH3; slingshot protein phosphatase 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102566039  CHRM5; cholinergic receptor muscarinic 5 [KO:K04133]
102566056  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
102566120  FAM49A; family with sequence similarity 49 member A [KO:K27976]
102566175  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102566357  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102566631  GIT1; GIT ArfGAP 1 [KO:K05737]
102566636  EZR; ezrin [KO:K08007]
102566947  FGD3; FYVE, RhoGEF and PH domain containing 3 [KO:K05722]
102567148  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102567234  WASF1; WAS protein family member 1 [KO:K05753]
102567239  APC; APC, WNT signaling pathway regulator [KO:K02085]
102567370  FGF2; fibroblast growth factor 2 [KO:K18497]
102567605  RGCC; regulator of cell cycle [KO:K26108]
102567702  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
102567804  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
102567810  DIAPH1; diaphanous related formin 1 [KO:K05740]
102567863  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102568064  F2; coagulation factor II, thrombin [KO:K01313] [EC:3.4.21.5]
102568338  [KO:K05692]
102568408  PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
102568490  PDGFA; platelet derived growth factor subunit A [KO:K04359]
102568505  PFN3; profilin 3 [KO:K05759]
102568562  GNA13; G protein subunit alpha 13 [KO:K04639]
102568609  SSH1; slingshot protein phosphatase 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102568638  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
102568685  FGF10; fibroblast growth factor 10 [KO:K04358]
102568693  ACTB; actin beta [KO:K05692]
102568735  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
102569016  MYL12A; myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
102569053  ITGAM; integrin subunit alpha M [KO:K06461]
102569106  PDGFC; platelet derived growth factor C [KO:K05450]
102569441  ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
102569599  IQGAP1; IQ motif containing GTPase activating protein 1 [KO:K16848]
102569658  ITGAV; integrin subunit alpha V [KO:K06487]
102569824  FN1; fibronectin 1 [KO:K05717]
102569952  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
102569963  VCL; vinculin [KO:K05700]
102570160  FGF1; fibroblast growth factor 1 [KO:K18496]
102570288  ITGB3; integrin subunit beta 3 [KO:K06493]
102570444  VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
102570463  CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
102570562  ITGA2B; integrin subunit alpha 2b [KO:K06476]
102570596  FGF17; fibroblast growth factor 17 [KO:K04358]
102570831  C7; complement C7 [KO:K03996]
102570878  APC2; APC2, WNT signaling pathway regulator [KO:K02085]
102570922  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102571057  [KO:K03995]
102571099  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
102571123  PAK3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
102571140  ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
102571296  [KO:K03995]
102571379  ITGA7; integrin subunit alpha 7 [KO:K06583]
102571601  PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
102571681  PAK6; p21 (RAC1) activated kinase 6 [KO:K05735] [EC:2.7.11.1]
102571877  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102571910  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
102571915  FGF20; fibroblast growth factor 20 [KO:K04358]
102571995  DOCK1; dedicator of cytokinesis 1 [KO:K13708]
102572032  PDGFD; platelet derived growth factor D [KO:K05450]
102572058  MOS; MOS proto-oncogene, serine/threonine kinase [KO:K04367] [EC:2.7.11.1]
102572183  FGF5; fibroblast growth factor 5 [KO:K04358]
102572322  ITGA10; integrin alpha-10 [KO:K06586]
102572451  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.39]
102572624  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
102572638  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102572653  FGF22; fibroblast growth factor 22 [KO:K04358]
102573027  PIP4K2C; phosphatidylinositol-5-phosphate 4-kinase type 2 gamma [KO:K00920] [EC:2.7.1.149]
102573090  FGF16; fibroblast growth factor 16 [KO:K04358]
102573231  PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase type 2 beta [KO:K00920] [EC:2.7.1.149]
