KEGG   PATHWAY: bacu04726
Entry
bacu04726                   Pathway                                
Name
Serotonergic synapse - Balaenoptera acutorostrata scammoni (minke whale)
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
Pathway map
bacu04726  Serotonergic synapse
bacu04726

Other DBs
GO: 0007210
Organism
Balaenoptera acutorostrata scammoni (minke whale) [GN:bacu]
Gene
103006656  TPH2; tryptophan hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
102997866  TPH1; tryptophan hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
102999539  DDC; dopa decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
103000979  SLC18A2; solute carrier family 18 member A2 [KO:K08155]
103003968  SLC18A1; solute carrier family 18 member A1 [KO:K08155]
103019389  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
103001906  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
102998540  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
103014409  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
103009628  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
103012145  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
103000850  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
103018216  GNAQ; G protein subunit alpha q [KO:K04634]
103020805  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
102997432  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
103007077  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
103006361  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
103010644  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103018280  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102999302  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103004532  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
103012542  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
103017540  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102999619  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103002590  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103008898  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
103009192  PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
103012091  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
103012675  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
102999275  PLA2G4B; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
103017669  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
103007607  cytochrome P450 2D14-like [KO:K07414] [EC:1.14.14.1]
103009115  ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
103020542  ALOX12; arachidonate 12-lipoxygenase, 12S type [KO:K00458] [EC:1.13.11.31]
103006231  ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
102998643  ALOX15B; arachidonate 15-lipoxygenase, type B [KO:K08022] [EC:1.13.11.33 1.13.11.-]
103003952  PTGS1; prostaglandin-endoperoxide synthase 1 [KO:K00509] [EC:1.14.99.1]
102999195  PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
103008798  HTR3B; 5-hydroxytryptamine receptor 3B [KO:K04819]
103011699  HTR3A; 5-hydroxytryptamine receptor 3A [KO:K04819]
103015736  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
102999070  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
103004734  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
103004432  GNAS; GNAS complex locus [KO:K04632]
103004158  neuroendocrine secretory protein 55-like [KO:K04632]
103006764  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
103000011  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
103008319  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103003546  KCNN2; potassium calcium-activated channel subfamily N member 2 [KO:K04943]
103020877  KCND2; potassium voltage-gated channel subfamily D member 2 [KO:K04892]
103012600  GABRB1; gamma-aminobutyric acid type A receptor beta1 subunit [KO:K05181]
103011442  GABRB3; gamma-aminobutyric acid type A receptor beta3 subunit [KO:K05181]
103001353  GABRB2; gamma-aminobutyric acid type A receptor beta2 subunit [KO:K05181]
103005728  RAPGEF3; Rap guanine nucleotide exchange factor 3 [KO:K08014]
103006217  APP; amyloid beta precursor protein [KO:K04520]
103013276  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
103006193  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
103019928  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
103013527  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
103015419  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
103011266  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
103005589  5-hydroxytryptamine receptor 5B-like [KO:K04161]
103017385  GNAI1; G protein subunit alpha i1 [KO:K04630]
103010531  GNAI2; G protein subunit alpha i2 [KO:K04630]
103008589  GNAI3; G protein subunit alpha i3 [KO:K04630]
103011674  GNAO1; G protein subunit alpha o1 [KO:K04534]
103006513  GNB1; G protein subunit beta 1 [KO:K04536]
103000308  GNB2; G protein subunit beta 2 [KO:K04537]
103008105  GNB3; G protein subunit beta 3 [KO:K07825]
103001811  GNB4; G protein subunit beta 4 [KO:K04538]
103000160  GNB5; G protein subunit beta 5 [KO:K04539]
103004854  GNG2; G protein subunit gamma 2 [KO:K07826]
103019275  GNG4; G protein subunit gamma 4 [KO:K04541]
103017244  GNG7; G protein subunit gamma 7 [KO:K04543]
