KEGG   PATHWAY: hgl04727
Entry
hgl04727                    Pathway                                
Name
GABAergic synapse - Heterocephalus glaber (naked mole-rat)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
hgl04727  GABAergic synapse
hgl04727

Other DBs
GO: 0051932
Organism
Heterocephalus glaber (naked mole-rat) [GN:hgl]
Gene
101717270  Slc38a1; solute carrier family 38 member 1 [KO:K14990]
101721683  Slc38a2; solute carrier family 38 member 2 [KO:K14207]
101705236  Gls2; glutaminase 2 [KO:K01425] [EC:3.5.1.2]
101719951  Gls; glutaminase [KO:K01425] [EC:3.5.1.2]
101725846  Gad1; glutamate decarboxylase 1 [KO:K01580] [EC:4.1.1.15]
101698166  Gad2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
101716322  glutamate decarboxylase 1-like [KO:K01580] [EC:4.1.1.15]
101725145  Slc32a1; solute carrier family 32 member 1 [KO:K15015]
101712584  Abat; 4-aminobutyrate aminotransferase [KO:K13524] [EC:2.6.1.19 2.6.1.22]
101719179  Gabra1; gamma-aminobutyric acid type A receptor alpha1 subunit [KO:K05175]
101720123  Gabra6; gamma-aminobutyric acid type A receptor alpha6 subunit [KO:K05175]
101718327  Gabra4; gamma-aminobutyric acid type A receptor alpha4 subunit [KO:K05175]
101720776  Gabra2; gamma-aminobutyric acid type A receptor alpha2 subunit [KO:K05175]
101714519  Gabra3; gamma-aminobutyric acid type A receptor alpha3 subunit [KO:K05175]
101712275  Gabra5; gamma-aminobutyric acid type A receptor alpha5 subunit [KO:K05175]
101721168  Gabrb2; gamma-aminobutyric acid type A receptor beta2 subunit [KO:K05181]
101717539  Gabrb1; gamma-aminobutyric acid type A receptor beta1 subunit [KO:K05181]
101711687  Gabrb3; gamma-aminobutyric acid type A receptor beta3 subunit [KO:K05181]
101718598  Gabrg2; gamma-aminobutyric acid type A receptor gamma2 subunit [KO:K05186]
101721607  Gabrg1; gamma-aminobutyric acid type A receptor gamma1 subunit [KO:K05186]
101712623  Gabrg3; gamma-aminobutyric acid type A receptor gamma3 subunit [KO:K05186]
101700143  Gabrd; gamma-aminobutyric acid type A receptor delta subunit [KO:K05184]
101722562  Gabre; gamma-aminobutyric acid type A receptor epsilon subunit [KO:K05185]
101714872  Gabrq; gamma-aminobutyric acid type A receptor theta subunit [KO:K05192]
101703647  Gabrp; gamma-aminobutyric acid type A receptor pi subunit [KO:K05189]
101707235  Prkaca; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101721558  Prkacb; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101703827  Src; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
101716044  Prkca; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
101722702  Prkcb; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
101698346  Prkcg; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
101706208  Gabarapl2; GABA type A receptor associated protein like 2 [KO:K08341]
101710547  Gabarapl1; GABA type A receptor associated protein like 1 [KO:K08341]
101711840  Gabarap; GABA type A receptor-associated protein [KO:K08341]
101723819  Nsf; N-ethylmaleimide sensitive factor, vesicle fusing ATPase [KO:K06027] [EC:3.6.4.6]
101701518  Trak2; trafficking kinesin protein 2 [KO:K15374]
101701018  Plcl1; phospholipase C like 1 [KO:K15375]
101725958  Gphn; gephyrin [KO:K15376] [EC:2.10.1.1 2.7.7.75]
101716676  Slc12a5; solute carrier family 12 member 5 [KO:K23967]
101724728  Gabrr1; gamma-aminobutyric acid type A receptor rho1 subunit [KO:K05190]
101724024  Gabrr2; gamma-aminobutyric acid type A receptor rho2 subunit [KO:K05190]
101699269  Gabrr3; gamma-aminobutyric acid type A receptor rho3 subunit [KO:K05190]
101725815  Cacna1a; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
101697609  Cacna1b; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
101717129  Cacna1c; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
101714832  Cacna1d; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
101722090  Cacna1f; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
101726232  Cacna1s; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
101719480  Gabbr1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
101719923  Gabbr2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
101698645  Gnai2; G protein subunit alpha i2 [KO:K04630]
101702965  Gnai1; G protein subunit alpha i1 [KO:K04630]
101703043  Gnai3; G protein subunit alpha i3 [KO:K04630]
101723580  Gnao1; G protein subunit alpha o1 [KO:K04534]
101703108  Gnb1; G protein subunit beta 1 [KO:K04536]
101711479  Gnb2; G protein subunit beta 2 [KO:K04537]
101718903  Gnb3; G protein subunit beta 3 [KO:K07825]
101714761  Gnb4; G protein subunit beta 4 [KO:K04538]
101698655  Gnb5; G protein subunit beta 5 [KO:K04539]
101719408  Gng2; G protein subunit gamma 2 [KO:K07826]
101726057  Gng3; G protein subunit gamma 3 [KO:K04540]
101696772  Gng4; G protein subunit gamma 4 [KO:K04541]
101718403  Gng5; G protein subunit gamma 5 [KO:K04542]
101711281  Gng7; G protein subunit gamma 7 [KO:K04543]
106007571  Gng8; G protein subunit gamma 8 [KO:K04544]
106007577  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101721082  Gng11; G protein subunit gamma 11 [KO:K04546]
101725110  Gng12; G protein subunit gamma 12 [KO:K04347]
101709292  Gng13; G protein subunit gamma 13 [KO:K04547]
101720513  Gngt1; G protein subunit gamma transducin 1 [KO:K04548]
101721190  Gngt2; G protein subunit gamma transducin 2 [KO:K04549]
101711366  Adcy1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
101718304  Adcy2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
101713887  Adcy3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
101719464  Adcy4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
101702436  Adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
101698189  Adcy6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
101712483  Adcy7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
101698293  Adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
101714605  Adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
101719327  Kcnj6; potassium voltage-gated channel subfamily J member 6 [KO:K05000]
101716075  Slc6a1; solute carrier family 6 member 1 [KO:K05034]
101697408  Slc6a13; solute carrier family 6 member 13 [KO:K05046]
101716874  Slc6a11; solute carrier family 6 member 11 [KO:K05044]
101725721  Slc6a12; solute carrier family 6 member 12 [KO:K05045]
101696542  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
101703275  Glul; glutamate-ammonia ligase [KO:K01915] [EC:6.3.1.2]
101696761  Slc38a3; solute carrier family 38 member 3 [KO:K13576]
101699470  Slc38a5; solute carrier family 38 member 5 [KO:K14992]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
hgl00020  Citrate cycle (TCA cycle)
hgl00250  Alanine, aspartate and glutamate metabolism
hgl04144  Endocytosis
hgl04721  Synaptic vesicle cycle
KO pathway
ko04727   
LinkDB

DBGET integrated database retrieval system