KEGG   PATHWAY: ely04261
Entry
ely04261                    Pathway                                
Name
Adrenergic signaling in cardiomyocytes - Epinephelus lanceolatus (giant grouper)
Description
Cardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, and alpha-1C). In the human heart the beta-1-AR is the pre- dominate receptor. Acute sympathetic stimulation of cardiac beta-1-ARs induces positive inotropic and chronotropic effects, the most effective mechanism to acutely increase output of the heart, by coupling to Gs, formation of cAMP by adenylyl cyclase (AC), and PKA- dependent phosphorylation of various target proteins (e.g., ryanodine receptor [RyR]; phospholamban [PLB], troponin I [TnI], and the L-type Ca2+ channel [LTCC]). Chronic beta-1-AR stimulation is detrimental and induces cardiomyocyte hypertrophy and apoptosis. beta-2-AR coupled to Gs exerts a proapoptotic action as well as beta-1-AR, while beta-2-AR coupled to Gi exerts an antiapoptotic action.
Class
Organismal Systems; Circulatory system
Pathway map
ely04261  Adrenergic signaling in cardiomyocytes
ely04261

Other DBs
GO: 0001997
Organism
Epinephelus lanceolatus (giant grouper) [GN:ely]
Gene
117246910  adrb1; beta-1 adrenergic receptor [KO:K04141]
117262340  beta-2 adrenergic receptor-like [KO:K04142]
117261449  adrb2a; adrenoceptor beta 2, surface a [KO:K04142]
117257069  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
117258383  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
117254244  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
117272452  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
117263948  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
117265672  adcy2a; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
117264741  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
117251312  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
117258192  adcy6b; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
117258226  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
117253092  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
117250016  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
117270489  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
117272061  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
117268794  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
117255130  adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
117265228  bves; blood vessel epicardial substance [KO:K21108]
117251323  popdc2; popeye domain-containing 2 isoform X1 [KO:K26206]
117265707  popdc3; popeye domain-containing protein 3 [KO:K26207]
117271223  potassium channel subfamily K member 2-like isoform X1 [KO:K04913]
117260159  potassium channel subfamily K member 2-like [KO:K04913]
117268372  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
117271818  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
117254444  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
117255397  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
117250162  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
117250223  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
117263377  atp1a3a; sodium/potassium-transporting ATPase subunit alpha-3a [KO:K01539] [EC:7.2.2.13]
117271639  atp1a2a; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
117265974  atp1a3b; sodium/potassium-transporting ATPase subunit alpha-3b isoform X1 [KO:K01539] [EC:7.2.2.13]
117250104  atp1b1b; sodium/potassium-transporting ATPase subunit beta-1b [KO:K01540]
117246116  sodium/potassium-transporting ATPase subunit beta-2-like [KO:K01540]
117265758  atp1b2b; sodium/potassium-transporting ATPase subunit beta-2b isoform X1 [KO:K01540]
117271854  sodium/potassium-transporting ATPase subunit beta-3-like [KO:K01540]
117266250  sodium/potassium-transporting ATPase subunit beta-3-like isoform X1 [KO:K01540]
117254338  atp1b1a; sodium/potassium-transporting ATPase subunit beta-1a [KO:K01540]
117260566  atp1b4; protein ATP1B4 [KO:K01540]
117263830  Na(+)/H(+) exchanger beta-like [KO:K05742]
117265759  slc9a1a; Na(+)/H(+) exchanger beta isoform X1 [KO:K05742]
117251582  kcnq1.1; potassium voltage-gated channel subfamily KQT member 1.1 [KO:K04926]
117261897  kcnq1.2; potassium voltage-gated channel subfamily KQT member 1 [KO:K04926]
117256551  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
117262414  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
117256931  atp2b2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
117258909  atp2b3b; plasma membrane calcium-transporting ATPase 3b isoform X1 [KO:K05850] [EC:7.2.2.10]
117249502  atp2b1a; plasma membrane calcium-transporting ATPase 1a isoform X1 [KO:K05850] [EC:7.2.2.10]
117245790  sodium/calcium exchanger 1-like [KO:K05849]
117246957  slc8a4a; solute carrier family 8 member 4a [KO:K05849]
117259628  sodium/calcium exchanger 2-like [KO:K05849]
117248541  slc8a1b; sodium/calcium exchanger 1b isoform X1 [KO:K05849]
117267254  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
117255567  slc8a1a; sodium/calcium exchanger 1a isoform X1 [KO:K05849]
117261918  sodium/calcium exchanger 2-like [KO:K05849]
117265098  sodium channel protein type 4 subunit alpha-like [KO:K04838]
117272115  sodium channel protein type 4 subunit alpha B-like [KO:K04838]
117263276  scn1bb; sodium channel, voltage-gated, type I, beta b [KO:K04845]
117265276  si:ch211-225p5.8; sodium channel subunit beta-1 [KO:K04845]
117265353  scn1ba; sodium channel, voltage-gated, type I, beta a [KO:K04845]
117245749  scn4bb; sodium channel, voltage-gated, type IV, beta b [KO:K04848]
117259682  LOW QUALITY PROTEIN: sodium channel subunit beta-4-like [KO:K04848]
117249155  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
117257145  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
117258176  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
117257982  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
