KEGG   PATHWAY: foc04120
Entry
foc04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Frankliniella occidentalis (western flower thrips)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
foc04120  Ubiquitin mediated proteolysis
foc04120

Other DBs
GO: 0016567
Organism
Frankliniella occidentalis (western flower thrips) [GN:foc]
Gene
113216694  uncharacterized protein LOC113216694 [KO:K04551]
113216116  uncharacterized protein LOC113216116 [KO:K08770]
113208853  polyubiquitin-B [KO:K08770]
113207785  ubiquitin-60S ribosomal protein L40 [KO:K02927]
113203885  ubiquitin-40S ribosomal protein S27a [KO:K02977]
113201768  ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
113207583  SUMO-activating enzyme subunit 1 [KO:K10684] [EC:6.2.1.45]
113214553  SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
113209089  NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
113206419  ubiquitin-conjugating enzyme E2 A isoform X1 [KO:K10573] [EC:2.3.2.23]
113212628  ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
113212711  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
113214153  ubiquitin-conjugating enzyme E2 T-like [KO:K06689] [EC:2.3.2.23]
113215599  ubiquitin-conjugating enzyme E2 D2B-like [KO:K06689] [EC:2.3.2.23]
113215719  uncharacterized protein LOC113215719 [KO:K06689] [EC:2.3.2.23]
113215960  uncharacterized protein LOC113215960 [KO:K20217] [EC:2.3.2.23]
113209608  ubiquitin-conjugating enzyme E2-24 kDa [KO:K20217] [EC:2.3.2.23]
113212581  ubiquitin-conjugating enzyme E2 E2-like [KO:K20217] [EC:2.3.2.23]
113207019  NEDD8-conjugating enzyme UBE2F [KO:K10687] [EC:2.3.2.34]
113217845  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
113211121  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
113218403  ubiquitin-conjugating enzyme E2 H [KO:K10576] [EC:2.3.2.23]
113216085  SUMO-conjugating enzyme UBC9 [KO:K10577]
113214589  ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
113206860  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
113215428  uncharacterized protein LOC113215428 [KO:K04649] [EC:2.3.2.23]
113215471  probable ubiquitin-conjugating enzyme E2 21 [KO:K04649] [EC:2.3.2.23]
113209891  ubiquitin-conjugating enzyme E2-22 kDa [KO:K04649] [EC:2.3.2.23]
113209777  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
113216631  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
113203156  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
113206915  (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O [KO:K10581] [EC:2.3.2.24]
113203332  ubiquitin-conjugating enzyme E2 Q2 [KO:K10582] [EC:2.3.2.23]
113211049  ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
113216064  ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
113203704  ubiquitin-conjugating enzyme E2 W isoform X1 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
113209036  ubiquitin-conjugating enzyme E2 Z-like [KO:K10585] [EC:2.3.2.23]
113204398  ubiquitin-conjugating enzyme E2 Z-like [KO:K10585] [EC:2.3.2.23]
127751139  ubiquitin-conjugating enzyme E2 Z-like [KO:K10585] [EC:2.3.2.23]
113204864  baculoviral IAP repeat-containing protein 6 [KO:K10586] [EC:2.3.2.23]
113207782  ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
113208950  ubiquitin-protein ligase E3B [KO:K10588] [EC:2.3.2.26]
113213495  ubiquitin-protein ligase E3C [KO:K10589] [EC:2.3.2.26]
113205595  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
113215068  E3 ubiquitin-protein ligase Su(dx) [KO:K05633] [EC:2.3.2.26]
113217674  E3 ubiquitin-protein ligase TRIP12 [KO:K10590] [EC:2.3.2.26]
113212990  E3 ubiquitin-protein ligase Nedd-4 isoform X1 [KO:K10591] [EC:2.3.2.26]
113214953  E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
113206740  E3 ubiquitin-protein ligase UBR5 [KO:K10593] [EC:2.3.2.26]
113201914  probable E3 ubiquitin-protein ligase HERC1 isoform X1 [KO:K10594] [EC:2.3.2.26]
113205593  E3 ubiquitin-protein ligase HERC2 [KO:K10595] [EC:2.3.2.26]
113209753  probable E3 ubiquitin-protein ligase HERC4 [KO:K10615] [EC:2.3.2.26]
113218263  ubiquitin conjugation factor E4 A [KO:K10596] [EC:2.3.2.27]
113208155  ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
113206935  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
113205058  RING-type E3 ubiquitin-protein ligase PPIL2 [KO:K10598] [EC:5.2.1.8]
113201788  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
113202530  RING finger protein 37 [KO:K10600]
113207599  E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
113205795  E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
113214199  uncharacterized protein LOC113214199 [KO:K04506] [EC:2.3.2.27]
113207164  uncharacterized protein LOC113207164 [KO:K04506] [EC:2.3.2.27]
113216540  E3 ubiquitin-protein ligase SIAH1A [KO:K04506] [EC:2.3.2.27]
113204182  E3 ubiquitin-protein ligase sina-like [KO:K04506] [EC:2.3.2.27]
113213546  TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
113213586  mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
