KEGG   PATHWAY: hrt04530
Entry
hrt04530                    Pathway                                
Name
Tight junction - Hirundo rustica (Barn swallow)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
hrt04530  Tight junction
hrt04530

Other DBs
GO: 0005923
Organism
Hirundo rustica (Barn swallow) [GN:hrt]
Gene
120757284  CLDN16; claudin-16 [KO:K06087]
120757304  CLDN18; claudin-18 isoform X1 [KO:K06087]
120757337  CLDN1; claudin-1 [KO:K06087]
120757402  claudin-19-like [KO:K06087]
120758758  CLDN12; claudin-12 [KO:K06087]
120753186  CLDN23; claudin-23 [KO:K06087]
120753447  CLDN22; claudin-22 [KO:K06087]
120765414  claudin-8-like [KO:K06087]
120765506  claudin-8-like [KO:K06087]
120760354  CLDN5; claudin-5 [KO:K06087]
120748970  CLDN10; claudin-10 isoform X1 [KO:K06087]
120749155  CLDN14; claudin-14 [KO:K06087]
120749502  CLDN34; claudin-34 [KO:K06087]
120761287  claudin-4-like [KO:K06087]
120761289  claudin-4-like [KO:K06087]
120761327  CLDN3; LOW QUALITY PROTEIN: claudin-3 [KO:K06087]
120750321  CLDN20; claudin-20 [KO:K06087]
120762005  CLDN2; claudin-2 [KO:K06087]
120762293  CLDN19; claudin-19 [KO:K06087]
120762319  claudin-16-like isoform X1 [KO:K06087]
120762618  CLDN25; putative claudin-25 [KO:K06087]
120757033  CLDN11; claudin-11 [KO:K06087]
120748150  OCLN; occludin [KO:K06088]
120748527  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
120762533  JAM3; junctional adhesion molecule C [KO:K06785]
120749930  BVES; blood vessel epicardial substance isoform X1 [KO:K21108]
120762393  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
120757551  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
120763355  partitioning defective 6 homolog gamma-like [KO:K06093]
120760294  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
120753967  PALS1; protein PALS1 [KO:K06091]
120755067  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
120763443  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
120756464  PATJ; inaD-like protein isoform X1 [KO:K06092]
120765135  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
120762219  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
120757030  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
120762016  AMOT; angiomotin isoform X1 [KO:K16819]
120757342  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
120748742  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
120759475  ARHGAP17; rho GTPase-activating protein 17 [KO:K20638]
120759467  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
120760419  NF2; merlin isoform X1 [KO:K16684]
120761483  merlin-like isoform X1 [KO:K16684]
120759463  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X2 [KO:K06094]
120761053  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
120756916  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
120766020  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
120752973  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
120759117  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
120763994  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
120752588  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
120759323  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
120755692  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
120751183  PARD3; LOW QUALITY PROTEIN: partitioning defective 3 homolog [KO:K04237]
120765479  TIAM1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
120758914  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
120750252  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
120748888  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
120761983  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
120758604  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
120765505  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
120758661  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
120764227  ARHGEF2; rho guanine nucleotide exchange factor 2 [KO:K12791]
120758077  RHOA; transforming protein RhoA [KO:K04513]
120750170  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
120757578  MARVELD3; MARVEL domain-containing protein 3 [KO:K21099]
120763438  MARVEL domain-containing protein 3-like isoform X1 [KO:K21099]
120765209  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X2 [KO:K04416] [EC:2.7.11.25]
120752924  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120759043  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
120755638  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120756728  transcription factor Jun [KO:K04448]
120756742  transcription factor Jun [KO:K04448]
120758344  antigen-presenting glycoprotein CD1d-like [KO:K06448]
120758423  T-cell surface glycoprotein CD1b-3-like isoform X1 [KO:K06448]
120751779  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
120751693  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
120764122  PCNA; proliferating cell nuclear antigen [KO:K04802]
120754042  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
120749442  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
120759162  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
120761017  NHERF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
120749813  EZR; ezrin [KO:K08007]
120747727  RDX; radixin isoform X1 [KO:K05762]
120764832  MSN; moesin isoform X1 [KO:K05763]
120750148  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
120758534  actin, cytoplasmic type 5 [KO:K05692]
120759701  ACTB; actin, cytoplasmic 1 [KO:K05692]
120760819  ACTG1; actin, cytoplasmic 2 [KO:K05692]
120758054  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X2 [KO:K04851]
120750435  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
120760123  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
120752311  hematopoietic lineage cell-specific protein-like [KO:K06106]
120754016  CTTN; src substrate cortactin isoform X1 [KO:K06106]
120749920  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
120754994  ACTR3B; actin-related protein 3B [KO:K18584]
120755166  ACTR3; actin-related protein 3 [KO:K18584]
120759547  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
120759548  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
120755490  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
120760594  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
120758167  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
120756693  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
120761661  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
120758662  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
120748267  vasodilator-stimulated phosphoprotein-like [KO:K06274]
120756314  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
120764337  RAB13; ras-related protein Rab-13 isoform X3 [KO:K06109]
120763349  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
120750173  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
120750590  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
120760725  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
120759495  EPB41L4B; band 4.1-like protein 4B isoform X1 [KO:K21111]
120763345  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
120765321  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
120756566  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
120760678  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
120756875  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
120764416  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X2 [KO:K07200]
120747591  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
120754968  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
120752177  MYH9; myosin-9 [KO:K10352]
120759740  MYH11; myosin-11 isoform X1 [KO:K10352]
120760999  MYH10; myosin-10 isoform X1 [KO:K10352]
120760134  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
120758110  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
120758125  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
120749275  IGSF5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
120758152  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
120759430  SYNPO; synaptopodin [KO:K21112]
120753895  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
120759895  MICALL2; MICAL-like protein 2 [KO:K21068]
120763547  RAB8A; ras-related protein Rab-8A [KO:K07901]
120758645  RAB8B; ras-related protein Rab-8B isoform X1 [KO:K07902]
120759090  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
120762694  RAP1A; ras-related protein Rap-1A [KO:K04353]
120749084  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
120750882  AFDN; afadin isoform X1 [KO:K05702]
120765110  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
120752511  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
120764801  RAP2C; ras-related protein Rap-2c [KO:K07839]
120765717  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
120751692  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
120752423  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
120764463  tubulin alpha-1B chain [KO:K07374]
120764464  TUBA1A; tubulin alpha-1A chain [KO:K07374]
120764465  tubulin alpha-1C chain [KO:K07374]
120754853  tubulin alpha-4A chain-like [KO:K07374]
120754957  tubulin alpha-5 chain [KO:K07374]
120757006  tubulin alpha-3 chain-like isoform X1 [KO:K07374]
120762739  tubulin alpha-8 chain [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
hrt04520  Adherens junction
hrt04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
LinkDB

DBGET integrated database retrieval system