102573274  MRAS; muscle RAS oncogene homolog [KO:K07831]
102573349  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
102573553  PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase type 2 alpha [KO:K00920] [EC:2.7.1.149]
102573610  CYFIP1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
102573657  WASL; Wiskott-Aldrich syndrome like [KO:K23612]
102573872  ACTN4; actinin alpha 4 [KO:K05699]
102573900  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102574037  DIAPH2; diaphanous related formin 2 [KO:K05741]
102574052  WASF2; WAS protein family member 2 [KO:K05748]
102574082  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
102574117  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
102574262  MYH11; myosin heavy chain 11 [KO:K10352]
102574273  ACTR2; ARP2 actin related protein 2 homolog [KO:K17260]
102574430  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102574445  [KO:K10352]
102574546  CHRM4; cholinergic receptor muscarinic 4 [KO:K04132]
102574628  [KO:K05759]
102574657  ARHGEF6; Rac/Cdc42 guanine nucleotide exchange factor 6 [KO:K05729]
102574658  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
102574772  ABI2; abl interactor 2 [KO:K05751]
102574789  GNG12; G protein subunit gamma 12 [KO:K04347]
102574794  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102574904  ITGAL; integrin subunit alpha L [KO:K05718]
102574925  ITGA8; integrin subunit alpha 8 [KO:K06584]
102575023  [KO:K05627]
102575025  CHRM2; cholinergic receptor muscarinic 2 [KO:K04130]
102575161  ITGA9; integrin subunit alpha 9 [KO:K06585]
102575277  ITGA1; integrin subunit alpha 1 [KO:K06480]
102575338  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102575553  MSN; moesin [KO:K05763]
102575554  SLC9A1; solute carrier family 9 member A1 [KO:K05742]
102575766  MYL9; myosin light chain 9 [KO:K12755]
102575802  ITGB1; integrin subunit beta 1 [KO:K05719]
102575936  [KO:K07827]
102576131  C8B; complement C8 beta chain [KO:K03998]
102576325  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
102576455  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102576524  INSRR; insulin receptor related receptor [KO:K05086] [EC:2.7.10.1]
102576591  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
102576616  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
102576889  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102576986  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102577004  FGF9; fibroblast growth factor 9 [KO:K04358]
102577059  C8A; complement C8 alpha chain [KO:K03997]
102577235  CHRM3; cholinergic receptor muscarinic 3 [KO:K04131]
102577269  TMSB4X; thymosin beta 4, X-linked [KO:K05764]
106736653  ACTR3; ARP3 actin related protein 3 homolog [KO:K18584]
106736741  ITGA3; integrin subunit alpha 3 [KO:K06482]
106736747  ACTN1; actinin alpha 1 [KO:K05699]
106736800  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
106736876  SCIN; scinderin [KO:K05768]
106736891  RDX; radixin [KO:K05762]
106736897  DIAPH3; diaphanous related formin 3 [KO:K05745]
106736955  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
106736963  ITGB6; integrin subunit beta 6 [KO:K06589]
106736974  ITGA11; integrin subunit alpha 11 [KO:K06587]
106736997  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106737014  FGF8; fibroblast growth factor 8 [KO:K04358]
106737085  TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
106737094  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
106737102  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
106737141  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
106737171  PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68]
106737254  ARHGEF1; Rho guanine nucleotide exchange factor 1 [KO:K12330]
106737342  [KO:K04371] [EC:2.7.11.24]
106737436  [KO:K26108]
106737658  PFN4; profilin family member 4 [KO:K05759]
106738920  [KO:K05734] [EC:2.7.11.1]
106739007  [KO:K12758]
109280173  FGF7; fibroblast growth factor 7 [KO:K04358]
109281004  PFN1; profilin 1 [KO:K05759]
109282845  [KO:K04371] [EC:2.7.11.24]
109282891  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
109286026  [KO:K27976]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
amj04010  MAPK signaling pathway
amj04510  Focal adhesion
amj04520  Adherens junction
KO pathway
ko04810   

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