KEGG   PATHWAY: cbai04726
Entry
cbai04726                   Pathway                                
Name
Serotonergic synapse - Camelus bactrianus (Bactrian camel)
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
Pathway map
cbai04726  Serotonergic synapse
cbai04726

Other DBs
GO: 0007210
Organism
Camelus bactrianus (Bactrian camel) [GN:cbai]
Gene
105076585  TPH1; tryptophan 5-hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
105072045  TPH2; tryptophan 5-hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
105065158  DDC; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
105080762  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
105069001  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
105076642  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
105079596  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
105079415  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105070011  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
105069822  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
105070455  HTR2C; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2C [KO:K04157]
105066136  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
105067298  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
105077045  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105082996  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
105082997  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
105070632  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
105074761  ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
105062304  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
105064212  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105063941  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105073669  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105074322  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105082839  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105069349  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105076930  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
105076933  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
105077055  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
105077056  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
105064543  cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
105081748  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
105081809  LOW QUALITY PROTEIN: cytochrome P450 2C21-like [KO:K07413] [EC:1.14.14.1]
105081810  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
105081811  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
105081813  cytochrome P450 2C18 isoform X1 [KO:K07413] [EC:1.14.14.1]
105073057  cytochrome P450 2D14 [KO:K07414] [EC:1.14.14.1]
105064824  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
105064834  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
105064844  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
105064851  cytochrome P450 2J2-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
105065015  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
105065850  cytochrome P450 4X1-like isoform X1 [KO:K07428] [EC:1.14.14.1]
105075631  ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
105077467  ALOX12; arachidonate 12-lipoxygenase, 12S-type [KO:K00458] [EC:1.13.11.31]
105077529  ALOX12B; arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
105066404  ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
105077528  ALOX15B; LOW QUALITY PROTEIN: arachidonate 15-lipoxygenase B [KO:K08022] [EC:1.13.11.33 1.13.11.-]
105069938  PTGS1; prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
105083396  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
105067858  HTR3A; 5-hydroxytryptamine receptor 3A isoform X1 [KO:K04819]
105067873  HTR3B; 5-hydroxytryptamine receptor 3B [KO:K04819]
105063348  5-hydroxytryptamine receptor 3C-like [KO:K04819]
105063349  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3C-like [KO:K04819]
105063351  HTR3E; 5-hydroxytryptamine receptor 3E isoform X1 [KO:K04819]
105063370  5-hydroxytryptamine receptor 3C-like [KO:K04819]
105069857  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
105070905  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
105081841  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
105071802  guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
105071803  neuroendocrine secretory protein 55 [KO:K04632]
105081635  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105075498  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105068302  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105082037  small conductance calcium-activated potassium channel protein 2 [KO:K04943]
105063141  KCND2; potassium voltage-gated channel subfamily D member 2 [KO:K04892]
105074917  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
105082619  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
105062094  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 [KO:K05181]
105076166  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
105070278  APP; amyloid beta A4 protein isoform X1 [KO:K04520]
105083087  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
105077950  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
105064142  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
105064436  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
105070863  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
105076125  5-hydroxytryptamine receptor 5B [KO:K04161]
105069453  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
105080234  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
105062385  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
105063651  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105078712  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
105071051  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105067755  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105071086  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
105063316  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
105080494  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105070137  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105075111  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
105069319  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4-like [KO:K04541]
105062549  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
105082939  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105068344  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
105065706  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
105082944  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
105067685  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105082649  DUSP1; LOW QUALITY PROTEIN: dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
105069943  HRAS; GTPase HRas isoform X1 [KO:K02833]
105062297  KRAS; GTPase KRas [KO:K07827]
105079555  NRAS; GTPase NRas [KO:K07828]
105079376  ARAF; LOW QUALITY PROTEIN: serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
105063019  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
105067475  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105069422  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105068402  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
105073404  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
105081914  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
105072485  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
105069587  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
105071238  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
105066815  TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964]
105071542  SLC6A4; sodium-dependent serotonin transporter [KO:K05037]
105079347  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
105079348  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
Compound
C00076  Calcium cation
C00078  L-Tryptophan
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00643  5-Hydroxy-L-tryptophan
C00696  Prostaglandin D2
C00780  Serotonin
C00909  Leukotriene A4
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C04822  8(R)-HPETE
C05356  5(S)-HPETE
C05635  5-Hydroxyindoleacetate
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14812  12(R)-HPETE
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14823  8(S)-HPETE
Reference
PMID:18676031
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
DOI:10.1016/j.tips.2008.06.007
Reference
PMID:16896947
  Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
  Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
  Journal
Cell Tissue Res 326:553-72 (2006)
DOI:10.1007/s00441-006-0286-1
Reference
PMID:11916537
  Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
  Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
  Journal
Pharmacol Ther 92:179-212 (2001)
DOI:10.1016/S0163-7258(01)00169-3
Reference
PMID:15034221
  Authors
Noda M, Higashida H, Aoki S, Wada K
  Title
Multiple signal transduction pathways mediated by 5-HT receptors.
  Journal
Mol Neurobiol 29:31-9 (2004)
DOI:10.1385/MN:29:1:31
Reference
PMID:20561690
  Authors
Daubert EA, Condron BG
  Title
Serotonin: a regulator of neuronal morphology and circuitry.
  Journal
Trends Neurosci 33:424-34 (2010)
DOI:10.1016/j.tins.2010.05.005
Reference
PMID:16826372
  Authors
Chameau P, van Hooft JA
  Title
Serotonin 5-HT(3) receptors in the central nervous system.
  Journal
Cell Tissue Res 326:573-81 (2006)
DOI:10.1007/s00441-006-0255-8
Reference
PMID:9651340
  Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
  Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
  Journal
J Biol Chem 273:17498-503 (1998)
DOI:10.1074/jbc.273.28.17498
Reference
PMID:19545642
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
DOI:10.1016/j.prostaglandins.2009.06.004
Reference
PMID:12676358
  Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
  Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
  Journal
Biochim Biophys Acta 1640:85-96 (2003)
DOI:10.1016/S0167-4889(03)00023-5
Reference
PMID:11701344
  Authors
Albert PR, Tiberi M
  Title
Receptor signaling and structure: insights from serotonin-1 receptors.
  Journal
Trends Endocrinol Metab 12:453-60 (2001)
DOI:10.1016/S1043-2760(01)00498-2
Reference
PMID:9658404
  Authors
Durham PL, Russo AF
  Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
  Journal
Mol Endocrinol 12:1002-9 (1998)
DOI:10.1210/mend.12.7.0135
Reference
PMID:15710402
  Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
  Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
  Journal
FEBS Lett 579:1136-42 (2005)
DOI:10.1016/j.febslet.2005.01.010
Reference
PMID:12543273
  Authors
Lezoualc'h F, Robert SJ
  Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
  Journal
Exp Gerontol 38:159-66 (2003)
DOI:10.1016/S0531-5565(02)00157-2
Reference
PMID:11043573
  Authors
Durham PL, Russo AF
  Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
  Journal
Mol Endocrinol 14:1570-82 (2000)
DOI:10.1210/mend.14.10.0529
Reference
PMID:9542727
  Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
  Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
  Journal
Neurochem Int 32:153-62 (1998)
DOI:10.1016/S0197-0186(97)00087-9
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Related
pathway
cbai00380  Tryptophan metabolism
cbai00590  Arachidonic acid metabolism
cbai04020  Calcium signaling pathway
cbai04721  Synaptic vesicle cycle
cbai04976  Bile secretion
KO pathway
ko04726   
LinkDB

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