117258407  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
117251027  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
117258405  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
117268247  voltage-dependent L-type calcium channel subunit beta-1-like isoform X1 [KO:K04862]
117264874  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
117258457  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04864]
117258595  voltage-dependent L-type calcium channel subunit beta-3-like isoform X1 [KO:K04864]
117251525  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
117255209  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
117249651  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a [KO:K04858]
117262199  LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
117257103  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
117257156  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
117257249  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
117258390  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
117249109  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
117261994  voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861]
117255813  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
117268168  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
117256041  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
117267877  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
117268287  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
117255857  voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
117255018  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
117267803  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
117254831  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
117267983  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
117264089  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
117265645  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
117263113  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
117265545  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
117263782  cacng8a; calcium channel, voltage-dependent, gamma subunit 8a [KO:K04873]
117266150  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
117250832  calmodulin-like protein 4 [KO:K02183]
117256979  calglandulin-like [KO:K02183]
117251861  calmodulin-like protein 4 [KO:K02183]
117270599  calmodulin-1 isoform X1 [KO:K02183]
117259781  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
117248328  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
117267056  calm1a; calmodulin-1a [KO:K02183]
117261975  calml4b; calmodulin-like protein 4 [KO:K02183]
117256057  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
117269440  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
117252481  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
117246069  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
117265015  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
117247050  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
117248372  calcium/calmodulin-dependent protein kinase type II delta chain isoform X1 [KO:K04515] [EC:2.7.11.17]
117247214  ryanodine receptor 2-like isoform X1 [KO:K04962]
117248117  ryr2b; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
117252712  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
117271769  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
117260490  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
117259927  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
117269535  ppp2r2ab; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
117252664  ppp2r2aa; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
117248308  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
117261035  ppp2r2ba; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
117261118  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
117255543  ppp2r2ca; protein phosphatase 2, regulatory subunit B, gamma a [KO:K04354]
117251569  ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
117247955  ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
117266802  ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
117270780  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
117246068  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
117271211  ppp2r5cb; protein phosphatase 2, regulatory subunit B', gamma b isoform X1 [KO:K11584]
117266982  ppp2r5eb; protein phosphatase 2, regulatory subunit B', epsilon isoform X1 [KO:K11584]
117248578  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
117267248  ppp2r5ca; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
117268590  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
117270724  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
117246188  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
117253113  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
117247036  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
117267401  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
117257805  tnnc1a; troponin C type 1a (slow) [KO:K05865]
117258686  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
117262293  tnnt2d; troponin T2d, cardiac [KO:K12045]
117257122  tnnt2b; troponin T, cardiac muscle isoforms isoform X1 [KO:K12045]
117258787  tnnt2a; troponin T type 2a (cardiac) isoform X1 [KO:K12045]
117249049  tnnt2c; troponin T2c, cardiac [KO:K12045]
117249263  tnnt2e; troponin T2e, cardiac isoform X1 [KO:K12045]
117262057  tpm1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
117253574  tropomyosin alpha-1 chain-like isoform X1 [KO:K10373]
117270216  tpm2; tropomyosin beta chain isoform X1 [KO:K10374]
117265784  tropomyosin alpha-3 chain-like isoform X1 [KO:K09290]
117248496  tropomyosin alpha-3 chain [KO:K09290]
117271526  tropomyosin alpha-1 chain isoform X1 [KO:K10375]
117254123  tpm4a; tropomyosin 4a isoform X1 [KO:K10375]
