KEGG   PATHWAY: bbis04145
Entry
bbis04145                   Pathway                                
Name
Phagosome - Bison bison bison (American bison)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
bbis04145  Phagosome
bbis04145

Other DBs
GO: 0045335
Organism
Bison bison bison (American bison) [GN:bbis]
Gene
104995886  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
104981179  STX12; syntaxin-12 [KO:K13813]
104988383  STX7; syntaxin-7 [KO:K08488]
104992781  ACTB; actin, cytoplasmic 1 [KO:K05692]
105000428  ACTG1; LOW QUALITY PROTEIN: actin, cytoplasmic 2 [KO:K05692]
104986622  CORO1A; coronin-1A [KO:K13882]
104994285  STX18; syntaxin-18 [KO:K08492]
104983367  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
104985847  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
104993295  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
104994538  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
104994546  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
104994573  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
104983766  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-37 alpha chain-like [KO:K06751]
104983816  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
104992400  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
104992401  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
104992404  HLA class II histocompatibility antigen, DRB1-1 beta chain-like isoform X1 [KO:K06752]
104992405  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
104992406  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
104998661  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
104994876  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]
104994877  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like isoform X1 [KO:K06752]
104994878  rano class II histocompatibility antigen, A beta chain-like isoform X1 [KO:K06752]
104994880  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
104994886  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
104994887  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
104994891  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
105000723  RAB5A; ras-related protein Rab-5A [KO:K07887]
104988054  RAB5B; ras-related protein Rab-5B [KO:K07888]
104990444  RAB5C; ras-related protein Rab-5C isoform X1 [KO:K07889]
104988402  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
104993281  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
104984539  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
105000433  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
104992453  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
104992530  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
104980929  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
105005478  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
104997360  ATP6V1C2; LOW QUALITY PROTEIN: V-type proton ATPase subunit C 2 [KO:K02148]
104993462  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
104992256  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
104987607  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
104982341  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
104981841  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
104989294  V-type proton ATPase subunit G 2-like [KO:K02152]
104985130  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
104996905  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
104991418  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
104986947  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform 3 isoform X1 [KO:K02154]
104999362  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform 4 [KO:K02154]
104989667  ATP6V0A2; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a isoform 2 [KO:K02154]
104990784  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform 1 [KO:K02154]
104993106  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
104996696  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
104987866  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
104998272  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
105004850  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
104993953  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
105001629  RAB7A; ras-related protein Rab-7a [KO:K07897]
104998816  RAB7B; ras-related protein Rab-7b [KO:K07898]
105003900  RILP; rab-interacting lysosomal protein isoform X1 [KO:K13883]
104997000  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
104987813  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
104988429  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
104991378  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
104996767  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
104985397  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
104986157  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
104992261  TUBA8; tubulin alpha-8 chain [KO:K07374]
104998531  tubulin alpha-1C chain [KO:K07374]
104993381  TUBA3E; tubulin alpha-3E chain [KO:K07374]
104994750  tubulin alpha-1A chain-like [KO:K07374]
105001471  TUBA1B; tubulin alpha-1B chain [KO:K07374]
105001472  TUBA1A; tubulin alpha-1A chain [KO:K07374]
