KEGG   PATHWAY: ecra03083
Entry
ecra03083                   Pathway                                
Name
Polycomb repressive complex - Etheostoma cragini (Arkansas darter)
Class
Genetic Information Processing; Chromosome
Pathway map
ecra03083  Polycomb repressive complex
ecra03083

Organism
Etheostoma cragini (Arkansas darter) [GN:ecra]
Gene
117957411  ezh1; histone-lysine N-methyltransferase EZH1 isoform X1 [KO:K17451] [EC:2.1.1.356]
117939277  eed; polycomb protein eed [KO:K11462]
117957813  polycomb protein suz12-B-like isoform X1 [KO:K11463]
117951802  suz12b; polycomb protein suz12-B isoform X1 [KO:K11463]
117942432  histone-binding protein RBBP7 isoform X1 [KO:K10752]
117935914  histone-binding protein RBBP4 isoform X1 [KO:K10752]
117956623  rbbp4; histone-binding protein RBBP4 isoform X1 [KO:K10752]
117945676  phf1; PHD finger protein 1 [KO:K11467]
117954196  mtf2; metal-response element-binding transcription factor 2 [KO:K11485]
117961889  lcor; ligand-dependent corepressor isoform X1 [KO:K26260]
117949123  zinc finger protein AEBP2-like isoform X1 [KO:K17452]
117938530  aebp2; zinc finger protein AEBP2 isoform X1 [KO:K17452]
117957330  jarid2b; protein Jumonji isoform X1 [KO:K11478]
117943781  bap1; ubiquitin carboxyl-terminal hydrolase BAP1 isoform X1 [KO:K08588] [EC:3.4.19.12]
117935880  asxl2; putative Polycomb group protein ASXL2 isoform X1 [KO:K11471]
117948140  asxl1; polycomb group protein ASXL1 isoform X1 [KO:K11471]
117951278  ogt.1; O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1 isoform X1 [KO:K09667] [EC:2.4.1.255]
117942906  hcfc1a; LOW QUALITY PROTEIN: host cell factor 1a [KO:K14966]
117936064  yy1a; transcriptional repressor protein YY1a [KO:K09201]
117961337  yy1b; transcriptional repressor protein YY1b isoform X1 [KO:K09201]
117939452  methyl-CpG-binding domain protein 5-like [KO:K23219]
117947310  mbd6; proline-rich protein 36 isoform X1 [KO:K26585]
117936807  forkhead box protein K2 [KO:K09404]
117958068  forkhead box protein K2 [KO:K09404]
117952907  foxk1; forkhead box protein K1 isoform X1 [KO:K09404]
117957207  E3 ubiquitin-protein ligase RING2-A-like [KO:K10695] [EC:2.3.2.27]
117954631  rnf2; E3 ubiquitin-protein ligase RING2 isoform X1 [KO:K10695] [EC:2.3.2.27]
117960230  polycomb complex protein BMI-1-like [KO:K11460]
117938317  bmi1a; polycomb complex protein BMI-1-A [KO:K11459]
117958189  cbx2; chromobox protein homolog 2 [KO:K11451]
117940816  chromobox protein homolog 2-like [KO:K11451]
117958387  cbx4; E3 SUMO-protein ligase CBX4 [KO:K11452] [EC:2.3.2.-]
117960078  E3 SUMO-protein ligase CBX4-like [KO:K11452] [EC:2.3.2.-]
117936580  cbx7b; chromobox protein homolog 7 [KO:K11454]
117958050  cbx7a; chromobox homolog 7a isoform X1 [KO:K11454]
117956322  cbx8b; chromobox protein homolog 8b [KO:K11455]
117957796  cbx8a; chromobox protein homolog 8a isoform X1 [KO:K11455]
117956432  polyhomeotic-like protein 1 isoform X1 [KO:K11456]
117946201  phc1; polyhomeotic-like protein 1 isoform X1 [KO:K11456]
117944041  phc2b; polyhomeotic-like protein 2b isoform X1 [KO:K11457]
117953568  phc3; polyhomeotic-like protein 3 isoform X1 [KO:K11458]
117950082  sex comb on midleg-like protein 2 isoform X1 [KO:K11465]
117946326  scml2; polycomb protein SCMH1 isoform X1 [KO:K11465]
117946431  polycomb protein SCMH1 isoform X1 [KO:K11461]
117938476  sfmbt2; scm-like with four MBT domains protein 2 isoform X1 [KO:K26269]
117944103  sfmbt1; scm-like with four MBT domains protein 1 isoform X1 [KO:K26269]
117935863  ubiquitin-conjugating enzyme E2 D2-like isoform X1 [KO:K06689] [EC:2.3.2.23]
117944269  ube2d4; ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
117936774  ube2d1b; ubiquitin-conjugating enzyme E2 D1b [KO:K06689] [EC:2.3.2.23]
117952063  ube2d2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
117960900  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
117942557  usp16; ubiquitin carboxyl-terminal hydrolase 16 [KO:K11844] [EC:3.4.19.12]
117946143  usp45; ubiquitin carboxyl-terminal hydrolase 45 isoform X1 [KO:K11844] [EC:3.4.19.12]
