KEGG   PATHWAY: kmr04625
Entry
kmr04625                    Pathway                                
Name
C-type lectin receptor signaling pathway - Kryptolebias marmoratus (mangrove rivulus)
Description
C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of one or more C-type lectin-like domains (CTLDs). CLRs function as pattern-recognition receptors (PRRs) for pathogen-derived ligands in dendric cells, macrophages, neutrophils, etc., such as Dectin-1 and Dectin-2 for recognition of fungi-derived B-glucan and high mannose-type carbohydrates. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
Class
Organismal Systems; Immune system
Pathway map
kmr04625  C-type lectin receptor signaling pathway
kmr04625

Organism
Kryptolebias marmoratus (mangrove rivulus) [GN:kmr]
Gene
108239982  GTPase HRas [KO:K02833]
108239964  kras; GTPase KRas isoform X1 [KO:K07827]
108243005  zgc:55558 [KO:K07827]
108238565  si:ch73-116o1.2; ras-related protein M-Ras [KO:K07831]
108229600  rras2; ras-related protein R-Ras2 [KO:K07830]
108248470  rras; ras-related protein R-Ras [KO:K07830]
108232050  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
108239405  rela; transcription factor p65 isoform X1 [KO:K04735]
108240923  relb; transcription factor RelB isoform X1 [KO:K09253]
108239606  interleukin-12 subunit alpha-like [KO:K05406]
108240891  il12a; interleukin-12 subunit alpha [KO:K05406]
108233659  si:dkey-88e18.2; interleukin-12 subunit beta [KO:K05425]
108238912  il12bb; interleukin-12 subunit beta [KO:K05425]
108245805  il12ba; interleukin 12Ba [KO:K05425]
108242738  il1b; interleukin-1 beta [KO:K04519]
108246454  syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
108247149  ptpn11a; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
108233149  ptpn11b; tyrosine-protein phosphatase non-receptor type 11b isoform X1 [KO:K07293] [EC:3.1.3.48]
108246150  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
108250658  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
108234021  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
108246223  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
108237447  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
108235741  itpr1a; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
108244393  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
108239960  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X2 [KO:K04959]
108251566  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
108228616  calm2a; calmodulin 2a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
108231843  calm1b; calmodulin-1b [KO:K02183]
108240935  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
108234765  calml4a; calmodulin-like protein 4a [KO:K02183]
108241768  calm1a; calmodulin-1a [KO:K02183]
108237970  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108234843  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
108246435  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
108236996  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108242565  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
108247263  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
108229266  nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
108234144  nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
108237581  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
108231519  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
108248250  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
108237384  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
108232776  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
108235691  il10; interleukin-10 [KO:K05443]
108245162  egr2b; early growth response protein 2b [KO:K12496]
108246627  early growth response protein 2b [KO:K12496]
108236438  egr3; early growth response protein 3 [KO:K12497]
108238364  ptgs2b; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
108235712  prkcda; protein kinase C, delta a isoform X1 [KO:K06068] [EC:2.7.11.13]
108242980  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108244549  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108229035  pycard; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
108245830  card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
108241637  bcl10; B-cell lymphoma/leukemia 10 [KO:K07368]
108229866  malt3; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369] [EC:3.4.22.-]
108233559  malt1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369] [EC:3.4.22.-]
108230600  malt2; MALT paracaspase 2 [KO:K07369] [EC:3.4.22.-]
108238317  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
108238318  caspase-8-like [KO:K04398] [EC:3.4.22.61]
108239714  casp10; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
108249185  ikbkg; NF-kappa-B essential modulator [KO:K07210]
108233707  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
108231757  nfkbiaa; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a [KO:K04734]
108241774  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
108228584  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
108248581  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
108237567  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
108233125  mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
108233159  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
108251045  mapk12b; mitogen-activated protein kinase 12b isoform X1 [KO:K04441] [EC:2.7.11.24]
108251047  mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
108244594  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
108246862  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
108230987  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108234067  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
108240588  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
108238338  transcription factor AP-1 [KO:K04448]
108230559  jun; transcription factor AP-1 [KO:K04448]
108239388  fcer1g; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
108243522  arhgef12a; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
108249419  transforming protein RhoA-like [KO:K04513]
108235763  transforming protein RhoA [KO:K04513]
108233110  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
108235231  rho-related GTP-binding protein RhoA-D [KO:K04513]
108235226  rho-related GTP-binding protein RhoC [KO:K04513]
108248931  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
108233907  kinase suppressor of Ras 1 isoform X1 [KO:K14958]
108239684  plk3; serine/threonine-protein kinase PLK3 isoform X1 [KO:K08862] [EC:2.7.11.21]
108231632  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
108237634  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
108235567  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
108250770  signal transducer and activator of transcription 1-alpha/beta-like isoform X3 [KO:K11220]
108229342  stat1a; signal transducer and activator of transcription 1a [KO:K11220]
108234714  irf9; interferon regulatory factor 9 [KO:K04693]
108235753  stat2; signal transducer and activator of transcription 2 [KO:K11221]
108244212  il17d; interleukin-17D [KO:K05492]
108248620  si:cabz01101003.1; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
108246647  cyldl; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
108244381  cyldb; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
108243338  cylda; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
108235482  bcl3; B-cell lymphoma 3 protein homolog [KO:K09258]
108235782  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
108235450  si:ch73-86n18.1; C-type lectin domain family 4 member E [KO:K10059]
108238323  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108239366  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108236692  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
108248584  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108238424  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108245882  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
108244850  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108250884  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108247561  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
108238336  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108234365  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108244154  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108236811  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108246299  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108238174  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108249644  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
108238035  irf1b; interferon regulatory factor 1b isoform X1 [KO:K09444]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00159  D-Mannose
C00165  Diacylglycerol
C00584  Prostaglandin E2
C00965  1,3-beta-D-Glucan
C01019  L-Fucose
C01245  D-myo-Inositol 1,4,5-trisphosphate
C16844  Hydroxyl radical
C21790  Mycobacterial trehalose dimycolate
C21791  Rhodocytin
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:27291962
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
C-type lectin receptors in the control of T helper cell differentiation.
