KEGG   PATHWAY: bbub04914
Entry
bbub04914                   Pathway                                
Name
Progesterone-mediated oocyte maturation - Bubalus bubalis (water buffalo)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
bbub04914  Progesterone-mediated oocyte maturation
bbub04914

Other DBs
GO: 0001556
Organism
Bubalus bubalis (water buffalo) [GN:bbub]
Gene
102403123  PGR; progesterone receptor isoform X2 [KO:K08556]
102415109  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102404517  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102395384  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
102404165  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102400519  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102404610  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102393434  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
102396572  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
102403452  MAPK9; mitogen-activated protein kinase 9 isoform X5 [KO:K04440] [EC:2.7.11.24]
102409665  MAPK12; mitogen-activated protein kinase 12 isoform X3 [KO:K04441] [EC:2.7.11.24]
102397149  MAPK14; mitogen-activated protein kinase 14 isoform X4 [KO:K04441] [EC:2.7.11.24]
102397694  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
102413668  GNAI2; guanine nucleotide-binding protein G(I) subunit alpha-2 [KO:K04630]
102401306  GNAI1; guanine nucleotide-binding protein G(I) subunit alpha-1 [KO:K04630]
102409247  GNAI3; guanine nucleotide-binding protein G(I) subunit alpha-3 [KO:K04630]
102415323  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102412622  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102407976  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
102408103  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
102405387  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
102407637  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
102410456  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
102395302  ADCY8; adenylate cyclase type 8 isoform X3 [KO:K08048] [EC:4.6.1.1]
102404282  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102392366  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
102413383  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X4 [KO:K04345] [EC:2.7.11.11]
102396023  AURKA; aurora kinase A [KO:K11481] [EC:2.7.11.1]
102394113  CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X4 [KO:K02602]
102402567  CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
102399802  CPEB2; cytoplasmic polyadenylation element-binding protein 2 isoform X10 [KO:K02602]
102392286  CPEB3; cytoplasmic polyadenylation element-binding protein 3 isoform X4 [KO:K02602]
102402623  speedy protein E4-like [KO:K08694]
102406574  SPDYC; speedy protein C [KO:K08694]
102395977  SPDYA; speedy protein A [KO:K08694]
102398457  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
102405957  CDK1; cyclin-dependent kinase 1 isoform X3 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
102398715  CCNA2; cyclin-A2 [KO:K06627]
102408087  CCNA1; cyclin-A1 [KO:K06627]
102397640  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
102389823  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
102409833  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
102406400  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
102410871  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
102396842  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102396206  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
102403296  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102396053  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X5 [KO:K04373] [EC:2.7.11.1]
102397451  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X3 [KO:K04373] [EC:2.7.11.1]
102411208  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
102409485  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X6 [KO:K04373] [EC:2.7.11.1]
102411391  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
102413044  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
102398229  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
102391097  CCNB3; G2/mitotic-specific cyclin-B3 isoform X2 [KO:K21771]
102408168  STK10; serine/threonine-protein kinase 10 [KO:K08837] [EC:2.7.11.1]
102407714  PLK1; serine/threonine-protein kinase PLK1 isoform X2 [KO:K06631] [EC:2.7.11.21]
102415490  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
102407953  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
102401152  CDC25C; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
102396436  INS; insulin [KO:K04526]
102392528  IGF1; insulin-like growth factor I isoform X6 [KO:K05459]
102403092  IGF1R; insulin-like growth factor 1 receptor isoform X2 [KO:K05087] [EC:2.7.10.1]
102397969  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102398761  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102391021  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
102394766  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
102392995  KRAS; GTPase KRas isoform X2 [KO:K07827]
102392863  ARAF; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
102401079  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
102412922  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102415397  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
102413631  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X2 [KO:K06679]
112586263  MAD2L1; LOW QUALITY PROTEIN: mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
102390519  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B isoform X1 [KO:K13728]
102394833  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
102396508  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
102392759  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
102389770  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
102415084  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
102397136  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
102401483  CDC16; cell division cycle protein 16 homolog [KO:K03353]
102415730  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
102405130  CDC23; cell division cycle protein 23 homolog isoform X1 [KO:K03355]
102416566  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
102401972  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
102397540  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
102397735  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
102404816  anaphase-promoting complex subunit 13 [KO:K12456]
102392555  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
102393627  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
102390707  KIF22; kinesin-like protein KIF22 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
bbub04010  MAPK signaling pathway
bbub04110  Cell cycle
KO pathway
ko04914   
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