117943492  rybpb; RING1 and YY1-binding protein B [KO:K11469]
117949460  YY1-associated factor 2-like [KO:K11468]
117938402  yaf2; YY1-associated factor 2 isoform X1 [KO:K11468]
117952135  pcgf1; polycomb group RING finger protein 1 isoform X1 [KO:K11487]
117951958  kdm2ab; lysine-specific demethylase 2A [KO:K10276] [EC:1.14.11.27]
117958690  kdm2aa; lysine (K)-specific demethylase 2Aa isoform X1 [KO:K10276] [EC:1.14.11.27]
117959062  lysine-specific demethylase 2B isoform X1 [KO:K10276] [EC:1.14.11.27]
117953204  bcor; BCL-6 corepressor [KO:K23215]
117940385  BCL-6 corepressor-like [KO:K23215]
117951862  bcorl1; BCL-6 corepressor-like protein 1 [KO:K26199]
117956006  skp1; S-phase kinase-associated protein 1 [KO:K03094]
117958230  usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
117951926  polycomb group RING finger protein 3 isoform X1 [KO:K11488]
117960320  pcgf5a; polycomb group RING finger protein 5-A isoform X1 [KO:K11489]
117956302  csnk2b; casein kinase II subunit beta [KO:K03115]
117946872  casein kinase II subunit beta [KO:K03115]
117955949  auts2a; autism susceptibility gene 2 protein [KO:K23214]
117936501  fbrs; autism susceptibility gene 2 protein homolog isoform X1 [KO:K26253]
117944197  fbrsl1; autism susceptibility gene 2 protein isoform X1 [KO:K26254]
117957691  dcaf7; DDB1- and CUL4-associated factor 7 [KO:K11805]
117937319  DDB1- and CUL4-associated factor 7-like [KO:K11805]
117946406  tex10; testis-expressed protein 10 homolog [KO:K14827]
117934766  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
117936554  ep300a; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
117958044  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
117958662  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
117959995  pcgf6; polycomb group RING finger protein 6 [KO:K11470]
117961016  si:ch211-195d17.2; transcription factor E2F6 [KO:K09390]
117953369  tfdp1a; transcription factor Dp-1a [KO:K04683]
117935588  protein max-like isoform X1 [KO:K04453]
117961465  max; protein max isoform X1 [KO:K04453]
117961510  magl; MAX gene-associated protein [KO:K23399]
117936562  l3mbtl2; lethal(3)malignant brain tumor-like protein 2 isoform X1 [KO:K24387]
117946545  l3mbtl1b; lethal(3)malignant brain tumor-like protein 4 isoform X1 [KO:K24387]
117947694  l3mbtl1; lethal(3)malignant brain tumor-like protein 1 isoform X1 [KO:K24387]
117956972  cbx3a; chromobox protein homolog 3a isoform X1 [KO:K11586]
117946348  cbx3b; chromobox protein homolog 3 isoform X1 [KO:K11586]
117958930  wdr5; WD repeat-containing protein 5 [KO:K14963]
117935546  histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
117956802  hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
Reference
PMID:21881606
  Authors
Richly H, Aloia L, Di Croce L
  Title
Roles of the Polycomb group proteins in stem cells and cancer.
  Journal
Cell Death Dis 2:e204 (2011)
DOI:10.1038/cddis.2011.84
Reference
PMID:28202673
  Authors
Chittock EC, Latwiel S, Miller TC, Muller CW
  Title
Molecular architecture of polycomb repressive complexes.
  Journal
Biochem Soc Trans 45:193-205 (2017)
DOI:10.1042/BST20160173
Reference
PMID:33202645
  Authors
Geng Z, Gao Z
  Title
Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms.
  Journal
Int J Mol Sci 21:ijms21228594 (2020)
DOI:10.3390/ijms21228594
Reference
PMID:35681061
  Authors
Kim JJ, Kingston RE
  Title
Context-specific Polycomb mechanisms in development.
  Journal
Nat Rev Genet 23:680-695 (2022)
DOI:10.1038/s41576-022-00499-0
Reference
PMID:36076977
  Authors
Dong GJ, Xu JL, Qi YR, Yuan ZQ, Zhao W
  Title
Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer.
  Journal
Int J Mol Sci 23:ijms23179574 (2022)
DOI:10.3390/ijms23179574
Reference
PMID:37086328
  Authors
Ryan CW, Peirent ER, Regan SL, Guxholli A, Bielas SL
  Title
H2A monoubiquitination: insights from human genetics and animal models.
  Journal
Hum Genet 10.1007/s00439-023-02557-x (2023)
DOI:10.1007/s00439-023-02557-x
KO pathway
ko03083   
LinkDB

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