113212570  E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
113211463  RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
113211278  death-associated inhibitor of apoptosis 2 [KO:K16060]
113213914  baculoviral IAP repeat-containing protein 2-like [KO:K16061]
113214762  death-associated inhibitor of apoptosis 1 isoform X1 [KO:K16061]
113206208  baculoviral IAP repeat-containing protein 3-like [KO:K16061]
113215906  E3 ubiquitin-protein ligase XIAP-like [KO:K16061]
113215964  baculoviral IAP repeat-containing protein 7 isoform X3 [KO:K16061]
113216838  death-associated inhibitor of apoptosis 2-like [KO:K16061]
113216836  baculoviral IAP repeat-containing protein 7-B-like [KO:K16061]
113207731  uncharacterized protein LOC113207731 [KO:K16061]
113208092  baculoviral IAP repeat-containing protein 2-like [KO:K16061]
113211537  death-associated inhibitor of apoptosis 1 isoform X1 [KO:K16061]
113212597  E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K04706] [EC:2.3.2.-]
113202786  E3 ubiquitin-protein ligase synoviolin B [KO:K10601] [EC:2.3.2.27]
113207045  uncharacterized protein LOC113207045 [KO:K10602] [EC:2.3.2.27]
113208599  uncharacterized protein LOC113208599 [KO:K10602] [EC:2.3.2.27]
113206708  E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
113212880  uncharacterized protein LOC113212880 [KO:K10607] [EC:2.3.2.27]
113213382  uncharacterized protein LOC113213382 [KO:K10607] [EC:2.3.2.27]
113213575  uncharacterized protein LOC113213575 isoform X2 [KO:K10607] [EC:2.3.2.27]
113205863  E3 ubiquitin-protein ligase rnf152-B-like [KO:K10607] [EC:2.3.2.27]
113206287  uncharacterized protein LOC113206287 [KO:K10607] [EC:2.3.2.27]
113207087  uncharacterized protein LOC113207087 [KO:K10607] [EC:2.3.2.27]
113217358  uncharacterized protein LOC113217358 [KO:K10607] [EC:2.3.2.27]
113208725  uncharacterized protein LOC113208725 [KO:K10607] [EC:2.3.2.27]
113210024  uncharacterized protein LOC113210024 isoform X1 [KO:K10607] [EC:2.3.2.27]
113210553  uncharacterized protein LOC113210553 [KO:K10607] [EC:2.3.2.27]
113211376  uncharacterized protein LOC113211376 isoform X1 [KO:K10607] [EC:2.3.2.27]
113201769  E3 ubiquitin-protein ligase TRIM37 [KO:K10608] [EC:2.3.2.27]
113211873  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
113208456  cullin-1 [KO:K03347]
113213403  S-phase kinase-associated protein 1-like [KO:K03094]
113212685  S-phase kinase-associated protein 1-like [KO:K03094]
113214546  F-box/WD repeat-containing protein 1A [KO:K03362]
113204821  uncharacterized protein LOC113204821 [KO:K03875]
113205756  S-phase kinase-associated protein 2 [KO:K03875]
113215176  uncharacterized protein LOC113215176 isoform X1 [KO:K03875]
113206717  uncharacterized protein LOC113206717 [KO:K03875]
113206745  uncharacterized protein LOC113206745 [KO:K03875]
113215554  uncharacterized protein LOC113215554 isoform X1 [KO:K03875]
113207325  uncharacterized protein LOC113207325 [KO:K03875]
113209149  uncharacterized protein LOC113209149 [KO:K03875]
113211511  uncharacterized protein LOC113211511 isoform X3 [KO:K03875]
113203842  F-box/WD repeat-containing protein 7 [KO:K10260]
113207318  uncharacterized protein LOC113207318 isoform X1 [KO:K10099]
113211727  uncharacterized protein LOC113211727 [KO:K10099]
113212558  cullin-2 [KO:K03870]
113211360  elongin-B [KO:K03873]
113217497  cullin-3 [KO:K03869]
113210352  kelch-like ECH-associated protein 1B isoform X1 [KO:K10456]
113210788  rho-related BTB domain-containing protein 1 [KO:K07868]
113210406  uncharacterized protein LOC113210406 [KO:K03876]
113209010  cullin-4A [KO:K10609]
113203498  DNA damage-binding protein 1 [KO:K10610]
113204678  DNA excision repair protein ERCC-8 [KO:K10570]
113208210  DET1 homolog [KO:K10571]
113211213  RING-box protein 2 [KO:K10611]
113203886  cullin-5 isoform X1 [KO:K10612]
113210429  anaphase-promoting complex subunit 2 [KO:K03349]
113217302  cell division cycle protein 20 homolog [KO:K03363]
113212912  fizzy-related protein homolog [KO:K03364]
113202332  fizzy-related protein homolog [KO:K03364]
113204908  anaphase-promoting complex subunit 1 [KO:K03348]
113204012  cell division cycle protein 27 homolog [KO:K03350]
113212913  anaphase-promoting complex subunit 4 [KO:K03351]
113202581  anaphase-promoting complex subunit 5 [KO:K03352]
113213732  cell division cycle protein 16 homolog [KO:K03353]
113211550  anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
113209387  cell division cycle protein 23 homolog [KO:K03355]
113203193  anaphase-promoting complex subunit 10 [KO:K03357]
113202572  anaphase-promoting complex subunit CDC26-like [KO:K03359]
113202206  anaphase-promoting complex subunit 13 isoform X1 [KO:K12456]
113212329  anaphase-promoting complex subunit 15B [KO:K25228]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
foc03050  Proteasome
KO pathway
ko04120   
LinkDB

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