104984835  tubulin alpha-3 chain-like [KO:K07374]
104984854  tubulin alpha-3 chain-like [KO:K07374]
105003795  tubulin alpha-4A chain [KO:K07374]
105003796  tubulin alpha-1D chain [KO:K07374]
104979917  TUBB4A; tubulin beta-4A chain [KO:K07375]
104994526  tubulin beta-7 chain [KO:K07375]
104983318  tubulin beta-2A chain-like [KO:K07375]
104983319  tubulin beta-2 chain-like [KO:K07375]
104989926  tubulin beta chain-like [KO:K07375]
104989979  TUBB1; tubulin beta-1 chain [KO:K07375]
105002478  TUBB6; tubulin beta-6 chain [KO:K07375]
104991455  TUBB3; tubulin beta-3 chain isoform X1 [KO:K07375]
104982200  LAMP1; LOW QUALITY PROTEIN: lysosome-associated membrane glycoprotein 1 [KO:K06528]
104982793  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
105003713  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
104995471  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
104980001  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
105004105  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
104985708  CTSV; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
104985727  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
104987659  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
104998764  SEC61A2; protein transport protein Sec61 subunit alpha isoform 2 isoform X1 [KO:K10956]
104983375  SEC61A1; protein transport protein Sec61 subunit alpha isoform 1 [KO:K10956]
104993682  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
104996344  protein transport protein Sec61 subunit beta [KO:K09481]
104990112  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
104994883  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
104994881  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
104999841  CALR; calreticulin [KO:K08057]
104981535  CANX; calnexin [KO:K08054]
104991487  immunoglobulin alpha Fc receptor-like isoform X1 [KO:K06513]
104987702  high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
104999189  low affinity immunoglobulin gamma Fc region receptor II-like [KO:K06472]
104999183  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560]
104999186  low affinity immunoglobulin gamma Fc region receptor III [KO:K06463]
104992161  C1R; complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
104986687  ITGAM; integrin alpha-M [KO:K06461]
104984916  ITGB2; integrin beta-2 [KO:K06464]
104979920  C3; complement C3 [KO:K03990]
104994757  COLEC11; collectin-11 [KO:K10066]
104980276  COLEC12; collectin-12 [KO:K10062]
105000624  MBL2; mannose-binding protein C [KO:K03991]
104984447  mannose-binding protein A-like [KO:K03991]
104984446  pulmonary surfactant-associated protein A [KO:K10067]
104984448  SFTPD; pulmonary surfactant-associated protein D isoform X1 [KO:K10068]
104984449  conglutinin [KO:K10068]
104984451  collectin-43 isoform X1 [KO:K10068]
104984467  conglutinin-like [KO:K10068]
104984884  collectin-46 [KO:K10068]
105002887  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105001056  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
105001611  ITGA5; integrin alpha-5 [KO:K06484]
105002990  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
105000519  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
104984522  ITGB5; integrin beta-5 [KO:K06588]
104994392  THBS1; thrombospondin-1 [KO:K16857]
104985778  THBS2; LOW QUALITY PROTEIN: thrombospondin-2 [KO:K04659]
104987407  THBS3; thrombospondin-3 [KO:K04659]
104993897  COMP; cartilage oligomeric matrix protein [KO:K04659]
104984732  THBS4; thrombospondin-4 [KO:K04659]
104989153  TLR2; toll-like receptor 2 [KO:K10159]
104984011  TLR6; toll-like receptor 6 [KO:K10169]
104994776  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
104996353  CD14; monocyte differentiation antigen CD14 [KO:K04391]
105000616  MRC2; C-type mannose receptor 2 [KO:K06560]
105002426  PLA2R1; secretory phospholipase A2 receptor [KO:K06560]
105003050  MRC1; macrophage mannose receptor 1 isoform X1 [KO:K06560]
104979767  CD209; CD209 antigen [KO:K06563]
105002128  CLEC7A; C-type lectin domain family 7 member A isoform X1 [KO:K10074]
105001928  MSR1; macrophage scavenger receptor types I and II isoform X1 [KO:K06558]
105003559  MARCO; macrophage receptor MARCO [KO:K13884]
105002130  OLR1; oxidized low-density lipoprotein receptor 1 isoform X1 [KO:K08763]
104989569  SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
104994511  platelet glycoprotein 4 [KO:K06259]
104994513  platelet glycoprotein 4-like [KO:K06259]
104994562  LOW QUALITY PROTEIN: platelet glycoprotein 4-like [KO:K06259]
104991474  cytochrome b-245 light chain [KO:K08009]
104979895  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
104992794  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104998946  NCF1; neutrophil cytosol factor 1 [KO:K08011]
104998082  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
105003405  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
bbis04142  Lysosome
bbis04144  Endocytosis
bbis04610  Complement and coagulation cascades
bbis04612  Antigen processing and presentation
bbis04620  Toll-like receptor signaling pathway
bbis04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   
LinkDB

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