102997635  GNG8; G protein subunit gamma 8 [KO:K04544]
103007358  GNG11; G protein subunit gamma 11 [KO:K04546]
103016707  GNG13; G protein subunit gamma 13 [KO:K04547]
103007657  GNGT1; G protein subunit gamma transducin 1 [KO:K04548]
103019939  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
103004641  DUSP1; dual specificity phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
103006545  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
103015457  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
103004931  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103020975  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
103002372  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
103014337  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103017381  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103007483  CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
103004988  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
103017653  KCNJ3; potassium voltage-gated channel subfamily J member 3 [KO:K04997]
103014208  KCNJ6; potassium voltage-gated channel subfamily J member 6 [KO:K05000]
103007029  KCNJ9; potassium voltage-gated channel subfamily J member 9 [KO:K05002]
103005183  KCNJ5; potassium voltage-gated channel subfamily J member 5 [KO:K04999]
103017673  TRPC1; transient receptor potential cation channel subfamily C member 1 [KO:K04964]
103009047  SLC6A4; solute carrier family 6 member 4 [KO:K05037]
103019850  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
103020125  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
Compound
C00076  Calcium cation
C00078  L-Tryptophan
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00643  5-Hydroxy-L-tryptophan
C00696  Prostaglandin D2
C00780  Serotonin
C00909  Leukotriene A4
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C04822  8(R)-HPETE
C05356  5(S)-HPETE
C05635  5-Hydroxyindoleacetate
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14812  12(R)-HPETE
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14823  8(S)-HPETE
Reference
PMID:18676031
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
DOI:10.1016/j.tips.2008.06.007
Reference
PMID:16896947
  Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
  Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
  Journal
Cell Tissue Res 326:553-72 (2006)
DOI:10.1007/s00441-006-0286-1
Reference
PMID:11916537
  Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
  Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
  Journal
Pharmacol Ther 92:179-212 (2001)
DOI:10.1016/S0163-7258(01)00169-3
Reference
PMID:15034221
  Authors
Noda M, Higashida H, Aoki S, Wada K
  Title
Multiple signal transduction pathways mediated by 5-HT receptors.
  Journal
Mol Neurobiol 29:31-9 (2004)
DOI:10.1385/MN:29:1:31
Reference
PMID:20561690
  Authors
Daubert EA, Condron BG
  Title
Serotonin: a regulator of neuronal morphology and circuitry.
  Journal
Trends Neurosci 33:424-34 (2010)
DOI:10.1016/j.tins.2010.05.005
Reference
PMID:16826372
  Authors
Chameau P, van Hooft JA
  Title
Serotonin 5-HT(3) receptors in the central nervous system.
  Journal
Cell Tissue Res 326:573-81 (2006)
DOI:10.1007/s00441-006-0255-8
Reference
PMID:9651340
  Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
  Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
  Journal
J Biol Chem 273:17498-503 (1998)
DOI:10.1074/jbc.273.28.17498
Reference
PMID:19545642
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
DOI:10.1016/j.prostaglandins.2009.06.004
Reference
PMID:12676358
  Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
  Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
  Journal
Biochim Biophys Acta 1640:85-96 (2003)
DOI:10.1016/S0167-4889(03)00023-5
Reference
PMID:11701344
  Authors
Albert PR, Tiberi M
  Title
Receptor signaling and structure: insights from serotonin-1 receptors.
  Journal
Trends Endocrinol Metab 12:453-60 (2001)
DOI:10.1016/S1043-2760(01)00498-2
Reference
PMID:9658404
  Authors
Durham PL, Russo AF
  Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
  Journal
Mol Endocrinol 12:1002-9 (1998)
DOI:10.1210/mend.12.7.0135
Reference
PMID:15710402
  Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
  Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
  Journal
FEBS Lett 579:1136-42 (2005)
DOI:10.1016/j.febslet.2005.01.010
Reference
PMID:12543273
  Authors
Lezoualc'h F, Robert SJ
  Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
  Journal
Exp Gerontol 38:159-66 (2003)
DOI:10.1016/S0531-5565(02)00157-2
Reference
PMID:11043573
  Authors
Durham PL, Russo AF
  Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
  Journal
Mol Endocrinol 14:1570-82 (2000)
DOI:10.1210/mend.14.10.0529
Reference
PMID:9542727
  Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
  Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
  Journal
Neurochem Int 32:153-62 (1998)
DOI:10.1016/S0197-0186(97)00087-9
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Related
pathway
bacu00380  Tryptophan metabolism
bacu00590  Arachidonic acid metabolism
bacu04020  Calcium signaling pathway
bacu04721  Synaptic vesicle cycle
bacu04976  Bile secretion
KO pathway
ko04726   
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