KEGG   PATHWAY: bdr03040
Entry
bdr03040                    Pathway                                
Name
Spliceosome - Bactrocera dorsalis (oriental fruit fly)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
bdr03040  Spliceosome
bdr03040

Other DBs
GO: 0005681
Organism
Bactrocera dorsalis (oriental fruit fly) [GN:bdr]
Gene
105222962  probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
105234120  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
125778620  ATP-dependent RNA helicase WM6-like [KO:K12812] [EC:5.6.2.7]
105222252  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
105226945  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
125776515  pre-mRNA-processing factor 17-like [KO:K12816]
125776516  pre-mRNA-processing factor 17-like [KO:K12816]
105226758  pre-mRNA-processing factor 17 [KO:K12816]
105226389  pre-mRNA-splicing factor 18 [KO:K12817]
105225073  ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
105226578  pre-mRNA-splicing factor Slu7 [KO:K12819]
105224524  putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 [KO:K12820] [EC:5.6.2.6]
105229784  small nuclear ribonucleoprotein-associated protein B [KO:K11086]
105233024  probable small nuclear ribonucleoprotein Sm D1 [KO:K11087]
105221915  probable small nuclear ribonucleoprotein Sm D2 [KO:K11096]
105221965  small nuclear ribonucleoprotein Sm D3 [KO:K11088]
105225404  probable small nuclear ribonucleoprotein E [KO:K11097]
105233046  small nuclear ribonucleoprotein F [KO:K11098]
105231970  probable small nuclear ribonucleoprotein G [KO:K11099]
105221767  U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
105231068  U1 small nuclear ribonucleoprotein C [KO:K11095]
105230192  pre-mRNA-processing factor 40 homolog A [KO:K12821]
105233342  RNA-binding protein 25 [KO:K12822]
105232490  ATP-dependent RNA helicase p62 isoform X1 [KO:K12823] [EC:5.6.2.7]
105225625  uncharacterized protein LOC105225625 [KO:K12823] [EC:5.6.2.7]
105228820  uncharacterized protein LOC105228820 [KO:K12823] [EC:5.6.2.7]
105230099  ATP-dependent RNA helicase p62 isoform X1 [KO:K12823] [EC:5.6.2.7]
105223220  transcription elongation regulator 1 isoform X1 [KO:K12824]
105222510  RNA-binding protein cabeza isoform X1 [KO:K13098]
105223055  probable U2 small nuclear ribonucleoprotein A' [KO:K11092]
105223179  U1 small nuclear ribonucleoprotein A [KO:K11094]
105222818  splicing factor 3A subunit 1 isoform X1 [KO:K12825]
105227839  splicing factor 3A subunit 2 [KO:K12826]
105230217  splicing factor 3A subunit 3 [KO:K12827]
105222758  splicing factor 3B subunit 1 [KO:K12828]
105230767  splicing factor 3B subunit 2 [KO:K12829]
105224424  splicing factor 3B subunit 3 [KO:K12830]
105223570  splicing factor 3B subunit 4 isoform X1 [KO:K12831]
105223226  splicing factor 3B subunit 5 [KO:K12832]
105232899  splicing factor 3B subunit 6 [KO:K12833]
105221825  PHD finger-like domain-containing protein 5A [KO:K12834]
105232657  ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
105223915  splicing factor U2af 38 kDa subunit [KO:K12836]
105222514  splicing factor U2AF 50 kDa subunit [KO:K12837]
105232162  poly(U)-binding-splicing factor half pint isoform X1 [KO:K12838]
105221843  survival of motor neuron-related-splicing factor 30 [KO:K12839]
105221820  splicing factor 45 [KO:K12840]
105224781  calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
105230638  U2 snRNP-associated SURP motif-containing protein [KO:K12842]
105223926  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
105232496  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
105228366  uncharacterized protein LOC105228366 [KO:K12623]
105232763  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
105225457  U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
105221775  U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
105223951  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
105224270  U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
105232896  U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
105230623  peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
