KEGG   PATHWAY: aoce04625
Entry
aoce04625                   Pathway                                
Name
C-type lectin receptor signaling pathway - Amphiprion ocellaris (clown anemonefish)
Description
C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of one or more C-type lectin-like domains (CTLDs). CLRs function as pattern-recognition receptors (PRRs) for pathogen-derived ligands in dendric cells, macrophages, neutrophils, etc., such as Dectin-1 and Dectin-2 for recognition of fungi-derived B-glucan and high mannose-type carbohydrates. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
Class
Organismal Systems; Immune system
Pathway map
aoce04625  C-type lectin receptor signaling pathway
aoce04625

Organism
Amphiprion ocellaris (clown anemonefish) [GN:aoce]
Gene
111584369  hras; GTPase HRas [KO:K02833]
111565328  GTPase HRas-like [KO:K07827]
111563125  kras; GTPase KRas isoform X1 [KO:K07827]
111579771  mras; ras-related protein M-Ras [KO:K07831]
111563272  rras2; ras-related protein R-Ras2 [KO:K07830]
111579421  ras-related protein R-Ras-like isoform X1 [KO:K07830]
111588716  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111582710  transcription factor p65-like isoform X1 [KO:K04735]
111563992  transcription factor p65-like isoform X1 [KO:K09253]
111572772  interleukin-12 subunit alpha-like [KO:K05406]
111567434  interleukin-12 subunit beta-like [KO:K05425]
111588038  il12b; interleukin-12 subunit beta isoform X1 [KO:K05425]
111566717  interleukin-12 subunit beta-like [KO:K05425]
111583887  interleukin-1 beta-like isoform X1 [KO:K04519]
111580399  interleukin-1 beta-like [KO:K04519]
111579152  syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
111567360  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
111572898  ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
111581683  mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
111570768  uncharacterized protein LOC111570768 [KO:K04466] [EC:2.7.11.25]
111581409  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
111567460  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
111577944  nfkb2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
111563111  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
111569665  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
111575102  itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
111568340  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
111579918  calml6; calmodulin-like protein 6 [KO:K02183]
111574006  calm2; calmodulin-2 [KO:K02183]
111568350  calml4; calmodulin-like protein 4 [KO:K02183]
111585476  calm1; calmodulin-1 [KO:K02183]
111566088  calmodulin [KO:K02183]
111582363  calmodulin isoform X1 [KO:K02183]
111567603  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111580436  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111586959  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
111587000  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform-like [KO:K04348] [EC:3.1.3.16]
111567114  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111567535  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111570968  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
111575245  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
111564871  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
111577020  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
111566224  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
111570181  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
111570183  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
111585277  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
111566563  il10; interleukin-10 [KO:K05443]
111562821  early growth response protein 2b-like [KO:K12496]
111569202  egr2; E3 SUMO-protein ligase EGR2 [KO:K12496]
111578645  egr3; LOW QUALITY PROTEIN: early growth response protein 3 [KO:K12497]
111585762  ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
111566615  prkcd; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
111565366  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
111578326  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111578016  pycard; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
111582467  caspase-1-like [KO:K01370] [EC:3.4.22.36]
111574080  card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
111567690  bcl10; B-cell lymphoma/leukemia 10 [KO:K07368]
111564943  mucosa-associated lymphoid tissue lymphoma translocation protein 1-like isoform X1 [KO:K07369] [EC:3.4.22.-]
111580172  mucosa-associated lymphoid tissue lymphoma translocation protein 1-like [KO:K07369] [EC:3.4.22.-]
111580392  malt1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369] [EC:3.4.22.-]
111588089  caspase-8-like [KO:K04398] [EC:3.4.22.61]
111588095  caspase-8-like [KO:K04398] [EC:3.4.22.61]
111588107  caspase-8-like [KO:K04398] [EC:3.4.22.61]
111586360  caspase-8-like [KO:K04398] [EC:3.4.22.61]
111582017  optineurin-like isoform X1 [KO:K07210]
111577292  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
111581711  nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
111577551  NF-kappa-B inhibitor alpha-like [KO:K04734]
111583748  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111579085  tumor necrosis factor-like [KO:K03156]
111575173  tumor necrosis factor-like [KO:K03156]
111573783  interleukin-6-like [KO:K05405]
111586917  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
111565824  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
111565847  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
111587875  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
111572700  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
111566984  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
111589175  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
111575648  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111577431  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
111569535  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
111582355  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111587627  jun; transcription factor AP-1 [KO:K04448]
111577530  transcription factor AP-1-like isoform X1 [KO:K04448]
111567948  E3 ubiquitin-protein ligase CBL-B-like isoform X1 [KO:K22517] [EC:2.3.2.27]
111562556  fcer1g; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
111579137  high affinity immunoglobulin epsilon receptor subunit gamma-like [KO:K07983]
111576229  rho guanine nucleotide exchange factor 12-like isoform X1 [KO:K07532]
111573843  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
111580849  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
111587485  rho-related GTP-binding protein RhoA-C [KO:K04513]
111568127  rho-related GTP-binding protein RhoA-B [KO:K04513]
111580690  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
111586271  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
111577493  kinase suppressor of Ras 1-like [KO:K14958]
111571754  ksr1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
111568077  plk3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
111577019  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
111566214  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
111566565  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
111572427  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
111563285  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
111576216  interferon regulatory factor 8-like isoform X1 [KO:K04693]
111566617  signal transducer and activator of transcription 1-alpha/beta-like [KO:K11221]
111584736  il17d; interleukin-17D [KO:K05492]
111585530  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
111572254  cyld; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
111579941  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
111582303  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
111564254  bcl3; B-cell lymphoma 3 protein [KO:K09258]
111566562  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
111573373  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111586024  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
111588464  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
111569702  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111581473  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111566849  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111573943  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
111569137  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
111586970  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
111566758  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111582380  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111587052  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
111584424  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111570511  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111581166  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111581655  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111566093  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111586407  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
111563857  irf1; interferon regulatory factor 1 isoform X1 [KO:K09444]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00159  D-Mannose
C00165  Diacylglycerol
C00584  Prostaglandin E2
C00965  1,3-beta-D-Glucan
C01019  L-Fucose
C01245  D-myo-Inositol 1,4,5-trisphosphate
C16844  Hydroxyl radical
C21790  Mycobacterial trehalose dimycolate
C21791  Rhodocytin
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:27291962
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
C-type lectin receptors in the control of T helper cell differentiation.