117256023  acta1a; actin alpha 1, skeletal muscle a [KO:K12314]
117252602  acta1b; actin alpha 1, skeletal muscle b [KO:K12314]
117270614  actc1a; actin, alpha cardiac muscle 1a [KO:K12314]
117266627  actin, alpha cardiac muscle 1 [KO:K12314]
117267022  actin, alpha cardiac [KO:K12314]
117264745  myosin-6-like isoform X1 [KO:K17751]
117270907  myh6; myosin-6 [KO:K17751]
117271987  myosin-7-like [KO:K17751]
117271988  myosin-7-like [KO:K17751]
117271989  myosin-7-like isoform X1 [KO:K17751]
117271990  LOW QUALITY PROTEIN: myosin-7-like [KO:K17751]
117256336  myl2a; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
117252834  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
117272251  myl13; myosin, light chain 13 [KO:K12749]
117268643  myl4; myosin light chain 4 [KO:K12750]
117269269  myosin light chain 4-like [KO:K12750]
117254926  pln; cardiac phospholamban [KO:K05852]
117268244  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
117269554  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
117253203  atp2a2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
117246849  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like isoform X1 [KO:K05853] [EC:7.2.2.10]
117255203  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
117268200  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
117247868  agt; angiotensinogen [KO:K09821]
117264461  agtr1b; type-1 angiotensin II receptor [KO:K04166]
117260717  type-2 angiotensin II receptor-like [KO:K04167]
117269515  adra1ab; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
117252356  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
117270361  alpha-1A adrenergic receptor-like [KO:K04136]
117260654  alpha-1A adrenergic receptor-like [KO:K04136]
117255024  adra1d; alpha-1D adrenergic receptor [KO:K04137]
117269641  guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04634]
117252448  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
117245782  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
117270860  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
117271061  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
117247302  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
117266757  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
117268354  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117255414  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
117256212  protein phosphatase 1 regulatory subunit 1A-like [KO:K08050]
117268290  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117253153  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117267206  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
117250102  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
117251482  creb1b; cyclic AMP-responsive element-binding protein 1b [KO:K05870]
117251515  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
117269048  atf4b; activating transcription factor 4b [KO:K04374]
117255624  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
117250858  creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
117251919  creb3l3l; cAMP responsive element binding protein 3-like 3 like [KO:K09048]
117253420  creb3l3a; cyclic AMP-responsive element-binding protein 3-like protein 3-A isoform X1 [KO:K09048]
117271672  cyclic AMP-responsive element-binding protein 3-like protein 3-B [KO:K09048]
117266051  cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
117255561  creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
117249402  creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
117263157  creb5a; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
117265323  creb5b; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
117263546  atf6b; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
117271519  crema; cAMP-responsive element modulator isoform X1 [KO:K09052]
117262998  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
117264318  apoptosis regulator Bcl-2-like [KO:K02161]
117257965  rapgef3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
117251637  rapgef4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
117272549  rap guanine nucleotide exchange factor 4-like isoform X1 [KO:K04351]
117257217  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
117258336  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
117258429  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
117258644  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
117253792  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
117248907  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
117249233  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
117262337  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
117257011  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
117257351  gnai2b; guanine nucleotide-binding protein G(i) subunit alpha-2b [KO:K04630]
117258430  gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
117249363  gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
117249572  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
117258808  si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
117268996  pik3r6b; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
117254817  pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
117255942  phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
117267965  phosphoinositide 3-kinase regulatory subunit 5-like isoform X1 [KO:K21290]
117259841  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117247924  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117267058  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117255629  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117268156  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00788  L-Adrenaline
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C07056  Isoproterenol
Reference
PMID:19883653
  Authors
Grimm M, Brown JH
  Title
Beta-adrenergic receptor signaling in the heart: role of CaMKII.