105227185  U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
105226454  NHP2-like protein 1 homolog [KO:K12845]
105228680  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
105222780  U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
105229208  U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
125776422  zinc finger matrin-type protein 2-like isoform X1 [KO:K12848]
125780162  zinc finger matrin-type protein 2-like [KO:K12848]
105228915  pre-mRNA-splicing factor 38 [KO:K12849]
105230356  pre-mRNA-splicing factor 38B isoform X1 [KO:K12850]
105233935  116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
105225930  putative U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
105223459  pre-mRNA-processing factor 6 [KO:K12855]
105230005  pre-mRNA-processing-splicing factor 8 [KO:K12856]
105229257  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
105230738  probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
105233650  thioredoxin-like protein 4A [KO:K12859]
105229955  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
105227152  cell division cycle 5-like protein [KO:K12860]
105223660  pre-mRNA-splicing factor SPF27 [KO:K12861]
105224235  pleiotropic regulator 1 [KO:K12862]
105233625  protein CWC15 homolog [KO:K12863]
105230851  beta-catenin-like protein 1 [KO:K12864]
105231830  heat shock 70 kDa protein cognate 2 [KO:K03283]
105224006  heat shock 70 kDa protein cognate 1 [KO:K03283]
105233698  heat shock protein 68 [KO:K03283]
125775801  heat shock protein 70-like [KO:K03283]
125775802  heat shock protein 70-like [KO:K03283]
125775803  heat shock protein 70-like [KO:K03283]
125775804  heat shock protein 70 [KO:K03283]
125775805  heat shock protein 70-like [KO:K03283]
125775806  heat shock protein 70-like [KO:K03283]
125776475  heat shock protein 68-like [KO:K03283]
125775287  heat shock protein 68-like isoform X1 [KO:K03283]
105229596  heat shock 70 kDa protein cognate 4 [KO:K03283]
105230421  heat shock protein 68 [KO:K03283]
105228610  uncharacterized protein LOC105228610 [KO:K12865]
105222750  WW domain-binding protein 11 [KO:K12866]
105225217  puff-specific protein Bx42 [KO:K06063]
105222218  pre-mRNA-splicing factor syf1 homolog [KO:K12867]
105226697  pre-mRNA-splicing factor Syf2 [KO:K12868]
105233481  protein crooked neck isoform X1 [KO:K12869]
105230988  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
105234002  peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
105228409  peptidyl-prolyl cis-trans isomerase E isoform X1 [KO:K09564] [EC:5.2.1.8]
105226397  LOW QUALITY PROTEIN: coiled-coil domain-containing protein 12 [KO:K12871]
105230381  pre-mRNA-splicing factor RBM22 [KO:K12872]
105221950  protein BUD31 homolog [KO:K12873]
105232689  RNA helicase aquarius [KO:K12874]
105222263  apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
105231060  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
105233501  RNA-binding protein 8A [KO:K12876]
105223862  protein mago nashi [KO:K12877]
105222803  THO complex subunit 1 [KO:K12878]
105228774  THO complex subunit 2 [KO:K12879]
105230994  THO complex subunit 3 [KO:K12880]
105223324  THO complex subunit 4 [KO:K12881]
105222193  nuclear cap-binding protein subunit 1 [KO:K12882]
105229552  nuclear cap-binding protein subunit 2 [KO:K12883]
105231719  heterogeneous nuclear ribonucleoprotein 87F isoform X1 [KO:K12741]
105232797  heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
105231036  heterogeneous nuclear ribonucleoprotein K homolog isoform X1 [KO:K12886]
105231625  serine/arginine-rich splicing factor 1A [KO:K12890]
105231627  probable splicing factor, arginine/serine-rich 3 [KO:K12890]
105231150  serine/arginine-rich splicing factor 2 [KO:K12891]
105222520  serine-arginine protein 55 [KO:K12893]
105231720  serine-arginine protein 55 isoform X1 [KO:K12893]
105233361  serine/arginine-rich splicing factor 7 [KO:K12896]
125775347  serine/arginine-rich splicing factor 3-like [KO:K12896]
105222300  transformer-2 sex-determining protein [KO:K12897]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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