  Journal
Nat Rev Immunol 16:433-48 (2016)
DOI:10.1038/nri.2016.55
Reference
PMID:21350579
  Authors
Hajishengallis G, Lambris JD
  Title
Microbial manipulation of receptor crosstalk in innate immunity.
  Journal
Nat Rev Immunol 11:187-200 (2011)
DOI:10.1038/nri2918
Reference
PMID:28604735
  Authors
Iliev ID, Leonardi I
  Title
Fungal dysbiosis: immunity and interactions at mucosal barriers.
  Journal
Nat Rev Immunol 17:635-646 (2017)
DOI:10.1038/nri.2017.55
Reference
PMID:25002863
  Authors
Richardson MB, Williams SJ
  Title
MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
  Journal
Front Immunol 5:288 (2014)
DOI:10.3389/fimmu.2014.00288
Reference
PMID:21924922
  Authors
Vautier S, MacCallum DM, Brown GD
  Title
C-type lectin receptors and cytokines in fungal immunity.
  Journal
Cytokine 58:89-99 (2012)
DOI:10.1016/j.cyto.2011.08.031
Reference
PMID:22170181
  Authors
Gauglitz GG, Callenberg H, Weindl G, Korting HC
  Title
Host defence against Candida albicans and the role of pattern-recognition receptors.
  Journal
Acta Derm Venereol 92:291-8 (2012)
DOI:10.2340/00015555-1250
Reference
PMID:22973279
  Authors
Cunha C, Carvalho A, Esposito A, Bistoni F, Romani L
  Title
DAMP signaling in fungal infections and diseases.
  Journal
Front Immunol 3:286 (2012)
DOI:10.3389/fimmu.2012.00286
Reference
PMID:29449845
  Authors
Tang J, Lin G, Langdon WY, Tao L, Zhang J
  Title
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.
  Journal
Front Immunol 9:123 (2018)
DOI:10.3389/fimmu.2018.00123
Reference
PMID:27999992
  Authors
Mayer S, Raulf MK, Lepenies B
  Title
C-type lectins: their network and roles in pathogen recognition and immunity.
  Journal
Histochem Cell Biol 147:223-237 (2017)
DOI:10.1007/s00418-016-1523-7
Reference
PMID:23570314
  Authors
Plato A, Willment JA, Brown GD
  Title
C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.
  Journal
Int Rev Immunol 32:134-56 (2013)
DOI:10.3109/08830185.2013.777065
Reference
PMID:22344277
  Authors
Dupaul-Chicoine J, Saleh M
  Title
A new path to IL-1beta production controlled by caspase-8.
  Journal
Nat Immunol 13:211-2 (2012)
DOI:10.1038/ni.2241
Reference
PMID:24009832
  Authors
Batbayar S, Lee DH, Kim HW
  Title
Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.
  Journal
Biomol Ther (Seoul) 20:433-45 (2012)
DOI:10.4062/biomolther.2012.20.5.433
Reference
PMID:28606994
  Authors
Bendickova K, Tidu F, Fric J
  Title
Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.
  Journal
EMBO Mol Med 9:990-999 (2017)
DOI:10.15252/emmm.201707698
Reference
PMID:18998127
  Authors
den Dunnen J, Gringhuis SI, Geijtenbeek TB
  Title
Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
  Journal
Cancer Immunol Immunother 58:1149-57 (2009)
DOI:10.1007/s00262-008-0615-1
Reference
PMID:28640912
  Authors
Marakalala MJ, Ndlovu H
  Title
Signaling C-type lectin receptors in antimycobacterial immunity.
  Journal
PLoS Pathog 13:e1006333 (2017)
DOI:10.1371/journal.ppat.1006333
Reference
PMID:24867235
  Authors
Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TB
  Title
Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation.
  Journal
Nat Commun 5:3898 (2014)
DOI:10.1038/ncomms4898
Reference
PMID:19521399
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
Signalling through C-type lectin receptors: shaping immune responses.
  Journal
Nat Rev Immunol 9:465-79 (2009)
DOI:10.1038/nri2569
Reference
PMID:19122653
  Authors
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB
  Title
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.
  Journal
Nat Immunol 10:203-13 (2009)
DOI:10.1038/ni.1692
KO pathway
ko04625   
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