  Journal
J Mol Cell Cardiol 48:322-30 (2010)
DOI:10.1016/j.yjmcc.2009.10.016
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:17988210
  Authors
Bers DM
  Title
Calcium cycling and signaling in cardiac myocytes.
  Journal
Annu Rev Physiol 70:23-49 (2008)
DOI:10.1146/annurev.physiol.70.113006.100455
Reference
PMID:20923637
  Authors
Soltis AR, Saucerman JJ
  Title
Synergy between CaMKII substrates and beta-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling.
  Journal
Biophys J 99:2038-47 (2010)
DOI:10.1016/j.bpj.2010.08.016
Reference
PMID:12439640
  Authors
Wallukat G
  Title
The beta-adrenergic receptors.
  Journal
Herz 27:683-90 (2002)
DOI:10.1007/s00059-002-2434-z
Reference
PMID:11604549
  Authors
Xiao RP
  Title
Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins.
  Journal
Sci STKE 2001:re15 (2001)
DOI:10.1126/stke.2001.104.re15
Reference
PMID:10571541
  Authors
Xiao RP, Cheng H, Zhou YY, Kuschel M, Lakatta EG
  Title
Recent advances in cardiac beta(2)-adrenergic signal transduction.
  Journal
Circ Res 85:1092-100 (1999)
DOI:10.1161/01.RES.85.11.1092
Reference
PMID:15979723
  Authors
Zheng M, Zhu W, Han Q, Xiao RP
  Title
Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling.
  Journal
Pharmacol Ther 108:257-68 (2005)
DOI:10.1016/j.pharmthera.2005.04.006
Reference
PMID:17826821
  Authors
Kuzumoto M, Takeuchi A, Nakai H, Oka C, Noma A, Matsuoka S
  Title
Simulation analysis of intracellular Na+ and Cl- homeostasis during beta 1-adrenergic stimulation of cardiac myocyte.
  Journal
Prog Biophys Mol Biol 96:171-86 (2008)
DOI:10.1016/j.pbiomolbio.2007.07.005
Reference
PMID:11805843
  Authors
Bers DM
  Title
Cardiac excitation-contraction coupling.
  Journal
Nature 415:198-205 (2002)
DOI:10.1038/415198a
Reference
PMID:20658186
  Authors
Ho D, Yan L, Iwatsubo K, Vatner DE, Vatner SF
  Title
Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.
  Journal
Heart Fail Rev 15:495-512 (2010)
DOI:10.1007/s10741-010-9183-5
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:15765137
  Authors
Yano M, Ikeda Y, Matsuzaki M
  Title
Altered intracellular Ca2+ handling in heart failure.
  Journal
J Clin Invest 115:556-64 (2005)
DOI:10.1172/JCI24159
Reference
PMID:15232578
  Authors
Wehrens XH, Marks AR
  Title
Novel therapeutic approaches for heart failure by normalizing calcium cycling.
  Journal
Nat Rev Drug Discov 3:565-73 (2004)
DOI:10.1038/nrd1440
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:18407781
  Authors
Barry SP, Davidson SM, Townsend PA
  Title
Molecular regulation of cardiac hypertrophy.
  Journal
Int J Biochem Cell Biol 40:2023-39 (2008)
DOI:10.1016/j.biocel.2008.02.020
Related
pathway
ely04020  Calcium signaling pathway
ely04260  Cardiac muscle contraction
KO pathway
ko04261   
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