  Journal
Nat Rev Immunol 16:433-48 (2016)
DOI:10.1038/nri.2016.55
Reference
PMID:21350579
  Authors
Hajishengallis G, Lambris JD
  Title
Microbial manipulation of receptor crosstalk in innate immunity.
  Journal
Nat Rev Immunol 11:187-200 (2011)
DOI:10.1038/nri2918
Reference
PMID:28604735
  Authors
Iliev ID, Leonardi I
  Title
Fungal dysbiosis: immunity and interactions at mucosal barriers.
  Journal
Nat Rev Immunol 17:635-646 (2017)
DOI:10.1038/nri.2017.55
Reference
PMID:25002863
  Authors
Richardson MB, Williams SJ
  Title
MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
  Journal
Front Immunol 5:288 (2014)
DOI:10.3389/fimmu.2014.00288
Reference
PMID:21924922
  Authors
Vautier S, MacCallum DM, Brown GD
  Title
C-type lectin receptors and cytokines in fungal immunity.
  Journal
Cytokine 58:89-99 (2012)
DOI:10.1016/j.cyto.2011.08.031
Reference
PMID:22170181
  Authors
Gauglitz GG, Callenberg H, Weindl G, Korting HC
  Title
Host defence against Candida albicans and the role of pattern-recognition receptors.
  Journal
Acta Derm Venereol 92:291-8 (2012)
DOI:10.2340/00015555-1250
Reference
PMID:22973279
  Authors
Cunha C, Carvalho A, Esposito A, Bistoni F, Romani L
  Title
DAMP signaling in fungal infections and diseases.
  Journal
Front Immunol 3:286 (2012)
DOI:10.3389/fimmu.2012.00286
Reference
PMID:29449845
  Authors
Tang J, Lin G, Langdon WY, Tao L, Zhang J
  Title
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.
  Journal
Front Immunol 9:123 (2018)
DOI:10.3389/fimmu.2018.00123
Reference
PMID:27999992
  Authors
Mayer S, Raulf MK, Lepenies B
  Title
C-type lectins: their network and roles in pathogen recognition and immunity.
  Journal
Histochem Cell Biol 147:223-237 (2017)
DOI:10.1007/s00418-016-1523-7
Reference
PMID:23570314
  Authors
Plato A, Willment JA, Brown GD
  Title
C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.
  Journal
Int Rev Immunol 32:134-56 (2013)
DOI:10.3109/08830185.2013.777065
Reference
PMID:22344277
  Authors
Dupaul-Chicoine J, Saleh M
  Title
A new path to IL-1beta production controlled by caspase-8.
  Journal
Nat Immunol 13:211-2 (2012)
DOI:10.1038/ni.2241
Reference
PMID:24009832
  Authors
Batbayar S, Lee DH, Kim HW
  Title
Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.
  Journal
Biomol Ther (Seoul) 20:433-45 (2012)
DOI:10.4062/biomolther.2012.20.5.433
Reference
PMID:28606994
  Authors
Bendickova K, Tidu F, Fric J
  Title
Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.
  Journal
EMBO Mol Med 9:990-999 (2017)
DOI:10.15252/emmm.201707698
Reference
PMID:18998127
  Authors
den Dunnen J, Gringhuis SI, Geijtenbeek TB
  Title
Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
  Journal
Cancer Immunol Immunother 58:1149-57 (2009)
DOI:10.1007/s00262-008-0615-1
Reference
PMID:28640912
  Authors
Marakalala MJ, Ndlovu H
  Title
Signaling C-type lectin receptors in antimycobacterial immunity.
  Journal
PLoS Pathog 13:e1006333 (2017)
DOI:10.1371/journal.ppat.1006333
Reference
PMID:24867235
  Authors
Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TB
  Title
Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation.
  Journal
Nat Commun 5:3898 (2014)
DOI:10.1038/ncomms4898
Reference
PMID:19521399
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
Signalling through C-type lectin receptors: shaping immune responses.
  Journal
Nat Rev Immunol 9:465-79 (2009)
DOI:10.1038/nri2569
Reference
PMID:19122653
  Authors
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB
  Title
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.
  Journal
Nat Immunol 10:203-13 (2009)
DOI:10.1038/ni.1692
KO pathway
ko04625   
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